MX348010B - Reprogramacion de celulas somaticas. - Google Patents
Reprogramacion de celulas somaticas.Info
- Publication number
- MX348010B MX348010B MX2009010847A MX2009010847A MX348010B MX 348010 B MX348010 B MX 348010B MX 2009010847 A MX2009010847 A MX 2009010847A MX 2009010847 A MX2009010847 A MX 2009010847A MX 348010 B MX348010 B MX 348010B
- Authority
- MX
- Mexico
- Prior art keywords
- somatic cells
- reprogramming
- differentiated
- methods
- cells
- Prior art date
Links
- 210000001082 somatic cell Anatomy 0.000 title abstract 5
- 230000008672 reprogramming Effects 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0273—Cloned vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8775—Murine embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
- C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91005—Transferases (2.) transferring one-carbon groups (2.1)
- G01N2333/91011—Methyltransferases (general) (2.1.1.)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Developmental Biology & Embryology (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Environmental Sciences (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92212107P | 2007-04-07 | 2007-04-07 | |
| US95934107P | 2007-07-12 | 2007-07-12 | |
| US3606508P | 2008-03-12 | 2008-03-12 | |
| PCT/US2008/004516 WO2008124133A1 (en) | 2007-04-07 | 2008-04-07 | Reprogramming of somatic cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2009010847A MX2009010847A (es) | 2010-04-27 |
| MX348010B true MX348010B (es) | 2017-05-23 |
Family
ID=39831277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015009872A MX352541B (es) | 2007-04-07 | 2008-04-07 | Reprogramación de células somáticas. |
| MX2009010847A MX348010B (es) | 2007-04-07 | 2008-04-07 | Reprogramacion de celulas somaticas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015009872A MX352541B (es) | 2007-04-07 | 2008-04-07 | Reprogramación de células somáticas. |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9382515B2 (enExample) |
| EP (3) | EP2145000A4 (enExample) |
| JP (8) | JP2010523117A (enExample) |
| CN (2) | CN101932705A (enExample) |
| AU (1) | AU2008236629B2 (enExample) |
| CA (2) | CA2683056C (enExample) |
| MX (2) | MX352541B (enExample) |
| RU (1) | RU2502799C2 (enExample) |
| WO (1) | WO2008124133A1 (enExample) |
Families Citing this family (159)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US8137907B2 (en) | 2005-01-03 | 2012-03-20 | Cold Spring Harbor Laboratory | Orthotopic and genetically tractable non-human animal model for liver cancer and the uses thereof |
| US20070044164A1 (en) | 2005-05-31 | 2007-02-22 | Cold Spring Harbor Laboratory | Methods for producing microRNAs |
| US7601699B2 (en) | 2005-08-01 | 2009-10-13 | Nupotential, Inc. | Production of reprogrammed cells with restored potential |
| AU2006325975B2 (en) | 2005-12-13 | 2011-12-08 | Kyoto University | Nuclear reprogramming factor |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| CA2683056C (en) | 2007-04-07 | 2020-03-24 | Whitehead Institute For Biomedical Research | Reprogramming of somatic cells |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| EP3078738B1 (en) * | 2007-08-31 | 2020-05-20 | Whitehead Institute for Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| US20110190729A1 (en) * | 2007-11-30 | 2011-08-04 | Cytomatrix Pty Ltd | Methods of inducing pluripotency involving sox2 protein |
| US20110190730A1 (en) * | 2007-11-30 | 2011-08-04 | Cytomatrix Pty Ltd | Methods of inducing pluripotency involving oct4 protein |
| JP5626619B2 (ja) * | 2008-12-08 | 2014-11-19 | 国立大学法人京都大学 | 効率的な核初期化方法 |
| JP5558097B2 (ja) * | 2007-12-10 | 2014-07-23 | 国立大学法人京都大学 | 効率的な核初期化方法 |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| CN102083982A (zh) * | 2008-04-07 | 2011-06-01 | 纽珀滕索有限公司 | 通过rna干扰引入复能基因而重编程细胞 |
| US20100279404A1 (en) | 2008-05-02 | 2010-11-04 | Shinya Yamanaka | Method of nuclear reprogramming |
| CN102725409B (zh) * | 2008-06-13 | 2016-03-30 | 怀特黑德生物医学研究所 | 细胞编程和重编程 |
| EP2295538B1 (en) * | 2008-07-07 | 2015-10-21 | Takara Bio Inc. | Method for production of pluripotent stem cell |
| EP2333050A4 (en) * | 2008-09-04 | 2013-07-03 | Riken | IPS CELLS FROM B-CELLS AND ITS APPLICATION |
| US20100062534A1 (en) * | 2008-09-09 | 2010-03-11 | The General Hospital Corporation | Inducible lentiviral vectors for reprogramming somatic cells |
| US20110318830A1 (en) * | 2008-11-12 | 2011-12-29 | The Regents Of The University Of California | Compositions and methods for re-programming and re-differentiating cells |
| KR20110102335A (ko) | 2008-12-23 | 2011-09-16 | 세게티스, 인코포레이티드. | 케탈 아미드 화합물, 제조 방법 및 적용분야 |
| CA2753845C (en) * | 2009-02-27 | 2019-10-29 | Kyoto University | Nuclear reprogramming substance comprising glis1 |
| EP2408904B1 (en) * | 2009-03-20 | 2017-10-18 | Mesoblast, Inc. | Production of reprogrammed pluripotent cells |
| CN101580816B (zh) * | 2009-04-23 | 2012-02-29 | 中国科学院广州生物医药与健康研究院 | 诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法 |
| US20110088107A1 (en) * | 2009-04-24 | 2011-04-14 | Yaqub Hanna | Compositions and methods for deriving or culturing pluripotent cells |
| WO2011006145A2 (en) | 2009-07-09 | 2011-01-13 | Whitehead Institute For Biomedical Research | Compositions and methods for mammalian genetics and uses thereof |
| EP2468312A4 (en) | 2009-08-19 | 2014-05-14 | Univ Tohoku | FOIL FOR CORNEAL TRANSPLANTS |
| KR20120061053A (ko) | 2009-08-27 | 2012-06-12 | 시냅틱 리서치, 엘엘씨 | 유도 만능 줄기(iPS) 세포 또는 조직 특이적 세포를 생성하기 위한 신규한 단백질 전달 시스템 |
| US9340772B2 (en) | 2009-10-29 | 2016-05-17 | Mcmaster University | Generating induced pluripotent stem cells and progenitor cells from fibroblasts |
| US9696297B2 (en) * | 2009-12-23 | 2017-07-04 | Salk Institute For Biological Studies | Method for preparing an X chromosome inactivated female human neural cell |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| US8765470B2 (en) | 2010-08-04 | 2014-07-01 | Cellular Dynamics International, Inc. | Reprogramming immortalized B-cells to induced pluripotent stem cells |
| CN103459611B (zh) | 2010-09-17 | 2016-11-02 | 哈佛大学校长及研究员协会 | 对多能干细胞的效用和安全性进行表征的功能基因组学研究 |
| JP5888753B2 (ja) | 2010-11-04 | 2016-03-22 | 国立大学法人京都大学 | 効率的な人工多能性幹細胞の樹立方法 |
| JP6029137B2 (ja) | 2010-12-03 | 2016-11-24 | 国立大学法人京都大学 | 効率的な人工多能性幹細胞の樹立方法 |
| JP6273842B2 (ja) * | 2011-02-25 | 2018-02-07 | 学校法人慶應義塾 | iPS細胞クローンの選択方法、及びその選択方法に用いる遺伝子の選択方法 |
| CN102731653B (zh) * | 2011-04-06 | 2013-12-11 | 李凌松 | 一种抗磷酸化Oct4蛋白的抗体及其应用 |
| GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
| GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| KR20250035015A (ko) | 2011-12-05 | 2025-03-11 | 팩터 바이오사이언스 인크. | 세포를 형질감염시키는 방법들 및 생성물들 |
| US20130202649A1 (en) * | 2012-01-17 | 2013-08-08 | The Board Of Trustees Of The Leland Stanford Junior University | Activation of innate immunity for nuclear reprogramming of somatic cells |
| WO2013163296A1 (en) | 2012-04-24 | 2013-10-31 | The Brigham And Women's Hospital, Inc. | Generating pluripotent cells de novo |
| JP2015521054A (ja) | 2012-06-05 | 2015-07-27 | カプリコール,インコーポレイテッド | 心臓組織から心臓幹細胞を作製するための最適化方法および心臓治療におけるそれらの使用 |
| WO2014028493A2 (en) | 2012-08-13 | 2014-02-20 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| EP2907870A4 (en) | 2012-10-09 | 2016-04-06 | Hayashi Nakanobu | REPROGRAMMING OF PEPTIDES AND USE THEREOF |
| US20140287932A1 (en) | 2012-10-25 | 2014-09-25 | Whitehead Institute For Biomedical Research | Super-enhancers and methods of use thereof |
| BR122019025681B1 (pt) | 2012-11-01 | 2023-04-18 | Factor Bioscience Inc | Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula |
| CA2895791A1 (en) | 2013-01-25 | 2014-07-31 | Xcell Biosciences, Inc. | Methods, compositions, kits, and systems for selective enrichment of target cells |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| EP4249507A3 (en) * | 2013-03-11 | 2023-12-27 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
| CN105247070A (zh) | 2013-03-15 | 2016-01-13 | 怀特黑德生物医学研究院 | 用于神经变性疾病的细胞性发现平台 |
| CN105531365A (zh) | 2013-04-23 | 2016-04-27 | 耶达研究及发展有限公司 | 分离的幼稚多能干细胞和产生所述细胞的方法 |
| CA2912172A1 (en) | 2013-06-05 | 2014-12-11 | Bellicum Pharmaceuticals, Inc. | Methods for inducing partial apoptosis using caspase polypeptides |
| EP3008229B1 (en) | 2013-06-10 | 2020-05-27 | President and Fellows of Harvard College | Early developmental genomic assay for characterizing pluripotent stem cell utility and safety |
| US20160222347A1 (en) | 2013-09-12 | 2016-08-04 | Kaneka Corporation | Method for inducing differentiation of induced pluripotent stem cells and method for selecting the same |
| US11767507B2 (en) | 2013-11-08 | 2023-09-26 | The Mclean Hospital Corporation | Methods for efficient generation of GABAergic interneurons from pluripotent stem cells |
| MX372651B (es) | 2014-01-31 | 2020-06-16 | Factor Bioscience Inc | ARN SINTÉTICO PARA SU Uso EN EL TRATAMIENTO DE LA EPIDERMÓLISIS AMPOLLOSA DISTRÓFICA. |
| WO2015120225A1 (en) * | 2014-02-10 | 2015-08-13 | The Board Of Trustees Of The Leland Stanford Junior University | ACTIVATION OF INNATE IMMUNITY FOR ENHANCED NUCLEAR REPROGRAMMING OF SOMATIC CELLS WITH mRNA |
| KR102443578B1 (ko) | 2014-03-19 | 2022-09-16 | 브이셀 세라퓨틱스 인코포레이티드 | 다능성 세포에 관한 방법 |
| CN108064274A (zh) | 2014-07-30 | 2018-05-22 | 耶达研究及发展有限公司 | 用于培养多能干细胞的培养基 |
| US11261453B2 (en) | 2014-09-12 | 2022-03-01 | Whitehead Institute For Biomedical Research | Cells expressing apolipoprotein E and uses thereof |
| EP3200808B1 (en) | 2014-10-03 | 2024-07-31 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| AU2016211688A1 (en) | 2015-01-26 | 2017-08-10 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
| JP7199809B2 (ja) | 2015-02-13 | 2023-01-06 | ファクター バイオサイエンス インコーポレイテッド | 核酸製品及びその投与方法 |
| US10961532B2 (en) * | 2015-04-07 | 2021-03-30 | The General Hospital Corporation | Methods for reactivating genes on the inactive X chromosome |
| ES2794628T3 (es) | 2015-04-15 | 2020-11-18 | Univ Massachusetts | Composiciones y métodos para la reactivación de cromosomas XI |
| US20170044609A1 (en) * | 2015-04-24 | 2017-02-16 | California Institute Of Technology | Reactivation of x chromosome genes |
| US11249071B2 (en) | 2015-04-24 | 2022-02-15 | California Institute Of Technology | Reactivation of x chromosome genes |
| RU2018106515A (ru) | 2015-07-21 | 2019-08-21 | Зе Чилдрен'С Медикал Сентер Корпорейшн | Pd-l1-экспрессирующие гемопоэтические стволовые клетки и применения |
| US10662409B2 (en) * | 2015-09-09 | 2020-05-26 | Trustees Of Tufts College | Methods of generating neural stem cells |
| US11253551B2 (en) | 2016-01-11 | 2022-02-22 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| CN105624117A (zh) * | 2016-01-18 | 2016-06-01 | 哈尔滨医科大学 | 一种低氧促进小鼠成纤维细胞重编程为心肌细胞的方法 |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| WO2017223199A1 (en) * | 2016-06-22 | 2017-12-28 | Xcell Biosciences, Inc. | Methods for increasing cell culture transfection efficiency and cellular reprogramming |
| EP3500585A4 (en) | 2016-08-17 | 2020-04-01 | Factor Bioscience Inc. | NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION |
| US11434476B2 (en) | 2016-08-19 | 2022-09-06 | Whitehead Institute For Biomedical Research | Methods of editing DNA methylation |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| CN106544315A (zh) * | 2016-10-12 | 2017-03-29 | 广东艾时代生物科技有限责任公司 | 一种脂肪间充质干细胞诱导成多能干细胞的方法 |
| WO2018081661A1 (en) | 2016-10-27 | 2018-05-03 | California Institute Of Technology | Hdac inhibitor compositions for reactivation of the x chromosome |
| US11944719B2 (en) | 2016-12-16 | 2024-04-02 | Iviva Medical, Inc. | Thin film interposition of basement membrane scaffolds |
| US11873496B2 (en) | 2017-01-09 | 2024-01-16 | Whitehead Institute For Biomedical Research | Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops |
| JPWO2018159805A1 (ja) | 2017-03-03 | 2020-01-09 | 国立大学法人京都大学 | 膵前駆細胞の製造方法 |
| US11345891B2 (en) * | 2017-04-05 | 2022-05-31 | Asgard Therapeutics Ab | Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof |
| EP3612191A4 (en) | 2017-04-19 | 2020-12-30 | Cedars-Sinai Medical Center | METHODS AND COMPOSITIONS FOR TREATING SKELETAL MUSCLE DYSTROPHY |
| WO2018230588A1 (ja) | 2017-06-14 | 2018-12-20 | 武田薬品工業株式会社 | 細胞封入デバイス |
| WO2019060708A1 (en) | 2017-09-22 | 2019-03-28 | The Children's Medical Center Corporation | TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS |
| KR20200091885A (ko) | 2017-11-30 | 2020-07-31 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 세포의 배양 방법 |
| PL241125B1 (pl) | 2017-11-30 | 2022-08-08 | Gdanski Univ Medyczny | Kompozycja farmaceutyczna do zastosowania jako środek do pobudzania regeneracji lub gojenia ran |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| WO2019124540A1 (ja) | 2017-12-22 | 2019-06-27 | 国立大学法人京都大学 | 細胞培養装置、培養液アスピレータ及び細胞培養方法 |
| CN108624621B (zh) * | 2018-01-17 | 2019-04-12 | 中国科学院上海生命科学研究院 | 非人灵长类的体细胞克隆动物的制备方法 |
| CN108103027B (zh) * | 2018-02-02 | 2021-12-24 | 中国医学科学院血液病医院(血液学研究所) | 高效率血细胞重编程同时实现基因编辑的方法 |
| WO2019152549A1 (en) | 2018-02-05 | 2019-08-08 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and y-rnas |
| TW201945536A (zh) | 2018-03-19 | 2019-12-01 | 國立大學法人京都大學 | 水凝膠膠囊 |
| EP3778587B1 (en) | 2018-03-30 | 2023-10-04 | Orizuru Therapeutics, Inc. | Heterocyclic compound |
| US20210054406A1 (en) | 2018-03-30 | 2021-02-25 | Kyoto University | Cell production method |
| EP3778869A4 (en) | 2018-03-30 | 2021-12-08 | Kyoto University | CARDIOMYOCYTE MATURATION PROMOTER |
| IL277806B2 (en) | 2018-04-23 | 2025-02-01 | Univ Kyoto | Growth inhibitor |
| SG11202101098YA (en) | 2018-08-03 | 2021-03-30 | Univ Kyoto | Cell production method |
| WO2020032179A1 (ja) | 2018-08-10 | 2020-02-13 | 国立大学法人京都大学 | Cd3陽性細胞の製造方法 |
| US20220145329A1 (en) | 2018-08-10 | 2022-05-12 | Kyoto University | Method for transfection into cardiomyocytes using cationic lipid |
| EA202190582A1 (ru) | 2018-08-22 | 2021-05-27 | Киото Юниверсити | Способ получения энтеральных нейральных клеток-предшественников |
| EP3845654A4 (en) | 2018-08-31 | 2022-05-11 | Noile-Immune Biotech, Inc. | Car-expressing t cells and car expression vector |
| EP3854869A4 (en) | 2018-09-19 | 2022-09-07 | Takeda Pharmaceutical Company Limited | INSULIN-PRODUCING CELLS |
| WO2020061591A1 (en) | 2018-09-21 | 2020-03-26 | President And Fellows Of Harvard College | Methods and compositions for treating diabetes, and methods for enriching mrna coding for secreted proteins |
| JP7553918B2 (ja) | 2018-10-15 | 2024-09-19 | 公立大学法人横浜市立大学 | 栄養組成物 |
| EP3904374A4 (en) | 2018-12-27 | 2022-09-21 | Kyoto University | OBJECT MODIFIED BY A T LYMPHOCYTE RECEPTOR |
| WO2020150391A1 (en) * | 2019-01-15 | 2020-07-23 | Falcon Therapeutics, Inc. | Engineered stem cell constructs and uses thereof |
| JP7508045B2 (ja) | 2019-02-01 | 2024-07-01 | 国立大学法人京都大学 | 細胞の検出方法 |
| CN113748213A (zh) | 2019-03-29 | 2021-12-03 | 公立大学法人横滨市立大学 | 筛选方法及毒性评价方法 |
| US12268715B2 (en) | 2019-04-10 | 2025-04-08 | Orizuru Therapeutics, Inc. | Method for producing biological tissue-like structure |
| WO2020230138A1 (en) | 2019-05-14 | 2020-11-19 | Aleph Farms Ltd. | Pluripotent cell aggregates and use thereof |
| JP7541700B2 (ja) | 2019-06-11 | 2024-08-29 | 国立大学法人京都大学 | 腎間質細胞の製造方法 |
| CN114450265B (zh) | 2019-07-03 | 2024-12-24 | 菲克特生物科学股份有限公司 | 阳离子脂质及其用途 |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| AU2020332643A1 (en) | 2019-08-20 | 2022-03-10 | Orizuru Therapeutics, Inc. | Method for enriching cardiac myocytes |
| CA3158631A1 (en) | 2019-10-21 | 2021-04-29 | Orizuru Therapeutics, Inc. | Growth inhibitor |
| WO2021085576A1 (ja) | 2019-11-01 | 2021-05-06 | 国立大学法人京都大学 | T細胞の製造方法 |
| AR120538A1 (es) | 2019-11-25 | 2022-02-23 | Univ Kyoto | Banco de células maestras de células t |
| WO2021187602A1 (ja) | 2020-03-19 | 2021-09-23 | 国立大学法人京都大学 | 心筋細胞の精製方法 |
| EP4123015A4 (en) | 2020-03-19 | 2024-05-22 | Orizuru Therapeutics, Inc. | Cardiomyocyte purification method |
| TW202204609A (zh) | 2020-03-31 | 2022-02-01 | 國立大學法人京都大學 | T前驅細胞的製造方法 |
| US20230227787A1 (en) | 2020-05-28 | 2023-07-20 | Orizuru Therapeutics, Inc. | Mass production method of uniform size cell aggregates |
| CN112201307B (zh) * | 2020-09-23 | 2024-09-17 | 温州医科大学 | 一种转录本注释方法以及筛选长非编码rna和内源逆转录病毒来源长非编码rna的方法 |
| JPWO2022107877A1 (enExample) | 2020-11-20 | 2022-05-27 | ||
| AU2022219794A1 (en) | 2021-02-09 | 2023-08-17 | Orizuru Therapeutics, Inc. | Maturation agent |
| CN116964193A (zh) | 2021-03-09 | 2023-10-27 | 国立大学法人东京医科齿科大学 | 细胞簇的制造方法 |
| CN117136231A (zh) | 2021-04-08 | 2023-11-28 | 武田药品工业株式会社 | 用于激活t细胞的方法 |
| CN113424794B (zh) * | 2021-04-16 | 2022-07-26 | 安徽农业大学 | 一种优质抗病型地方鸡新品系选育方法 |
| WO2022230919A1 (ja) | 2021-04-28 | 2022-11-03 | 国立大学法人 東京医科歯科大学 | 細胞の製造方法 |
| CN113278686A (zh) * | 2021-06-11 | 2021-08-20 | 扬州大学 | 一种研究dna甲基化调控重编程过程的方法 |
| US20240400993A1 (en) | 2021-09-27 | 2024-12-05 | Kyoto University | Method for producing t cell |
| WO2023149555A1 (ja) | 2022-02-04 | 2023-08-10 | 国立大学法人京都大学 | T細胞の製造方法 |
| CN119256076A (zh) | 2022-03-23 | 2025-01-03 | 国立大学法人京都大学 | 用于产生调节性t细胞的方法 |
| AU2023262842A1 (en) | 2022-04-25 | 2024-09-12 | Orizuru Therapeutics, Inc. | Maturing agent having both of alk5 inhibitory activity and cdk8/19 inhibitory activity |
| JPWO2023243627A1 (enExample) | 2022-06-17 | 2023-12-21 | ||
| KR20250036837A (ko) | 2022-07-14 | 2025-03-14 | 오리즈루 세라퓨틱스 가부시키가이샤 | 세포 이식용의 피브린 겔 시트 |
| CN119698464A (zh) | 2022-07-25 | 2025-03-25 | 国立大学法人京都大学 | 从灵长类的胚胎卵巢细胞诱导卵泡的体外培养法 |
| EP4563703A4 (en) | 2022-07-26 | 2025-09-24 | Univ Kyoto | ARTIFICIAL RECEIVER HAVING A LOAD-SHEDDING STRUCTURE |
| CN120051562A (zh) | 2022-08-05 | 2025-05-27 | 国立大学法人京都大学 | 用于产生心肌的方法 |
| JPWO2024034559A1 (enExample) | 2022-08-08 | 2024-02-15 | ||
| WO2024050517A1 (en) * | 2022-09-02 | 2024-03-07 | The University Of North Carolina At Chapel Hill | Methods of making and using anticancer reprogrammed b cells |
| WO2024070494A1 (ja) | 2022-09-26 | 2024-04-04 | 国立大学法人京都大学 | 膵内胚葉細胞の製造方法 |
| AU2023353929A1 (en) | 2022-09-26 | 2025-05-01 | Kyoto University | T cell production method |
| WO2024071280A1 (ja) | 2022-09-29 | 2024-04-04 | 国立大学法人京都大学 | 腎毒性評価方法 |
| CN120302984A (zh) | 2022-11-16 | 2025-07-11 | 学校法人关西医科大学 | 着床促进药和其筛选系统 |
| WO2025038494A1 (en) | 2023-08-11 | 2025-02-20 | Tune Therapeutics, Inc. | Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation |
| WO2025059073A1 (en) | 2023-09-11 | 2025-03-20 | Tune Therapeutics, Inc. | Epigenetic editing methods and systems for differentiating stem cells |
| WO2025106897A1 (en) * | 2023-11-16 | 2025-05-22 | Colossal Biosciences Inc. | Methods and compositions for creating induced pluripotent stem cells |
| WO2025260068A1 (en) | 2024-06-14 | 2025-12-18 | Tune Therapeutics, Inc. | Lipid nanoparticle formulation for delivery of nucleic acids to cells |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68218A (en) | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
| US5041138A (en) | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
| US4846835A (en) | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
| US5646008A (en) | 1993-06-22 | 1997-07-08 | The Regent Of The University Of Michigan | Vertebrate apoptosis gene: compositions and methods |
| US5824837A (en) | 1993-07-22 | 1998-10-20 | Merck & Co., Inc. | Expression of human interleukin-1β in a transgenic animal |
| US5723331A (en) | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
| US5698446A (en) | 1994-09-07 | 1997-12-16 | Chiron Corporation | Methods and compositions for inhibiting production of replication competent virus |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9809178D0 (en) * | 1998-04-29 | 1998-07-01 | Univ Edinburgh | Nuclear reprogramming of somatic cells |
| WO2000027995A1 (en) | 1998-11-09 | 2000-05-18 | Monash University | Embryonic stem cells |
| JP4523169B2 (ja) * | 1999-02-04 | 2010-08-11 | プルリステム リミテッド | 造血幹細胞および/または前駆細胞を維持および増加するための方法および装置 |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| AU2002242173A1 (en) | 2001-02-15 | 2002-08-28 | Whithead Institute For Biomedical Research | Stem cell identification |
| US20020137460A1 (en) * | 2001-03-08 | 2002-09-26 | Howard Sun | Universal multi-band (5 bands and more) keyless RF remote control unit using bluetooth radio module as the base |
| JP4183614B2 (ja) | 2001-05-31 | 2008-11-19 | 伸弥 山中 | Es細胞特異的発現遺伝子 |
| JP2003033179A (ja) | 2001-07-05 | 2003-02-04 | Asahi Kasei Corp | 可逆的遺伝子導入ベクター |
| WO2003027277A1 (en) | 2001-09-21 | 2003-04-03 | Japan Science And Technology Corporation | Method of screening reporgramming factor, reprogramming factor screened by the method, method of using the reprogramming factor, method of differentiating undifferentiated fused cells and method of constructing cell, tissues and organs |
| DE10162080A1 (de) | 2001-12-10 | 2003-06-26 | Albrecht Mueller | Verfahren zur Herstellung von Stammzellen mit erhöhtem Entwicklungspotential |
| GB0202149D0 (en) | 2002-01-30 | 2002-03-20 | Univ Edinburgh | Pluripotency determining factors and uses thereof |
| GB0211904D0 (en) | 2002-05-23 | 2002-07-03 | Medical Res Council | Nuclear transfer |
| CA2493768A1 (en) | 2002-07-23 | 2004-01-29 | Nanodiagnostics, Inc. | Embryonic stem cell markers and uses thereof |
| PL1641914T3 (pl) * | 2003-06-27 | 2017-01-31 | DePuy Synthes Products, Inc. | Komórki pochodzące z poporodowej tkanki łożyska oraz sposoby uzyskiwania i zastosowania tych komórek |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US7964401B2 (en) * | 2004-02-19 | 2011-06-21 | Kyoto University | Screening method for somatic cell nuclear reprogramming substance affecting ECAT2 and ECAT3 |
| EP1574499A1 (en) | 2004-03-08 | 2005-09-14 | DKFZ Deutsches Krebsforschungszentrum | Inhibitors of DNA methylation in tumor cells |
| BRPI0509179A (pt) * | 2004-03-23 | 2007-09-18 | Daiichi Asubio Pharma Co Ltd | método de crescimento de célula tronco pluripotente |
| WO2006050257A2 (en) | 2004-10-29 | 2006-05-11 | Massachusetts Institute Of Tecchnology | Detection of ion channel or receptor activity |
| WO2006116803A1 (en) * | 2005-04-29 | 2006-11-09 | Innovative Dairy Products Pty Ltd As Trustee For The Participants Of The Cooperative Research Centre For Innovative Dairy Products | A method for producing stem cells or stem cell-like cells from mammalian embryos |
| WO2007007054A1 (en) | 2005-07-08 | 2007-01-18 | Cancer Research Technology Limited | Phthalamides, succinimides and related compounds and their use as pharmaceuticals |
| US7601699B2 (en) | 2005-08-01 | 2009-10-13 | Nupotential, Inc. | Production of reprogrammed cells with restored potential |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| AU2006325975B2 (en) | 2005-12-13 | 2011-12-08 | Kyoto University | Nuclear reprogramming factor |
| GB0615327D0 (en) | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
| US7875741B2 (en) | 2006-06-27 | 2011-01-25 | Jawaharlal Nehru Centre For Advanced Scientific Research | Site-specific inhibitors of histone methyltransferase [HMTase] and process of preparation thereof |
| DK3399025T3 (da) * | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| CA2683056C (en) | 2007-04-07 | 2020-03-24 | Whitehead Institute For Biomedical Research | Reprogramming of somatic cells |
| WO2009032456A2 (en) * | 2007-08-01 | 2009-03-12 | Primegen Biotech Llc | Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state |
| EP3078738B1 (en) * | 2007-08-31 | 2020-05-20 | Whitehead Institute for Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| US20110151447A1 (en) | 2007-11-06 | 2011-06-23 | Children's Medical Center Corporation | Method to produce induced pluripotent stem (ips) cells from non-embryonic human cells |
| WO2009117439A2 (en) | 2008-03-17 | 2009-09-24 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| EP2268796A1 (en) | 2008-03-17 | 2011-01-05 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Vectors and methods for generating vector-free induced pluripotent stem (ips) cells using site-specific recombination |
| US20100279404A1 (en) | 2008-05-02 | 2010-11-04 | Shinya Yamanaka | Method of nuclear reprogramming |
| CN102725409B (zh) | 2008-06-13 | 2016-03-30 | 怀特黑德生物医学研究所 | 细胞编程和重编程 |
| WO2010033920A2 (en) | 2008-09-19 | 2010-03-25 | Whitehead Institute For Biomedical Research | Compositions and methods for enhancing cell reprogramming |
| CA2688804A1 (en) | 2008-12-17 | 2010-06-17 | The Uab Research Foundation | Polycistronic vector for human induced pluripotent stem cell production |
-
2008
- 2008-04-07 CA CA2683056A patent/CA2683056C/en active Active
- 2008-04-07 RU RU2009140903/10A patent/RU2502799C2/ru active
- 2008-04-07 MX MX2015009872A patent/MX352541B/es unknown
- 2008-04-07 CN CN2008800151822A patent/CN101932705A/zh active Pending
- 2008-04-07 AU AU2008236629A patent/AU2008236629B2/en active Active
- 2008-04-07 CN CN201610213311.5A patent/CN105861443A/zh active Pending
- 2008-04-07 EP EP08742630A patent/EP2145000A4/en not_active Ceased
- 2008-04-07 CA CA3071055A patent/CA3071055A1/en active Pending
- 2008-04-07 JP JP2010502158A patent/JP2010523117A/ja not_active Withdrawn
- 2008-04-07 EP EP21162420.0A patent/EP3878949B1/en active Active
- 2008-04-07 EP EP20120003893 patent/EP2626416A3/en not_active Ceased
- 2008-04-07 US US12/595,041 patent/US9382515B2/en active Active
- 2008-04-07 MX MX2009010847A patent/MX348010B/es active IP Right Grant
- 2008-04-07 WO PCT/US2008/004516 patent/WO2008124133A1/en not_active Ceased
-
2014
- 2014-08-29 US US14/473,250 patent/US9714414B2/en active Active
- 2014-12-12 JP JP2014251545A patent/JP2015051022A/ja not_active Withdrawn
-
2016
- 2016-11-14 JP JP2016221842A patent/JP2017035113A/ja not_active Withdrawn
-
2017
- 2017-05-26 US US15/607,028 patent/US10093904B2/en active Active
-
2018
- 2018-02-20 JP JP2018027715A patent/JP2018086017A/ja not_active Withdrawn
- 2018-09-28 US US16/147,003 patent/US20190241874A1/en not_active Abandoned
-
2019
- 2019-10-04 JP JP2019183743A patent/JP6934501B2/ja active Active
- 2019-10-04 JP JP2019183744A patent/JP2020014480A/ja not_active Withdrawn
-
2021
- 2021-12-16 JP JP2021204107A patent/JP2022031941A/ja active Pending
-
2024
- 2024-01-04 JP JP2024000151A patent/JP2024024049A/ja active Pending
- 2024-10-15 US US18/916,572 patent/US20250188423A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX348010B (es) | Reprogramacion de celulas somaticas. | |
| AU2009257219A8 (en) | Programming and reprogramming of cells | |
| WO2010033906A3 (en) | Efficient induction of pluripotent stem cells using small molecule compounds | |
| MY159971A (en) | Multipotent/pluripotent cells and methods | |
| WO2008118820A3 (en) | Somatic cell reprogramming | |
| WO2009126655A3 (en) | Reprogramming a cell by inducing a pluripotent gene through use of a small molecule modulator | |
| WO2010124142A3 (en) | Cell compositions derived from dedifferentiated reprogrammed cells | |
| WO2011071476A3 (en) | Compositions and methods for engineering cells | |
| WO2009143421A3 (en) | Methods for promoting fusion and reprogramming of somatic cells | |
| WO2011082038A3 (en) | Improved reprogramming compositions | |
| WO2010111422A3 (en) | Induced pluripotent stem cell generation using two factors and p53 inactivation | |
| MX2010002028A (es) | Metodos y composiciones para modular celulas t. | |
| WO2007089798A3 (en) | Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof | |
| WO2008036374A3 (en) | Allogeneic stem cell transplants in non-conditioned recipients | |
| EP2374871A4 (en) | PLURIPOTENTIAL STEM CELLS, METHOD FOR THEIR PRODUCTION AND USE | |
| WO2010120785A3 (en) | Methods and compositions for stem cell cultures | |
| WO2010088633A3 (en) | Novel cell lines and methods | |
| WO2010009015A3 (en) | Production of pluripotent cells through inhibition of bright/arid3a function | |
| PH12012500818A1 (en) | Pluripotent stem cells | |
| MX2010000348A (es) | Cultivo de celulas madre pluripotentes individuales. | |
| WO2007008758A3 (en) | Methods for identifying agents and conditions that modulate neurogenesis | |
| WO2009102569A3 (en) | Cell lines and methods for making and using them | |
| MY146352A (en) | Adipose derived adult stem cells in hepatic regeneration | |
| EP2408904A4 (en) | PREPARATION OF REPROGRAMMED PLURIPOTENTIAL CELLS | |
| WO2010093655A3 (en) | Enhanced method for producing stem-like cells from somatic cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |