BG48618A1 - Method for preparing riphampycin - Google Patents

Method for preparing riphampycin

Info

Publication number
BG48618A1
BG48618A1 BG8308388A BG8308388A BG48618A1 BG 48618 A1 BG48618 A1 BG 48618A1 BG 8308388 A BG8308388 A BG 8308388A BG 8308388 A BG8308388 A BG 8308388A BG 48618 A1 BG48618 A1 BG 48618A1
Authority
BG
Bulgaria
Prior art keywords
riphampycin
resulting product
dissolved
preparing
aminopiperazine
Prior art date
Application number
BG8308388A
Inventor
Khristo D Vasilev
Nadja S Martinova
Original Assignee
Nauchen Inst Promishlena Mikro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nauchen Inst Promishlena Mikro filed Critical Nauchen Inst Promishlena Mikro
Priority to BG8308388A priority Critical patent/BG48618A1/en
Publication of BG48618A1 publication Critical patent/BG48618A1/en

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Abstract

The riphampycin obtained is intended for use as an antibacterial antibiotic in medicine. At a shortened duration of the process and a reduced number of solvents employed, the yield and the purity of the final product are increased. According to the method, condensation of 3-formyl-rifamycin and 1-methyl-H-aminopiperazine is carried out and after that, the resulting product is recrystallized from propanol, the uncrystallized residues are concentrated to obtain a thick pulp and are subsequently dissolved in chloroform, and treated with a water solution of sodium ascorbate at pH of 5.5-6.5. After concentrating to a viscous-like bulk, the resulting product is dissolved in isopropanol.
BG8308388A 1988-02-23 1988-02-23 Method for preparing riphampycin BG48618A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG8308388A BG48618A1 (en) 1988-02-23 1988-02-23 Method for preparing riphampycin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG8308388A BG48618A1 (en) 1988-02-23 1988-02-23 Method for preparing riphampycin

Publications (1)

Publication Number Publication Date
BG48618A1 true BG48618A1 (en) 1991-04-15

Family

ID=3920177

Family Applications (1)

Application Number Title Priority Date Filing Date
BG8308388A BG48618A1 (en) 1988-02-23 1988-02-23 Method for preparing riphampycin

Country Status (1)

Country Link
BG (1) BG48618A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014026254A1 (en) 2012-08-13 2014-02-20 Adipharm Ead Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin sv and 3-formylrifamycin s and a process of their preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014026254A1 (en) 2012-08-13 2014-02-20 Adipharm Ead Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin sv and 3-formylrifamycin s and a process of their preparation
US9682997B2 (en) 2012-08-13 2017-06-20 Adipharm Ead Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin SV and 3-formylrifamycin S and a process of their preparation
US9981985B2 (en) 2012-08-13 2018-05-29 Adipharm Ead Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin SV and 3-formylrifamycin S and a process of their preparation

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