IN2015DN02009A - - Google Patents
Info
- Publication number
- IN2015DN02009A IN2015DN02009A IN2009DEN2015A IN2015DN02009A IN 2015DN02009 A IN2015DN02009 A IN 2015DN02009A IN 2009DEN2015 A IN2009DEN2015 A IN 2009DEN2015A IN 2015DN02009 A IN2015DN02009 A IN 2015DN02009A
- Authority
- IN
- India
- Prior art keywords
- formylrifamycine
- preparation
- cinnamyl
- piperazinyl
- amino derivatives
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 2
- 125000004193 piperazinyl group Chemical group 0.000 abstract 2
- 229930189077 Rifamycin Natural products 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960003292 rifamycin Drugs 0.000 abstract 1
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Inorganic Chemistry (AREA)
Abstract
The present invention related to a process of preparation of pharmaceuti cally acceptable formulations containing as active substance 3 (4 cinnamyl l piperazinyl) amino derivatives of 3 formylrifamycine SV and 3 formylrifamycine S which possess high activity against Gram positive and Gram negative microorganisms as well as against tuberculous micobacteria (including atypical and rifamycin resistant) and to a method for the preparation of 3 (4 cinnamyl l piperazinyl) amino derivatives of 3 formylrifamycine SV and 3 formylrifamycine S. The method for the preparation of pharmaceutical compositions is readily feasible and does not require special equipment for its implementation. The process for preparing thecompounds is characterized by high yield and purity using an environmental clean solvent ethanol and water in the preparation and isolation of substances and the absence of residual organic solvents in the final product.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG11128812 | 2012-08-13 | ||
| PCT/BG2013/000041 WO2014026254A1 (en) | 2012-08-13 | 2013-08-09 | Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin sv and 3-formylrifamycin s and a process of their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN02009A true IN2015DN02009A (en) | 2015-08-14 |
Family
ID=50101135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2009DEN2015 IN2015DN02009A (en) | 2012-08-13 | 2013-08-09 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9682997B2 (en) |
| EP (1) | EP2882435B8 (en) |
| JP (2) | JP6400580B2 (en) |
| KR (1) | KR102210848B1 (en) |
| CN (2) | CN104736152B (en) |
| BR (1) | BR112015002945B1 (en) |
| CA (1) | CA2881958C (en) |
| EA (1) | EA029363B1 (en) |
| ES (1) | ES2876004T3 (en) |
| HK (2) | HK1206980A1 (en) |
| HU (1) | HUE054955T2 (en) |
| IN (1) | IN2015DN02009A (en) |
| MX (1) | MX2015001963A (en) |
| PL (1) | PL2882435T3 (en) |
| PT (1) | PT2882435T (en) |
| UA (1) | UA120030C2 (en) |
| WO (1) | WO2014026254A1 (en) |
| ZA (1) | ZA201501268B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019003076A1 (en) * | 2017-06-26 | 2019-01-03 | Biofer S.P.A. | Pyrido-imidazo rifamycin derivatives as antibacterial agent |
| TWI731295B (en) * | 2019-01-24 | 2021-06-21 | 宏碁股份有限公司 | Display apparatus and method for controlling display apparatus |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1478563A (en) | 1975-03-05 | 1977-07-06 | Lepetit Spa | Rifamycin derivatives |
| GR64108B (en) | 1977-04-15 | 1980-01-24 | Dso Pharmachim | Method for the preparation of azomethine-derivatives of rifamycin s.v |
| US4179439A (en) * | 1977-07-01 | 1979-12-18 | Intreprinderea De Antibiotice Iasi | Rifamycins and method for their preparation |
| US4193020A (en) | 1978-05-22 | 1980-03-11 | Sperry Rand Corporation | Phase lock control system with trajectory correction |
| JPS5738742A (en) * | 1980-08-21 | 1982-03-03 | Kawasaki Kasei Chem Ltd | Preparation of 1,4-dihydroanthraquinone |
| JPS5695190A (en) * | 1980-09-17 | 1981-08-01 | Intorepurinderea De Anteibiote | Manufacture of rifamycin derivative |
| IT1201963B (en) * | 1983-03-24 | 1989-02-02 | Prodotti Antibiotici Spa | DERIVATIVES OF THE REFAMICINE AND PROCEDURE FOR THEIR PREPARATION |
| JPS6143132A (en) * | 1984-08-06 | 1986-03-01 | Takeda Chem Ind Ltd | Quinone derivative, its preparation, and pharmaceutical composition containing same |
| JPS63501712A (en) * | 1985-10-18 | 1988-07-14 | チバ−ガイギ− アクチエンゲゼルシヤフト | Substituted 4-benzylpiperazinyl compounds |
| IT1202424B (en) * | 1987-01-26 | 1989-02-09 | Prodotti Antibiotici Spa | SALTS OF A RIFAMICINIC DERIVATIVE |
| EP0284552A1 (en) * | 1987-03-06 | 1988-09-28 | Ciba-Geigy Ag | 4-Benzyl-piperazinyl-hydrazones |
| BG48618A1 (en) | 1988-02-23 | 1991-04-15 | Nauchen Inst Promishlena Mikro | Method for preparing riphampycin |
| JPH02215716A (en) * | 1989-02-08 | 1990-08-28 | Farmitalia Carlo Erba Spa | Drug composition containing 3-( n-piperidiomethyl-azino)methylrifamycin s as active ingredient |
| US5095108A (en) * | 1990-08-28 | 1992-03-10 | Technologichen Kombinat Za Promishlena Microbiologia | Non-solvated crystalline form "A" of 3-(4-cynnamyl-1-piperazinyl)iminomethylrifamycine SV and a method of its production |
| BG64021B1 (en) * | 1998-11-04 | 2003-10-31 | КОНСТАНТИНОВА Румяна | Sodium salt of 3-(4-cinnamyl-1-piperazinyl)-iminomethyl rifamycin and method for its preparation |
| DE10015814A1 (en) * | 2000-03-30 | 2001-10-11 | Max Planck Gesellschaft | Medicines to stimulate leukopoiesis, treat tumors and protozoan diseases and process for its manufacture |
| DE10038101A1 (en) * | 2000-08-04 | 2002-02-14 | Degussa | Process for the preparation of 2- (4-methyl-3-pentenyl) anthraquinone |
| UA80393C2 (en) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Pharmaceutical preparation comprising an pde inhibitor dispersed on a matrix |
| JP5236944B2 (en) * | 2004-07-22 | 2013-07-17 | カムブァ、アイピー、ヴェンチュァズ、エル、ピー | Rifamycin derivatives for treating microbial infections |
| GB0505909D0 (en) * | 2005-03-23 | 2005-04-27 | Univ Leeds | Formulations |
-
2013
- 2013-08-09 PT PT138294459T patent/PT2882435T/en unknown
- 2013-08-09 IN IN2009DEN2015 patent/IN2015DN02009A/en unknown
- 2013-08-09 ES ES13829445T patent/ES2876004T3/en active Active
- 2013-08-09 BR BR112015002945-0A patent/BR112015002945B1/en active IP Right Grant
- 2013-08-09 PL PL13829445T patent/PL2882435T3/en unknown
- 2013-08-09 US US14/421,364 patent/US9682997B2/en active Active
- 2013-08-09 MX MX2015001963A patent/MX2015001963A/en unknown
- 2013-08-09 KR KR1020157006421A patent/KR102210848B1/en active IP Right Grant
- 2013-08-09 CN CN201380053241.6A patent/CN104736152B/en active Active
- 2013-08-09 JP JP2015526838A patent/JP6400580B2/en active Active
- 2013-08-09 UA UAA201502014A patent/UA120030C2/en unknown
- 2013-08-09 WO PCT/BG2013/000041 patent/WO2014026254A1/en active Application Filing
- 2013-08-09 HU HUE13829445A patent/HUE054955T2/en unknown
- 2013-08-09 EP EP13829445.9A patent/EP2882435B8/en active Active
- 2013-08-09 CA CA2881958A patent/CA2881958C/en active Active
- 2013-08-09 EA EA201590278A patent/EA029363B1/en unknown
- 2013-08-09 CN CN201711346387.6A patent/CN107840854A/en active Pending
-
2015
- 2015-02-25 ZA ZA2015/01268A patent/ZA201501268B/en unknown
- 2015-08-06 HK HK15107597.5A patent/HK1206980A1/en unknown
-
2017
- 2017-06-14 US US15/622,880 patent/US9981985B2/en active Active
-
2018
- 2018-06-27 HK HK18108267.9A patent/HK1248691A1/en unknown
- 2018-09-04 JP JP2018165179A patent/JP6694029B2/en active Active
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