MXPA03006666A - Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso. - Google Patents

Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso.

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Publication number
MXPA03006666A
MXPA03006666A MXPA03006666A MXPA03006666A MXPA03006666A MX PA03006666 A MXPA03006666 A MX PA03006666A MX PA03006666 A MXPA03006666 A MX PA03006666A MX PA03006666 A MXPA03006666 A MX PA03006666A MX PA03006666 A MXPA03006666 A MX PA03006666A
Authority
MX
Mexico
Prior art keywords
compounds
binding compounds
cyclophilin binding
cyp
cyclophilin
Prior art date
Application number
MXPA03006666A
Other languages
English (en)
Spanish (es)
Inventor
Hamilton Gregory
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of MXPA03006666A publication Critical patent/MXPA03006666A/es

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1158985B1 (en) 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
US6924312B2 (en) * 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
AU2002356525A1 (en) * 2001-09-24 2003-04-07 Elan Pharmaceuticals, Inc. Substituted amines for the treatment of neurological disorders
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
NZ566263A (en) 2002-05-24 2009-09-25 Millennium Pharm Inc CCR9 inhibitors and methods of use thereof
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
KR100874292B1 (ko) 2002-11-18 2008-12-18 케모센트릭스 아릴 술폰아마이드
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
KR101077808B1 (ko) * 2002-12-11 2011-10-28 닛산 가가쿠 고교 가부시키 가이샤 신규 디아미노벤젠 유도체, 그것을 사용한 폴리이미드전구체 및 폴리이미드, 및 액정 배향 처리제
ATE552236T1 (de) * 2003-01-14 2012-04-15 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren zur behandlung von herzinsuffizienz
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
EP1599216B9 (en) * 2003-02-04 2015-02-11 Cornell Research Foundation, Inc. Methods for preventing mitochondrial permeability transition
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
EP1636585B2 (en) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl ureas with kinase inhibiting activity
EP1663978B1 (en) 2003-07-23 2007-11-28 Bayer Pharmaceuticals Corporation Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
TW200510305A (en) 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
MXPA06003951A (es) * 2003-10-07 2006-06-27 Renovis Inc Derivados de amida como ligandos del canal de ion y composiciones farmaceuticas y sus metodos de uso.
TW200529812A (en) 2003-12-26 2005-09-16 Chugai Pharmaceutical Co Ltd Benzamide derivatives
CA3024434A1 (en) 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
ES2522579T3 (es) 2004-06-17 2014-11-17 Cytokinetics, Inc. Compuestos, composiciones y métodos
PL1781604T3 (pl) * 2004-06-23 2014-01-31 Synta Pharmaceuticals Corp Sole bis(tiohydrazydoamidu) do leczenia nowotworów
US7176222B2 (en) 2004-07-27 2007-02-13 Cytokinetics, Inc. Syntheses of ureas
AU2005306471B2 (en) * 2004-11-19 2009-12-17 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amides) for increasing Hsp70 expression
EA200701835A1 (ru) * 2005-02-28 2008-02-28 Реновис, Инк. Амидные производные в качестве лигандов ионных каналов, их фармацевтические композиции и способы их применения
US7576099B2 (en) * 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
DE102005015255A1 (de) * 2005-04-04 2006-10-05 Merck Patent Gmbh Acylhydrazide
US7312181B2 (en) 2005-04-08 2007-12-25 Cropsolution, Inc. Acylated thiosemicarbazides as herbicides
MX2007012688A (es) * 2005-04-15 2008-03-14 Synta Pharmaceuticals Corp Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida.
US7709683B2 (en) 2005-05-16 2010-05-04 Synta Pharmaceuticals Corp. Synthesis of bis(thio-hydrazide amide) salts
US7538223B2 (en) * 2005-08-04 2009-05-26 Cytokinetics, Inc. Compounds, compositions and methods
US7678832B2 (en) * 2005-08-16 2010-03-16 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation
US7825120B2 (en) * 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
ES2419007T3 (es) * 2005-12-15 2013-08-19 Cytokinetics, Inc. Ciertas entidades químicas, composiciones y procedimientos
EP1959947A2 (en) * 2005-12-15 2008-08-27 Cytokinetics, Inc. Certain chemical entities, compositions and methods
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
WO2007078815A2 (en) * 2005-12-16 2007-07-12 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
WO2007078839A2 (en) * 2005-12-19 2007-07-12 Cytokinetics, Inc. Compounds, compositions and methods
RU2475478C2 (ru) * 2006-08-21 2013-02-20 Синта Фармасьютиклз Корп. Соединения для лечения пролиферативных расстройств
JP2010502616A (ja) * 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ
WO2008033494A2 (en) * 2006-09-15 2008-03-20 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
MX2009003981A (es) * 2006-10-26 2009-04-27 Amgen Inc Agentes moduladores del receptor de calcio.
JP2010531638A (ja) 2007-06-12 2010-09-30 ケース ウエスタン リザーブ ユニバーシティ 標的化された細胞死
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
KR101558222B1 (ko) * 2012-09-12 2015-10-12 경희대학교 산학협력단 사이클로필린 ａ를 포함하는 탈모 방지 및 발모 개선을 위한 조성물
KR102301867B1 (ko) 2013-12-18 2021-09-15 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Nrf2 조절제
SI3782996T1 (sl) 2015-06-15 2024-06-28 Glaxosmithkline Intellectual Property Development Limited Nrf2 regulatorji
EP3766878B1 (en) 2015-06-15 2022-03-16 GlaxoSmithKline Intellectual Property Development Limited Nrf2 regulators
US10364256B2 (en) 2015-10-06 2019-07-30 Glaxosmithkline Intellectual Property Development Limited Biaryl pyrazoles as NRF2 regulators
CN108713019B (zh) 2016-03-17 2021-06-15 豪夫迈·罗氏有限公司 具有作为taar的激动剂的活性的5-乙基-4-甲基-吡唑-3-甲酰胺衍生物
WO2018062954A1 (ko) * 2016-09-30 2018-04-05 (주)나노믹스 사이클로필린 기능 저해제 및 사용방법
GB2595502B (en) * 2020-05-28 2023-01-11 Chopra Sunil Compounds, compositions and methods for the treatment or prevention of hair loss
US12391640B2 (en) 2022-03-02 2025-08-19 Horizon Therapeutics Ireland Dac Process of making a crystalline EDG-2 receptor antagonist

Family Cites Families (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2333552A (en) 1939-09-04 1943-11-02 Winthrop Chem Co Inc Process of manufacturing diphenylsulphone derivatives and product obtainable by suchprocess
US2328490A (en) 1939-09-04 1943-08-31 Winthrop Chem Co Inc Diphenylsulphone derivative
US2395484A (en) 1943-04-16 1946-02-26 Du Pont Bis sulphonamides of naphthol sulphonyl chlorides with aromatic diamines
US2635535A (en) 1946-01-31 1953-04-21 Du Pont Mordanting
US2593563A (en) * 1949-05-02 1952-04-22 Max N Huffman Phloroglucinol derivatives
US2714613A (en) 1953-10-08 1955-08-02 Ciba Pharm Prod Inc Di-(p-substituted phenyl)-thioureas
CH459172A (de) * 1961-09-11 1968-07-15 Wander Ag Dr A Verfahren zur Herstellung mehrbasischer Verbindungen
US3872157A (en) 1967-10-23 1975-03-18 Stauffer Chemical Co Substituted anilide carbamates
US3821200A (en) 1968-01-16 1974-06-28 Toms River Chemical Corp Nitrodiphenylamine dyestuffs
US3673241A (en) 1968-04-04 1972-06-27 Ciba Geigy Corp Substituted benzaldehyde guanylhydrazones
US3941581A (en) 1970-03-16 1976-03-02 Stauffer Chemical Company Meta-bis anilide derivatives and their utility as herbicides
US3867426A (en) 1970-10-02 1975-02-18 Monsanto Co Herbicidal meta-bifunctional benzenes
US3876797A (en) * 1970-12-09 1975-04-08 Aldrich Chem Co Inc Di-substituted ' -phenethylcarbamic acid esters in the treatment of parkinsonism
US3829463A (en) 1971-05-19 1974-08-13 Upjohn Co Oxime substituted carbanilates
US3829464A (en) 1971-05-19 1974-08-13 Upjohn Co Benzaldoxime-meta-carbamates
US3981914A (en) 1971-08-03 1976-09-21 Minnesota Mining And Manufacturing Company N-alkylsulfonylperfluoroalkanesulfonanilides
US4028093A (en) 1971-09-09 1977-06-07 Stauffer Chemical Company Meta-bis anilide derivatives and their utility as herbicides
US3937729A (en) 1971-09-15 1976-02-10 Stauffer Chemical Company Meta-bis anilide derivatives and their utility as herbicides
US3880642A (en) 1971-11-12 1975-04-29 Stauffer Chemical Co Bis-anilide compositions as algicidal agents
DE2334607A1 (de) 1973-07-07 1975-01-30 Bayer Ag Sulfonyloxyphenylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als herbizide
US4238503A (en) 1974-02-19 1980-12-09 Stauffer Chemical Company Anilide urea biocides
FR2297212A1 (fr) 1975-01-13 1976-08-06 Stauffer Chemical Co Composes nouveaux consistant en des thiomethyl aryl urees et leur application en tant qu'herbicides
US4031127A (en) 1975-08-06 1977-06-21 Eastman Kodak Company Acyl hydrazino thiourea derivatives as photographic nucleating agents
US4044147A (en) 1976-05-26 1977-08-23 Pfizer Inc. N-(acyl)-p-amino-N'-(monosubstituted)-benzamide anti-ulcer agents
US4041070A (en) 1976-07-14 1977-08-09 American Cyanamid Company Tetrahydro-4-imino-1-naphthylureas
DE2703838A1 (de) 1977-01-31 1978-08-10 Basf Ag Diurethane
JPS5937492B2 (ja) 1977-11-28 1984-09-10 富士写真フイルム株式会社 直接ポジハロゲン化銀感光材料
IL56012A (en) 1977-11-29 1983-07-31 Takeda Chemical Industries Ltd N-(2-fluoro-4-bromo(or chloro)phenyl)-3,4,5,6-tetrahydrophthalamic acid derivatives,their preparation,and herbicidal compositions comprising them
JPS5930257B2 (ja) 1978-04-06 1984-07-26 富士写真フイルム株式会社 直接ポジハロゲン化銀感光材料
JPS5533439A (en) 1978-08-31 1980-03-08 Konishiroku Photo Ind Co Ltd 2-sulfamoyl-5-sulfamido-1-naphthol
DE2844806A1 (de) 1978-10-11 1980-04-24 Schering Ag Carbanilsaeure- eckige klammer auf 3-(alkylcarbonylamino)-phenyl eckige klammer zu -ester, verfahren zur herstellung dieser verbindungen sowie diese enthaltendes herbizides mittel
JPS5931691B2 (ja) 1978-11-30 1984-08-03 富士写真フイルム株式会社 直接ポジハロゲン化銀感光材料
DE2909198A1 (de) 1979-03-08 1980-09-11 Basf Ag Phenylcarbamidsaeurechloride und verfahren zu ihrer herstellung
DE2921216A1 (de) 1979-05-25 1980-12-04 Teschemacher Hansjoerg Pharmakologisch aktive peptide
DE2928485A1 (de) 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen
US4410697A (en) 1980-01-25 1983-10-18 Reanal Finomvegyszergyar Process for the preparation of N-aryl-N'-(mono- or di substituted)-urea derivatives
US4373017A (en) 1980-03-05 1983-02-08 Konishiroku Photo Industry Co., Ltd. Photosensitive compound and photosensitive material containing it
IL62973A0 (en) 1980-06-02 1981-07-31 Basf Ag Aralkylphenylureas,their manufacture and their use as herbicides
HU185294B (en) 1980-12-29 1984-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted urea derivatives
US4384996A (en) 1981-01-09 1983-05-24 Sandoz Ltd. Novel cyclosporins
US4468405A (en) 1981-07-30 1984-08-28 The Dow Chemical Company Substituted N-aroyl N'-phenyl urea compounds
JPS58121148A (ja) 1982-01-11 1983-07-19 Olympus Optical Co Ltd 光学的情報記録再生装置
US4387106A (en) 1982-01-26 1983-06-07 American Cyanamid Company Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
US4623662A (en) 1985-05-23 1986-11-18 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US4473579A (en) 1982-01-26 1984-09-25 American Cyanamid Company Antiatherosclerotic tetrasubstituted ureas and thioureas
DE3217619A1 (de) 1982-05-11 1983-11-17 Bayer Ag, 5090 Leverkusen 2,4-dihalogenbenzoyl-(thio)harnstoffe, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US5003106A (en) 1983-07-19 1991-03-26 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US4544654A (en) 1984-03-20 1985-10-01 Schering A.G. Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof
US5288914A (en) 1984-08-27 1994-02-22 The Dow Chemical Company Poly(arylcyclobutenes)
US4608082A (en) 1985-02-19 1986-08-26 Union Carbide Corporation Herbicidal cycloalkenyl acetamides
EP0194972B1 (en) 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
SE447579B (sv) 1985-04-01 1986-11-24 Biopool Ab Solubiliserbar, fibrinbaserad komposition och anvendning av kompositionen vid bestemning av fibrinolysparametrar
US5462927A (en) 1985-04-30 1995-10-31 The Administrators Of The Tulane Educational Fund Peptides aiding nerve regeneration
US5057610A (en) 1986-04-25 1991-10-15 Ciba-Geigy Corporation Compositions stabilized with substituted amino carbamates
DE3636190A1 (de) 1986-10-24 1988-04-28 Bayer Ag Verfahren zur herstellung von n,n-diaryl-harnstoffen
US4764503A (en) 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
US5015644A (en) 1987-06-02 1991-05-14 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
US4885276A (en) 1987-06-03 1989-12-05 Merck & Co., Inc. Cyclosporin analogs with modified "C-9 amino acids"
ATE110784T1 (de) 1987-06-19 1994-09-15 Sandoz Ag Zyklische peptolide.
US5019646A (en) 1987-08-25 1991-05-28 Regents Of The University Of Minnesota Polypeptides with fibronectin activity
US4914188A (en) 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US4855478A (en) 1987-11-30 1989-08-08 Ici Americas Inc. N,N'-diaryl-N-alkylureas and method of use
US5166429A (en) 1988-01-20 1992-11-24 Yamanouchi Pharmaceutical Co., Ltd. Diurea derivatives useful as medicaments and processes for the preparation thereof
US5227492A (en) 1988-01-20 1993-07-13 Yamanouchi Pharmaceutical Co., Ltd. Diurea derivatives useful as medicaments and processes for the preparation thereof
US5134121A (en) 1988-03-28 1992-07-28 Regents Of The University Of California Nerve growth factor peptides
US5030653A (en) 1988-03-30 1991-07-09 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US4868210A (en) 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
FR2639636B1 (fr) 1988-11-30 1994-03-04 Novapharme Nouveaux composes heterocycliques a activite anticonvulsivante, procede de preparation et compositions therapeutiques les contenant
US5187270A (en) 1988-12-27 1993-02-16 Millipore Corporation Racemization free attachment of amino acids to a solid phase
US5023077A (en) 1989-01-24 1991-06-11 Aphton Corporation Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
CA2010770A1 (en) 1989-03-09 1990-09-09 Dinesh N. Khanna Bis-n,n' nitro or amino benzoyl aminophenols
US4959500A (en) 1989-05-23 1990-09-25 Ethyl Corporation Polybrominated bis sulfonamides
US5100899A (en) 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5284826A (en) 1989-07-24 1994-02-08 Sandoz Ltd. 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins
US5198582A (en) 1989-11-02 1993-03-30 Lucky Ltd. Process for preparing symmetric N,N'-disubstituted aromatic urea
JPH06104651B2 (ja) 1989-11-02 1994-12-21 株式会社ラッキー Ｎ，ｎ’―置換ウレアの製造方法
US5661182A (en) 1990-02-12 1997-08-26 Virginia Commonwealth University Method for lowering oxygen affinity of hemoglobin in redcell suspensions, in whole blood and in vivo
US5250701A (en) 1990-02-12 1993-10-05 Center For Innovative Technology Allosteric hemoglobin modifiers which decrease oxygen affinity in blood
US5432191A (en) 1990-02-12 1995-07-11 The Center For Innovative Technology Allosteric hemoglobin modifiers to decrease oxygen affinity in blood
US5122511A (en) 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
FR2659982B1 (fr) 1990-03-23 1995-10-20 Serbio Utilisation de substrats chromogenes dans la determination de candida.
US5198551A (en) 1990-04-10 1993-03-30 The United States Of America As Represented By The United States Department Of Energy Polyamide thermosets
EP0451790A1 (de) 1990-04-12 1991-10-16 Hoechst Aktiengesellschaft 3,5-disubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu deren Herstellung, diese enthaltende Mittel und ihre Verwendung
US5545719A (en) 1990-05-01 1996-08-13 Neuromedica, Inc. Nerve growth peptides
DE4014655A1 (de) 1990-05-08 1991-11-14 Behringwerke Ag Peptidamide, verfahren zu deren herstellung und diese enthaltende mittel als fibrin/thrombin-gerinnungsinhibitoren
US5192773A (en) 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
US5276182A (en) 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
US5099059A (en) 1990-08-20 1992-03-24 Baker Don R Substituted phenyl carbamates and their use as herbicides
US5250717A (en) 1990-10-22 1993-10-05 Ethyl Corporation Process for preparing N,N-diarylthioureas and arylisothiocyanates
US5321009A (en) 1991-04-03 1994-06-14 American Home Products Corporation Method of treating diabetes
US5414118A (en) 1991-04-12 1995-05-09 Asahi Kasei Kogyo Kabushiki Kaisha Diaminourea compound and process for production thereof and high heat resistant polyurethaneurea and process for production thereof
AT397384B (de) 1991-08-16 1994-03-25 Chemie Linz Gmbh Verfahren zur herstellung reiner n,n'-unsymmetrisch substituierter phenylharnstoffe
US5424063A (en) 1992-01-09 1995-06-13 The Dow Chemical Company Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process
US5326856A (en) 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
DE4215592A1 (de) 1992-05-12 1993-11-18 Bayer Ag Verfahren zur Herstellung von N-acylierten p-Aminophenolen
EP0647135A4 (en) 1992-06-22 1995-07-05 Cancer Soc Auckland Div Nz Inc SUBSTITUTED BIS-PHENYL DERIVATIVES WITH CYTOTOXIC EFFECTIVENESS AND ACTIVITY AGAINST CANCER.
JP2782142B2 (ja) 1992-07-23 1998-07-30 カルピス株式会社 アンジオテンシン変換酵素阻害剤及びその製造法
IL106998A0 (en) 1992-09-17 1993-12-28 Univ Florida Brain-enhanced delivery of neuroactive peptides by sequential metabolism
US5451677A (en) 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
JP3603315B2 (ja) 1993-02-19 2004-12-22 日本製紙株式会社 近赤外線吸収剤およびそれを含有した熱線遮蔽材
US6030991A (en) 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
CA2123728A1 (en) 1993-05-21 1994-11-22 Noriyoshi Sueda Urea derivatives and their use as acat inhibitors
US5798355A (en) 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
US5846981A (en) 1993-05-28 1998-12-08 Gpi Nil Holdings Inc. Inhibitors of rotamase enzyme activity
US5464820A (en) 1993-06-22 1995-11-07 The University Hospital Specific inhibitors of tissue kallikrein
JP3894949B2 (ja) 1993-06-30 2007-03-22 ザ、ウェルカム、ファンデーション、リミテッド 抗アテローム性動脈硬化症ジアリール化合物
US5534529A (en) 1993-06-30 1996-07-09 Sankyo Company, Limited Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
US5858327A (en) 1993-09-03 1999-01-12 Resolutions Pharmaceuticals, Inc. Hydrazino-type N2 S2 radionuclide chelating compounds
US5576335A (en) 1994-02-01 1996-11-19 Nisshin Flour Milling Co., Ltd. Urea derivatives and their use as ACAT inhibitors
US5898029A (en) 1994-04-12 1999-04-27 The John Hopkins University Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors
DE4413265A1 (de) 1994-04-16 1995-10-19 Basf Ag Hydroxyphenylharnstoffe
KR100287579B1 (ko) * 1994-05-31 2001-05-02 야스이 쇼사꾸 나프탈렌유도체
SE520730C2 (sv) 1995-01-20 2003-08-19 Eskil Elmer Behandling av hjärnischemi och hjärnskador med ett neuroprotektivt läkemedel
US5624937A (en) 1995-03-02 1997-04-29 Eli Lilly And Company Chemical compounds as inhibitors of amyloid beta protein production
GB2300187B (en) 1995-04-28 1998-09-02 Hodogaya Chemical Co Ltd Cure-accelerator for epoxy resin
US5559150A (en) 1995-06-06 1996-09-24 3-Dimensional Pharmaceuticals, Inc. N,N-disulfonylated aminobenzene carboxlic acids and the use thereof as thrombin inhibitors
US5612378A (en) 1995-06-06 1997-03-18 3-Dimensional Pharmaceuticals, Inc. Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5696135A (en) 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5741819A (en) * 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
US5614547A (en) 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
GB9511694D0 (en) 1995-06-09 1995-08-02 Fujisawa Pharmaceutical Co Benzamide derivatives
JP3337593B2 (ja) 1995-06-22 2002-10-21 日本精工株式会社 転がり軸受用グリース組成物
US5567831A (en) 1995-08-16 1996-10-22 Duguesne University Of The Holy Ghost Non-steroidal sulfatase inhibitor compounds and their method of use
IL123164A (en) 1995-08-30 2001-03-19 Searle & Co Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them
US5801197A (en) 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
JP3089350B2 (ja) 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
CA2197364A1 (en) 1996-02-15 1997-08-16 Toshikazu Suzuki Phenol compound and process for preparing the same
US6005008A (en) 1996-02-16 1999-12-21 Smithkline Beecham Corporation IL-8 receptor antagonists
US5840305A (en) 1996-03-14 1998-11-24 The Picower Institute For Medical Research Treatment of HIV-Infection by interfering with host cell cyclophilin receptor activity
ES2160949T3 (es) 1996-03-29 2001-11-16 Searle & Co Derivados de fenilen-sulfonamida sustituidos en meta.
CZ425598A3 (cs) 1996-06-27 1999-08-11 Smithkline Beecham Corporation Antagonista IL-8 receptoru
US6083986A (en) 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5786378A (en) 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US5780484A (en) 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds
US5811434A (en) 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
US5994398A (en) 1996-12-11 1999-11-30 Elan Pharmaceuticals, Inc. Arylsulfonamides as phospholipase A2 inhibitors
US5874449A (en) 1996-12-31 1999-02-23 Gpi Nil Holdings, Inc. N-linked sulfonamides of heterocyclic thioesters
US5721256A (en) 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds
ZA98825B (en) * 1997-02-27 1998-10-19 Guilford Pharm Inc Method of using neurotrophic carbamates and ureas
US5846979A (en) * 1997-02-28 1998-12-08 Gpi Nil Holdings, Inc. N-oxides of heterocyclic esters, amides, thioesters, and ketones
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
US6121323A (en) 1997-12-03 2000-09-19 3M Innovative Properties Company Bishydroxyureas
WO1999062511A1 (en) * 1998-06-02 1999-12-09 Bristol-Myers Squibb Company Neurotrophic difluoroamide agents
JP2003508512A (ja) * 1999-09-08 2003-03-04 ギルフォード ファーマシュウティカルズ インコーポレイテッド 非ペプチド性サイクロフィリン結合化合物とその用途
US7331908B2 (en) 2001-03-23 2008-02-19 Extreme Degree Fitness, Inc. Multi-function weight training apparatus
US20030005509A1 (en) 2001-05-18 2003-01-09 Kelzer Robert A. Head gear apparatus for use with a nasal mask

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