ES2572137T3 - Procedimiento para la síntesis de mandipropamida y derivados de la misma - Google Patents
Procedimiento para la síntesis de mandipropamida y derivados de la mismaInfo
- Publication number
- ES2572137T3 ES2572137T3 ES06765248T ES06765248T ES2572137T3 ES 2572137 T3 ES2572137 T3 ES 2572137T3 ES 06765248 T ES06765248 T ES 06765248T ES 06765248 T ES06765248 T ES 06765248T ES 2572137 T3 ES2572137 T3 ES 2572137T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- carbon atoms
- halogen
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un procedimiento para la preparación de un compuesto de fórmula (I)**Fórmula** en donde: R es un grupo alquinilo; R1 es alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquil-alquilo, fenilo y fenilalquilo, siendo posible, a su vez, que todos los grupos precedentes porten uno o más átomos de halógeno idénticos o diferentes; alcoxi; alqueniloxi; alquiniloxi; alcoxialquilo; haloalcoxi; alquiltio; haloalquiltio; alquilsulfonilo; formilo; alcanoílo; hidroxi; halógeno; ciano; nitro; amino; alquilamino; dialquilamino; carboxilo; alcoxicarbonilo; alqueniloxicarbonilo; o alquiniloxicarbonilo; y n es un número entero de 0 a 3, comprendiendo dicho procedimiento: (i) la reacción de un compuesto de fórmula (III)**Fórmula** en donde R, R1 y n son como se ha indicado antes para el compuesto de fórmula (I); m y m' son independientemente 0 ó 1, y cuando cualquiera de m y m' es 0, el otro es 1, y A es un grupo alcanodiilo, alquenodiilo o alquinodiilo que contiene al menos dos átomos de carbono (y adecuadamente que tiene hasta ocho átomos de carbono), opcionalmente sustituido con uno o más grupos seleccionados independientemente de halógeno, hidroxi, alcoxi, dialquil C1-4-amino o ciano; o m y m' son ambos 1, A es un grupo alcanotriilo, alquenotriilo o alquinotriilo que contiene al menos tres átomos de carbono (y de manera adecuada que tiene hasta ocho átomos de carbono), opcionalmente sustituido con uno o más grupos seleccionados independientemente de halógeno, hidroxi, alcoxi, dialquil C1-4-amino o ciano; y en donde si el grupo A contiene tres o más átomos de carbono, uno o más de los átomos de carbono pueden estar cada uno opcionalmente reemplazado por un átomo de oxígeno, con la condición de que haya al menos un átomo de carbono entre cualquiera de dos átomos de oxígeno en la molécula, con un compuesto de fórmula (IV)**Fórmula** para dar un compuesto de fórmula (II)**Fórmula** en donde R, R1 y n son como se ha indicado anteriormente para el compuesto de fórmula (I), y la reacción del compuesto de fórmula (II) con en donde **Fórmula** es un grupo lábil, para dar el compuesto de fórmula (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0516705.1A GB0516705D0 (en) | 2005-08-15 | 2005-08-15 | Process |
| PCT/GB2006/002946 WO2007020381A2 (en) | 2005-08-15 | 2006-08-08 | Process for the synthesis of mandipropamid and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2572137T3 true ES2572137T3 (es) | 2016-05-30 |
Family
ID=35098316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06765248T Active ES2572137T3 (es) | 2005-08-15 | 2006-08-08 | Procedimiento para la síntesis de mandipropamida y derivados de la misma |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8129560B2 (es) |
| EP (1) | EP1919857B1 (es) |
| JP (1) | JP5350790B2 (es) |
| KR (1) | KR101305928B1 (es) |
| CN (1) | CN101243040B (es) |
| AR (2) | AR057741A1 (es) |
| AU (1) | AU2006281293B2 (es) |
| BR (1) | BRPI0616593B1 (es) |
| CA (1) | CA2619435C (es) |
| CR (1) | CR9710A (es) |
| EC (1) | ECSP088183A (es) |
| ES (1) | ES2572137T3 (es) |
| GB (1) | GB0516705D0 (es) |
| GT (1) | GT200600369A (es) |
| HN (1) | HN2006029142A (es) |
| HU (1) | HUE028929T2 (es) |
| IL (3) | IL188919A (es) |
| MX (1) | MX2008001794A (es) |
| MY (1) | MY150654A (es) |
| NZ (1) | NZ574781A (es) |
| PL (1) | PL1919857T3 (es) |
| RU (1) | RU2470914C9 (es) |
| TW (2) | TWI399363B (es) |
| UA (1) | UA90810C2 (es) |
| WO (1) | WO2007020381A2 (es) |
| ZA (1) | ZA200800691B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808764D0 (en) * | 2008-05-14 | 2008-06-18 | Syngenta Ltd | Process |
| JP5747625B2 (ja) | 2011-04-12 | 2015-07-15 | 住友化学株式会社 | マンデロニトリル化合物の製造方法 |
| WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| JP2015511940A (ja) | 2012-02-03 | 2015-04-23 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 殺菌性ピリミジン化合物 |
| WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| EP2809659A1 (en) | 2012-02-03 | 2014-12-10 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113720A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113778A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113788A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| CN110204556B (zh) * | 2019-07-16 | 2020-09-18 | 重庆医药高等专科学校 | (rs)-甲氧基头孢西丁的制备方法 |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1030756A (en) * | 1963-04-01 | 1966-05-25 | Boots Pure Drug Co Ltd | Anti-inflammatory compositions comprising biphenylyl-alkane derivatives |
| US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
| DK133742B (da) | 1970-10-30 | 1976-07-12 | Merck & Co Inc | Fremgangsmåde til fremstilling af 2-acetamidoethyl-(3-trifluormethylphenoxy)-(4-chlorphenyl)-acetat. |
| FR2120246A5 (es) * | 1970-12-03 | 1972-08-18 | Micsunescu Francine | |
| FR2131802A7 (en) * | 1971-03-11 | 1972-11-17 | Micsunescu Francine | Galvanizing bath brigenting agents - produced by reacting aromatic aldehydes or ketones with acetylenic alcohols |
| FR2259160A1 (en) * | 1974-01-29 | 1975-08-22 | Popescu Francine | Electrolytic bath contg acetal or ketal brightners - for use in prodn of electrolytic high gloss zinc coatings |
| GT199800109A (es) * | 1997-08-06 | 2000-01-13 | Derivados de n-sulfonilglicinalquiniloxifenetilamida microbicidas. | |
| GB9804265D0 (en) * | 1998-02-27 | 1998-04-22 | Ciba Geigy Ag | Organic compounds |
| TW564244B (en) * | 1999-01-11 | 2003-12-01 | Novartis Ag | Novel propargylether derivatives |
| GB0011944D0 (en) | 2000-05-17 | 2000-07-05 | Novartis Ag | Organic compounds |
| GB0108339D0 (en) * | 2001-04-03 | 2001-05-23 | Syngenta Participations Ag | Organics compounds |
| GB0127559D0 (en) * | 2001-11-16 | 2002-01-09 | Syngenta Participations Ag | Organic compounds |
| GB0127554D0 (en) * | 2001-11-16 | 2002-01-09 | Syngenta Participations Ag | Organic compounds |
| US20060041144A1 (en) * | 2002-08-19 | 2006-02-23 | Takashi Komori | Phenylpyridine compound and fungicidal compostion containing the same |
| JP2006182761A (ja) * | 2004-12-02 | 2006-07-13 | Hokko Chem Ind Co Ltd | アセトニトリル化合物および農園芸用殺菌剤 |
-
2005
- 2005-08-15 GB GBGB0516705.1A patent/GB0516705D0/en not_active Ceased
-
2006
- 2006-08-01 TW TW095128089A patent/TWI399363B/zh active
- 2006-08-01 TW TW102113033A patent/TWI428314B/zh active
- 2006-08-08 RU RU2008110063/04A patent/RU2470914C9/ru active
- 2006-08-08 US US12/063,907 patent/US8129560B2/en active Active
- 2006-08-08 AU AU2006281293A patent/AU2006281293B2/en active Active
- 2006-08-08 UA UAA200814871A patent/UA90810C2/ru unknown
- 2006-08-08 MX MX2008001794A patent/MX2008001794A/es active IP Right Grant
- 2006-08-08 PL PL06765248.7T patent/PL1919857T3/pl unknown
- 2006-08-08 EP EP06765248.7A patent/EP1919857B1/en active Active
- 2006-08-08 ES ES06765248T patent/ES2572137T3/es active Active
- 2006-08-08 BR BRPI0616593-1A patent/BRPI0616593B1/pt active IP Right Grant
- 2006-08-08 JP JP2008526532A patent/JP5350790B2/ja active Active
- 2006-08-08 HU HUE06765248A patent/HUE028929T2/en unknown
- 2006-08-08 KR KR1020087003753A patent/KR101305928B1/ko active IP Right Grant
- 2006-08-08 CN CN2006800297859A patent/CN101243040B/zh active Active
- 2006-08-08 CA CA2619435A patent/CA2619435C/en active Active
- 2006-08-08 NZ NZ574781A patent/NZ574781A/en active Application Filing
- 2006-08-08 WO PCT/GB2006/002946 patent/WO2007020381A2/en active Application Filing
- 2006-08-09 AR ARP060103483A patent/AR057741A1/es active IP Right Grant
- 2006-08-11 GT GT200600369A patent/GT200600369A/es unknown
- 2006-08-11 MY MYPI20063914 patent/MY150654A/en unknown
- 2006-08-15 HN HN2006029142A patent/HN2006029142A/es unknown
-
2008
- 2008-01-21 IL IL188919A patent/IL188919A/en active IP Right Grant
- 2008-01-23 ZA ZA2008/00691A patent/ZA200800691B/en unknown
- 2008-02-01 CR CR9710A patent/CR9710A/es unknown
- 2008-02-13 EC EC2008008183A patent/ECSP088183A/es unknown
-
2010
- 2010-07-15 AR ARP100102586A patent/AR080271A2/es active IP Right Grant
-
2013
- 2013-05-16 IL IL226403A patent/IL226403A0/en unknown
- 2013-05-16 IL IL226404A patent/IL226404A0/en unknown
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