MX2012002276A - Compuestos eteres aralquil bencilicos, proceso de preparacion de los mismos, compuestos intermediarios, uso de dichos compuestos, metodo de tratamiento y/o prevencion, composicion farmaceutica y medicamento que contiene dichos compuestos. - Google Patents

Compuestos eteres aralquil bencilicos, proceso de preparacion de los mismos, compuestos intermediarios, uso de dichos compuestos, metodo de tratamiento y/o prevencion, composicion farmaceutica y medicamento que contiene dichos compuestos.

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Publication number
MX2012002276A
MX2012002276A MX2012002276A MX2012002276A MX2012002276A MX 2012002276 A MX2012002276 A MX 2012002276A MX 2012002276 A MX2012002276 A MX 2012002276A MX 2012002276 A MX2012002276 A MX 2012002276A MX 2012002276 A MX2012002276 A MX 2012002276A
Authority
MX
Mexico
Prior art keywords
compounds
stands
hydrogen
aryl
halogen
Prior art date
Application number
MX2012002276A
Other languages
English (en)
Inventor
Artur Franz Keppler
Sergio Luiz Sacurai
Marcio Henrique Zaim
Carlos Eduardo Da Costa Touzarim
Original Assignee
Biolab Sanus Farmaceutica Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43627099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012002276(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biolab Sanus Farmaceutica Ltda filed Critical Biolab Sanus Farmaceutica Ltda
Publication of MX2012002276A publication Critical patent/MX2012002276A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C22/00—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
    • C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
    • C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
    • C07C22/08—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención describe nuevos compuestos antifúngicos que son éteres aralquil bencílicos, de la fórmula (I): (ver fórmula (I)) donde: Ar representa arilo, imidazolilo, 1,2,4-triazolilo o bencimidazolilo; R1, R2, R4 y R5 representan, en forma independiente, hidrógeno, halógeno, alquilo C1-6; R3 representa halógeno, alquilo C1-6 u O-R', donde R' representa hidrógeno o alquilos inferiores; R6 representa arilo, arilo sustituido, trifluorometilo, triclorometilo u O-R', donde R' representa hidrógeno o alquilos inferiores, siendo los sustituyentes del arilo un halógeno o un radical tetrazolilo; n y m representan, en forma independiente, un número entero comprendido entre 0 y5; con la condición de que, cuando Ar fuera imidazolilo, R3 fuera cloro, R6 fuera p-fenilo y R1, R2, R4 y R5 fueran hidrógenos, n deba ser diferente de 2, y cuando n y m fuera diferente de 0 y 1, R3 o R6 puedan ser representados por sustituyentes no necesariamente iguales La presente invención también se refiere a las sales, solvatos, prodrogas, ésteres, enantiómeros y/o diastereoisómeros farmacéuticamente aceptables, o mezclas de dichos compuestos, a los procesos para la preparación de dichos compuestos, a los compuestos intermediarios, a las composiciones farmacéuticas que comprenden dichos compuestos y/o derivados, a los medicamentos que comprenden dichos compuestos y/o derivados, como así también a los usos y métodos de dichos compuestos y/o derivados para el tratamiento y/o la prevención de condiciones y/o enfermedades causadas por microorganismos tales como hongos, bacterias y/o protozoarios, para la inhibición de la proliferación y/o supervivencia de dichos microorganismos, para el tratamiento y/o la prevención de la colonización de microorganismos en un individuo, y para la fabricación de un medicamento.
MX2012002276A 2009-08-28 2010-08-27 Compuestos eteres aralquil bencilicos, proceso de preparacion de los mismos, compuestos intermediarios, uso de dichos compuestos, metodo de tratamiento y/o prevencion, composicion farmaceutica y medicamento que contiene dichos compuestos. MX2012002276A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0904249-0A BRPI0904249B1 (pt) 2009-08-28 2009-08-28 Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, uso dos referidos compostos, composição farmacêutica
PCT/BR2010/000276 WO2011022798A1 (pt) 2009-08-28 2010-08-27 Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, compostos intermediários, uso dos referidos compostos, método de tratamento e/ou prevenção, composição farmacêutica e medicamento contendo os mesmos

Publications (1)

Publication Number Publication Date
MX2012002276A true MX2012002276A (es) 2012-04-19

Family

ID=43627099

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012002276A MX2012002276A (es) 2009-08-28 2010-08-27 Compuestos eteres aralquil bencilicos, proceso de preparacion de los mismos, compuestos intermediarios, uso de dichos compuestos, metodo de tratamiento y/o prevencion, composicion farmaceutica y medicamento que contiene dichos compuestos.

Country Status (24)

Country Link
US (1) US8975289B2 (es)
EP (1) EP2471781B1 (es)
JP (1) JP5718334B2 (es)
KR (1) KR101765752B1 (es)
CN (1) CN102625800A (es)
AR (1) AR078115A1 (es)
AU (1) AU2010286266B2 (es)
BR (1) BRPI0904249B1 (es)
CA (1) CA2771044C (es)
CL (1) CL2012000463A1 (es)
DK (1) DK2471781T3 (es)
ES (1) ES2606168T3 (es)
HU (1) HUE032199T2 (es)
IL (1) IL218044A (es)
IN (1) IN2012DN00611A (es)
MX (1) MX2012002276A (es)
PE (1) PE20120921A1 (es)
PL (1) PL2471781T3 (es)
PT (1) PT2471781T (es)
RU (1) RU2548009C2 (es)
SG (1) SG178298A1 (es)
UA (1) UA108479C2 (es)
WO (1) WO2011022798A1 (es)
ZA (1) ZA201201442B (es)

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CN102579829B (zh) * 2012-03-06 2013-09-18 康莉 一种治疗牛放线菌病的中药组合物及其制备方法
CN104016837B (zh) * 2014-05-26 2016-08-24 武汉有机实业有限公司 4,4’-二甲基二苄基醚的制备方法
RU2603622C1 (ru) * 2015-06-25 2016-11-27 Федеральное государственное бюджетное научное учреждение "Прикаспийский зональный научно-исследовательский ветеринарный институт" Комплексный метод лечения тейлериоза мелкого рогатого скота
CN108047147A (zh) * 2017-12-08 2018-05-18 长江大学 一类三唑类化合物以及作为杀菌剂的用途
KR101983575B1 (ko) * 2017-12-21 2019-06-03 대한민국 신균주 세라토바시디움 속 js1289 및 이의 용도
US20220267280A1 (en) * 2019-08-16 2022-08-25 Purdue Research Foundation Small molecule stimulators of the core particle of the proteasome

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Also Published As

Publication number Publication date
BRPI0904249A2 (pt) 2011-05-17
CL2012000463A1 (es) 2012-09-21
HUE032199T2 (en) 2017-08-28
EP2471781B1 (en) 2016-09-07
SG178298A1 (en) 2012-03-29
IL218044A0 (en) 2012-04-30
JP5718334B2 (ja) 2015-05-13
AU2010286266B2 (en) 2015-02-12
BRPI0904249B1 (pt) 2018-03-06
AR078115A1 (es) 2011-10-12
US20120196908A1 (en) 2012-08-02
EP2471781A1 (en) 2012-07-04
EP2471781A4 (en) 2013-01-23
US8975289B2 (en) 2015-03-10
RU2548009C2 (ru) 2015-04-10
KR20120050490A (ko) 2012-05-18
CN102625800A (zh) 2012-08-01
CA2771044A1 (en) 2011-03-03
RU2012110925A (ru) 2013-10-10
IL218044A (en) 2017-02-28
PE20120921A1 (es) 2012-08-01
ZA201201442B (en) 2012-10-31
PT2471781T (pt) 2016-12-15
KR101765752B1 (ko) 2017-08-07
DK2471781T3 (da) 2017-01-02
JP2013503111A (ja) 2013-01-31
AU2010286266A1 (en) 2012-04-05
IN2012DN00611A (es) 2015-06-12
UA108479C2 (en) 2015-05-12
PL2471781T3 (pl) 2017-08-31
CA2771044C (en) 2017-07-04
ES2606168T3 (es) 2017-03-23
WO2011022798A1 (pt) 2011-03-03

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