MX2019005330A - Esteroides y conjugados de proteinas de los mismos. - Google Patents
Esteroides y conjugados de proteinas de los mismos.Info
- Publication number
- MX2019005330A MX2019005330A MX2019005330A MX2019005330A MX2019005330A MX 2019005330 A MX2019005330 A MX 2019005330A MX 2019005330 A MX2019005330 A MX 2019005330A MX 2019005330 A MX2019005330 A MX 2019005330A MX 2019005330 A MX2019005330 A MX 2019005330A
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- conjugates
- steroids
- gcs
- glucocorticoids
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title abstract 2
- 239000003862 glucocorticoid Substances 0.000 abstract 3
- 229940037128 systemic glucocorticoids Drugs 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen aquí conjugados de esteroide de proteína que son útiles, por ejemplo, para la entrega específica a objetivo de glucocorticoides (GCs) a las células.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662419365P | 2016-11-08 | 2016-11-08 | |
US201762508317P | 2017-05-18 | 2017-05-18 | |
PCT/US2017/060434 WO2018089373A2 (en) | 2016-11-08 | 2017-11-07 | Steroids and protein-conjugates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019005330A true MX2019005330A (es) | 2019-09-11 |
Family
ID=60409441
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019005330A MX2019005330A (es) | 2016-11-08 | 2017-11-07 | Esteroides y conjugados de proteinas de los mismos. |
MX2021012927A MX2021012927A (es) | 2016-11-08 | 2019-05-07 | Esteroides y conjugados de proteinas de los mismos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021012927A MX2021012927A (es) | 2016-11-08 | 2019-05-07 | Esteroides y conjugados de proteinas de los mismos. |
Country Status (16)
Country | Link |
---|---|
US (4) | US10711032B2 (es) |
EP (1) | EP3538539A2 (es) |
JP (2) | JP7330101B2 (es) |
KR (2) | KR20240025695A (es) |
CN (2) | CN110291097A (es) |
AU (1) | AU2017359043B2 (es) |
BR (1) | BR112019009019A2 (es) |
CA (1) | CA3042428A1 (es) |
CL (1) | CL2019001259A1 (es) |
CO (1) | CO2019005966A2 (es) |
IL (2) | IL266353B2 (es) |
MX (2) | MX2019005330A (es) |
PH (1) | PH12019501021A1 (es) |
SG (1) | SG10202104259RA (es) |
WO (1) | WO2018089373A2 (es) |
ZA (1) | ZA201902871B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220119529A (ko) | 2016-06-02 | 2022-08-29 | 애브비 인코포레이티드 | 글루코코르티코이드 수용체 작용제 및 이의 면역접합체 |
US10711032B2 (en) | 2016-11-08 | 2020-07-14 | Regeneron Pharmaceuticals, Inc. | Steroids and protein-conjugates thereof |
AU2018270784B2 (en) | 2017-05-18 | 2024-05-16 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
CA3080857A1 (en) * | 2017-11-07 | 2019-05-16 | Regeneron Pharmaceuticals, Inc. | Hydrophilic linkers for antibody drug conjugates |
WO2019106609A1 (en) | 2017-12-01 | 2019-06-06 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
SG11202006510XA (en) | 2018-01-08 | 2020-08-28 | Regeneron Pharma | Steroids and antibody-conjugates thereof |
KR20210008008A (ko) | 2018-05-09 | 2021-01-20 | 리제너론 파마슈티칼스 인코포레이티드 | 항-msr1 항체 및 이의 사용 방법 |
EA202191430A1 (ru) * | 2018-11-20 | 2021-11-29 | Регенерон Фармасьютикалз, Инк. | Производные бис-октагидрофенантренкарбоксамида и их белковые конъюгаты |
TW202120500A (zh) | 2019-08-02 | 2021-06-01 | 美商梅爾莎納醫療公司 | 干擾素基因刺激蛋白(sting)激動劑化合物及用途 |
IL295312A (en) | 2020-02-28 | 2022-10-01 | Regeneron Pharma | Bispecific antigen binding molecules that bind her2 and methods of using them |
WO2022015656A1 (en) | 2020-07-13 | 2022-01-20 | Regeneron Pharmaceuticals, Inc. | Camptothecin analogs conjugated to a glutamine residue in a protein, and their use |
CA3190569A1 (en) | 2020-10-22 | 2022-04-28 | Christopher Daly | Anti-fgfr2 antibodies and methods of use thereof |
KR20230107261A (ko) | 2020-11-10 | 2023-07-14 | 리제너론 파마슈티칼스 인코포레이티드 | 셀레늄 항체 접합물 |
CA3200768A1 (en) * | 2020-12-04 | 2022-06-09 | Scott Hilderbrand | Antibody-oligonucleotide complexes and uses thereof |
WO2022135332A1 (zh) * | 2020-12-21 | 2022-06-30 | 映恩生物制药(苏州)有限公司 | 一种甾体偶联物 |
WO2022166779A1 (zh) * | 2021-02-04 | 2022-08-11 | 上海森辉医药有限公司 | 糖皮质激素受体激动剂的药物偶联物及其在医药上的应用 |
WO2022171101A1 (zh) * | 2021-02-10 | 2022-08-18 | 映恩生物制药(苏州)有限公司 | 一种甾体偶联物 |
TW202304462A (zh) | 2021-03-23 | 2023-02-01 | 美商美國禮來大藥廠 | 糖皮質素受體激動劑 |
TW202304464A (zh) | 2021-03-23 | 2023-02-01 | 美商美國禮來大藥廠 | 新穎糖皮質素受體激動劑 |
AR125079A1 (es) | 2021-03-23 | 2023-06-07 | Lilly Co Eli | Agonistas de receptores de glucocorticoides sustituidos con carboxi |
CN113264983A (zh) * | 2021-05-20 | 2021-08-17 | 联宁(苏州)生物制药有限公司 | 一种用于抗体偶联药物的连接子lnd1088的合成方法 |
CN117500816A (zh) * | 2021-08-26 | 2024-02-02 | 映恩生物制药(苏州)有限公司 | 一种甾体化合物及其缀合物 |
CN114394933B (zh) * | 2022-01-07 | 2023-08-22 | 厦门沃克沃德医药科技有限公司 | 11,12-二氢-γ-氧代-二苯并[f]偶氮-5-(6h)-丁酸的合成方法 |
US20230287138A1 (en) | 2022-01-12 | 2023-09-14 | Regneron Pharmaceuticals, Inc. | Protein-drug conjugates comprising camptothecin analogs and methods of use thereof |
US20240067640A1 (en) | 2022-03-11 | 2024-02-29 | Firefly Bio, Inc. | Phenyl maleimide linker agents |
US20240082414A1 (en) | 2022-05-13 | 2024-03-14 | Eli Lilly And Company | Human tumor necrosis factor alpha antibody glucocorticoid conjugates |
TW202400266A (zh) * | 2022-05-18 | 2024-01-01 | 大陸商成都百利多特生物藥業有限責任公司 | 配體藥物偶聯物及其應用 |
JP2024526428A (ja) | 2022-06-02 | 2024-07-18 | イーライ リリー アンド カンパニー | ヒトインターロイキン-4受容体アルファ抗体グルココルチコイドコンジュゲート |
WO2023250341A2 (en) | 2022-06-22 | 2023-12-28 | Eli Lilly And Company | Human cd33 antibodies and glucocorticoid conjugates |
US20240218011A1 (en) | 2022-07-21 | 2024-07-04 | Firefly Bio, Inc. | Glucocorticoid receptor agonists and conjugates thereof |
WO2024064779A1 (en) | 2022-09-22 | 2024-03-28 | Eli Lilly And Company | Glucocorticoid receptor agonists |
US20240269308A1 (en) | 2022-12-21 | 2024-08-15 | Regeneron Pharmaceuticals, Inc. | Prodrugs of topoisomerase i inhibitor for adc conjugations and methods of use thereof |
WO2024140838A1 (zh) * | 2022-12-28 | 2024-07-04 | 映恩生物制药(苏州)有限公司 | 抗bdca2抗体-药物偶联物及其用途 |
WO2024153162A1 (en) * | 2023-01-18 | 2024-07-25 | Shanghai Micurx Pharmaceutical Co., Ltd. | Peptide-drug conjugates for targeted therapy of renal diseases |
Family Cites Families (148)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2737518A (en) * | 1955-01-19 | 1956-03-06 | Schering Corp | 1-hydroxycortisone, 1-hydroxyhydrocortisone and esters thereof |
US2968655A (en) * | 1956-11-23 | 1961-01-17 | Upjohn Co | 11-oxygenated-6-methyl progesterone and intermediates therefor |
US2920999A (en) | 1957-06-07 | 1960-01-12 | Pfizer & Co C | 21-nitrogen derivatives of corticosteroids |
DE1165595B (de) | 1958-03-04 | 1964-03-19 | Olin Mathieson | Verfahren zur Herstellung von Triamcinolonacetonid-21-hemisuccinat und dessen Salzen |
GB889766A (en) | 1958-03-04 | 1962-02-21 | Olin Mathieson | Improvements in steroids and the synthesis thereof |
US3197469A (en) | 1958-08-06 | 1965-07-27 | Pharmaceutical Res Products In | 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor |
US3007923A (en) * | 1959-01-22 | 1961-11-07 | Lab Francais Chimiotherapie | Process for the fluorination of 9beta, 11beta-epoxy and 5alpha, 6alpha-epoxy steroids |
GB898295A (en) | 1959-03-18 | 1962-06-06 | Upjohn Co | Improvements in or relating to steroids and the manufacture thereof |
US3033873A (en) | 1960-05-11 | 1962-05-08 | Pfizer & Co C | 21-aminomethyl-pregnenes |
US3033874A (en) | 1960-05-11 | 1962-05-08 | Pfizer & Co C | 17beta-propenoyl steroids and process for preparing same |
US3020275A (en) | 1960-06-07 | 1962-02-06 | American Cyanamid Co | 21-nitrogen substituted steroids of the pregnane series and methods of preparing the same |
DE1169444B (de) * | 1961-02-22 | 1964-05-06 | Schering Ag | Verfahren zur Herstellung von ?-16ª-Methylsteroiden |
US3047468A (en) * | 1961-06-06 | 1962-07-31 | American Cyanamid Co | Method of preparing delta1, 4-3-keto steroids of the pregnane series |
US3383394A (en) * | 1965-08-30 | 1968-05-14 | Schering Corp | Novel 17-acylating process and products thereof |
US3798216A (en) | 1969-03-07 | 1974-03-19 | Fabrication Des Antibiotique S | 9-fluoro-11beta,21-dihydroxy-16alpha,17-(2-propenylidenedioxy)-pregna-1,4-diene-3,20-dione and derivatives thereof |
DE2047105C3 (de) | 1970-09-18 | 1979-02-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 17-Chlorsteroide und Verfahren zu ihrer Herstellung |
IT1057859B (it) | 1972-04-28 | 1982-03-30 | Sigma Tao Ind Farmaceutiche Sp | Perivato del triamoinolone |
SE378109B (es) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
SE378110B (es) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
US4076737A (en) | 1975-02-20 | 1978-02-28 | Ciba-Geigy Corporation | Aldehydes of the pregnane series and derivatives thereof |
IL73337A (en) | 1984-10-28 | 1988-09-30 | Yissum Res Dev Co | Antitumor steroid-platinum complexes and method for the preparation thereof |
ES8605537A1 (es) | 1985-07-03 | 1986-02-01 | Elmu Sa | Procedimiento de obtencion de cetales ciclicos de corticoi- des y sus 21-c esteres |
SE8604059D0 (sv) | 1986-09-25 | 1986-09-25 | Astra Pharma Prod | A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5116829A (en) | 1990-04-23 | 1992-05-26 | Kao Corporation | Steroid compounds |
US5183815A (en) | 1991-01-22 | 1993-02-02 | Merck & Co., Inc. | Bone acting agents |
WO1992022653A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | Method for making humanized antibodies |
BR9307746A (pt) | 1993-01-08 | 1995-11-14 | Astra Ab | Derivados de esteróides especificos para otratamento de cólon e ileo |
DE4311987A1 (de) | 1993-04-07 | 1994-10-13 | Schering Ag | Neue Glucocorticoide |
US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
US5837698A (en) | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
WO2000049993A2 (en) | 1999-02-24 | 2000-08-31 | Nitromed, Inc. | Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20070258987A1 (en) | 2000-11-28 | 2007-11-08 | Seattle Genetics, Inc. | Recombinant Anti-Cd30 Antibodies and Uses Thereof |
SE0101220D0 (sv) | 2001-04-04 | 2001-04-04 | Astrazeneca Ab | New use |
US6908934B2 (en) | 2001-06-11 | 2005-06-21 | Merck & Co., Inc. | Therapeutic compounds for treating dyslipidemic conditions |
ITMI20020148A1 (it) | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
US20050009798A1 (en) | 2002-02-20 | 2005-01-13 | Sepracor Inc. | Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists |
US7190468B2 (en) | 2002-07-17 | 2007-03-13 | Hewlett-Packard Development Company, L.P. | Background document rendering system and method |
US7659241B2 (en) | 2002-07-31 | 2010-02-09 | Seattle Genetics, Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
US7985422B2 (en) | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
US20040157810A1 (en) | 2002-08-23 | 2004-08-12 | Teicher Martin H. | Corticosteroid conjugates and uses thereof |
CN102516417B (zh) | 2002-09-06 | 2014-12-10 | 天蓝制药公司 | 用于传递治疗剂的以环糊精为基础的聚合物 |
CN1414008A (zh) | 2002-10-17 | 2003-04-30 | 南开大学 | 含氮甾体化合物及其制备方法 |
US7015349B2 (en) | 2003-03-26 | 2006-03-21 | The Gillette Company | Reduction of hair growth |
BR122018071808B8 (pt) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugado |
WO2005063777A1 (en) | 2003-12-23 | 2005-07-14 | Corus Pharma | Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation |
US20050192257A1 (en) | 2004-02-26 | 2005-09-01 | Peyman Gholam A. | Predictors for patients at risk for glaucoma from steroid therapy |
TW200539855A (en) | 2004-03-15 | 2005-12-16 | Wyeth Corp | Calicheamicin conjugates |
BRPI0510883B8 (pt) | 2004-06-01 | 2021-05-25 | Genentech Inc | composto conjugado de droga e anticorpo, composição farmacêutica, método de fabricação de composto conjugado de droga e anticorpo e usos de uma formulação, de um conjugado de droga e anticorpo e um agente quimioterapêutico e de uma combinação |
EP1602931A1 (en) | 2004-06-03 | 2005-12-07 | Universiteit Leiden | SR-A antagonists |
US7541330B2 (en) | 2004-06-15 | 2009-06-02 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
EP1625854B1 (en) | 2004-08-09 | 2008-10-15 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Albumin conjugates containing a glucuronic linker |
TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
CA2587589A1 (en) | 2004-11-29 | 2006-06-22 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
WO2006135371A1 (en) | 2005-06-09 | 2006-12-21 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
AU2006259604A1 (en) | 2005-06-14 | 2006-12-28 | Gilead Sciences, Inc. | Substituted phenylphosphates as mutual prodrugs of steroids and beta -agonists for the treatment of pulmonary inflammation and bronchoconstriction |
WO2007056181A2 (en) | 2005-11-02 | 2007-05-18 | Sicor, Inc. | Process for the preparation of ciclesonide |
ES2400965T3 (es) | 2005-12-22 | 2013-04-15 | Baxter International Inc. | Ensayo mejorado de activación de monicitos con mayor capacidad para detectar contaminantes pirotécnicos no endotoxínicos en productos médicos |
US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
CA2677442A1 (en) | 2007-02-05 | 2008-08-14 | Nicox S.A. | Nitric oxide releasing steroids |
WO2008122039A2 (en) | 2007-04-02 | 2008-10-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selenocysteine mediated hybrid antibody molecules |
EP3561513A1 (en) | 2007-05-23 | 2019-10-30 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
CN101784565B (zh) | 2007-06-25 | 2014-12-10 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
WO2009001364A2 (en) | 2007-06-28 | 2008-12-31 | Capsutech Ltd | Targeting conjugates comprising active agents encapsulated in cyclodextrin-containing polymers |
CN101397328A (zh) | 2007-09-27 | 2009-04-01 | 天津药业研究院有限公司 | 一氧化氮供体型糖皮质激素 |
DK2214646T3 (da) | 2007-10-05 | 2021-10-04 | Univ Wayne State | Dendrimers for sustained release of compounds |
MX2010007023A (es) * | 2007-12-21 | 2010-09-30 | Schering Corp | Agonistas del receptor glucocorticoide sustituido de c20-c21. |
WO2009085880A2 (en) * | 2007-12-21 | 2009-07-09 | Schering Corporation | C-21 thioethers as glucocorticoid receptor agonists |
EP2276506A4 (en) | 2008-04-30 | 2014-05-07 | Immunogen Inc | EFFICIENT CONJUGATES AND HYDROPHILIC BINDER |
EP2294077A1 (en) | 2008-06-10 | 2011-03-16 | Gilead Sciences, Inc. | Corticosteroid linked beta-agonist compounds for use in therapy |
AU2009275358C1 (en) | 2008-07-21 | 2015-09-24 | Polytherics Limited | Novel reagents and method for conjugating biological molecules |
AU2009273251B2 (en) | 2008-07-22 | 2014-12-18 | Ablynx Nv | Amino acid sequences directed against multitarget scavenger receptors and polypeptides |
CA2754589C (en) | 2009-03-09 | 2013-07-16 | Mikasa Seiyaku Co., Ltd. | Steroid compound |
WO2010126953A1 (en) | 2009-04-29 | 2010-11-04 | Gilead Sciences, Inc. | Corticosteroid linked beta-agonist compounds for use in therapy |
WO2010132743A1 (en) | 2009-05-15 | 2010-11-18 | Gilead Sciences, Inc. | Corticosteroid beta-agonist compounds for use in therapy |
DK2889624T3 (en) | 2009-08-10 | 2018-12-10 | Ucl Business Plc | Reversible covalent bonding of functional molecules |
WO2011020107A2 (en) | 2009-08-14 | 2011-02-17 | Georgetown University | Compositions and methods for detection and treatment of breast cancer |
GB0917044D0 (en) | 2009-09-29 | 2009-11-18 | Cytoguide As | Agents, uses and methods |
GB0917054D0 (en) * | 2009-09-29 | 2009-11-11 | Cytoguide As | Agents, uses and methods |
WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
WO2011090940A1 (en) | 2010-01-19 | 2011-07-28 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
US9375473B2 (en) | 2010-02-19 | 2016-06-28 | Cornell Research Foundation, Inc. | Method to treat autoimmune demyelinating diseases and other autoimmune or inflammatory diseases |
PE20130342A1 (es) | 2010-04-15 | 2013-04-20 | Spirogen Sarl | Pirrolobenzodiacepinas y conjugados de las mismas |
WO2012005982A2 (en) | 2010-07-06 | 2012-01-12 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Reporter for rna polymerase ii termination |
NZ606824A (en) | 2010-08-02 | 2015-05-29 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
UA109150C2 (xx) | 2010-09-01 | 2015-07-27 | Аміди n-(тетразол-5-іл)- або n-(триазол-5-іл)арилкарбонової кислоти та їх застосування як гербіцидів | |
AU2011320318B9 (en) | 2010-10-29 | 2015-11-19 | Immunogen, Inc. | Non-antagonistic EGFR-binding molecules and immunoconjugates thereof |
US20120302505A1 (en) | 2011-04-21 | 2012-11-29 | Fetzer Oliver S | Cyclodextrin-based polymers for therapeutic delivery |
MX345538B (es) | 2011-05-27 | 2017-02-03 | Ambrx Inc | Composiciones que contienen, metodos que incluyen, y usos de derivados de dolastatina enlazados a aminoacidos no naturales. |
US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
US9526798B2 (en) | 2011-10-14 | 2016-12-27 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
US9399073B2 (en) | 2011-10-14 | 2016-07-26 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines |
CN104011018B (zh) | 2011-10-14 | 2016-12-14 | 麦迪穆有限责任公司 | 可用于制备吡咯并苯并二氮杂卓的合成方法和中间体 |
BR112014009055B1 (pt) | 2011-10-14 | 2021-12-14 | Seattle Genetics, Inc. | Compostos pirrolobenzodiazepinas, conjugados alvos, ligante de fármaco e uso dos ditos conjugados para tratar uma doença proliferativa |
WO2013068874A1 (en) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Antibody-drug conjugates |
MX2014006739A (es) | 2011-12-05 | 2015-06-05 | Igenica Biotherapeutics Inc | Conjugados de anticuerpo-farmaco y compuestos relacionados, composiciones , y metodos. |
GB201122325D0 (en) | 2011-12-23 | 2012-02-01 | Cytoguide As | Novel formulations |
AU2013274078A1 (en) | 2012-06-14 | 2015-01-29 | Ambrx, Inc. | Anti-PSMA antibodies conjugated to nuclear receptor ligand polypeptides |
CA2885169C (en) | 2012-10-11 | 2021-06-22 | Ascendis Pharma A/S | Diagnosis, prevention and treatment of diseases of the joint |
AU2013331440A1 (en) | 2012-10-16 | 2015-04-30 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
SI2911699T1 (en) | 2012-10-23 | 2018-04-30 | Synaffix B.V. | MODIFIED AGAINST, PROTITELO-KONJUGAT AND PROCESS FOR THEIR PREPARATION |
WO2014065575A1 (ko) | 2012-10-25 | 2014-05-01 | 주식회사유한양행 | 4,5-다이하이드로-1h-피라졸 유도체 또는 그의 염 및 이를 포함하는 약학 조성물 |
PT2935331T (pt) | 2012-12-24 | 2018-06-04 | Abbvie Inc | Proteínas de ligação ao recetor de prolactina e suas utilizações |
CN105189546B (zh) | 2013-03-13 | 2022-09-02 | 西雅图基因公司 | 环糊精和抗体-药物偶联物制剂 |
US20160082119A1 (en) | 2013-04-22 | 2016-03-24 | Avelas Biosciences, Inc. | Selective drug delivery compositions and methods of use |
WO2014197854A1 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Novel linkers for antibody-drug conjugates and related compounds, compositions, and methods of use |
CA2914189C (en) | 2013-06-21 | 2023-03-14 | Innate Pharma | Enzymatic conjugation of polypeptides |
EP3020417A4 (en) | 2013-07-10 | 2017-01-18 | Seikagaku Corporation | Pharmaceutical composition for respiratory administration |
TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗-prlr抗體及其用途 |
EA201690780A1 (ru) | 2013-10-15 | 2016-08-31 | Сиэтл Дженетикс, Инк. | Пегилированные лекарственные средства-линкеры для улучшенной фармакокинетики конъюгатов лиганд-лекарственное средство |
GB201320091D0 (en) | 2013-11-14 | 2014-01-01 | Univ Manchester | Selective glucocorticoid receptor ligands |
CN103694375B (zh) | 2013-12-13 | 2016-10-05 | 北京大学 | 一种三萜-环糊精共价化合物及其制备方法和用途 |
US10485811B2 (en) | 2014-01-24 | 2019-11-26 | Centre National De La Recherche Scientifique | Orally available compounds, a process for preparing the same and their uses as anti-adhesive drugs for treating E. coli induced inflammatory bowel diseases such as crohn's disease |
EP3125943A4 (en) | 2014-04-04 | 2017-12-06 | Merck Sharp & Dohme Corp. | Phosphate based linkers for intracellular delivery of drug conjugates |
WO2015155998A1 (en) | 2014-04-10 | 2015-10-15 | Daiichi Sankyo Company, Limited | Anti-her3 antibody-drug conjugate |
US20170189549A1 (en) | 2014-06-13 | 2017-07-06 | Glykos Finland Oy | Payload-Polymer-Protein Conjugates |
CN107206102A (zh) | 2014-12-03 | 2017-09-26 | 豪夫迈·罗氏有限公司 | 抗金黄色葡萄球菌抗体利福霉素缀合物及其用途 |
CN107249642A (zh) | 2014-12-03 | 2017-10-13 | 豪夫迈·罗氏有限公司 | 抗金黄色葡萄球菌抗体利福霉素缀合物及其用途 |
WO2016094517A1 (en) | 2014-12-09 | 2016-06-16 | Abbvie Inc. | Bcl-xl inhibitory compounds and antibody drug conjugates including the same |
CN111620861A (zh) | 2014-12-09 | 2020-09-04 | 艾伯维公司 | 具有低细胞渗透性的bcl-xl抑制性化合物以及包括它的抗体药物缀合物 |
EP3250211B1 (en) | 2015-01-30 | 2021-12-22 | Coral Drugs Pvt. Ltd. | Novel process for preparation of glucocorticoid steroids |
EP3253212A4 (en) | 2015-02-06 | 2018-09-19 | Sorrento Therapeutics, Inc. | Antibody drug conjugates |
WO2017006279A1 (en) | 2015-07-08 | 2017-01-12 | Aten Porus Lifesciences | Cyclodextrin-polymer complexes and compostions and methods of making and using the same |
WO2017044983A1 (en) | 2015-09-10 | 2017-03-16 | Shasqi, Inc. | Bioorthogonal compositions |
US11510993B2 (en) | 2015-10-06 | 2022-11-29 | Merck Sharp & Dohme Llc | Antibody drug conjugate for anti-inflammatory applications |
EP3407916B1 (en) | 2016-01-29 | 2023-12-20 | Merck Sharp & Dohme LLC | Phosphonate linkers and their use to facilitate cellular retention of compounds |
US11786603B2 (en) | 2016-02-26 | 2023-10-17 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
EA201892040A1 (ru) | 2016-03-25 | 2019-04-30 | Сиэтл Дженетикс, Инк. | Способ получения пегилированных соединений лекарственный препарат - линкер и их промежуточных соединений |
GB201608936D0 (en) | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
KR20220119529A (ko) | 2016-06-02 | 2022-08-29 | 애브비 인코포레이티드 | 글루코코르티코이드 수용체 작용제 및 이의 면역접합체 |
JP2019522643A (ja) | 2016-06-08 | 2019-08-15 | アッヴィ・インコーポレイテッド | 抗cd98抗体及び抗体薬物コンジュゲート |
CA3037732A1 (en) | 2016-09-23 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof |
US10711032B2 (en) | 2016-11-08 | 2020-07-14 | Regeneron Pharmaceuticals, Inc. | Steroids and protein-conjugates thereof |
KR20240110082A (ko) | 2017-02-28 | 2024-07-12 | 이뮤노젠 아이엔씨 | 자기희생적 펩티드 링커 및 이들의 접합체를 갖는 메이탄시노이드 유도체 |
AU2018270784B2 (en) | 2017-05-18 | 2024-05-16 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
MA47392B1 (fr) | 2017-05-18 | 2021-09-30 | Regeneron Pharma | Bis-octahydrophénanthrène carboxamides et leurs conjugués protéiques |
EP3630189A4 (en) | 2017-05-24 | 2021-06-23 | The Board of Regents of The University of Texas System | LINKER FOR ANTIBODY MEDICINAL CONJUGATES |
CN109106951A (zh) | 2017-08-18 | 2019-01-01 | 四川百利药业有限责任公司 | 一种喜树碱-抗体偶联物 |
WO2019034177A1 (zh) | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | 具有两种不同药物的抗体药物偶联物 |
CA3080857A1 (en) | 2017-11-07 | 2019-05-16 | Regeneron Pharmaceuticals, Inc. | Hydrophilic linkers for antibody drug conjugates |
SG11202006510XA (en) | 2018-01-08 | 2020-08-28 | Regeneron Pharma | Steroids and antibody-conjugates thereof |
JP7430643B2 (ja) | 2018-04-06 | 2024-02-13 | シージェン インコーポレイテッド | カンプトテシンペプチドコンジュゲート |
KR20210008008A (ko) | 2018-05-09 | 2021-01-20 | 리제너론 파마슈티칼스 인코포레이티드 | 항-msr1 항체 및 이의 사용 방법 |
WO2020132483A1 (en) | 2018-12-21 | 2020-06-25 | Regeneron Pharmaceuticals, Inc. | Rifamycin analogs and antibody-drug conjugates thereof |
SG11202107212QA (en) | 2019-01-08 | 2021-07-29 | Regeneron Pharma | Traceless linkers and protein-conjugates thereof |
-
2017
- 2017-11-07 US US15/806,197 patent/US10711032B2/en active Active
- 2017-11-07 KR KR1020247004647A patent/KR20240025695A/ko active Application Filing
- 2017-11-07 JP JP2019523684A patent/JP7330101B2/ja active Active
- 2017-11-07 KR KR1020197015823A patent/KR20190074310A/ko not_active Application Discontinuation
- 2017-11-07 CN CN201780082517.1A patent/CN110291097A/zh active Pending
- 2017-11-07 CN CN202211283749.2A patent/CN115651056A/zh active Pending
- 2017-11-07 CA CA3042428A patent/CA3042428A1/en active Pending
- 2017-11-07 IL IL266353A patent/IL266353B2/en unknown
- 2017-11-07 SG SG10202104259RA patent/SG10202104259RA/en unknown
- 2017-11-07 IL IL307357A patent/IL307357A/en unknown
- 2017-11-07 MX MX2019005330A patent/MX2019005330A/es unknown
- 2017-11-07 WO PCT/US2017/060434 patent/WO2018089373A2/en active Application Filing
- 2017-11-07 BR BR112019009019A patent/BR112019009019A2/pt unknown
- 2017-11-07 AU AU2017359043A patent/AU2017359043B2/en active Active
- 2017-11-07 EP EP17801239.9A patent/EP3538539A2/en active Pending
-
2018
- 2018-11-06 US US16/761,493 patent/US20210332080A1/en active Pending
-
2019
- 2019-05-07 CL CL2019001259A patent/CL2019001259A1/es unknown
- 2019-05-07 ZA ZA2019/02871A patent/ZA201902871B/en unknown
- 2019-05-07 MX MX2021012927A patent/MX2021012927A/es unknown
- 2019-05-08 PH PH12019501021A patent/PH12019501021A1/en unknown
- 2019-06-07 CO CONC2019/0005966A patent/CO2019005966A2/es unknown
-
2020
- 2020-04-24 US US16/858,458 patent/US11760775B2/en active Active
-
2023
- 2023-07-28 US US18/361,275 patent/US20240101594A1/en active Pending
- 2023-08-08 JP JP2023129158A patent/JP2023153988A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US11760775B2 (en) | 2023-09-19 |
JP7330101B2 (ja) | 2023-08-21 |
MX2021012927A (es) | 2022-01-31 |
WO2018089373A9 (en) | 2018-07-12 |
US20240101594A1 (en) | 2024-03-28 |
IL266353B1 (en) | 2023-11-01 |
CL2019001259A1 (es) | 2019-07-19 |
IL266353A (en) | 2019-06-30 |
CN115651056A (zh) | 2023-01-31 |
AU2017359043A1 (en) | 2019-05-23 |
US20210332080A1 (en) | 2021-10-28 |
US10711032B2 (en) | 2020-07-14 |
IL307357A (en) | 2023-11-01 |
SG10202104259RA (en) | 2021-06-29 |
WO2018089373A3 (en) | 2018-06-21 |
ZA201902871B (en) | 2023-12-20 |
PH12019501021A1 (en) | 2019-06-24 |
JP2023153988A (ja) | 2023-10-18 |
CO2019005966A2 (es) | 2019-07-10 |
JP2019536765A (ja) | 2019-12-19 |
CA3042428A1 (en) | 2018-05-17 |
CN110291097A (zh) | 2019-09-27 |
US20210040144A1 (en) | 2021-02-11 |
KR20190074310A (ko) | 2019-06-27 |
EP3538539A2 (en) | 2019-09-18 |
AU2017359043B2 (en) | 2022-06-16 |
WO2018089373A2 (en) | 2018-05-17 |
US20180155389A1 (en) | 2018-06-07 |
KR20240025695A (ko) | 2024-02-27 |
IL266353B2 (en) | 2024-03-01 |
BR112019009019A2 (pt) | 2019-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12019501021A1 (en) | Steroids and protein-conjugates thereof | |
PH12020551044A1 (en) | Steroids and antibody-conjugates thereof | |
PH12017502390A1 (en) | Constructs targeting ny-eso-1 peptide/mhc complexes and uses thereof | |
MX2018011706A (es) | Composicion farmaceutica de hormona esteroide. | |
BR112018014760A2 (pt) | anticorpos anti-ror1, anticorpos biespecíficos para ror1 x cd3 e métodos de uso dos mesmos | |
MX2018015272A (es) | Anticuerpos anti-cd98 y conjugados de anticuerpo y farmaco. | |
MY186708A (en) | Constructs targeting afp peptide/mhc complexes and uses thereof | |
EP3426257A4 (en) | NEUROACTIVE STEROIDS, COMPOSITIONS AND USES THEREOF | |
MX2018003689A (es) | Proteinas de union a pd-1 y metodos para usarlas. | |
MX2017014056A (es) | Construcciones dirigidas a complejos de peptido e7 del subtipo 16 del virus de papiloma humano (hpv16-e7)/complejo principal de histocompatibilidad (mhc) y sus usos. | |
MX360666B (es) | Composiciones de yodopovidona estables con antiinflamatorios esteroides y no esteroides. | |
MA40459A (fr) | Anticorps anti-age pour le traitement de l'inflammation et de troubles auto-immuns | |
MX2018015274A (es) | Anticuerpos anti-cd98 y conjugados de anticuerpo y farmaco. | |
ZA201807920B (en) | Anti¿gitr antibodies and uses thereof | |
WO2020051333A8 (en) | Anti-avb8 antibodies and compositions and uses thereof | |
BR112018075651A2 (pt) | anticorpos anti-cd98 e conjugados anticorpo fármaco | |
WO2018119425A3 (en) | Anti-lilrb3 antibodies and methods of use thereof | |
EP3462875A4 (en) | COMPOSITIONS AND METHODS WITH THE ANDERSTENONE, TESTOSTERONE, PROGESTERONE AND ESTROGEN PHEROMONIC COMPOUNDS | |
PH12018500159A1 (en) | Constructs targeting psa peptide/mhc complexes and uses thereof | |
MX2018010491A (es) | Proceso para la preparacion de un conjugado anticuerpo-rifamicina. | |
JOP20210014A1 (ar) | تركيبات مضادات fcrn وطرق استخدامها | |
WO2018175740A8 (en) | Anti-tmeff1 antibodies and antibody drug conjugates | |
CY1125282T1 (el) | Υδροξυλιωση στη θεση 21 των στεροειδων | |
MX2019005933A (es) | Polipeptidos biespecificos para gitr y ctla-4. | |
EP3886921A4 (en) | ACTINIUM 225 AND ACTINIUM 227 CONJUGATED ANTIBODIES, COMPOSITIONS AND METHODS RELATED |