MA27796A1 - Composes n-heterocycliques condenses et leur utilisation comme antagonistes des recepteurs de crf - Google Patents
Composes n-heterocycliques condenses et leur utilisation comme antagonistes des recepteurs de crfInfo
- Publication number
- MA27796A1 MA27796A1 MA28585A MA28585A MA27796A1 MA 27796 A1 MA27796 A1 MA 27796A1 MA 28585 A MA28585 A MA 28585A MA 28585 A MA28585 A MA 28585A MA 27796 A1 MA27796 A1 MA 27796A1
- Authority
- MA
- Morocco
- Prior art keywords
- group
- substituted
- groups
- formula
- optionally substituted
- Prior art date
Links
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- -1 -C (O) R2 Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052757 nitrogen Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 101800000414 Corticotropin Proteins 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
- 229960000258 corticotropin Drugs 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000003488 releasing hormone Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D487/04—Ortho-condensed systems
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- Physical Education & Sports Medicine (AREA)
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- Orthopedic Medicine & Surgery (AREA)
Abstract
"Composés N-hétérocycliques condensés et leur utilisation comme antagonistes des récepteurs de CRF" La présente invention propose des composés de formule (I), ainsi que leurs stéréoisomères, leurs précurseurs médicamenteux et leurs sels ou produits de solvatation pharmaceutiquement acceptables (formule (I)), ligne discontinue peut représente un groupe formule dans laquelle la représenter une double liaison aryle ou hétéroaryle, chacun de ces groupes pouvant être substitué avec 1 à 4 groupes J choisis entre des groupes : halogéno, alkyle en C1 à C6, alkoxy en C1 à C6, halogénalkyle en C1 à C6, alcényle en C2 à C6, alcynyle en C2 à C6, halogénalkoxy en C1 à C6, -C(O)R2, nitro, hydroxy, -NR3R4, cyano ou un groupe Z ; R1 représente un atome d'hydrogène, un groupe cycloalkyle en C3 à C7, alkyle en C1 à C6, alkoxy en C1 à C6, thioalkyle en C1 à C6, alcényle en C2 à C6, alcynyle en C2 à C6, halogénalkyle en C1 à C6, halogénalkoxy en C1 à C6, halogéno, NR3R4 ou cyano ; D, G représente un groupe -C- facultativement substitué ; X représente un atome de carbone ou d'azote ; Y représente un atome d'azote ou un groupe -C- facultativement substitué ; W représente un groupe tétra- à octogonal qui peut être saturé ou qui peut contenir une à trois doubles liaisons, et dans lequel : - un atome de carbone est remplacé par un groupe carbonyle ou S(0)m ; et un à quatre atomes de carbone qui peuvent être facultativement remplacés par un atome d'oxygène ou d'azote ou un groupe NR12, S(0)m ou carbonyle, et ce noyau peut être en outre substitué avec 1 à 8 substituants ; Z représente un hétérocycle penta- ou hexagonal, qui peut être substitué avec 1 à 8 groupes R5 ou un noyau phényle qui peut être substitué avec 1 à 4 substituants ; m représente un nombre entier de 0 à 2 ; des procédés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement d'affections à médiation par le facteur de libération de corticotrophine (CRF).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0308208.8A GB0308208D0 (en) | 2003-04-09 | 2003-04-09 | Chemical compounds |
US48532203P | 2003-07-07 | 2003-07-07 |
Publications (1)
Publication Number | Publication Date |
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MA27796A1 true MA27796A1 (fr) | 2006-03-01 |
Family
ID=33312357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28585A MA27796A1 (fr) | 2003-04-09 | 2005-11-08 | Composes n-heterocycliques condenses et leur utilisation comme antagonistes des recepteurs de crf |
Country Status (21)
Country | Link |
---|---|
US (2) | US7427630B2 (fr) |
EP (3) | EP1611133B1 (fr) |
JP (2) | JP4866722B2 (fr) |
KR (1) | KR20060021826A (fr) |
CN (1) | CN1805958A (fr) |
AR (1) | AR044005A1 (fr) |
AT (2) | ATE473226T1 (fr) |
AU (1) | AU2004232551C1 (fr) |
BR (1) | BRPI0409117A (fr) |
CA (1) | CA2521929C (fr) |
DE (2) | DE602004027998D1 (fr) |
GB (1) | GB0308208D0 (fr) |
IS (1) | IS8119A (fr) |
MA (1) | MA27796A1 (fr) |
MX (1) | MXPA05010874A (fr) |
NO (1) | NO20055238L (fr) |
NZ (1) | NZ542780A (fr) |
PL (1) | PL378755A1 (fr) |
RU (1) | RU2382785C2 (fr) |
TW (1) | TW200508232A (fr) |
WO (2) | WO2004094420A1 (fr) |
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-
2003
- 2003-04-09 GB GBGB0308208.8A patent/GB0308208D0/en not_active Ceased
-
2004
- 2004-04-07 EP EP04726237A patent/EP1611133B1/fr not_active Expired - Lifetime
- 2004-04-07 CN CNA2004800161898A patent/CN1805958A/zh active Pending
- 2004-04-07 AU AU2004232551A patent/AU2004232551C1/en not_active Ceased
- 2004-04-07 TW TW093109539A patent/TW200508232A/zh unknown
- 2004-04-07 WO PCT/IB2004/001350 patent/WO2004094420A1/fr active Application Filing
- 2004-04-07 DE DE602004027998T patent/DE602004027998D1/de not_active Expired - Lifetime
- 2004-04-07 AT AT04726237T patent/ATE473226T1/de not_active IP Right Cessation
- 2004-04-07 RU RU2005134652/04A patent/RU2382785C2/ru not_active IP Right Cessation
- 2004-04-07 KR KR1020057019098A patent/KR20060021826A/ko not_active Application Discontinuation
- 2004-04-07 BR BRPI0409117-5A patent/BRPI0409117A/pt not_active IP Right Cessation
- 2004-04-07 JP JP2006506558A patent/JP4866722B2/ja not_active Expired - Fee Related
- 2004-04-07 EP EP08169936A patent/EP2186813A1/fr not_active Withdrawn
- 2004-04-07 PL PL378755A patent/PL378755A1/pl not_active Application Discontinuation
- 2004-04-07 AR ARP040101187A patent/AR044005A1/es unknown
- 2004-04-07 CA CA2521929A patent/CA2521929C/fr not_active Expired - Fee Related
- 2004-04-07 MX MXPA05010874A patent/MXPA05010874A/es active IP Right Grant
- 2004-04-07 NZ NZ542780A patent/NZ542780A/en unknown
- 2004-04-07 US US10/552,493 patent/US7427630B2/en not_active Expired - Lifetime
- 2004-04-08 EP EP04726587A patent/EP1618107B1/fr not_active Expired - Lifetime
- 2004-04-08 JP JP2006506536A patent/JP2006522798A/ja active Pending
- 2004-04-08 DE DE602004027900T patent/DE602004027900D1/de not_active Expired - Lifetime
- 2004-04-08 WO PCT/IB2004/001283 patent/WO2004094419A1/fr active Application Filing
- 2004-04-08 AT AT04726587T patent/ATE472547T1/de not_active IP Right Cessation
-
2005
- 2005-11-08 MA MA28585A patent/MA27796A1/fr unknown
- 2005-11-08 NO NO20055238A patent/NO20055238L/no not_active Application Discontinuation
- 2005-11-08 IS IS8119A patent/IS8119A/is unknown
-
2007
- 2007-10-31 US US11/931,313 patent/US20110172255A1/en not_active Abandoned
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