UA108527C2 - Preparation process of rifamycin group antibiotics watersoluble form - Google Patents

Preparation process of rifamycin group antibiotics watersoluble form

Info

Publication number
UA108527C2
UA108527C2 UAA201309032A UAA201309032A UA108527C2 UA 108527 C2 UA108527 C2 UA 108527C2 UA A201309032 A UAA201309032 A UA A201309032A UA A201309032 A UAA201309032 A UA A201309032A UA 108527 C2 UA108527 C2 UA 108527C2
Authority
UA
Ukraine
Prior art keywords
rifamycin
preparation process
group
watersoluble
rifamycin group
Prior art date
Application number
UAA201309032A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Владімір Євстахієвіч Бабій
Алєксєй Владіміровіч Ігнатьєв
Свєтлана Еммануіловна Гєльпєріна
Ольга Олєговна Максімєнко
Людміла Вітальєвна Ванчугова
Єлєна Владіміровна Шіпуло
Original Assignee
Общєство С Огранічєнной Отвєтствєнностью "Научно-Проізводствєнний Комплєкс "Наносістєма"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общєство С Огранічєнной Отвєтствєнностью "Научно-Проізводствєнний Комплєкс "Наносістєма" filed Critical Общєство С Огранічєнной Отвєтствєнностью "Научно-Проізводствєнний Комплєкс "Наносістєма"
Publication of UA108527C2 publication Critical patent/UA108527C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to the field of medicine, pharmaceutics, nano-technology and colloidal chemistry, in particular to a method for producing a watersoluble pharmaceutical form (pharmaceutical composition) of an antibiotic obtained from the rifamycin group, such a) dissolving the antibiotic of the rifamycin group in an organic solvent selected from the group of solvents miscible with water (acetone ethanol, isopropanol) b) adding to the solution obtained in the step a), of the aqueous albumin solution obtained by dissolving 1-10% w/v albumin in sterile demineralized water; c) mixing the obtatained mixture; d) filtration; d) adding a cryoprotectant; e) freezing; g) freeze-drying or spraying.
UAA201309032A 2010-12-27 2011-12-21 Preparation process of rifamycin group antibiotics watersoluble form UA108527C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EA201001854A EA021117B1 (en) 2010-12-27 2010-12-27 Method for producing a water-soluble pharmaceutical composition of an antibiotic from the group consisting of rifamycins, and pharmaceutical composition for treating tuberculosis and diseases associated with helicobacter pylori
PCT/EA2011/000014 WO2012089220A1 (en) 2010-12-27 2011-12-21 Method for producing a water-soluble medicinal form of an antibiotic from the group consisting of rifamycins, and composition produced by said method

Publications (1)

Publication Number Publication Date
UA108527C2 true UA108527C2 (en) 2015-05-12

Family

ID=46382331

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201309032A UA108527C2 (en) 2010-12-27 2011-12-21 Preparation process of rifamycin group antibiotics watersoluble form

Country Status (5)

Country Link
AP (1) AP2013007013A0 (en)
EA (1) EA021117B1 (en)
UA (1) UA108527C2 (en)
WO (1) WO2012089220A1 (en)
ZA (1) ZA201305684B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2540510C2 (en) * 2013-06-10 2015-02-10 Общество с ограниченной ответственностью "Научно-Производственный Комплекс "Наноситема" Method of obtaining biocompatible gallium(iii)-containing highly disperse particles for manufacturing diagnostic preparations for positron-emission tomography
RU2015133801A (en) * 2014-01-09 2017-02-16 Камус Фарма Пвт. Лтд. Lyophilized formulations for parenteral use
CN105012249A (en) * 2014-04-30 2015-11-04 北京星昊医药股份有限公司 Injection rifampicin and preparing method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100528160C (en) * 2006-06-29 2009-08-19 西北农林科技大学 An antibacterial rifampicin nanoemulsion and preparation method thereof
RU2337711C1 (en) * 2007-04-04 2008-11-10 Общество С Ограниченной Ответственностью "Научно-Производственный Комплекс "Наносистема" Agent for bacterial infections treatment
EA200801388A1 (en) * 2008-06-20 2009-08-28 Ооо «Нпк "Наносистема"» PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF TUBERCULOSIS AND DISEASES MEDIATED BY HELICOBACTER PILORY BASED ON POLYMERIC NANOPARTICLES, ITS TREATMENT METHOD AND TREATMENT METHOD
EA013569B1 (en) * 2009-02-24 2010-06-30 Ооо "Научно-Производственный Комплекс "Наносистема"" Pharmaceutical composition of rifabutin for treating tuberculosis and other diseases mediated by helicobacter pylori, method of production thereof and method for treatment thereof
EA013570B1 (en) * 2009-02-24 2010-06-30 Ооо "Научно-Производственный Комплекс "Наносистема"" Pharmaceutical composition for treating tuberculosis and diseases mediated by helicobacter pylori based on solid lipid nanoparticles and a method for the treatment of tuberculosis

Also Published As

Publication number Publication date
EA021117B1 (en) 2015-04-30
AP2013007013A0 (en) 2013-07-31
WO2012089220A1 (en) 2012-07-05
ZA201305684B (en) 2014-10-29
EA201001854A1 (en) 2012-06-29

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