JP7481115B2 - Ｒａｄ１９０１－２ｈｃｌの多形性形態 - Google Patents
Ｒａｄ１９０１－２ｈｃｌの多形性形態 Download PDFInfo
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- JP7481115B2 JP7481115B2 JP2019536266A JP2019536266A JP7481115B2 JP 7481115 B2 JP7481115 B2 JP 7481115B2 JP 2019536266 A JP2019536266 A JP 2019536266A JP 2019536266 A JP2019536266 A JP 2019536266A JP 7481115 B2 JP7481115 B2 JP 7481115B2
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Classifications
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- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- Conductive Materials (AREA)
- Medicinal Preparation (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Indole Compounds (AREA)
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| SG11202013177WA (en) * | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
| UA130036C2 (uk) * | 2018-12-06 | 2025-10-22 | Радіус Фармасеутікалс, Інк. | Спосіб лікування стійкого до інгібітору cdk4/6 раку |
| KR20210127961A (ko) | 2019-02-12 | 2021-10-25 | 래디어스 파마슈티컬스, 인코포레이티드 | 방법 및 화합물 |
| WO2023064519A1 (en) | 2021-10-14 | 2023-04-20 | Teva Pharmaceuticals International Gmbh | Solid state forms of elacestrant and processes for preparation thereof |
| WO2023224961A1 (en) | 2022-05-16 | 2023-11-23 | Exelixis, Inc. | Cancer therapy using a combination of a cdk7 inhibitor with an oral serd |
| US20250282711A1 (en) | 2022-05-25 | 2025-09-11 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystalline form of elacestrant and preparation method and use thereof |
| WO2024104268A1 (zh) * | 2022-11-15 | 2024-05-23 | 苏州科睿思制药有限公司 | 艾拉司群二盐酸盐的共晶及其制备方法和用途 |
| WO2024252263A1 (en) | 2023-06-05 | 2024-12-12 | Berlin-Chemie Ag | Solid elacestrant dihydrochloride compositions, methods of making the same, and methods of treatment using the same |
| EP4574811A1 (en) | 2023-12-22 | 2025-06-25 | Sandoz Ag | Crystalline forms of elacestrant dihydrochloride |
| WO2025158416A1 (en) | 2024-01-25 | 2025-07-31 | Assia Chemical Industries Ltd. | Solid state forms of elacestrant and processes for preparation thereof |
| WO2025181825A2 (en) * | 2024-02-26 | 2025-09-04 | Msn Laboratories Private Limited, R&D Center | Solid state forms of Elacestrant dihydrochloride and their processes for the preparation |
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| WO2016176665A1 (en) | 2015-04-29 | 2016-11-03 | Radius Health, Inc. | Methods of treating cancer |
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