IN2015DN02009A - - Google Patents

Info

Publication number
IN2015DN02009A
IN2015DN02009A IN2009DEN2015A IN2015DN02009A IN 2015DN02009 A IN2015DN02009 A IN 2015DN02009A IN 2009DEN2015 A IN2009DEN2015 A IN 2009DEN2015A IN 2015DN02009 A IN2015DN02009 A IN 2015DN02009A
Authority
IN
India
Prior art keywords
formylrifamycine
preparation
cinnamyl
piperazinyl
amino derivatives
Prior art date
Application number
Inventor
Kiril Asenov Ninov
DIMOVA Velichka llieva APOSTOLOVA
Evtimia Ivanova Stefanova
Rossen Krumov Koytchev
Original Assignee
Adipharm Ead
Fudulov Bozhidar Lyubenov
Fudulov Lyibomir Bozhidarov
Ditchev Consulting Ood
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adipharm Ead, Fudulov Bozhidar Lyubenov, Fudulov Lyibomir Bozhidarov, Ditchev Consulting Ood filed Critical Adipharm Ead
Publication of IN2015DN02009A publication Critical patent/IN2015DN02009A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Chemistry (AREA)

Abstract

The present invention related to a process of preparation of pharmaceuti cally acceptable formulations containing as active substance 3 (4 cinnamyl l piperazinyl) amino derivatives of 3 formylrifamycine SV and 3 formylrifamycine S which possess high activity against Gram positive and Gram negative microorganisms as well as against tuberculous micobacteria (including atypical and rifamycin resistant) and to a method for the preparation of 3 (4 cinnamyl l piperazinyl) amino derivatives of 3 formylrifamycine SV and 3 formylrifamycine S. The method for the preparation of pharmaceutical compositions is readily feasible and does not require special equipment for its implementation. The process for preparing thecompounds is characterized by high yield and purity using an environmental clean solvent ethanol and water in the preparation and isolation of substances and the absence of residual organic solvents in the final product.
IN2009DEN2015 2012-08-13 2013-08-09 IN2015DN02009A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BG11128812 2012-08-13
PCT/BG2013/000041 WO2014026254A1 (en) 2012-08-13 2013-08-09 Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin sv and 3-formylrifamycin s and a process of their preparation

Publications (1)

Publication Number Publication Date
IN2015DN02009A true IN2015DN02009A (en) 2015-08-14

Family

ID=50101135

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2009DEN2015 IN2015DN02009A (en) 2012-08-13 2013-08-09

Country Status (18)

Country Link
US (2) US9682997B2 (en)
EP (1) EP2882435B8 (en)
JP (2) JP6400580B2 (en)
KR (1) KR102210848B1 (en)
CN (2) CN104736152B (en)
BR (1) BR112015002945B1 (en)
CA (1) CA2881958C (en)
EA (1) EA029363B1 (en)
ES (1) ES2876004T3 (en)
HK (1) HK1248691A1 (en)
HU (1) HUE054955T2 (en)
IN (1) IN2015DN02009A (en)
MX (1) MX380259B (en)
PL (1) PL2882435T3 (en)
PT (1) PT2882435T (en)
UA (1) UA120030C2 (en)
WO (1) WO2014026254A1 (en)
ZA (1) ZA201501268B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX386622B (en) * 2017-06-26 2025-03-19 Biofer Spa PYRIDO-IMIDAZO RIFAMYCIN DERIVATIVES AS AN ANTIBACTERIAL AGENT
TWI731295B (en) * 2019-01-24 2021-06-21 宏碁股份有限公司 Display apparatus and method for controlling display apparatus

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1478563A (en) 1975-03-05 1977-07-06 Lepetit Spa Rifamycin derivatives
GR64108B (en) 1977-04-15 1980-01-24 Dso Pharmachim Method for the preparation of azomethine-derivatives of rifamycin s.v
US4179439A (en) * 1977-07-01 1979-12-18 Intreprinderea De Antibiotice Iasi Rifamycins and method for their preparation
US4193020A (en) 1978-05-22 1980-03-11 Sperry Rand Corporation Phase lock control system with trajectory correction
JPS5738742A (en) * 1980-08-21 1982-03-03 Kawasaki Kasei Chem Ltd Preparation of 1,4-dihydroanthraquinone
JPS5695190A (en) * 1980-09-17 1981-08-01 Intorepurinderea De Anteibiote Manufacture of rifamycin derivative
IT1201963B (en) * 1983-03-24 1989-02-02 Prodotti Antibiotici Spa DERIVATIVES OF THE REFAMICINE AND PROCEDURE FOR THEIR PREPARATION
JPS6143132A (en) * 1984-08-06 1986-03-01 Takeda Chem Ind Ltd Quinone derivative, its preparation, and pharmaceutical composition containing same
WO1987002361A1 (en) * 1985-10-18 1987-04-23 Ciba-Geigy Ag Substituted 4-benzyl-piperazinyl compounds
IT1202424B (en) * 1987-01-26 1989-02-09 Prodotti Antibiotici Spa SALTS OF A RIFAMICINIC DERIVATIVE
EP0284552A1 (en) * 1987-03-06 1988-09-28 Ciba-Geigy Ag 4-Benzyl-piperazinyl-hydrazones
BG48618A1 (en) 1988-02-23 1991-04-15 Nauchen Inst Promishlena Mikro Method for preparing riphampycin
JPH02215716A (en) * 1989-02-08 1990-08-28 Farmitalia Carlo Erba Spa Drug composition containing 3-( n-piperidiomethyl-azino)methylrifamycin s as active ingredient
US5095108A (en) 1990-08-28 1992-03-10 Technologichen Kombinat Za Promishlena Microbiologia Non-solvated crystalline form "A" of 3-(4-cynnamyl-1-piperazinyl)iminomethylrifamycine SV and a method of its production
BG64021B1 (en) * 1998-11-04 2003-10-31 КОНСТАНТИНОВА Румяна Sodium salt of 3-(4-cinnamyl-1-piperazinyl)-iminomethyl rifamycin and method for its preparation
DE10015814A1 (en) * 2000-03-30 2001-10-11 Max Planck Gesellschaft Medicines to stimulate leukopoiesis, treat tumors and protozoan diseases and process for its manufacture
DE10038101A1 (en) * 2000-08-04 2002-02-14 Degussa Process for the preparation of 2- (4-methyl-3-pentenyl) anthraquinone
UA80393C2 (en) * 2000-12-07 2007-09-25 Алтана Фарма Аг Pharmaceutical preparation comprising an pde inhibitor dispersed on a matrix
US7226931B2 (en) * 2004-07-22 2007-06-05 Cumbre Pharmaceuticals Inc. (R/S) rifamycin derivatives, their preparations and pharmaceutical compositions
GB0505909D0 (en) * 2005-03-23 2005-04-27 Univ Leeds Formulations

Also Published As

Publication number Publication date
HUE054955T2 (en) 2021-10-28
BR112015002945A8 (en) 2018-01-16
US20170283433A1 (en) 2017-10-05
JP6694029B2 (en) 2020-05-13
MX2015001963A (en) 2015-06-04
EP2882435B8 (en) 2024-01-03
CN104736152A (en) 2015-06-24
UA120030C2 (en) 2019-09-25
JP6400580B2 (en) 2018-10-03
MX380259B (en) 2025-03-12
CA2881958A1 (en) 2014-02-20
US9682997B2 (en) 2017-06-20
EP2882435B1 (en) 2021-03-17
BR112015002945A2 (en) 2017-12-05
BR112015002945B1 (en) 2021-08-31
PT2882435T (en) 2021-06-18
WO2014026254A1 (en) 2014-02-20
PL2882435T3 (en) 2021-10-04
EP2882435A1 (en) 2015-06-17
HK1248691A1 (en) 2018-10-19
EA029363B1 (en) 2018-03-30
CA2881958C (en) 2019-08-27
US20150368263A1 (en) 2015-12-24
KR20150042275A (en) 2015-04-20
HK1206980A1 (en) 2016-01-22
ES2876004T3 (en) 2021-11-11
EA201590278A1 (en) 2015-07-30
ZA201501268B (en) 2016-01-27
JP2015528823A (en) 2015-10-01
CN107840854A (en) 2018-03-27
US9981985B2 (en) 2018-05-29
EP2882435A4 (en) 2017-05-03
CN104736152B (en) 2018-01-23
KR102210848B1 (en) 2021-02-02
JP2018199718A (en) 2018-12-20

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