MX375482B - Composición y método para estabilizar ácidos nucleicos en muestras biológicas. - Google Patents

Composición y método para estabilizar ácidos nucleicos en muestras biológicas.

Info

Publication number
MX375482B
MX375482B MX2016011495A MX2016011495A MX375482B MX 375482 B MX375482 B MX 375482B MX 2016011495 A MX2016011495 A MX 2016011495A MX 2016011495 A MX2016011495 A MX 2016011495A MX 375482 B MX375482 B MX 375482B
Authority
MX
Mexico
Prior art keywords
biological samples
composition
nucleic acids
stabilizing
stabilizing nucleic
Prior art date
Application number
MX2016011495A
Other languages
English (en)
Other versions
MX2016011495A (es
Inventor
Carlos Alberto Merino HERNANDEZ
Evgueni Vladimirovitch Doukhanine
Hyman Chaim Birnboim
Lindsay Pozza
Original Assignee
Dna Genotek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dna Genotek Inc filed Critical Dna Genotek Inc
Publication of MX2016011495A publication Critical patent/MX2016011495A/es
Publication of MX375482B publication Critical patent/MX375482B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Se divulgan métodos, composiciones y kits para estabilizar el ácido desoxirribonucleico (ADN) tanto humano como microbiano presente en muestras biológicas complejas, tales como heces. En particular, se divulgan composiciones acuosas para estabilizar el ADN contenido en las muestras biológicas a temperatura ambiente, junto con métodos asociados y kits usando la misma. En un aspecto, las composiciones comprenden un agente quelante en una concentración de por lo menos alrededor de 150 mM, y la composición tiene un pH de al menos alrededor de 9.5.
MX2016011495A 2014-03-07 2015-03-06 Composición y método para estabilizar ácidos nucleicos en muestras biológicas. MX375482B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461949692P 2014-03-07 2014-03-07
US201462057769P 2014-09-30 2014-09-30
PCT/CA2015/050173 WO2015131291A1 (en) 2014-03-07 2015-03-06 Composition and method for stabilizing nucleic acids in biological samples

Publications (2)

Publication Number Publication Date
MX2016011495A MX2016011495A (es) 2017-07-11
MX375482B true MX375482B (es) 2025-03-06

Family

ID=54054312

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011495A MX375482B (es) 2014-03-07 2015-03-06 Composición y método para estabilizar ácidos nucleicos en muestras biológicas.

Country Status (18)

Country Link
US (2) US10435735B2 (es)
EP (1) EP3114225B1 (es)
JP (1) JP6670765B2 (es)
KR (1) KR102392407B1 (es)
CN (1) CN106255753B (es)
AU (1) AU2015226811B2 (es)
CA (1) CA2941764C (es)
DK (1) DK3114225T3 (es)
ES (1) ES2880310T3 (es)
IL (1) IL247662B2 (es)
MX (1) MX375482B (es)
PL (1) PL3114225T3 (es)
PT (1) PT3114225T (es)
RU (1) RU2717644C2 (es)
SA (2) SA521421271B1 (es)
SG (2) SG11201607364RA (es)
WO (1) WO2015131291A1 (es)
ZA (1) ZA201906139B (es)

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