MX383786B - Formas polimorficas de rad1901-2hcl. - Google Patents

Formas polimorficas de rad1901-2hcl.

Info

Publication number
MX383786B
MX383786B MX2019007748A MX2019007748A MX383786B MX 383786 B MX383786 B MX 383786B MX 2019007748 A MX2019007748 A MX 2019007748A MX 2019007748 A MX2019007748 A MX 2019007748A MX 383786 B MX383786 B MX 383786B
Authority
MX
Mexico
Prior art keywords
rad1901
2hcl
polymorphic forms
forms
various polymorphic
Prior art date
Application number
MX2019007748A
Other languages
English (en)
Spanish (es)
Other versions
MX2019007748A (es
Inventor
Alex Eberlin
Jonathan Blake Mckenzie
Joshua Kyle Bolger
Michael Markey
Michael Paul Cruskie
Pratik Sheth
Richard Edwards
Original Assignee
Radius Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62709319&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX383786(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Radius Pharmaceuticals Inc filed Critical Radius Pharmaceuticals Inc
Publication of MX2019007748A publication Critical patent/MX2019007748A/es
Publication of MX383786B publication Critical patent/MX383786B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Conductive Materials (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Indole Compounds (AREA)
MX2019007748A 2017-01-05 2018-01-05 Formas polimorficas de rad1901-2hcl. MX383786B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762442921P 2017-01-05 2017-01-05
PCT/US2018/012714 WO2018129419A1 (en) 2017-01-05 2018-01-05 Polymorphic forms of rad1901-2hcl

Publications (2)

Publication Number Publication Date
MX2019007748A MX2019007748A (es) 2019-09-09
MX383786B true MX383786B (es) 2025-03-14

Family

ID=62709319

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2019007748A MX383786B (es) 2017-01-05 2018-01-05 Formas polimorficas de rad1901-2hcl.
MX2022007801A MX2022007801A (es) 2017-01-05 2019-06-26 Formas polimorficas de rad1901-2hcl.
MX2020010555A MX2020010555A (es) 2017-01-05 2019-06-26 Formas polimorficas de rad1901-2hcl.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2022007801A MX2022007801A (es) 2017-01-05 2019-06-26 Formas polimorficas de rad1901-2hcl.
MX2020010555A MX2020010555A (es) 2017-01-05 2019-06-26 Formas polimorficas de rad1901-2hcl.

Country Status (21)

Country Link
US (5) US10385008B2 (OSRAM)
EP (2) EP3565542B1 (OSRAM)
JP (3) JP7481115B2 (OSRAM)
KR (4) KR102322802B1 (OSRAM)
CN (2) CN117417263A (OSRAM)
AU (3) AU2018205285C9 (OSRAM)
CA (1) CA3047411A1 (OSRAM)
DK (1) DK3565542T3 (OSRAM)
ES (1) ES2981967T3 (OSRAM)
FI (1) FI3565542T3 (OSRAM)
HR (1) HRP20240923T1 (OSRAM)
HU (1) HUE067541T2 (OSRAM)
IL (3) IL292245B2 (OSRAM)
LT (1) LT3565542T (OSRAM)
MX (3) MX383786B (OSRAM)
PL (1) PL3565542T3 (OSRAM)
PT (1) PT3565542T (OSRAM)
RS (1) RS65694B1 (OSRAM)
SI (1) SI3565542T1 (OSRAM)
SM (1) SMT202400280T1 (OSRAM)
WO (1) WO2018129419A1 (OSRAM)

Families Citing this family (14)

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EP3565542B1 (en) * 2017-01-05 2024-04-10 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
SG11202013177WA (en) * 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
WO2020118213A1 (en) * 2018-12-06 2020-06-11 Radius Pharmaceuticals, Inc. Methods for treating cancer resistant to cdk4/6 inhibitors
MA54946A (fr) 2019-02-12 2021-12-22 Radius Pharmaceuticals Inc Procédés et composés
WO2023064519A1 (en) 2021-10-14 2023-04-20 Teva Pharmaceuticals International Gmbh Solid state forms of elacestrant and processes for preparation thereof
WO2023224961A1 (en) 2022-05-16 2023-11-23 Exelixis, Inc. Cancer therapy using a combination of a cdk7 inhibitor with an oral serd
CN119343330A (zh) * 2022-05-25 2025-01-21 苏州科睿思制药有限公司 艾拉司群二盐酸盐的晶型及其制备方法和用途
WO2024104268A1 (zh) * 2022-11-15 2024-05-23 苏州科睿思制药有限公司 艾拉司群二盐酸盐的共晶及其制备方法和用途
WO2024252263A1 (en) 2023-06-05 2024-12-12 Berlin-Chemie Ag Solid elacestrant dihydrochloride compositions, methods of making the same, and methods of treatment using the same
EP4574811A1 (en) 2023-12-22 2025-06-25 Sandoz Ag Crystalline forms of elacestrant dihydrochloride
WO2025158416A1 (en) 2024-01-25 2025-07-31 Assia Chemical Industries Ltd. Solid state forms of elacestrant and processes for preparation thereof
WO2025181825A2 (en) * 2024-02-26 2025-09-04 Msn Laboratories Private Limited, R&D Center Solid state forms of Elacestrant dihydrochloride and their processes for the preparation
WO2025210676A1 (en) * 2024-03-30 2025-10-09 Msn Laboratories Private Limited, R&D Center Novel crystalline forms of Elacestrant dihydrochloride and processes for their preparation
CN118652186A (zh) * 2024-05-23 2024-09-17 奥锐特药业(天津)有限公司 艾拉司群二盐酸盐的新晶型及其制备方法和用途

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