CN104736152B - 包含3‑甲酰基利福霉素sv和3‑甲酰基利福霉素s的3‑(4‑肉桂基‑1‑哌嗪基)氨基衍生物的药物制剂以及它们的制备方法 - Google Patents
包含3‑甲酰基利福霉素sv和3‑甲酰基利福霉素s的3‑(4‑肉桂基‑1‑哌嗪基)氨基衍生物的药物制剂以及它们的制备方法 Download PDFInfo
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- CN104736152B CN104736152B CN201380053241.6A CN201380053241A CN104736152B CN 104736152 B CN104736152 B CN 104736152B CN 201380053241 A CN201380053241 A CN 201380053241A CN 104736152 B CN104736152 B CN 104736152B
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- China
- Prior art keywords
- rifamycin
- formoxyl
- cinnamyl
- compound
- sodium
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Inorganic Chemistry (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711346387.6A CN107840854A (zh) | 2012-08-13 | 2013-08-09 | 3‑甲酰基利福霉素sv的3‑(4‑肉桂基‑1‑哌嗪基)氨基衍生物的用途和制备方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG11128812 | 2012-08-13 | ||
BG111288 | 2012-08-13 | ||
PCT/BG2013/000041 WO2014026254A1 (en) | 2012-08-13 | 2013-08-09 | Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin sv and 3-formylrifamycin s and a process of their preparation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711346387.6A Division CN107840854A (zh) | 2012-08-13 | 2013-08-09 | 3‑甲酰基利福霉素sv的3‑(4‑肉桂基‑1‑哌嗪基)氨基衍生物的用途和制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104736152A CN104736152A (zh) | 2015-06-24 |
CN104736152B true CN104736152B (zh) | 2018-01-23 |
Family
ID=50101135
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711346387.6A Pending CN107840854A (zh) | 2012-08-13 | 2013-08-09 | 3‑甲酰基利福霉素sv的3‑(4‑肉桂基‑1‑哌嗪基)氨基衍生物的用途和制备方法 |
CN201380053241.6A Active CN104736152B (zh) | 2012-08-13 | 2013-08-09 | 包含3‑甲酰基利福霉素sv和3‑甲酰基利福霉素s的3‑(4‑肉桂基‑1‑哌嗪基)氨基衍生物的药物制剂以及它们的制备方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711346387.6A Pending CN107840854A (zh) | 2012-08-13 | 2013-08-09 | 3‑甲酰基利福霉素sv的3‑(4‑肉桂基‑1‑哌嗪基)氨基衍生物的用途和制备方法 |
Country Status (18)
Country | Link |
---|---|
US (2) | US9682997B2 (zh) |
EP (1) | EP2882435B8 (zh) |
JP (2) | JP6400580B2 (zh) |
KR (1) | KR102210848B1 (zh) |
CN (2) | CN107840854A (zh) |
BR (1) | BR112015002945B1 (zh) |
CA (1) | CA2881958C (zh) |
EA (1) | EA029363B1 (zh) |
ES (1) | ES2876004T3 (zh) |
HK (2) | HK1206980A1 (zh) |
HU (1) | HUE054955T2 (zh) |
IN (1) | IN2015DN02009A (zh) |
MX (1) | MX2015001963A (zh) |
PL (1) | PL2882435T3 (zh) |
PT (1) | PT2882435T (zh) |
UA (1) | UA120030C2 (zh) |
WO (1) | WO2014026254A1 (zh) |
ZA (1) | ZA201501268B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3645539T3 (pl) | 2017-06-26 | 2021-10-25 | Biofer S.P.A. | Pochodne pirydoimidazoryfamycyny jako środek przeciwbakteryjny |
TWI731295B (zh) * | 2019-01-24 | 2021-06-21 | 宏碁股份有限公司 | 顯示裝置以及控制顯示裝置的方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4918066A (en) * | 1985-10-18 | 1990-04-17 | Ciba-Geigy Corporation | Substituted 4-benzylpiperazinyl compounds |
US5095108A (en) * | 1990-08-28 | 1992-03-10 | Technologichen Kombinat Za Promishlena Microbiologia | Non-solvated crystalline form "A" of 3-(4-cynnamyl-1-piperazinyl)iminomethylrifamycine SV and a method of its production |
US6476036B1 (en) * | 1998-11-04 | 2002-11-05 | Roumiana Gueorguieva Konstantinova | Sodium salt of 3-(4-cinnamyl-1-piperazinyl)-imino-methyl rifamycin SV |
CN101065385A (zh) * | 2004-07-22 | 2007-10-31 | 坎布里制药公司 | 治疗微生物感染的利福霉素衍生物 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1478563A (en) | 1975-03-05 | 1977-07-06 | Lepetit Spa | Rifamycin derivatives |
GR64108B (en) * | 1977-04-15 | 1980-01-24 | Dso Pharmachim | Method for the preparation of azomethine-derivatives of rifamycin s.v |
US4179439A (en) * | 1977-07-01 | 1979-12-18 | Intreprinderea De Antibiotice Iasi | Rifamycins and method for their preparation |
US4193020A (en) | 1978-05-22 | 1980-03-11 | Sperry Rand Corporation | Phase lock control system with trajectory correction |
JPS5738742A (en) * | 1980-08-21 | 1982-03-03 | Kawasaki Kasei Chem Ltd | Preparation of 1,4-dihydroanthraquinone |
JPS5695190A (en) * | 1980-09-17 | 1981-08-01 | Intorepurinderea De Anteibiote | Manufacture of rifamycin derivative |
IT1201963B (it) * | 1983-03-24 | 1989-02-02 | Prodotti Antibiotici Spa | Derivati delle rifamicine e procedimento per la loro preparazione |
JPS6143132A (ja) * | 1984-08-06 | 1986-03-01 | Takeda Chem Ind Ltd | キノン誘導体,その製造法およびそれを含んでなる医薬組成物 |
IT1202424B (it) * | 1987-01-26 | 1989-02-09 | Prodotti Antibiotici Spa | Sali di un derivato rifamicinico |
EP0284552A1 (de) * | 1987-03-06 | 1988-09-28 | Ciba-Geigy Ag | 4-Benzyl-piperazinyl-Hydrazone |
BG48618A1 (en) | 1988-02-23 | 1991-04-15 | Nauchen Inst Promishlena Mikro | Method for preparing riphampycin |
JPH02215716A (ja) * | 1989-02-08 | 1990-08-28 | Farmitalia Carlo Erba Spa | 3―(n―ピペリジノメチル―アジノ)メチルリファマイシンsを活性成分として含有する薬剤組成物 |
DE10015814A1 (de) * | 2000-03-30 | 2001-10-11 | Max Planck Gesellschaft | Arzneimittel zur Stimulierung der Leukopoese, zur Behandlung von Tumor- und Protozoenerkrankungen und Verfahren zu seiner Herstellung |
DE10038101A1 (de) * | 2000-08-04 | 2002-02-14 | Degussa | Verfahren zur Herstellung von 2-(4-Methyl-3-pentenyl)-anthrachinon |
UA80393C2 (uk) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
GB0505909D0 (en) * | 2005-03-23 | 2005-04-27 | Univ Leeds | Formulations |
-
2013
- 2013-08-09 UA UAA201502014A patent/UA120030C2/uk unknown
- 2013-08-09 CN CN201711346387.6A patent/CN107840854A/zh active Pending
- 2013-08-09 EA EA201590278A patent/EA029363B1/ru unknown
- 2013-08-09 BR BR112015002945-0A patent/BR112015002945B1/pt active IP Right Grant
- 2013-08-09 CN CN201380053241.6A patent/CN104736152B/zh active Active
- 2013-08-09 PT PT138294459T patent/PT2882435T/pt unknown
- 2013-08-09 US US14/421,364 patent/US9682997B2/en active Active
- 2013-08-09 IN IN2009DEN2015 patent/IN2015DN02009A/en unknown
- 2013-08-09 WO PCT/BG2013/000041 patent/WO2014026254A1/en active Application Filing
- 2013-08-09 CA CA2881958A patent/CA2881958C/en active Active
- 2013-08-09 EP EP13829445.9A patent/EP2882435B8/en active Active
- 2013-08-09 ES ES13829445T patent/ES2876004T3/es active Active
- 2013-08-09 MX MX2015001963A patent/MX2015001963A/es unknown
- 2013-08-09 KR KR1020157006421A patent/KR102210848B1/ko active IP Right Grant
- 2013-08-09 JP JP2015526838A patent/JP6400580B2/ja active Active
- 2013-08-09 PL PL13829445T patent/PL2882435T3/pl unknown
- 2013-08-09 HU HUE13829445A patent/HUE054955T2/hu unknown
-
2015
- 2015-02-25 ZA ZA2015/01268A patent/ZA201501268B/en unknown
- 2015-08-06 HK HK15107597.5A patent/HK1206980A1/zh unknown
-
2017
- 2017-06-14 US US15/622,880 patent/US9981985B2/en active Active
-
2018
- 2018-06-27 HK HK18108267.9A patent/HK1248691A1/zh unknown
- 2018-09-04 JP JP2018165179A patent/JP6694029B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4918066A (en) * | 1985-10-18 | 1990-04-17 | Ciba-Geigy Corporation | Substituted 4-benzylpiperazinyl compounds |
US5095108A (en) * | 1990-08-28 | 1992-03-10 | Technologichen Kombinat Za Promishlena Microbiologia | Non-solvated crystalline form "A" of 3-(4-cynnamyl-1-piperazinyl)iminomethylrifamycine SV and a method of its production |
US6476036B1 (en) * | 1998-11-04 | 2002-11-05 | Roumiana Gueorguieva Konstantinova | Sodium salt of 3-(4-cinnamyl-1-piperazinyl)-imino-methyl rifamycin SV |
CN101065385A (zh) * | 2004-07-22 | 2007-10-31 | 坎布里制药公司 | 治疗微生物感染的利福霉素衍生物 |
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Effective date of registration: 20180301 Address after: Bulgaria Sofia Co-patentee after: In Ibo Mil Bo Zhidanuofufudulu husband Patentee after: The single joint-stock company of A Dipamu Co-patentee after: Base Lille A Senuofu Nino husband Co-patentee after: Wei Lishikaliliewaa Persian Tuo Luowa-Di Mowa Co-patentee after: Yi Futi meter Ya Yiwan Nova Si Daifan Nova Co-patentee after: Luo Sen Crewe is husband Coe Te Qiefu not Co-patentee after: Di Teqiefu seeks advice from Co., Ltd Address before: Bulgaria Sofia Co-patentee before: Bo Daerliubienuofu Fu Dulufu Patentee before: The single joint-stock company of A Dipamu Co-patentee before: In Ibo Mil Bo Zhidanuofufudulu husband Co-patentee before: Base Lille A Senuofu Nino husband Co-patentee before: Wei Lishikaliliewaa Persian Tuo Luowa-Di Mowa Co-patentee before: Yi Futi meter Ya Yiwan Nova Si Daifan Nova Co-patentee before: Luo Sen Crewe is husband Coe Te Qiefu not Co-patentee before: Di Teqiefu seeks advice from Co., Ltd |
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