MA31319B1 - Dérivés de sulfonylamides destines au traitement d'une croissance cellulaire anormale - Google Patents
Dérivés de sulfonylamides destines au traitement d'une croissance cellulaire anormaleInfo
- Publication number
- MA31319B1 MA31319B1 MA32288A MA32288A MA31319B1 MA 31319 B1 MA31319 B1 MA 31319B1 MA 32288 A MA32288 A MA 32288A MA 32288 A MA32288 A MA 32288A MA 31319 B1 MA31319 B1 MA 31319B1
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- derivatives
- sulfonilamide
- abnormal growth
- mammals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
LA PRÉSENTE INVENTION PORTE SUR UN COMPOSÉ DE LA FORMULE (I) DANS LAQUELLE R1 À R6, A, B, N ET M SONT TELS QUE DÉFINIS ICI. DE TELS NOUVEAUX DÉRIVÉS DE SULFONYLE AMIDE SONT UTILES DANS LE TRAITEMENT D'UNE CROISSANCE CELLULAIRE ANORMALE, TELLE QUE LE CANCER, DANS LES MAMMIFÈRES. CETTE INVENTION PORTE ÉGALEMENT SUR UN PROCÉDÉ D'UTILISATION DE TELS COMPOSÉS DANS LE TRAITEMENT D'UNE CROISSANCE CELLULAIRE ANORMALE DANS LES MAMMIFÈRES, NOTAMMENT LES ÊTRES HUMAINS, ET SUR DES COMPOSITIONS PHARMACEUTIQUES CONTENANT DE TELS COMPOSÉS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91259707P | 2007-04-18 | 2007-04-18 | |
PCT/IB2008/000845 WO2008129380A1 (fr) | 2007-04-18 | 2008-04-07 | Dérivés de sulfonyle amide pour le traitement d'une croissance cellulaire anormale |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31319B1 true MA31319B1 (fr) | 2010-04-01 |
Family
ID=39646361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32288A MA31319B1 (fr) | 2007-04-18 | 2009-10-16 | Dérivés de sulfonylamides destines au traitement d'une croissance cellulaire anormale |
Country Status (33)
Country | Link |
---|---|
US (12) | US7928109B2 (fr) |
EP (1) | EP2146779B1 (fr) |
JP (1) | JP4782239B2 (fr) |
KR (1) | KR101132880B1 (fr) |
CN (2) | CN103951658B (fr) |
AP (1) | AP2009005010A0 (fr) |
AR (1) | AR066125A1 (fr) |
AU (1) | AU2008240359B2 (fr) |
BR (1) | BRPI0810411B8 (fr) |
CA (1) | CA2684447C (fr) |
CL (1) | CL2008001076A1 (fr) |
CO (1) | CO6260093A2 (fr) |
CU (1) | CU23813A3 (fr) |
DK (1) | DK2146779T3 (fr) |
DO (1) | DOP2009000248A (fr) |
EA (1) | EA016679B1 (fr) |
EC (1) | ECSP099694A (fr) |
ES (1) | ES2593486T3 (fr) |
GE (1) | GEP20125581B (fr) |
GT (1) | GT200900272A (fr) |
HK (2) | HK1136985A1 (fr) |
IL (3) | IL201468A (fr) |
MA (1) | MA31319B1 (fr) |
MX (1) | MX2009011090A (fr) |
NI (1) | NI200900190A (fr) |
NZ (1) | NZ580372A (fr) |
PA (1) | PA8777101A1 (fr) |
PE (1) | PE20090434A1 (fr) |
TN (1) | TN2009000428A1 (fr) |
TW (1) | TWI369205B (fr) |
UA (1) | UA97834C2 (fr) |
UY (1) | UY31026A1 (fr) |
WO (1) | WO2008129380A1 (fr) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2593486T3 (es) * | 2007-04-18 | 2016-12-09 | Pfizer Products Inc. | Derivados de sulfonil amida para el tratamiento del crecimiento celular anómalo |
UY31714A (es) * | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
US8372974B2 (en) * | 2008-03-20 | 2013-02-12 | Boehringer Ingelheim International Gmbh | Regioselective preparation of substituted pyrimidines |
WO2009122180A1 (fr) * | 2008-04-02 | 2009-10-08 | Medical Research Council | Dérivés de pyrimidine capables d’inhiber une ou plusieurs kinases |
WO2010025831A1 (fr) * | 2008-09-03 | 2010-03-11 | Bayer Cropscience Ag | Anilinopyrimidines à substitution hétérocyclique en tant que fongicides |
UY32240A (es) * | 2008-11-14 | 2010-06-30 | Boeringer Ingelheim Kg | Nuevas 2,4-diaminopirimidinas, sus sales farmacéuticamente aceptables, composiciones conteniéndolas y aplicaciones. |
JP2010111702A (ja) * | 2009-02-16 | 2010-05-20 | Tetsuya Nishio | 複素環化合物、その製造法および用途 |
CN101812016B (zh) * | 2009-02-23 | 2013-01-16 | 浙江海翔药业股份有限公司 | 一种制备依托昔布中间体-6-甲基烟酸及其酯的方法 |
EP2261211A1 (fr) * | 2009-05-20 | 2010-12-15 | Université de Lille 2 Droit et Santé | Dérivés de 1,4-dihydropyridine et leurs utilisations |
TW201100441A (en) * | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
JP5684245B2 (ja) | 2009-06-05 | 2015-03-11 | セファロン、インク. | 1,2,4−トリアゾロ[1,5a]ピリジン誘導体の調製および使用 |
WO2011018517A1 (fr) | 2009-08-14 | 2011-02-17 | Boehringer Ingelheim International Gmbh | Préparation régiosélective de dérivés de 2-amino-5-trifluorométhylpyrimidine |
US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
WO2011107585A1 (fr) | 2010-03-04 | 2011-09-09 | Cellzome Limited | Dérivés d'urée substituée par un morpholino en tant qu'inhibiteurs de mtor |
WO2011144742A1 (fr) | 2010-05-21 | 2011-11-24 | Chemilia Ab | Nouveaux dérivés de pyrimidine |
EA201291220A1 (ru) * | 2010-06-04 | 2013-07-30 | Ф.Хоффманн-Ля Рош Аг | Производные аминопиримидина в качестве модуляторов lrrk2 |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
US9133224B2 (en) | 2010-11-29 | 2015-09-15 | OSI Pharmaceuticals, LLC | Macrocyclic kinase inhibitors |
EP2675793B1 (fr) | 2011-02-17 | 2018-08-08 | Cancer Therapeutics Crc Pty Limited | Inhibiteurs de fak |
EP2675794B1 (fr) | 2011-02-17 | 2019-02-13 | Cancer Therapeutics Crc Pty Limited | Inhibiteurs sélectifs de fak |
DK2688883T3 (en) | 2011-03-24 | 2016-09-05 | Noviga Res Ab | pyrimidine |
PL2699553T3 (pl) | 2011-04-22 | 2024-03-25 | Signal Pharmaceuticals, Llc | Podstawione diaminokarboksyamido- i diaminokarbonitrylo-pirymidyny, ich kompozycje i sposoby leczenia nimi |
CA2843195A1 (fr) * | 2011-07-28 | 2013-01-31 | Cellzome Limited | Analogues d'heterocyclyl-pyrimidine en tant qu'inhibiteurs de jak |
RU2564419C1 (ru) * | 2011-07-28 | 2015-09-27 | Целльзом Лимитид | Гетероциклические аналоги пиримидина в качестве ингибиторов jak |
CA2849189A1 (fr) | 2011-09-21 | 2013-03-28 | Cellzome Limited | Uree substituee par un groupe morpholino ou derives carbamate comme inhibiteurs de mtor |
JP5995977B2 (ja) | 2011-10-07 | 2016-09-21 | セルゾーム リミテッド | Mtor阻害剤としてのモルホリノ置換二環式ピリミジン尿素またはカルバメート誘導体 |
CN104169272A (zh) | 2011-12-23 | 2014-11-26 | 赛尔佐姆有限公司 | 作为激酶抑制剂的嘧啶-2,4-二胺衍生物 |
SG10201507865QA (en) * | 2012-03-06 | 2015-10-29 | Cephalon Inc | Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor |
AU2013265307B2 (en) | 2012-05-24 | 2016-04-07 | Cellzome Limited | Heterocyclyl pyrimidine analogues as TYK2 inhibitors |
ES2870562T3 (es) * | 2014-01-09 | 2021-10-27 | Verastem Inc | Composiciones y procedimientos para el tratamiento del crecimiento celular anormal |
NZ715903A (en) | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
ES2779975T3 (es) | 2014-02-07 | 2020-08-21 | Verastem Inc | Métodos y composiciones para tratar el crecimiento celular anormal |
JP6663857B2 (ja) | 2014-05-14 | 2020-03-13 | ファイザー・インク | ピラゾロピリジンおよびピラゾロピリミジン |
BR112017012795A2 (pt) | 2014-12-16 | 2018-01-02 | Signal Pharmaceuticals, Llc | Formulações de 2-(terc-butilamino)-4-((1r,3r,4r)-3- hidroxi-4-metilciclo-hexilamino)-pirimidina-5- carboxamida |
JP6903577B2 (ja) | 2014-12-16 | 2021-07-14 | シグナル ファーマシューティカルズ,エルエルシー | 皮膚におけるc−Jun N末端キナーゼの阻害の測定方法 |
WO2016100452A2 (fr) * | 2014-12-17 | 2016-06-23 | Celgene Avilomics Research, Inc. | Composés hétéroaryle et utilisations associées |
CA2975260C (fr) | 2015-01-29 | 2024-05-21 | Signal Pharmaceuticals Llc | Isotopologues de 2-(tert-butylamino)-4-((1r,3r,4r) -3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
US10532056B2 (en) | 2015-06-29 | 2020-01-14 | Verastem, Inc. | Therapeutic compositions, combinations, and methods of use |
EP3325432B1 (fr) | 2015-07-24 | 2020-09-02 | Celgene Corporation | Procédés de synthèse de chlorhydrate de (1r,2r,5r)-5-amino-2-méthylcyclohexanol et intermédiaires utiles à cet effet |
CN105111204B (zh) * | 2015-08-14 | 2016-09-14 | 天津小新医药科技有限公司 | 吡啶盐类酪氨酸激酶抑制剂、制备方法及其用途 |
CN105153150B (zh) * | 2015-08-14 | 2016-09-14 | 天津小新医药科技有限公司 | 一类吡啶盐类jak抑制剂、制备方法及其用途 |
CN105503860B (zh) * | 2015-10-13 | 2017-03-01 | 天津小新医药科技有限公司 | 一类腈基取代的吡啶盐类jak抑制剂、制备方法及其用途 |
US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
CN106279011A (zh) * | 2016-08-16 | 2017-01-04 | 成都百事兴科技实业有限公司 | 一种2,4‑二羟基‑6‑甲基烟酸乙酯的制备方法 |
WO2019117813A1 (fr) * | 2017-12-15 | 2019-06-20 | National University Of Singapore | Agents thérapeutiques ciblant une kinase d'adhésion focale pour le traitement du glaucome et de la fibrose |
CN112218658A (zh) | 2018-03-12 | 2021-01-12 | 国家健康科学研究所 | 热量限制模拟物用于增强癌症治疗的化学免疫疗法的用途 |
JP2021528370A (ja) * | 2018-05-07 | 2021-10-21 | ヒノバ ファーマシューティカルズ インコーポレイテッド | 重水素化デファクチニブ化合物及びその使用 |
WO2020006724A1 (fr) * | 2018-07-05 | 2020-01-09 | 清华大学 | Composé de dégradation ciblée de protéine fak et utilisation associée |
WO2020069117A1 (fr) * | 2018-09-27 | 2020-04-02 | Dana-Farber Cancer Institute, Inc. | Dégradation de fak ou fak et alk par conjugaison d'inhibiteurs de fak et d'alk avec des ligands de ligase e3 et procédés d'utilisation |
AU2019414550B2 (en) * | 2018-12-27 | 2022-09-22 | Hinova Pharmaceuticals Inc. | FAK inhibitor and drug combination thereof |
WO2021047783A1 (fr) | 2019-09-13 | 2021-03-18 | The Institute Of Cancer Research: Royal Cancer Hospital | Vs-6063 en combinaison avec ch5126766 pour le traitement du cancer |
CN112592318B (zh) * | 2020-12-12 | 2022-05-03 | 贵州医科大学 | 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用 |
CN112624966B (zh) * | 2020-12-25 | 2022-12-23 | 杭州澳赛诺生物科技有限公司 | 一种2-氨甲基-4-甲基-5-吡啶羧酸的合成方法 |
KR20230117416A (ko) * | 2021-01-18 | 2023-08-08 | 하이노바 파마슈티컬스 인코포레이티드 | 아미노피리미딘계 fak 억제제 화합물의 합성 방법 |
CN113372334B (zh) * | 2021-05-25 | 2022-05-03 | 贵州医科大学 | 2-(4-甲氨酰基)苯胺基-4-氨基-5-三氟甲基嘧啶衍生物及其应用 |
CA3220357A1 (en) * | 2021-05-25 | 2022-12-01 | Jing Li | Pharmaceutical composition for treatment of cancer and use thereof |
CN114716385B (zh) * | 2022-04-08 | 2024-03-12 | 北京师范大学 | 靶向粘着斑激酶的化合物及制备方法和应用 |
US11873296B2 (en) | 2022-06-07 | 2024-01-16 | Verastem, Inc. | Solid forms of a dual RAF/MEK inhibitor |
WO2024071371A1 (fr) * | 2022-09-30 | 2024-04-04 | ユビエンス株式会社 | Composé hétérocyclique |
CN117105916B (zh) * | 2023-10-23 | 2024-01-16 | 希格生科(深圳)有限公司 | 苯并呋喃类化合物及其医药用途 |
Family Cites Families (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507146A (en) | 1982-12-28 | 1985-03-26 | Ciba-Geigy Corporation | 2,4-Diamino-6-halo-5-trifluoromethylpyrimidines having herbicidal activity |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
WO1992020642A1 (fr) | 1991-05-10 | 1992-11-26 | Rhone-Poulenc Rorer International (Holdings) Inc. | Composes aryle et heteroaryle bis monocycliques et/ou bicycliques qui inhibent la tyrosine kinase d'un recepteur du egf et/ou du pdgf |
NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
GB9314884D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Tricyclic derivatives |
GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
CN1142817A (zh) | 1993-10-12 | 1997-02-12 | 杜邦麦克制药有限公司 | 1n-烷基-n-芳基嘧啶胺及其衍生物 |
GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
GB9424233D0 (en) | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
US5861510A (en) | 1995-04-20 | 1999-01-19 | Pfizer Inc | Arylsulfonyl hydroxamic acid derivatives as MMP and TNF inhibitors |
DK0780386T3 (da) | 1995-12-20 | 2003-02-03 | Hoffmann La Roche | Matrixmetalloproteaseinhibitorer |
GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
TW440563B (en) | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
EP0818442A3 (fr) | 1996-07-12 | 1998-12-30 | Pfizer Inc. | Dérivés cycliques de sulfones comme inhibiteurs de métalloprotéinase et de la production du facteur de nécrose des tumeurs |
WO1998002434A1 (fr) | 1996-07-13 | 1998-01-22 | Glaxo Group Limited | Composes heterocycliques condenses en tant qu'inhibiteurs de la proteine tyrosine kinase |
DE69718472T2 (de) | 1996-07-13 | 2003-11-06 | Glaxo Group Ltd | Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren |
HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
KR20000067904A (ko) | 1996-07-18 | 2000-11-25 | 디. 제이. 우드, 스피겔 알렌 제이 | 매트릭스 메탈로프로테아제의 포스피네이트계 억제제 |
WO1998007697A1 (fr) | 1996-08-23 | 1998-02-26 | Pfizer Inc. | Derives de l'acide arylsulfonylamino hydroxamique |
ATE272640T1 (de) | 1997-01-06 | 2004-08-15 | Pfizer | Cyclische sulfonderivate |
DK0977733T3 (da) | 1997-02-03 | 2003-11-24 | Pfizer Prod Inc | Arylsulfonylaminohydroxamsyrederivater |
AU5493598A (en) | 1997-02-07 | 1998-08-26 | Pfizer Inc. | N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases |
YU37499A (sh) | 1997-02-11 | 2002-09-19 | Pfizer Inc. | Derivati arilsulfonil hidroksamske kiseline |
CN1171866C (zh) | 1997-08-08 | 2004-10-20 | 辉瑞产品公司 | 芳氧基芳基磺酰氨基异羟肟酸衍生物 |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
CN1297447A (zh) | 1998-02-17 | 2001-05-30 | 图拉列克股份有限公司 | 抗病毒嘧啶衍生物 |
PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
IT1302431B1 (it) * | 1998-08-12 | 2000-09-05 | Alasi Di Arcieri Franco & C S | Dispositivo di controllo di accessi in rete tramite il riconoscimentoveloce di trame applicative che soddisfano un insieme di regole |
DK1004578T3 (da) | 1998-11-05 | 2004-06-28 | Pfizer Prod Inc | 5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater |
CA2349832A1 (fr) | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Derives de benzenesulfonamide et leur utilisation comme inhibiteurs de mek |
EP1081137A1 (fr) | 1999-08-12 | 2001-03-07 | Pfizer Products Inc. | Inhibiteurs sélectifs de l'aggrécanase pour le traitement de l'ostéoarthrite |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004888D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
US6525051B2 (en) | 2000-03-27 | 2003-02-25 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
CA2407754C (fr) | 2000-05-08 | 2009-09-15 | Janssen Pharmaceutica N.V. | Promedicaments a base de pyrimidines inhibant la replication du vih |
AU783981C (en) | 2000-05-08 | 2007-05-03 | Janssen Pharmaceutica N.V. | HIV replication inhibitors |
US6630469B2 (en) * | 2000-05-09 | 2003-10-07 | Bristol-Myers Squibb Company | 5-HT7 receptor antagonists |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
US6853233B1 (en) * | 2000-09-13 | 2005-02-08 | Infineon Technologies Ag | Level-shifting circuitry having “high” output impedance during disable mode |
IT1319686B1 (it) | 2000-12-12 | 2003-10-23 | C D Farmasint S R L | Procedimento di preparazione di citalopram. |
IL156369A0 (en) | 2000-12-21 | 2004-01-04 | Vertex Pharma | Pyrazole derivatives and pharmaceutical compositions containing the same |
RS94703A (en) * | 2001-05-29 | 2007-02-05 | Schering Aktiengesellschaft, | Cdk inhibiting pyrimidines, production thereof and their use as medicaments |
US20040171630A1 (en) | 2001-06-19 | 2004-09-02 | Yuntae Kim | Tyrosine kinase inhibitors |
HUP0402352A2 (hu) * | 2001-06-19 | 2005-02-28 | Bristol-Myers Squibb Co. | Foszfodiészteráz (PDE) 7 inhibitorként alkalmazható pirimidinszármazékok és ezeket tartalmazó gyógyszerkészítmények |
JO3429B1 (ar) * | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
WO2003030909A1 (fr) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- et 4-aminopyrimidines n-substituees par un noyau bicyclique utilisees comme inhibiteurs de kinases dans le traitement du cancer |
WO2003040141A1 (fr) | 2001-09-28 | 2003-05-15 | Bayer Pharmaceuticals Corporation | Composes d'oxazolyl-phenyl-2,4-diamino-pyrimidine, et methodes de traitement de troubles hyperproliferatifs |
CA2463989C (fr) | 2001-10-17 | 2012-01-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Derives pyrimidine, compositions pharmaceutiques contenant ces composes, utilisation et procede de fabrication de ces composes |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
US7008378B2 (en) * | 2002-03-07 | 2006-03-07 | Dean Melanie A | Patient conditional diagnosis assessment and symptom tracking system |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
WO2003095448A1 (fr) * | 2002-05-06 | 2003-11-20 | Bayer Pharmaceuticals Corporation | Derives de pyridinyl amino pyrimidine utilises dans le traitement des troubles de l'hyperproliferation |
US7449456B2 (en) * | 2002-06-28 | 2008-11-11 | Astellas Pharma, Inc. | Diaminopyrimidinecarboxamide derivative |
CN1678321A (zh) | 2002-07-29 | 2005-10-05 | 里格尔药品股份有限公司 | 用2,4-嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
AU2003285007A1 (en) | 2002-10-30 | 2004-06-07 | Merck & Co., Inc. | Kinase inhibitors |
WO2004048343A1 (fr) | 2002-11-28 | 2004-06-10 | Schering Aktiengesellschaft | Pyrimidines inhibitrices de chk-, pdk- et de akt, production et utilisation de ces composes comme agents pharmaceutiques |
UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
SE0203820D0 (sv) * | 2002-12-20 | 2002-12-20 | Astrazeneca Ab | chemical compounds |
US7109337B2 (en) * | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
CA2529611C (fr) * | 2002-12-20 | 2009-12-15 | Pfizer Products Inc. | Derives de pyrimidine destines au traitement de la croissance cellulaire anormale |
CL2004000192A1 (es) | 2003-02-07 | 2005-03-18 | Janssen Pharmaceutica Nv | Uso de compuestos derivados de 2-aminopirimidina para preparar un medicamento para la prevencion de una infeccion por vih relaciones sexuales o un contacto intimo en la pareja. |
GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
US20050014753A1 (en) * | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
US7504396B2 (en) | 2003-06-24 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
WO2005003103A2 (fr) | 2003-06-30 | 2005-01-13 | Astrazeneca Ab | Nouveaux heterocycles 2,4,6-trisubstitues et utilisations de ceux-ci |
WO2005009980A1 (fr) | 2003-07-22 | 2005-02-03 | Neurogen Corporation | Analogues de pyridin-2-ylamine substitues |
ES2424881T3 (es) | 2003-08-15 | 2013-10-09 | Novartis Ag | 2,4-Di(fenilamino)-pirimidinas útiles en el tratamiento de enfermedades neoplásicas, trastornos inflamatorios y del sistema inmunitario |
CA2537373C (fr) * | 2003-09-05 | 2009-10-20 | Pfizer Products Inc. | Synthese selective de pyrimidines substituees en cf3 |
US7363505B2 (en) * | 2003-12-03 | 2008-04-22 | Pen-One Inc | Security authentication method and system |
BRPI0510980A (pt) * | 2004-05-14 | 2007-11-27 | Pfizer Prod Inc | derivados de pirimidina para o tratamento do crescimento anormal de células |
CA2566477A1 (fr) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Derives de pyrimidine destines au traitement de croissance cellulaire anormale |
AP2241A (en) * | 2004-05-14 | 2011-06-01 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth. |
BRPI0510963A (pt) | 2004-05-14 | 2007-11-20 | Pfizer Prod Inc | derivados pirimidina para o tratamento do crescimento anormal de células |
EP1598343A1 (fr) * | 2004-05-19 | 2005-11-23 | Boehringer Ingelheim International GmbH | Dérivés de 2-arylaminopyrimidines comme des inhibiteurs de PLK |
PE20060530A1 (es) | 2004-06-04 | 2006-06-28 | Arena Pharm Inc | Aril y heteroaril derivados sustituidos como moduladores del metabolismo de la glucosa |
AU2005262322B2 (en) | 2004-07-01 | 2012-07-26 | Synta Pharmaceuticals Corp. | 2-substituted heteroaryl compounds |
US7521457B2 (en) * | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
TW200626559A (en) * | 2004-10-13 | 2006-08-01 | Wyeth Corp | Anilino-pyrimidine analogs |
US7919487B2 (en) | 2004-11-10 | 2011-04-05 | Synta Pharmaceuticals Corporation | Heteroaryl compounds |
WO2006053112A1 (fr) | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Procede destine a preparer des composes de pyrimidine trisubstitue |
WO2007014011A2 (fr) | 2005-07-21 | 2007-02-01 | Ardea Biosciences, Inc. | Inhibiteurs n-(arylamino)-sulfonamide de mek |
US8722884B2 (en) | 2005-12-01 | 2014-05-13 | Verastem, Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
EA014551B1 (ru) | 2005-12-21 | 2010-12-30 | Пфайзер Продактс Инк. | Пиримидиновые производные для лечения аномального клеточного роста |
ES2593486T3 (es) * | 2007-04-18 | 2016-12-09 | Pfizer Products Inc. | Derivados de sulfonil amida para el tratamiento del crecimiento celular anómalo |
-
2008
- 2008-04-07 ES ES08719431.2T patent/ES2593486T3/es active Active
- 2008-04-07 CA CA2684447A patent/CA2684447C/fr active Active
- 2008-04-07 EP EP08719431.2A patent/EP2146779B1/fr active Active
- 2008-04-07 NZ NZ580372A patent/NZ580372A/en unknown
- 2008-04-07 AU AU2008240359A patent/AU2008240359B2/en active Active
- 2008-04-07 GE GEAP200811513A patent/GEP20125581B/en unknown
- 2008-04-07 UA UAA200910461A patent/UA97834C2/ru unknown
- 2008-04-07 CN CN201410067096.3A patent/CN103951658B/zh active Active
- 2008-04-07 DK DK08719431.2T patent/DK2146779T3/en active
- 2008-04-07 EA EA200901250A patent/EA016679B1/ru not_active IP Right Cessation
- 2008-04-07 BR BRPI0810411A patent/BRPI0810411B8/pt active IP Right Grant
- 2008-04-07 CN CN200880019325.7A patent/CN101678215B/zh active Active
- 2008-04-07 WO PCT/IB2008/000845 patent/WO2008129380A1/fr active Application Filing
- 2008-04-07 JP JP2010503606A patent/JP4782239B2/ja active Active
- 2008-04-07 KR KR1020097023931A patent/KR101132880B1/ko active IP Right Grant
- 2008-04-07 AP AP2009005010A patent/AP2009005010A0/xx unknown
- 2008-04-07 MX MX2009011090A patent/MX2009011090A/es active IP Right Grant
- 2008-04-15 CL CL200801076A patent/CL2008001076A1/es unknown
- 2008-04-16 PA PA20088777101A patent/PA8777101A1/es unknown
- 2008-04-16 UY UY31026A patent/UY31026A1/es not_active Application Discontinuation
- 2008-04-17 US US12/105,151 patent/US7928109B2/en active Active
- 2008-04-17 PE PE2008000674A patent/PE20090434A1/es not_active Application Discontinuation
- 2008-04-17 TW TW097113908A patent/TWI369205B/zh active
- 2008-04-18 AR ARP080101626A patent/AR066125A1/es not_active Application Discontinuation
-
2009
- 2009-10-12 IL IL201468A patent/IL201468A/en not_active IP Right Cessation
- 2009-10-16 DO DO2009000248A patent/DOP2009000248A/es unknown
- 2009-10-16 MA MA32288A patent/MA31319B1/fr unknown
- 2009-10-16 GT GT200900272A patent/GT200900272A/es unknown
- 2009-10-16 EC EC2009009694A patent/ECSP099694A/es unknown
- 2009-10-16 TN TNP2009000428A patent/TN2009000428A1/fr unknown
- 2009-10-16 CU CU20090175A patent/CU23813A3/es not_active IP Right Cessation
- 2009-10-16 NI NI200900190A patent/NI200900190A/es unknown
- 2009-10-16 CO CO09115844A patent/CO6260093A2/es not_active Application Discontinuation
-
2010
- 2010-05-19 HK HK10104930.3A patent/HK1136985A1/xx unknown
- 2010-05-19 HK HK15100919.1A patent/HK1200450A1/xx unknown
-
2011
- 2011-03-11 US US13/045,923 patent/US8247411B2/en active Active
-
2012
- 2012-07-24 US US13/557,049 patent/US8440822B2/en active Active
-
2013
- 2013-03-29 US US13/853,483 patent/US20140100368A1/en not_active Abandoned
-
2014
- 2014-05-08 IL IL232511A patent/IL232511B/en active IP Right Grant
- 2014-11-24 US US14/552,153 patent/US20150080368A1/en not_active Abandoned
-
2016
- 2016-01-19 US US15/000,944 patent/US20160130250A1/en not_active Abandoned
- 2016-09-12 US US15/263,041 patent/US20170001981A1/en not_active Abandoned
-
2017
- 2017-04-20 US US15/492,719 patent/US20170327485A1/en not_active Abandoned
-
2018
- 2018-04-05 US US15/946,117 patent/US10450297B2/en active Active
- 2018-07-12 IL IL260560A patent/IL260560B/en active IP Right Grant
-
2019
- 2019-09-11 US US16/567,675 patent/US20200002310A1/en not_active Abandoned
-
2021
- 2021-08-27 US US17/458,862 patent/US20220251066A1/en not_active Abandoned
-
2023
- 2023-03-15 US US18/121,809 patent/US20240109862A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA31319B1 (fr) | Dérivés de sulfonylamides destines au traitement d'une croissance cellulaire anormale | |
TN2009000544A1 (fr) | Derives de benzimidazole | |
TNSN06370A1 (fr) | Derives de pyrimidine pour le traitement d'une croissance cellulaire anormale | |
TNSN08270A1 (fr) | Dérivés pyrimidiques destinés à traiter une croissance cellulaire anormale | |
MA31419B1 (fr) | Derives de pyridine | |
MA28747B1 (fr) | Dérivés de pyridine | |
MA30428B1 (fr) | Derives de dihydropyrazolopyrimidinones | |
MA29926B1 (fr) | Derives de pyrazine | |
TNSN05073A1 (fr) | Quinazolinones spirocondensees nouvelles et leur utilisation comme inhibiteurs de phosphodiesterase | |
MA27389A1 (fr) | Derives de benzimidazole nouveaux utiles comme agents antiproliferatifs. | |
MA30911B1 (fr) | Nouveaux derives de sulfonamide en tant qu'antagonistes de bradykinine | |
MA31894B1 (fr) | Composes organiques | |
MA28328A1 (fr) | Combinaisons d'agents actifs synergiques fongicides | |
MA30289B1 (fr) | Dérivés d'amines | |
MA26727A1 (fr) | Derives nouveaux de pyrimidine inhibiteurs de sorbitol deshydrogenase, leur procede de preparation et compositions pharmaceutiques les contenant | |
MA30718B1 (fr) | Derives de pyridin-4-yle en tant qu'agents immunomodulateurs. | |
MA27347A1 (fr) | Inhibiteurs de protease du vih, compositions les contenant, leurs utilisations pharmaceutiques et matieres pour leur synthese | |
AR062176A1 (es) | Derivados de nicotinamida, una composicion farmaceutica que los comprende y su uso para tratar enfermedades asociadas con miosina de musculo liso o miosina no muscular | |
MA27930A1 (fr) | Derives de nicotinamide utiles comme inhibiteurs de pde4 | |
BRPI0610644B8 (pt) | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. | |
MA30142B1 (fr) | Agonistes du recepteur de neuropeptide-2 | |
MA30916B1 (fr) | Nouveaux derives de benzamide en tant qu'antagonistes de bradykinine | |
CA2495960A1 (fr) | Nouveau procede de synthese du (7-methoxy-1-naphtyl)acetonitrile et application a la synthese de l'agomelatine | |
MA30596B1 (fr) | 18-methyl-19-nor-androst-4-en-17,17-spiroethers (18-methyl-19-nor-20-spirox-4-en-3-one) et preparations pharmaceutiques les contenant. | |
TN2011000252A1 (fr) | Lactames servant d'inhibiteurs de beta-secretase |