MX2017013878A - Amplificación de discordancias optimizadas multiplicadas (moma) - reacción en cadena de polimerasa (pcr) en tiempo real, para evaluar el ácido desoxirribonucleico (adn) libre de celula. - Google Patents

Amplificación de discordancias optimizadas multiplicadas (moma) - reacción en cadena de polimerasa (pcr) en tiempo real, para evaluar el ácido desoxirribonucleico (adn) libre de celula.

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Publication number
MX2017013878A
MX2017013878A MX2017013878A MX2017013878A MX2017013878A MX 2017013878 A MX2017013878 A MX 2017013878A MX 2017013878 A MX2017013878 A MX 2017013878A MX 2017013878 A MX2017013878 A MX 2017013878A MX 2017013878 A MX2017013878 A MX 2017013878A
Authority
MX
Mexico
Prior art keywords
moma
real time
time pcr
free dna
assessing cell
Prior art date
Application number
MX2017013878A
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English (en)
Inventor
Michael Mitchell
Tomita Mitchell Aoy
Stamm Karl
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Medical College Of Wisconsin Inc
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Publication date
Application filed by Medical College Of Wisconsin Inc filed Critical Medical College Of Wisconsin Inc
Publication of MX2017013878A publication Critical patent/MX2017013878A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Esta invención se refiere a métodos y composiciones para evaluar la cantidad de ácidos nucleicos no nativos en una muestra, tal como de un sujeto; los métodos y composiciones provistos en la presente se pueden usar para determinar el riesgo de una condición, tal como el rechazo de trasplante, en un sujeto.
MX2017013878A 2015-04-30 2016-04-29 Amplificación de discordancias optimizadas multiplicadas (moma) - reacción en cadena de polimerasa (pcr) en tiempo real, para evaluar el ácido desoxirribonucleico (adn) libre de celula. MX2017013878A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562155453P 2015-04-30 2015-04-30
PCT/US2016/030313 WO2016176662A1 (en) 2015-04-30 2016-04-29 Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna

Publications (1)

Publication Number Publication Date
MX2017013878A true MX2017013878A (es) 2018-06-22

Family

ID=56027193

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017013878A MX2017013878A (es) 2015-04-30 2016-04-29 Amplificación de discordancias optimizadas multiplicadas (moma) - reacción en cadena de polimerasa (pcr) en tiempo real, para evaluar el ácido desoxirribonucleico (adn) libre de celula.

Country Status (12)

Country Link
US (1) US20180142296A1 (es)
EP (1) EP3289102A1 (es)
JP (2) JP2018514219A (es)
CN (1) CN107849604A (es)
AU (2) AU2016255573A1 (es)
BR (1) BR112017023232A2 (es)
CA (1) CA2984352A1 (es)
EA (1) EA201792389A1 (es)
HK (1) HK1252152A1 (es)
IL (2) IL255301B (es)
MX (1) MX2017013878A (es)
WO (1) WO2016176662A1 (es)

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* Cited by examiner, † Cited by third party
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US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US10179937B2 (en) 2014-04-21 2019-01-15 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
EP2854058A3 (en) 2010-05-18 2015-10-28 Natera, Inc. Methods for non-invasive pre-natal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
CA2870969C (en) 2012-04-19 2023-10-03 Aoy Tomita Mitchell Highly sensitive surveillance using detection of cell free dna
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
AU2017258801A1 (en) 2016-04-29 2018-12-20 The Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (MOMA)-target number
CA3022548A1 (en) * 2016-04-29 2017-11-02 The Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing fetal well being
CN109715826A (zh) * 2016-04-29 2019-05-03 威斯康星州立大学医学院 用于评估癌症的多重优化错配扩增（moma）实时pcr
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
MX2019005199A (es) * 2016-11-02 2019-10-14 Medical College Wisconsin Inc Métodos para evaluar el riesgo usando and libre de células total y específico.
US20190360033A1 (en) * 2016-11-02 2019-11-28 The Medical College Of Wisconsin, Inc. Methods for assessing risk using mismatch amplification and statistical methods
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CA3067634A1 (en) * 2017-06-20 2018-12-27 The Medical College Of Wisconsin, Inc. Assessing conditions in transplant subjects using donor-specific cell-free dna
AU2018288832A1 (en) 2017-06-20 2020-01-16 The Medical College Of Wisconsin, Inc. Assessing transplant complication risk with total cell-free DNA
CA3067635A1 (en) * 2017-06-20 2018-12-27 The Medical College Of Wisconsin, Inc. Transplant patient monitoring with cell-free dna
CN111183232A (zh) * 2017-08-17 2020-05-19 泰诊断有限公司 确定不具有供体基因型的供体无细胞dna的方法
CA3085565A1 (en) 2017-12-15 2019-06-20 Acrannolife Genomics Pvt. Ltd. A non-invasive method for monitoring transplanted organ status in organ-transplant recipients
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3899033A4 (en) * 2018-12-17 2022-10-19 The Medical College of Wisconsin, Inc. RISK ASSESSMENT WITH TOTAL ACELLULAR DNA
WO2020206290A1 (en) * 2019-04-03 2020-10-08 The Medical College Of Wisconsin, Inc. Methods for assessing risk using total cell-free dna
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
WO2021236962A1 (en) 2020-05-20 2021-11-25 The Medical College Of Wisconsin, Inc. Compositions and methods for inhibiting cytokine-release syndrome

Family Cites Families (6)

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ATE340871T1 (de) * 2001-12-24 2006-10-15 Wolfgang Prof Holzgreve Verfahren zur nicht-invasiven diagnose von transplantationen und transfusionen
DK2496720T3 (da) * 2009-11-06 2020-09-28 Univ Leland Stanford Junior Ikke-invasiv diagnose af transplantatafstødning i organ-transplanterede patienter
US20130143219A1 (en) * 2010-01-28 2013-06-06 Medical College of Wisconsin Inc. Methods and compositions for high yield, specific amplification
WO2011118603A1 (ja) * 2010-03-24 2011-09-29 凸版印刷株式会社 競合プライマーによる標的塩基配列の検出方法
CA2870969C (en) * 2012-04-19 2023-10-03 Aoy Tomita Mitchell Highly sensitive surveillance using detection of cell free dna
DK3004388T4 (da) * 2013-05-29 2023-08-28 Chronix Biomedical Påvisning og kvantificering af cellefrit dna fra donor i kredsløbet hos organtransplantatmodtagere

Also Published As

Publication number Publication date
WO2016176662A1 (en) 2016-11-03
IL255301A0 (en) 2017-12-31
EP3289102A1 (en) 2018-03-07
EA201792389A1 (ru) 2018-05-31
CA2984352A1 (en) 2016-11-03
AU2022203482A1 (en) 2022-06-09
JP2022002508A (ja) 2022-01-11
HK1252152A1 (zh) 2019-05-17
JP2018514219A (ja) 2018-06-07
IL289404A (en) 2022-02-01
US20180142296A1 (en) 2018-05-24
BR112017023232A2 (pt) 2018-08-07
AU2016255573A1 (en) 2017-12-21
CN107849604A (zh) 2018-03-27
IL255301B (en) 2022-02-01

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