EA201071227A1 - (5r)-1,5-диарил-4,5-дигидро-1h-пиразол-3-карбоксамидиновые производные, обладающие св1-антагонистической активностью - Google Patents

(5r)-1,5-диарил-4,5-дигидро-1h-пиразол-3-карбоксамидиновые производные, обладающие св1-антагонистической активностью

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Publication number
EA201071227A1
EA201071227A1 EA201071227A EA201071227A EA201071227A1 EA 201071227 A1 EA201071227 A1 EA 201071227A1 EA 201071227 A EA201071227 A EA 201071227A EA 201071227 A EA201071227 A EA 201071227A EA 201071227 A1 EA201071227 A1 EA 201071227A1
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EA
Eurasian Patent Office
Prior art keywords
diaryl
dihydro
derivatives
pyrazol
possessing
Prior art date
Application number
EA201071227A
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English (en)
Inventor
Йозефус Х. М. Ланге
Арнольд П. Ден Хартог
Бернард Й. Ван Влиет
Original Assignee
Эбботт Хелткэа Продактс Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Эбботт Хелткэа Продактс Б.В. filed Critical Эбботт Хелткэа Продактс Б.В.
Publication of EA201071227A1 publication Critical patent/EA201071227A1/ru

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к (5R)-1,5-диарил-4,5-дигидро-1Н-пиразол-3-карбоксамидиновым производным как каннабиноидным антагонистам CBрецепторов, способам получения таких соединений, новым промежуточным химическим соединениям, применяемым для синтеза названных дигидропиразольных производных, способам получения таких промежуточных соединений, фармацевтическим композициям, содержащим одно или несколько таких дигидропиразольных производных в качестве активного ингредиента, а также к применению таких фармацевтических композиций для лечения психических и неврологических расстройств, связанных с каннабиноидными рецепторами. Соединения имеют формулу (I), где символы имеют значения, данные в описании изобретения.
EA201071227A 2008-04-23 2009-04-22 (5r)-1,5-диарил-4,5-дигидро-1h-пиразол-3-карбоксамидиновые производные, обладающие св1-антагонистической активностью EA201071227A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08155009 2008-04-23
PCT/EP2009/054788 WO2009130234A1 (en) 2008-04-23 2009-04-22 (5r)-1,5-diaryl-4,5-dihydro-1h-pyrazole-3-carboxamidine derivatives having cb1-antagonistic activity

Publications (1)

Publication Number Publication Date
EA201071227A1 true EA201071227A1 (ru) 2011-04-29

Family

ID=39811909

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201071227A EA201071227A1 (ru) 2008-04-23 2009-04-22 (5r)-1,5-диарил-4,5-дигидро-1h-пиразол-3-карбоксамидиновые производные, обладающие св1-антагонистической активностью

Country Status (15)

Country Link
US (1) US20110053983A1 (ru)
EP (1) EP2274298A1 (ru)
JP (1) JP2011518800A (ru)
KR (1) KR20110005722A (ru)
CN (1) CN102112466A (ru)
AR (1) AR071487A1 (ru)
AU (1) AU2009239984A1 (ru)
BR (1) BRPI0911222A2 (ru)
CA (1) CA2721908A1 (ru)
EA (1) EA201071227A1 (ru)
IL (1) IL208286A0 (ru)
MX (1) MX2010011615A (ru)
TW (1) TW200948798A (ru)
WO (1) WO2009130234A1 (ru)
ZA (1) ZA201007254B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009140210A2 (en) * 2008-05-12 2009-11-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Radiotracers for imaging cannabinoid sub-type1 (cb1) receptor
WO2014208939A1 (en) * 2013-06-28 2014-12-31 Hanmi Pharm. Co., Ltd. 1,5-diaryl-4,5-dihydro-1h-pyrazole-3-carboxamidine derivatives as cannabinoid cb1 receptor antagonist, method for preparing same, and pharmaceutical composition comprising same
KR20150113762A (ko) * 2014-03-31 2015-10-08 한미약품 주식회사 황 작용기를 포함하는 4,5-다이하이드로-1h-피라졸-3-카복스이미드아마이드 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2311972T3 (es) * 2004-01-30 2009-02-16 Solvay Pharmaceuticals B.V. Derivados 1,3,5-trisubstituidos de 4,5-dihidro-1h-pirazol que tienen actividad antagonista de cb1.
EP1743892A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments

Also Published As

Publication number Publication date
WO2009130234A1 (en) 2009-10-29
TW200948798A (en) 2009-12-01
ZA201007254B (en) 2011-06-29
AR071487A1 (es) 2010-06-23
US20110053983A1 (en) 2011-03-03
CA2721908A1 (en) 2009-10-29
EP2274298A1 (en) 2011-01-19
MX2010011615A (es) 2011-02-23
KR20110005722A (ko) 2011-01-18
AU2009239984A1 (en) 2009-10-29
JP2011518800A (ja) 2011-06-30
BRPI0911222A2 (pt) 2016-10-18
CN102112466A (zh) 2011-06-29
IL208286A0 (en) 2010-12-30

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