MXPA04007433A - Procedimiento para preparar dispersiones solidas amorfas homogeneas de farmaco secadas por pulverizacion utilizando un dispositivo de secado por pulverizacion modificado. - Google Patents

Procedimiento para preparar dispersiones solidas amorfas homogeneas de farmaco secadas por pulverizacion utilizando un dispositivo de secado por pulverizacion modificado.

Info

Publication number
MXPA04007433A
MXPA04007433A MXPA04007433A MXPA04007433A MXPA04007433A MX PA04007433 A MXPA04007433 A MX PA04007433A MX PA04007433 A MXPA04007433 A MX PA04007433A MX PA04007433 A MXPA04007433 A MX PA04007433A MX PA04007433 A MXPA04007433 A MX PA04007433A
Authority
MX
Mexico
Prior art keywords
spray
drying apparatus
dried solid
solid amorphous
amorphous drug
Prior art date
Application number
MXPA04007433A
Other languages
English (en)
Inventor
Heather Lynn Melcher Deibele
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MXPA04007433A publication Critical patent/MXPA04007433A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Drying Of Solid Materials (AREA)
  • Disintegrating Or Milling (AREA)
  • Glanulating (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Se mejoran los procedimientos de secado por pulverizacion convencionales mediante la incorporacion de una tobera de presion, una placa difusora para mejorar el flujo del gas de secado y una extension de la camara de secado para aumentar el tiempo de secado, conduciendo dichas mejoras a la formacion de dispersiones solidas homogeneas de farmacos en polimeros potenciadores de la concentracion.
MXPA04007433A 2002-02-01 2003-01-20 Procedimiento para preparar dispersiones solidas amorfas homogeneas de farmaco secadas por pulverizacion utilizando un dispositivo de secado por pulverizacion modificado. MXPA04007433A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35408002P 2002-02-01 2002-02-01
PCT/IB2003/000144 WO2003063822A2 (en) 2002-02-01 2003-01-20 Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus

Publications (1)

Publication Number Publication Date
MXPA04007433A true MXPA04007433A (es) 2004-10-11

Family

ID=27663286

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04007433A MXPA04007433A (es) 2002-02-01 2003-01-20 Procedimiento para preparar dispersiones solidas amorfas homogeneas de farmaco secadas por pulverizacion utilizando un dispositivo de secado por pulverizacion modificado.

Country Status (23)

Country Link
US (6) US6763607B2 (es)
EP (1) EP1469833B1 (es)
JP (2) JP4865989B2 (es)
KR (1) KR100664822B1 (es)
CN (1) CN1309370C (es)
BR (1) BR0307333A (es)
CA (1) CA2472028C (es)
ES (1) ES2878403T3 (es)
GT (1) GT200300018A (es)
HK (1) HK1074164A1 (es)
HN (1) HN2003000053A (es)
IL (1) IL162819A0 (es)
MX (1) MXPA04007433A (es)
PA (1) PA8565301A1 (es)
PE (1) PE20030805A1 (es)
PL (1) PL372247A1 (es)
PT (1) PT1469833T (es)
RS (1) RS61604A (es)
RU (1) RU2278659C9 (es)
TW (1) TW200302749A (es)
UY (1) UY27640A1 (es)
WO (1) WO2003063822A2 (es)
ZA (1) ZA200404882B (es)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6924133B1 (en) * 1999-10-01 2005-08-02 Novozymes A/S Spray dried enzyme product
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US7115279B2 (en) * 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
JP2004534812A (ja) * 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク 薬物および中性ポリマーの分散物の医薬組成物
BR0211028A (pt) * 2001-06-22 2004-06-15 Pfizer Prod Inc Solução aquosa, método para formação de associações de fármaco e polìmero, composições farmacêuticas, método para formação de uma composição farmacêutica e produto
US20050191359A1 (en) * 2001-09-28 2005-09-01 Solubest Ltd. Water soluble nanoparticles and method for their production
US20050226934A1 (en) * 2001-09-28 2005-10-13 Solubest Ltd. Inclusion complexes of active compounds in acrylate (co)polymers and methods for their production
US20050227911A1 (en) * 2001-09-28 2005-10-13 Solubest Ltd. Hydrophilic dispersions of nanoparticles of inclusion complexes of macromolecules
US20050249786A1 (en) * 2001-09-28 2005-11-10 Solubest Ltd. Hydrophilic dispersions of nanoparticles of inclusion complexes of amorphous compounds
US20050233003A1 (en) * 2001-09-28 2005-10-20 Solubest Ltd. Hydrophilic dispersions of nanoparticles of inclusion complexes of salicylic acid
JP4865989B2 (ja) * 2002-02-01 2012-02-01 ベンド・リサーチ・インコーポレーテッド 改良された噴霧乾燥装置を使用する均質な噴霧乾燥された固体の非晶質薬物分散物を製造する方法
KR100758045B1 (ko) * 2002-02-01 2007-09-11 화이자 프로덕츠 인크. 압력 노즐을 이용하여 균질한 분무 건조된 비결정질 고체약물 분산제를 제조하는 방법
CA2496441C (en) 2002-08-12 2010-03-16 Pfizer Products Inc. Pharmaceutical compositions of semi-ordered drugs and polymers
US20040242670A1 (en) * 2003-06-02 2004-12-02 Sonny Sebastian Process for preparation of amorphous atorvastatin calcium
KR20060015750A (ko) * 2003-06-03 2006-02-20 테바 파마슈티컬 인더스트리즈 리미티드 지프라시돈 ＨＣｌ의 다형 형태 및 그 제조 방법
US8651113B2 (en) * 2003-06-18 2014-02-18 Swr&D Inc. Magnetically responsive nanoparticle therapeutic constructs and methods of making and using
US7344491B1 (en) 2003-11-26 2008-03-18 Nanobiomagnetics, Inc. Method and apparatus for improving hearing
US7723311B2 (en) * 2003-06-18 2010-05-25 Nanobiomagnetics, Inc. Delivery of bioactive substances to target cells
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
BRPI0418330A (pt) * 2003-12-31 2007-05-02 Pfizer Prod Inc composições sólidas de drogas de solubilidade baixa e poloxámeros
JP2007517015A (ja) * 2003-12-31 2007-06-28 ファイザー・プロダクツ・インク 低溶解性薬物、ポロキサマーおよび安定化ポリマーの安定化された医薬用固体組成物
US20050163906A1 (en) * 2004-01-28 2005-07-28 Guillermo Silva Coconut beverage and method of producing the same
US8207232B2 (en) 2004-05-28 2012-06-26 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
CA2560984A1 (en) 2004-06-01 2005-12-15 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for preparation of amorphous form of a drug
CN1307974C (zh) * 2004-08-10 2007-04-04 上海信谊康捷药业有限公司 含极微量药物的制剂生产工艺
JP2007519758A (ja) 2004-12-01 2007-07-19 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 結晶マクロライドの生成方法
WO2006062980A2 (en) * 2004-12-07 2006-06-15 Nektar Therapeutics Stable non-crystalline formulation comprising tiagabine
US8617604B2 (en) 2005-02-03 2013-12-31 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
WO2006098834A2 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of ziprasidone mesylate
EP1858892A1 (en) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd Anhydrous ziprasidone mesylate and a process for its preparation
CA2608952A1 (en) * 2005-05-19 2006-11-23 Dwayne Thomas Friesen Pharmaceutical compostions comprising an amorphous form of a vegf-r inhibitor
CN101272848B (zh) * 2005-07-28 2013-03-13 Isp投资有限公司 改进喷雾干燥的粉末和颗粒材料性质的方法，以及由此生产的产品
WO2007056205A2 (en) * 2005-11-04 2007-05-18 Eastman Chemical Company Carboxyalkylcellulose esters for administration of poorly soluble pharmaceutically active agents
RS20090406A (en) * 2006-03-20 2010-12-31 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions
GB0613925D0 (en) * 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
CA2667668A1 (en) * 2006-10-06 2008-04-10 N.V. Organon Amorphous asenapine and processes for preparing same
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
EP2112925A4 (en) * 2006-11-15 2013-01-09 Abbott Lab SOLID PHARMACEUTICAL DOSAGE FORMULATIONS
WO2008076780A2 (en) * 2006-12-14 2008-06-26 Isp Investments Inc. Amorphous valsartan and the production thereof
WO2008080037A2 (en) * 2006-12-21 2008-07-03 Isp Investments Inc. Carotenoids of enhanced bioavailability
RU2462673C2 (ru) * 2006-12-29 2012-09-27 Базелль Полиолефин Италия С.Р.Л. Способ и устройство для сушки полимера
JP5508859B2 (ja) * 2007-01-26 2014-06-04 アイエスピー インヴェストメンツ インコーポレイテッド 噴霧乾燥製品を製造するための調剤処理方法
US20080181961A1 (en) * 2007-01-26 2008-07-31 Isp Investments, Inc. Amorphous oxcarbazepine and the production thereof
EP2158029B1 (en) * 2007-04-10 2019-05-29 Gea Process Engineering Inc. Process gas filter and process for cleaning the same
WO2008137134A2 (en) 2007-05-01 2008-11-13 Teva Pharmaceuticals Usa, Inc. Amorphous eletriptan hydrobromide and process for preparing it and other forms of eletriptan hydrobromide
US8256134B2 (en) * 2007-06-25 2012-09-04 Pulse Holdings LLC Drying apparatus and methods for ethanol production
US7937850B2 (en) * 2007-06-25 2011-05-10 J. Jireh Holdings Llc Methods and apparatus for drying condensed distiller's solubles (CDS) to produce dried distiller's solubles (DDS)
US8347525B2 (en) * 2007-09-24 2013-01-08 Inhalation Sciences Sweden Ab System and method for producing dry formulations
US8517723B2 (en) 2007-10-01 2013-08-27 Pulse Holdings, LLC Methods for drying a viral vaccine
WO2009052246A1 (en) * 2007-10-17 2009-04-23 Ovokaitys, Todd, F. Process for the modification of the solid state of a compound and co-amorphous compositions produced with same
TWI435726B (zh) * 2007-10-17 2014-05-01 Todd F Ovokaitys 室溫下穩定之非晶形阿斯匹靈及其製備方法
US8268354B2 (en) * 2007-11-07 2012-09-18 Aridis Pharmaceuticals Sonic low pressure spray drying
KR100917185B1 (ko) 2007-11-13 2009-09-15 (주)아모레퍼시픽 고분자 입자제조장치, 고분자입자 제조방법 및 이 방법에의해 제조된 고분자 입자를 포함하는 조성물
WO2009085637A1 (en) * 2007-12-21 2009-07-09 Url Pharma, Inc. Amorphous metaxalone and amorphous dispersions thereof
US7988074B2 (en) * 2008-03-05 2011-08-02 J. Jireh Holdings Llc Nozzle apparatus for material dispersion in a dryer and methods for drying materials
US20100048524A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
SE532388C2 (sv) * 2008-03-14 2010-01-12 Tetra Laval Holdings & Finance Förpackningslaminat och -behållare med två separata gasbarriärskikt samt metod för deras framställning
AU2010210422A1 (en) 2009-02-05 2011-08-18 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens
EP2411137B1 (en) 2009-03-27 2016-09-07 Bend Research, Inc. Spray-drying process
MX2011013080A (es) 2009-06-16 2012-01-20 Pfizer Formas de dosis de apixaban.
KR20130109092A (ko) 2010-06-09 2013-10-07 아보트 러보러터리즈 키나제 억제제를 함유하는 고체 분산물
WO2011154014A1 (en) * 2010-06-11 2011-12-15 Gea Process Engineering A/S Controlled humidity drying
US9084944B2 (en) 2010-09-03 2015-07-21 Bend Research, Inc. Spray-drying apparatus and methods of using the same
EP2611529B1 (en) 2010-09-03 2019-01-23 Bend Research, Inc. Spray-drying method
EP2618924A1 (en) * 2010-09-24 2013-07-31 Bend Research, Inc. High-temperature spray drying process and apparatus
US8939388B1 (en) 2010-09-27 2015-01-27 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9332776B1 (en) 2010-09-27 2016-05-10 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
WO2012087350A2 (en) * 2010-12-21 2012-06-28 President And Fellows Of Harvard College Spray drying techniques
CA2823628A1 (en) 2011-01-05 2012-07-12 Hospira, Inc. Spray drying vancomycin
BR112013022788A2 (pt) 2011-03-08 2016-12-06 Zalicus Pharmaceuticals Ltd "composição farmacêutica compreendendo uma dispersão sólida de 1-(4-benzidrilpiperazin-1-il)-3,3-difenilpropan-1-ona"
JP5781706B2 (ja) * 2011-12-29 2015-09-24 アッヴィ・アイルランド・アンリミテッド・カンパニー Ｈｃｖ阻害剤を含む固体組成物
PL2858989T3 (pl) 2012-05-17 2020-11-16 Genentech, Inc. Amorficzna postać inhibującego AKT związku pirymidynylo-cyklopentanu, kompozycje oraz ich sposoby
EP2745901A1 (en) * 2012-12-19 2014-06-25 Urea Casale SA Method for transforming a prilling tower, in particular in a plant for the synthesis of urea
SG11201506021XA (en) 2013-01-31 2015-08-28 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
CN105163735B (zh) 2013-02-01 2018-12-11 格力尔罗格克斯股份有限公司 用于治疗神经退行性疾病和其他疾病的组合物和方法
EP4066841A1 (en) 2013-03-14 2022-10-05 University of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
CN104043104B (zh) 2013-03-15 2018-07-10 浙江创新生物有限公司 含盐酸万古霉素的喷雾干粉及其工业化制备方法
SG11201600525XA (en) 2013-08-12 2016-02-26 Tokai Pharmaceuticals Inc Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
MX2016002185A (es) 2013-08-27 2016-06-06 Gilead Pharmasset Llc Formulacion combinada de dos compuestos antivirales.
US20150064252A1 (en) 2013-08-27 2015-03-05 Gilead Pharmasset Llc Solid dispersion formulation of an antiviral compound
US9511341B2 (en) * 2013-08-30 2016-12-06 Sunny Pharmtech Inc. Method for preparing acetazolamide sodium powder
MX2016006087A (es) * 2013-11-11 2016-08-12 Impax Laboratories Inc Formulaciones de desintegracion rapida y metodos de uso.
PT107567B (pt) * 2014-03-31 2019-02-13 Hovione Farm S A Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
PT107568B (pt) * 2014-03-31 2018-11-05 Hovione Farm S A Processo de secagem por atomização para a produção de pós com propriedades melhoradas.
US10076512B2 (en) 2014-05-01 2018-09-18 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
US10040728B2 (en) 2014-06-06 2018-08-07 Todd Frank Ovokaitys Methods and compositions for increasing the bioactivity of nutrients
US9561184B2 (en) 2014-09-19 2017-02-07 Velico Medical, Inc. Methods and systems for multi-stage drying of plasma
JP6650933B2 (ja) 2014-10-31 2020-02-19 ベンド リサーチ， インコーポレイテッド マトリックス中に分散された活性薬剤ドメインを形成するためのプロセス
IL235751A0 (en) * 2014-11-18 2015-02-26 Omrix Biopharmaceuticals Ltd An addition to the spray dryer
DK3285768T3 (da) 2015-04-21 2021-01-25 Eiger Biopharmaceuticals Inc Farmaceutiske sammensætninger omfattende lonafarnib og ritonavir
US20170135969A1 (en) 2015-11-12 2017-05-18 Jds Therapeutics, Llc Topical arginine-silicate-inositol for wound healing
CN109071496B (zh) 2016-03-31 2021-07-30 武田药品有限公司 异喹啉基三唑酮复合物
AU2017248828A1 (en) 2016-04-15 2018-11-01 Janssen Sciences Ireland Uc Combinations and methods comprising a capsid assembly inhibitor
US20170296993A1 (en) * 2016-04-18 2017-10-19 Premex S.A. Multiple modular system for the formation of particles in powder and microcapsule form for different processes
US10967345B2 (en) 2016-04-18 2021-04-06 Premex S.A.S. Multiple modular system for the formation of particles in powder and microcapsule form for different processes
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
BR102017011025A2 (pt) 2016-06-02 2017-12-19 Gilead Pharmasset Llc Formulation of combination of three antiviral compounds
JP2019526638A (ja) 2016-09-01 2019-09-19 ジェイディーエス・セラピューティクス、エルエルシー ビオチン酸マグネシウム組成物および使用方法
WO2018075865A1 (en) 2016-10-21 2018-04-26 Glialogix, Inc. Compositions for the treatment of neurodegenerative diseases
US9861945B1 (en) 2017-08-04 2018-01-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9993787B1 (en) 2017-08-04 2018-06-12 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10155234B1 (en) 2017-08-04 2018-12-18 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10486173B2 (en) 2017-08-04 2019-11-26 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
WO2019028446A1 (en) 2017-08-04 2019-02-07 ZoomEssence, Inc. APPARATUS AND METHOD FOR HIGH-PERFORMANCE SPRAY DRYING
CN107843102A (zh) * 2017-11-29 2018-03-27 成都市菜达人农业科技有限公司 一种离心式大米烘干装置
US20190231705A1 (en) * 2018-01-29 2019-08-01 Merck Sharp & Dohme Corp. High drug load polymeric nanoparticle formulations and methods of making and using same
SG11202007198WA (en) 2018-01-31 2020-08-28 Deciphera Pharmaceuticals Llc Combination therapy for the treatment of gastrointestinal stromal tumors
CN111867582A (zh) 2018-03-14 2020-10-30 爱尔兰詹森科学公司 衣壳组装调节剂给药方案
US10569244B2 (en) 2018-04-28 2020-02-25 ZoomEssence, Inc. Low temperature spray drying of carrier-free compositions
CN113329680A (zh) 2018-11-02 2021-08-31 营养21有限责任公司 用于改善视频游戏者认知功能的含有肌醇稳定的精氨酸硅酸盐复合物和肌醇的组合物
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
BR112022002609A2 (pt) 2019-08-12 2022-08-09 Deciphera Pharmaceuticals Llc Métodos de tratamento de tumores estromais gastrointestinais
WO2021030405A1 (en) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib for treating gastrointestinal stromal tumors
EP4076413A1 (en) 2019-12-16 2022-10-26 Nutrition 21, LLC Methods of production of arginine-silicate complexes
KR20220123058A (ko) 2019-12-30 2022-09-05 데시페라 파마슈티칼스, 엘엘씨. 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물
WO2021138483A1 (en) 2019-12-30 2021-07-08 Deciphera Pharmaceuticals, Llc Amorphous kinase inhibitor formulations and methods of use thereof
DK4084778T3 (da) 2019-12-30 2023-12-11 Deciphera Pharmaceuticals Llc Amorfe kinaseinhibitorformuleringer og fremgangsmåder til anvendelse deraf
CN112539604B (zh) * 2020-11-27 2022-07-29 济南森峰激光科技股份有限公司 一种用于激光熔覆粉末的干燥装置
WO2022165358A1 (en) * 2021-01-29 2022-08-04 ChromaDex Inc. Ethyl cellulose based coatings for microencapsulation of nicotinamide riboside and other nicotinyl riboside compounds
CN114353499B (zh) * 2022-02-10 2023-01-24 安徽海蓝生物科技有限公司 一种l-酒石酸生物制备用流化床及其制备工艺
AU2023220955A1 (en) * 2022-02-18 2024-08-15 Viking Therapeutics, Inc. ORAL DOSAGE FORMS OF TRβ AGONIST VK2809 FOR THE TREATMENT OF LIVER DISORDERS AND METHODS OF PREPARING THE SAME
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors
US12083447B2 (en) 2022-09-15 2024-09-10 Velico Medical, Inc. Alignment of a disposable for a spray drying plasma system
US11841189B1 (en) 2022-09-15 2023-12-12 Velico Medical, Inc. Disposable for a spray drying system
US11975274B2 (en) 2022-09-15 2024-05-07 Velico Medical, Inc. Blood plasma product
US11998861B2 (en) 2022-09-15 2024-06-04 Velico Medical, Inc. Usability of a disposable for a spray drying plasma system

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL46210C (es) 1936-06-19
US2460546A (en) 1942-10-01 1949-02-01 C H Wheeler Mfg Co Method and apparatus for treating materials
US2531343A (en) * 1944-12-11 1950-11-21 Swift & Co Manufacture of dried egg material
GB1131242A (en) 1965-02-18 1968-10-23 Gen Foods Ltd Improvements in or relating to spray-drying apparatus
US3324567A (en) * 1965-07-19 1967-06-13 Nat Dairy Prod Corp Drying method and apparatus
SE364170B (es) 1969-02-01 1974-02-18 Morinaga Milk Industry Co Ltd
DE2201111A1 (de) 1971-01-19 1972-07-27 Niro Atomizer As Zerstaeubungstrocknungsvorrichtung zur Herstellung von Pulver,z.B. Milchpulver
IT1025765B (it) 1974-11-18 1978-08-30 Gastaldi Francesco Essiccatore perfezionato a spruzzo
US4056599A (en) 1975-10-20 1977-11-01 Bechtel International Corporation Process for the recovery of magnesium chloride hydrate and potassium chloride from carnallite and bischofite
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
US4187617A (en) 1978-12-18 1980-02-12 Becker James J Jr Spray dryer
US4380491A (en) 1981-08-26 1983-04-19 Combustion Engineering, Inc. Spray nozzle assembly for spray dryer
US4865989A (en) 1981-12-22 1989-09-12 U.C. Regents Eukaryotic vectors and plasmids having PGK regulatory signals
US5209821A (en) * 1985-05-09 1993-05-11 Purdue Research Foundation Apparatus for removing volatiles from, or dehydrating, liquid products
US4702799A (en) 1985-09-03 1987-10-27 Nestec S.A. Dryer and drying method
US5227017A (en) * 1988-01-29 1993-07-13 Ohkawara Kakohki Co., Ltd. Spray drying apparatus equipped with a spray nozzle unit
IT1230095B (it) 1989-04-27 1991-10-05 Parenta Srl Procedimento per la preparazione di forme sterili di polveri iniettabili di antibiotici.
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US5000947A (en) 1989-05-30 1991-03-19 Moleculon, Inc. Shaped articles containing liquefiable powders for delivery of cosmetic and other personal care agents
PT96229B (pt) 1989-12-22 1998-06-30 Syntex Pharma Int Processo para a preparacao de composicoes farmaceuticas em po, secas por pulverizacao, directamente compressiveis em comprimidos, contendo naproxeno ou naproxeno sodico
ES2071049T3 (es) 1990-11-29 1995-06-16 Faulding F H & Co Ltd Procedimiento para producir polvos cargados de liquido.
KR0159947B1 (ko) 1991-03-12 1998-11-16 마사아키 오카와라 분수형 가압 2류체 노즐 장치와 그것을 편입하여 이루어지는 스프레이 드라이어 장치, 및 가압 2류체에 있어서의 액적 경 제어법
WO1992018106A1 (en) * 1991-04-16 1992-10-29 Nippon Shinyaku Co., Ltd. Method of manufacturing solid dispersion
DE4244466C2 (de) 1992-12-24 1995-02-23 Pharmatech Gmbh Verfahren zur Herstellung von Pseudolatices und Mikro- oder Nanopartikeln und deren Verwendung zur Herstellung von pharmazeutischen Präparaten
US5615493A (en) * 1994-03-11 1997-04-01 Niro Holding A/S/ Spray drying device
RO114740B1 (ro) 1994-05-06 1999-07-30 Pfizer Compozitie cu eliberare controlata, procedeu de obtinere a acesteia si metoda de tratament
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
JP3440623B2 (ja) * 1995-04-20 2003-08-25 三菱化学株式会社 二流体ノズルを用いる噴霧乾燥方法
DK0832066T3 (da) 1995-06-06 2001-11-19 Pfizer Substituerede N-(indol-2-carbonyl)amider og derivater som glycogenphosphorylaseinhibitorer
WO1996041632A1 (en) 1995-06-08 1996-12-27 Janssen Pharmaceutica N.V. Starch microsphere anti migraine composition
NL1000611C2 (nl) * 1995-06-20 1996-12-23 Stork Friesland Bv Inrichting, alsmede werkwijze voor het bereiden van een gesproeidroogd produkt.
AUPN605795A0 (en) 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
DE19542442A1 (de) 1995-11-14 1997-05-15 Wacker Chemie Gmbh Verfahren zur Herstellung von in Wasser redispergierbaren, Organosiliciumverbindungen enthaltenden Pulverzusammensetzungen
US5858409A (en) * 1996-04-17 1999-01-12 Fmc Corporation Hydrolyzed cellulose granulations for pharmaceuticals
US20030064108A1 (en) 1996-04-23 2003-04-03 Stefan Lukas Taste masked pharmaceutical compositions
AUPN969796A0 (en) 1996-05-07 1996-05-30 F.H. Faulding & Co. Limited Taste masked liquid suspensions
US6121283A (en) * 1996-11-27 2000-09-19 Pfizer Inc Apo B-secretion/MTP inhibitory amides
DK0901786T3 (da) 1997-08-11 2007-10-08 Pfizer Prod Inc Faste farmaceutiske dispersioner med foröget biotilgængelighed
JP3651220B2 (ja) * 1998-01-07 2005-05-25 三菱化学株式会社 噴霧乾燥機およびこれを用いる噴霧乾燥方法
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
GT199900147A (es) * 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
EP1027887B1 (en) 1999-02-10 2008-08-13 Pfizer Products Inc. Matrix controlled release device
EP1027888B1 (en) 1999-02-10 2009-06-10 Pfizer Products Inc. Osmotic system for delivery of solid amorphous dispersions of drugs
ES2307482T3 (es) 1999-02-10 2008-12-01 Pfizer Products Inc. Dispersiones farmaceuticas solidas.
US6253463B1 (en) * 1999-04-26 2001-07-03 Niro A/S Method of spray drying
WO2000074835A1 (en) * 1999-06-08 2000-12-14 Niro A/S A process and a plant for spray drying
IL148630A0 (en) 1999-09-16 2002-09-12 Axys Pharm Inc Compounds and pharmaceutical compositions for inhibiting cathepsin s
CO5271716A1 (es) * 1999-11-30 2003-04-30 Pfizer Prod Inc Cristales de 4- carboxamino 1,2,3,4-tetrahidroquinolina 2- sustituida
JP5159012B2 (ja) 1999-12-23 2013-03-06 メイン・ファ−マ・インタ−ナショナル・プロプライエタリ−・リミテッド 不良溶解性の薬物に対する改良された医薬組成物
CN1309370A (zh) 2000-02-14 2001-08-22 顾丽萍 在网络或互联网络上进行文件或数据库搜索的方法及系统
WO2001068645A2 (en) 2000-03-15 2001-09-20 Axys Pharmaceuticals, Inc. N-cyanomethylcarboxamides and their use as protease inhibitors
AR027656A1 (es) 2000-03-16 2003-04-09 Pfizer Prod Inc Composiciones farmaceuticas de inhibidores de la glucogeno-fosforilasa
GT200100039A (es) * 2000-03-16 2001-12-31 Pfizer Inhibidor de la glucogeno fosforilasa.
US7115279B2 (en) * 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
EP1186347A1 (de) * 2000-09-05 2002-03-13 F. Hoffmann-La Roche Ag Verfahren und Vorrichtung zum Zerstäuben von Flüssigkeiten
US6848197B2 (en) 2001-04-18 2005-02-01 Advanced Inhalation Research, Inc. Control of process humidity to produce large, porous particles
BR0211028A (pt) 2001-06-22 2004-06-15 Pfizer Prod Inc Solução aquosa, método para formação de associações de fármaco e polìmero, composições farmacêuticas, método para formação de uma composição farmacêutica e produto
JP2005523262A (ja) 2002-02-01 2005-08-04 ファイザー・プロダクツ・インク 薬物及び親油性ミクロ相形成物質の非晶質分散物の医薬組成物
KR100758045B1 (ko) 2002-02-01 2007-09-11 화이자 프로덕츠 인크. 압력 노즐을 이용하여 균질한 분무 건조된 비결정질 고체약물 분산제를 제조하는 방법
AR038375A1 (es) 2002-02-01 2005-01-12 Pfizer Prod Inc Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo
BR0307332A (pt) 2002-02-01 2004-12-07 Pfizer Prod Inc Formas de dosagem farmacêuticas de liberação controlada de um inibidor da proteìna de transferência do éster de colesterol
JP4865989B2 (ja) * 2002-02-01 2012-02-01 ベンド・リサーチ・インコーポレーテッド 改良された噴霧乾燥装置を使用する均質な噴霧乾燥された固体の非晶質薬物分散物を製造する方法
PL215865B1 (pl) 2002-03-05 2014-02-28 Axys Pharmaceuticals Zwiazek, kompozycja farmaceutyczna i zastosowanie zwiazku
US6820865B2 (en) 2003-01-21 2004-11-23 David Nicholson Low Nozzle valve type spray dryer
US7357849B2 (en) 2005-09-01 2008-04-15 Watervap, Llc Method and system for separating solids from liquids

Also Published As

Publication number Publication date
US8343550B2 (en) 2013-01-01
US20030163931A1 (en) 2003-09-04
RU2004123625A (ru) 2006-01-27
WO2003063822A2 (en) 2003-08-07
RU2278659C9 (ru) 2007-02-20
CA2472028C (en) 2010-03-30
JP4865989B2 (ja) 2012-02-01
US20040194338A1 (en) 2004-10-07
CN1309370C (zh) 2007-04-11
UY27640A1 (es) 2003-09-30
RU2278659C2 (ru) 2006-06-27
ZA200404882B (en) 2005-07-29
PE20030805A1 (es) 2003-09-19
PL372247A1 (en) 2005-07-11
CN1625389A (zh) 2005-06-08
JP2009149683A (ja) 2009-07-09
US6973741B2 (en) 2005-12-13
ES2878403T3 (es) 2021-11-18
US9339467B2 (en) 2016-05-17
WO2003063822A3 (en) 2003-11-13
GT200300018A (es) 2003-09-22
IL162819A0 (en) 2005-11-20
JP2005517689A (ja) 2005-06-16
BR0307333A (pt) 2004-12-07
PT1469833T (pt) 2021-07-13
US20110277339A1 (en) 2011-11-17
KR20040079970A (ko) 2004-09-16
US8828443B2 (en) 2014-09-09
PA8565301A1 (es) 2003-09-05
TW200302749A (en) 2003-08-16
EP1469833B1 (en) 2021-05-19
US6763607B2 (en) 2004-07-20
KR100664822B1 (ko) 2007-01-04
US20140017314A1 (en) 2014-01-16
US20150028503A1 (en) 2015-01-29
HN2003000053A (es) 2003-10-09
EP1469833A2 (en) 2004-10-27
HK1074164A1 (en) 2005-11-04
US20040185112A1 (en) 2004-09-23
RS61604A (en) 2006-10-27
CA2472028A1 (en) 2003-08-07

Similar Documents

Publication Publication Date Title
MXPA04007433A (es) Procedimiento para preparar dispersiones solidas amorfas homogeneas de farmaco secadas por pulverizacion utilizando un dispositivo de secado por pulverizacion modificado.
NO20061360L (no) Apparat for varmesproytebelegging
WO2007030645A3 (en) High energy dissociation for mercury control systems
RS67304A (en) Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles
TW200714843A (en) A vapor drying method and an apparatus
AU4133899A (en) A process and a plant for spray drying
WO2005056150A3 (en) Method and apparatus for simultaneous heat and mass transfer utilizing a carrier-gas at various absolute pressures
TW200710348A (en) Gas combustion apparatus
NO20054985L (no) Integrert prosessering av naturgass til vaeskeprodukter
WO2008127765A3 (en) Multi-output valve useful to promote non-stationary flame
TW200744929A (en) Process for pneumatic delivery of water-absorbing polymer particles
DK1667790T3 (da) Apparat og fremgangsmåde til fremstilling af partikler
WO2007023980A3 (en) Fuel cell
AU2003291971A1 (en) Nozzle for atomising a liquid by means of a gas and method of atomising
WO2007001838A3 (en) Methods and apparatus for igniting a low pressure plasma
TW200734494A (en) Microwave plasma abatement apparatus
EP1481957A4 (en) PROCESS FOR THE PREPARATION OF FLUOROMONOMER
WO2009077100A8 (de) Verfahren zur herstellung wasserabsorbierender polymerpartikel
WO2004026969A3 (de) Vorrichtung und verfahren zur kontrollierten erzeugung von nano-russpartikeln
NO20082686L (no) Innretning og fremgangsmate for mating av partikler inn i en strom
EP1304314A3 (en) Cement dispersant, its production process, and cement composition using the cement dispersant
WO2007099530A3 (en) Integrated cooling system
MY152649A (en) Separation system and method
MY160783A (en) Method for producing semiconductor encapsulating resin composition and pulverizing apparatus
WO2015022083A3 (en) C-converter having a filtering function

Legal Events

Date Code Title Description
FA Abandonment or withdrawal