BRPI0409117A - compostos n-heterocìclios condensados e seu uso como antagonistas do receptor de crf - Google Patents
compostos n-heterocìclios condensados e seu uso como antagonistas do receptor de crfInfo
- Publication number
- BRPI0409117A BRPI0409117A BRPI0409117-5A BRPI0409117A BRPI0409117A BR PI0409117 A BRPI0409117 A BR PI0409117A BR PI0409117 A BRPI0409117 A BR PI0409117A BR PI0409117 A BRPI0409117 A BR PI0409117A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- alkyl
- halo
- alkoxy
- nitrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 5
- -1 C (O) R 2 ~ Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 229910052757 nitrogen Chemical group 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 102400000739 Corticotropin Human genes 0.000 abstract 1
- 101800000414 Corticotropin Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005055 alkyl alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
- 229960000258 corticotropin Drugs 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D487/04—Ortho-condensed systems
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
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- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Neurology (AREA)
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- Diabetes (AREA)
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- Addiction (AREA)
- Endocrinology (AREA)
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- Otolaryngology (AREA)
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- Hospice & Palliative Care (AREA)
Abstract
"COMPOSTOS N-HETEROCìCLICOS CONDENSADOS E SEU USO COMO ANTAGONISTAS DO RECEPTOR DE CRF". A presente invenção providencia compostos de fórmula (I), incluindo os estereoisómeros, prodrogas e sãos farmaceuticamente aceitáveis ou solvatos destes (Fórmula I) em que a linha tracejada pode representar uma dupla ligação; R é arila ou heteroarila, cada um dos quais podendo ser substituídos com 1 a 4 grupos J selecionados dentre: halogênio, C~ 1-6~ alquila, C~ 1-6~ alcóxi, halo C~ 1-6~ alquila, C~ 2-6~ alquenila, C~ 2-6~ alquinila, halo C~ 1-6~ alquila alcóxi, C(O)R~ 2~, nitro, hidróxi, NR~3~R~ 4~ ciano ou um grupo Z, R~ 1~ é hidrogênio, C~ 3-7~ cicloalquila, C~ 1-6~ alquila, C~ 1-6~ alcóxi, C~ 1-6~ tioalquila, C~ 2-6~ alquenila, C~ 2-6~ alquinila, halo C~ 1-6~ alquila, halo C~ 1-6~ alcóxi, halogênio, NR~ 3~R~ 4~ ou ciano; D, G é -C- opcionalmente substituído, X é carbono ou nitrogênio; Y é nitrogênio ou -C- opcionalmente substituído; W é um anel de 4-8 membros, que pode ser saturado ou pode conter uma a três duplas ligações, e em que: um átomo de carbono é substituído por uma carbonila ou S(O)~ m~ e um a quatro átomos de carbono podem, opcionalmente, ser substituídos por oxigênio, nitrogênio ou NR~ 12~, S(O)~ m~, carbonila e tal anel pode ser ainda substituído por 1 a 8 substituintes; Z é um heterociclo de 5-6 membros, que pode ser substituído por 1 a 8 grupos R~ 5~, ou um anel fenila, que pode ser substituído por 1 a 4 substituintes, m é um inteiro de 0 a 2; a processos para sua preparação, a composições farmacêuticas que os contém e a seu uso no tratamento de condições mediadas pelo fator de liberação de corticotropina (CRF).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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GBGB0308208.8A GB0308208D0 (en) | 2003-04-09 | 2003-04-09 | Chemical compounds |
US48532203P | 2003-07-07 | 2003-07-07 | |
PCT/IB2004/001350 WO2004094420A1 (en) | 2003-04-09 | 2004-04-07 | Condensed n-heterocyclic compounds and their use as crf receptor antagonists |
Publications (1)
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BRPI0409117A true BRPI0409117A (pt) | 2006-03-28 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BRPI0409117-5A BRPI0409117A (pt) | 2003-04-09 | 2004-04-07 | compostos n-heterocìclios condensados e seu uso como antagonistas do receptor de crf |
Country Status (21)
Country | Link |
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US (2) | US7427630B2 (pt) |
EP (3) | EP1611133B1 (pt) |
JP (2) | JP4866722B2 (pt) |
KR (1) | KR20060021826A (pt) |
CN (1) | CN1805958A (pt) |
AR (1) | AR044005A1 (pt) |
AT (2) | ATE473226T1 (pt) |
AU (1) | AU2004232551C1 (pt) |
BR (1) | BRPI0409117A (pt) |
CA (1) | CA2521929C (pt) |
DE (2) | DE602004027998D1 (pt) |
GB (1) | GB0308208D0 (pt) |
IS (1) | IS8119A (pt) |
MA (1) | MA27796A1 (pt) |
MX (1) | MXPA05010874A (pt) |
NO (1) | NO20055238L (pt) |
NZ (1) | NZ542780A (pt) |
PL (1) | PL378755A1 (pt) |
RU (1) | RU2382785C2 (pt) |
TW (1) | TW200508232A (pt) |
WO (2) | WO2004094420A1 (pt) |
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2003
- 2003-04-09 GB GBGB0308208.8A patent/GB0308208D0/en not_active Ceased
-
2004
- 2004-04-07 RU RU2005134652/04A patent/RU2382785C2/ru not_active IP Right Cessation
- 2004-04-07 DE DE602004027998T patent/DE602004027998D1/de not_active Expired - Lifetime
- 2004-04-07 CN CNA2004800161898A patent/CN1805958A/zh active Pending
- 2004-04-07 CA CA2521929A patent/CA2521929C/en not_active Expired - Fee Related
- 2004-04-07 JP JP2006506558A patent/JP4866722B2/ja not_active Expired - Fee Related
- 2004-04-07 BR BRPI0409117-5A patent/BRPI0409117A/pt not_active IP Right Cessation
- 2004-04-07 US US10/552,493 patent/US7427630B2/en not_active Expired - Lifetime
- 2004-04-07 AR ARP040101187A patent/AR044005A1/es unknown
- 2004-04-07 PL PL378755A patent/PL378755A1/pl not_active Application Discontinuation
- 2004-04-07 AT AT04726237T patent/ATE473226T1/de not_active IP Right Cessation
- 2004-04-07 WO PCT/IB2004/001350 patent/WO2004094420A1/en active Application Filing
- 2004-04-07 EP EP04726237A patent/EP1611133B1/en not_active Expired - Lifetime
- 2004-04-07 EP EP08169936A patent/EP2186813A1/en not_active Withdrawn
- 2004-04-07 NZ NZ542780A patent/NZ542780A/en unknown
- 2004-04-07 KR KR1020057019098A patent/KR20060021826A/ko not_active Application Discontinuation
- 2004-04-07 TW TW093109539A patent/TW200508232A/zh unknown
- 2004-04-07 MX MXPA05010874A patent/MXPA05010874A/es active IP Right Grant
- 2004-04-07 AU AU2004232551A patent/AU2004232551C1/en not_active Ceased
- 2004-04-08 EP EP04726587A patent/EP1618107B1/en not_active Expired - Lifetime
- 2004-04-08 DE DE602004027900T patent/DE602004027900D1/de not_active Expired - Lifetime
- 2004-04-08 JP JP2006506536A patent/JP2006522798A/ja active Pending
- 2004-04-08 AT AT04726587T patent/ATE472547T1/de not_active IP Right Cessation
- 2004-04-08 WO PCT/IB2004/001283 patent/WO2004094419A1/en active Application Filing
-
2005
- 2005-11-08 IS IS8119A patent/IS8119A/is unknown
- 2005-11-08 NO NO20055238A patent/NO20055238L/no not_active Application Discontinuation
- 2005-11-08 MA MA28585A patent/MA27796A1/fr unknown
-
2007
- 2007-10-31 US US11/931,313 patent/US20110172255A1/en not_active Abandoned
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