NO20062255L - 4-anilino-3-kinolinkarbonitriler for behandling av kronisk myelogenos leukemi (CML) - Google Patents

4-anilino-3-kinolinkarbonitriler for behandling av kronisk myelogenos leukemi (CML)

Info

Publication number
NO20062255L
NO20062255L NO20062255A NO20062255A NO20062255L NO 20062255 L NO20062255 L NO 20062255L NO 20062255 A NO20062255 A NO 20062255A NO 20062255 A NO20062255 A NO 20062255A NO 20062255 L NO20062255 L NO 20062255L
Authority
NO
Norway
Prior art keywords
cml
treatment
myelogenous leukemia
chronic myelogenous
carbonitriles
Prior art date
Application number
NO20062255A
Other languages
English (en)
Inventor
Frank Charles Boschelli
Kim Timothy Arndt
Jennifer Michele Golas
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34590192&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20062255(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20062255L publication Critical patent/NO20062255L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Forbindelser med formel I hvor n er et helt tall fra 1-3; X er N, CH, forutsatt at når X er N er n 2 eller 3; R er alkyl med 1 til 3 karbonatomer; R1 er 2,4-diCl, 5-OMe; 2,4-diCl; 3,4,5-tri-OMe; 2-Cl, 5-OMe; 2-Me, 5-OMe; 2,4-di-Me; 2,4-diMe-5-OMe, 2,4-diCl, 5-OEt; R2 er alkyl med 1 til 2 karbonatomer og farmasøytisk akseptable salter derav er anvendelige for behandling av kronisk myelogen leukemi (CML).
NO20062255A 2003-11-06 2006-05-19 4-anilino-3-kinolinkarbonitriler for behandling av kronisk myelogenos leukemi (CML) NO20062255L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51781903P 2003-11-06 2003-11-06
PCT/US2004/036722 WO2005046693A1 (en) 2003-11-06 2004-11-03 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml)

Publications (1)

Publication Number Publication Date
NO20062255L true NO20062255L (no) 2006-08-01

Family

ID=34590192

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062255A NO20062255L (no) 2003-11-06 2006-05-19 4-anilino-3-kinolinkarbonitriler for behandling av kronisk myelogenos leukemi (CML)

Country Status (18)

Country Link
US (2) US7417148B2 (no)
EP (1) EP1680119A1 (no)
JP (1) JP2007533655A (no)
KR (1) KR20060118461A (no)
CN (1) CN1874776A (no)
AU (1) AU2004289243B2 (no)
BR (1) BRPI0416289A (no)
CA (1) CA2543163A1 (no)
CO (1) CO5690608A2 (no)
CR (1) CR8350A (no)
EC (1) ECSP066548A (no)
IL (1) IL175424A0 (no)
MX (1) MXPA06004744A (no)
NO (1) NO20062255L (no)
RU (1) RU2006113691A (no)
SG (1) SG146681A1 (no)
WO (1) WO2005046693A1 (no)
ZA (1) ZA200603596B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2543163A1 (en) * 2003-11-06 2005-05-26 Wyeth 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml)
CA2612333C (en) * 2005-06-17 2013-12-17 The Board Of Regents Of The University Of Texas System Inhibition of osteolytic lesions by src kinase inhibitors
MX2007016542A (es) * 2005-06-24 2008-03-04 Wyeth Corp 4-anilino-3-quinolinocarbonitrilos para el tratamiento de cancer.
US20080119463A1 (en) * 2006-11-16 2008-05-22 Wyeth 4-Anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (AML)
WO2008060283A1 (en) * 2006-11-16 2008-05-22 Wyeth 4-anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (aml)
WO2008064004A2 (en) * 2006-11-16 2008-05-29 Wyeth 4-anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (aml)
CA2964162C (en) * 2007-06-01 2019-12-31 Wyeth Llc Treatment of imatinib resistant leukemia using 4-aminoquinoline-3-carbonitriles having mutation in the bcrabl gene
WO2013187967A1 (en) 2012-06-15 2013-12-19 Institute For Cancer Research D/B/A The Research Institute Of Fox Case Cancer Center ("Fox Chase Cancer Center") Sensitization of cancer cells to dna damage by inhibiting kinases essential for dna damage checkpoint control
CN104797267A (zh) 2012-06-26 2015-07-22 德玛医药 使用卫康醇、二乙酰二脱水卫矛醇、二溴卫矛醇或类似物或其衍生物治疗具有基因多型性或ahi1失调或突变患者的抗酪氨酸激酶抑制剂的恶性肿瘤的方法
WO2015123758A1 (en) 2014-02-20 2015-08-27 Apotex Inc. Bosutinib forms and preparation methods thereof
WO2016114322A1 (ja) 2015-01-13 2016-07-21 国立大学法人京都大学 筋萎縮性側索硬化症の予防及び／又は治療剤
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
EP3953450A1 (en) 2019-04-09 2022-02-16 Massachusetts Institute Of Technology A micro physiological model for neuronal and muscular diseases and disorders
WO2022053130A1 (en) 2020-09-09 2022-03-17 Sid Alex Group, S.R.O. Antago-mir-155 for treatment of v-src, c-src-tyrosine kinase-induced cancers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
TWI275390B (en) * 2002-04-30 2007-03-11 Wyeth Corp Process for the preparation of 7-substituted-3- quinolinecarbonitriles
TW200423938A (en) * 2003-02-21 2004-11-16 Wyeth Corp 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-3-quinolinecarbonitriles for the treatment of ischemic injury
CA2543163A1 (en) * 2003-11-06 2005-05-26 Wyeth 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml)

Also Published As

Publication number Publication date
BRPI0416289A (pt) 2007-01-23
CO5690608A2 (es) 2006-10-31
CN1874776A (zh) 2006-12-06
RU2006113691A (ru) 2007-12-20
US7417148B2 (en) 2008-08-26
KR20060118461A (ko) 2006-11-23
US20050101780A1 (en) 2005-05-12
JP2007533655A (ja) 2007-11-22
SG146681A1 (en) 2008-10-30
AU2004289243B2 (en) 2010-07-22
WO2005046693A1 (en) 2005-05-26
ZA200603596B (en) 2009-12-30
IL175424A0 (en) 2008-04-13
CA2543163A1 (en) 2005-05-26
EP1680119A1 (en) 2006-07-19
MXPA06004744A (es) 2006-07-05
AU2004289243A1 (en) 2005-05-26
US20100029677A1 (en) 2010-02-04
ECSP066548A (es) 2006-10-17
CR8350A (es) 2006-10-06
US7919625B2 (en) 2011-04-05

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