MX380259B - Formulaciones farmacéuticas que contienen derivados con 3-(4-cinamil-1-piperazinil)-amino de 3-formilrifamicina sv y 3-formilrifamicina s y un proceso para su preparación. - Google Patents
Formulaciones farmacéuticas que contienen derivados con 3-(4-cinamil-1-piperazinil)-amino de 3-formilrifamicina sv y 3-formilrifamicina s y un proceso para su preparación.Info
- Publication number
- MX380259B MX380259B MX2015001963A MX2015001963A MX380259B MX 380259 B MX380259 B MX 380259B MX 2015001963 A MX2015001963 A MX 2015001963A MX 2015001963 A MX2015001963 A MX 2015001963A MX 380259 B MX380259 B MX 380259B
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- formylrifamycine
- formylrifamycin
- cinnamyl
- piperazinyl
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- BBNQHOMJRFAQBN-UPZFVJMDSA-N 3-formylrifamycin sv Chemical compound OC1=C(C(O)=C2C)C3=C(O)C(C=O)=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O BBNQHOMJRFAQBN-UPZFVJMDSA-N 0.000 title 1
- 150000001412 amines Chemical class 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229930189077 Rifamycin Natural products 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229960003292 rifamycin Drugs 0.000 abstract 1
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Inorganic Chemistry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG11128812 | 2012-08-13 | ||
| PCT/BG2013/000041 WO2014026254A1 (en) | 2012-08-13 | 2013-08-09 | Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin sv and 3-formylrifamycin s and a process of their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015001963A MX2015001963A (es) | 2015-06-04 |
| MX380259B true MX380259B (es) | 2025-03-12 |
Family
ID=50101135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015001963A MX380259B (es) | 2012-08-13 | 2013-08-09 | Formulaciones farmacéuticas que contienen derivados con 3-(4-cinamil-1-piperazinil)-amino de 3-formilrifamicina sv y 3-formilrifamicina s y un proceso para su preparación. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9682997B2 (en:Method) |
| EP (1) | EP2882435B8 (en:Method) |
| JP (2) | JP6400580B2 (en:Method) |
| KR (1) | KR102210848B1 (en:Method) |
| CN (2) | CN107840854A (en:Method) |
| BR (1) | BR112015002945B1 (en:Method) |
| CA (1) | CA2881958C (en:Method) |
| EA (1) | EA029363B1 (en:Method) |
| ES (1) | ES2876004T3 (en:Method) |
| HK (1) | HK1248691A1 (en:Method) |
| HU (1) | HUE054955T2 (en:Method) |
| IN (1) | IN2015DN02009A (en:Method) |
| MX (1) | MX380259B (en:Method) |
| PL (1) | PL2882435T3 (en:Method) |
| PT (1) | PT2882435T (en:Method) |
| UA (1) | UA120030C2 (en:Method) |
| WO (1) | WO2014026254A1 (en:Method) |
| ZA (1) | ZA201501268B (en:Method) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2020102511A (ru) | 2017-06-26 | 2021-07-27 | Биофер С.П.А. | Соединения пиридо-имидазо рифамицина в качестве антибактериального средства |
| TWI731295B (zh) * | 2019-01-24 | 2021-06-21 | 宏碁股份有限公司 | 顯示裝置以及控制顯示裝置的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1478563A (en) | 1975-03-05 | 1977-07-06 | Lepetit Spa | Rifamycin derivatives |
| GR64108B (en) * | 1977-04-15 | 1980-01-24 | Dso Pharmachim | Method for the preparation of azomethine-derivatives of rifamycin s.v |
| US4179439A (en) * | 1977-07-01 | 1979-12-18 | Intreprinderea De Antibiotice Iasi | Rifamycins and method for their preparation |
| US4193020A (en) | 1978-05-22 | 1980-03-11 | Sperry Rand Corporation | Phase lock control system with trajectory correction |
| JPS5738742A (en) * | 1980-08-21 | 1982-03-03 | Kawasaki Kasei Chem Ltd | Preparation of 1,4-dihydroanthraquinone |
| JPS5695190A (en) * | 1980-09-17 | 1981-08-01 | Intorepurinderea De Anteibiote | Manufacture of rifamycin derivative |
| IT1201963B (it) * | 1983-03-24 | 1989-02-02 | Prodotti Antibiotici Spa | Derivati delle rifamicine e procedimento per la loro preparazione |
| JPS6143132A (ja) * | 1984-08-06 | 1986-03-01 | Takeda Chem Ind Ltd | キノン誘導体，その製造法およびそれを含んでなる医薬組成物 |
| DE3574142D1 (en) * | 1985-10-18 | 1989-12-14 | Ciba Geigy Ag | Substituted 4-benzyl-piperazinyl compounds |
| IT1202424B (it) * | 1987-01-26 | 1989-02-09 | Prodotti Antibiotici Spa | Sali di un derivato rifamicinico |
| EP0284552A1 (de) * | 1987-03-06 | 1988-09-28 | Ciba-Geigy Ag | 4-Benzyl-piperazinyl-Hydrazone |
| BG48618A1 (en) | 1988-02-23 | 1991-04-15 | Nauchen Inst Promishlena Mikro | Method for preparing riphampycin |
| JPH02215716A (ja) * | 1989-02-08 | 1990-08-28 | Farmitalia Carlo Erba Spa | ３―（ｎ―ピペリジノメチル―アジノ）メチルリファマイシンｓを活性成分として含有する薬剤組成物 |
| US5095108A (en) * | 1990-08-28 | 1992-03-10 | Technologichen Kombinat Za Promishlena Microbiologia | Non-solvated crystalline form "A" of 3-(4-cynnamyl-1-piperazinyl)iminomethylrifamycine SV and a method of its production |
| BG64021B1 (bg) * | 1998-11-04 | 2003-10-31 | КОНСТАНТИНОВА Румяна | Натриева сол на 3-(4-цинамил-1-пиперазинил)-иминометил рифамицин и метод за получаването й |
| DE10015814A1 (de) * | 2000-03-30 | 2001-10-11 | Max Planck Gesellschaft | Arzneimittel zur Stimulierung der Leukopoese, zur Behandlung von Tumor- und Protozoenerkrankungen und Verfahren zu seiner Herstellung |
| DE10038101A1 (de) * | 2000-08-04 | 2002-02-14 | Degussa | Verfahren zur Herstellung von 2-(4-Methyl-3-pentenyl)-anthrachinon |
| UA80393C2 (uk) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| JP5153329B2 (ja) * | 2004-07-22 | 2013-02-27 | カムブァ、アイピー、ヴェンチュァズ、エル、ピー | （ｒ／ｓ）リファマイシン誘導体、その調製、および医薬組成物 |
| GB0505909D0 (en) * | 2005-03-23 | 2005-04-27 | Univ Leeds | Formulations |
-
2013
- 2013-08-09 IN IN2009DEN2015 patent/IN2015DN02009A/en unknown
- 2013-08-09 CA CA2881958A patent/CA2881958C/en active Active
- 2013-08-09 HU HUE13829445A patent/HUE054955T2/hu unknown
- 2013-08-09 JP JP2015526838A patent/JP6400580B2/ja not_active Expired - Fee Related
- 2013-08-09 PL PL13829445T patent/PL2882435T3/pl unknown
- 2013-08-09 UA UAA201502014A patent/UA120030C2/uk unknown
- 2013-08-09 CN CN201711346387.6A patent/CN107840854A/zh active Pending
- 2013-08-09 MX MX2015001963A patent/MX380259B/es unknown
- 2013-08-09 WO PCT/BG2013/000041 patent/WO2014026254A1/en active Application Filing
- 2013-08-09 BR BR112015002945-0A patent/BR112015002945B1/pt not_active IP Right Cessation
- 2013-08-09 ES ES13829445T patent/ES2876004T3/es active Active
- 2013-08-09 EA EA201590278A patent/EA029363B1/ru unknown
- 2013-08-09 KR KR1020157006421A patent/KR102210848B1/ko active Active
- 2013-08-09 EP EP13829445.9A patent/EP2882435B8/en active Active
- 2013-08-09 US US14/421,364 patent/US9682997B2/en not_active Expired - Fee Related
- 2013-08-09 PT PT138294459T patent/PT2882435T/pt unknown
- 2013-08-09 CN CN201380053241.6A patent/CN104736152B/zh active Active
-
2015
- 2015-02-25 ZA ZA2015/01268A patent/ZA201501268B/en unknown
-
2017
- 2017-06-14 US US15/622,880 patent/US9981985B2/en active Active
-
2018
- 2018-06-27 HK HK18108267.9A patent/HK1248691A1/zh unknown
- 2018-09-04 JP JP2018165179A patent/JP6694029B2/ja active Active
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