SG10202104259RA - Steroids and protein-conjugates thereof - Google Patents
Steroids and protein-conjugates thereofInfo
- Publication number
- SG10202104259RA SG10202104259RA SG10202104259RA SG10202104259RA SG10202104259RA SG 10202104259R A SG10202104259R A SG 10202104259RA SG 10202104259R A SG10202104259R A SG 10202104259RA SG 10202104259R A SG10202104259R A SG 10202104259RA SG 10202104259R A SG10202104259R A SG 10202104259RA
- Authority
- SG
- Singapore
- Prior art keywords
- steroids
- conjugates
- protein
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662419365P | 2016-11-08 | 2016-11-08 | |
US201762508317P | 2017-05-18 | 2017-05-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202104259RA true SG10202104259RA (en) | 2021-06-29 |
Family
ID=60409441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202104259RA SG10202104259RA (en) | 2016-11-08 | 2017-11-07 | Steroids and protein-conjugates thereof |
Country Status (16)
Country | Link |
---|---|
US (4) | US10711032B2 (en) |
EP (1) | EP3538539A2 (en) |
JP (2) | JP7330101B2 (en) |
KR (2) | KR20240025695A (en) |
CN (2) | CN110291097A (en) |
AU (1) | AU2017359043B2 (en) |
BR (1) | BR112019009019A2 (en) |
CA (1) | CA3042428A1 (en) |
CL (1) | CL2019001259A1 (en) |
CO (1) | CO2019005966A2 (en) |
IL (2) | IL307357A (en) |
MX (2) | MX2019005330A (en) |
PH (1) | PH12019501021A1 (en) |
SG (1) | SG10202104259RA (en) |
WO (1) | WO2018089373A2 (en) |
ZA (1) | ZA201902871B (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2745748C2 (en) | 2016-06-02 | 2021-03-31 | Эббви Инк. | Agonist of the glucocorticoid receptor and its immunoconjugates |
JP7330101B2 (en) | 2016-11-08 | 2023-08-21 | レゲネロン ファーマシューティカルス,インコーポレーテッド | Steroids and their protein conjugates |
EP3624894A1 (en) | 2017-05-18 | 2020-03-25 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
KR20200085807A (en) | 2017-11-07 | 2020-07-15 | 리제너론 파마슈티칼스 인코포레이티드 | Hydrophilic linker for antibody drug conjugates |
PT3658192T (en) | 2017-12-01 | 2021-06-25 | Abbvie Inc | Glucocorticoid receptor agonist and immunoconjugates thereof |
JP7366028B2 (en) * | 2018-01-08 | 2023-10-20 | レゲネロン ファーマシューティカルス,インコーポレーテッド | Steroids and their antibody conjugates |
JP2021523147A (en) | 2018-05-09 | 2021-09-02 | レゲネロン ファーマシューティカルス,インコーポレーテッド | Anti-MSR1 antibody and how to use it |
CA3149482A1 (en) | 2019-08-02 | 2021-02-11 | Mersana Therapeutics, Inc. | Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer |
JP2023515941A (en) | 2020-02-28 | 2023-04-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Bispecific antigen-binding molecules that bind to HER2 and methods of using the same |
IL299153A (en) | 2020-07-13 | 2023-02-01 | Regeneron Pharma | Camptothecin analogs conjugated to a glutamine residue in a protein, and their use |
IL301702A (en) | 2020-10-22 | 2023-05-01 | Regeneron Pharma | Anti-fgfr2 antibodies and methods of use thereof |
EP4243876A1 (en) | 2020-11-10 | 2023-09-20 | Regeneron Pharmaceuticals, Inc. | Selenium antibody conjugates |
WO2022120132A1 (en) * | 2020-12-04 | 2022-06-09 | Dyne Therapeutics, Inc. | Antibody-oligonucleotide complexes and uses thereof |
WO2022135332A1 (en) * | 2020-12-21 | 2022-06-30 | 映恩生物制药(苏州)有限公司 | Steroid conjugate |
EP4289857A1 (en) * | 2021-02-04 | 2023-12-13 | Shanghai Senhui Medicine Co., Ltd. | Drug conjugate of glucocorticoid receptor agonist, and application thereof in medicine |
WO2022171101A1 (en) * | 2021-02-10 | 2022-08-18 | 映恩生物制药(苏州)有限公司 | Steroid conjugate |
TW202304462A (en) | 2021-03-23 | 2023-02-01 | 美商美國禮來大藥廠 | Glucocorticoid receptor agonists |
AR125084A1 (en) | 2021-03-23 | 2023-06-07 | Lilly Co Eli | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS |
AR125079A1 (en) | 2021-03-23 | 2023-06-07 | Lilly Co Eli | CARBOXY-SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS |
CN113264983A (en) * | 2021-05-20 | 2021-08-17 | 联宁(苏州)生物制药有限公司 | Synthetic method of linker LND1088 for antibody-conjugated drug |
WO2023025248A1 (en) * | 2021-08-26 | 2023-03-02 | 映恩生物制药(苏州)有限公司 | Steroid compound and conjugate thereof |
CN114394933B (en) * | 2022-01-07 | 2023-08-22 | 厦门沃克沃德医药科技有限公司 | Synthesis method of 11, 12-dihydro-gamma-oxo-dibenzo [ F ] azo-5- (6H) -butyric acid |
WO2023137026A1 (en) | 2022-01-12 | 2023-07-20 | Regeneron Pharmaceuticals, Inc. | Camptothecin analogs conjugated to a glutamine residue in a protein, and their use |
US20240067640A1 (en) | 2022-03-11 | 2024-02-29 | Firefly Bio, Inc. | Phenyl maleimide linker agents |
US20240082414A1 (en) | 2022-05-13 | 2024-03-14 | Eli Lilly And Company | Human tumor necrosis factor alpha antibody glucocorticoid conjugates |
TW202400266A (en) * | 2022-05-18 | 2024-01-01 | 大陸商成都百利多特生物藥業有限責任公司 | Ligand-drug conjugate and use thereof |
WO2023235738A1 (en) | 2022-06-02 | 2023-12-07 | Eli Lilly And Company | Human interleukin-4 receptor alpha antibody glucocorticoid conjugates |
WO2023250341A2 (en) | 2022-06-22 | 2023-12-28 | Eli Lilly And Company | Human cd33 antibodies and glucocorticoid conjugates |
WO2024020164A2 (en) | 2022-07-21 | 2024-01-25 | Firefly Bio, Inc. | Glucocorticoid receptor agonists and conjugates thereof |
WO2024064779A1 (en) | 2022-09-22 | 2024-03-28 | Eli Lilly And Company | Glucocorticoid receptor agonists |
Family Cites Families (148)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2737518A (en) * | 1955-01-19 | 1956-03-06 | Schering Corp | 1-hydroxycortisone, 1-hydroxyhydrocortisone and esters thereof |
US2968655A (en) * | 1956-11-23 | 1961-01-17 | Upjohn Co | 11-oxygenated-6-methyl progesterone and intermediates therefor |
US2920999A (en) | 1957-06-07 | 1960-01-12 | Pfizer & Co C | 21-nitrogen derivatives of corticosteroids |
GB889766A (en) | 1958-03-04 | 1962-02-21 | Olin Mathieson | Improvements in steroids and the synthesis thereof |
DE1165595B (en) | 1958-03-04 | 1964-03-19 | Olin Mathieson | Process for the preparation of triamcinolone acetonide-21-hemisuccinate and its salts |
US3197469A (en) | 1958-08-06 | 1965-07-27 | Pharmaceutical Res Products In | 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor |
US3007923A (en) * | 1959-01-22 | 1961-11-07 | Lab Francais Chimiotherapie | Process for the fluorination of 9beta, 11beta-epoxy and 5alpha, 6alpha-epoxy steroids |
GB898295A (en) | 1959-03-18 | 1962-06-06 | Upjohn Co | Improvements in or relating to steroids and the manufacture thereof |
US3033874A (en) | 1960-05-11 | 1962-05-08 | Pfizer & Co C | 17beta-propenoyl steroids and process for preparing same |
US3033873A (en) | 1960-05-11 | 1962-05-08 | Pfizer & Co C | 21-aminomethyl-pregnenes |
US3020275A (en) | 1960-06-07 | 1962-02-06 | American Cyanamid Co | 21-nitrogen substituted steroids of the pregnane series and methods of preparing the same |
DE1169444B (en) * | 1961-02-22 | 1964-05-06 | Schering Ag | Process for the preparation of ?-16ª‡-methyl steroids |
US3047468A (en) * | 1961-06-06 | 1962-07-31 | American Cyanamid Co | Method of preparing delta1, 4-3-keto steroids of the pregnane series |
US3383394A (en) * | 1965-08-30 | 1968-05-14 | Schering Corp | Novel 17-acylating process and products thereof |
US3798216A (en) | 1969-03-07 | 1974-03-19 | Fabrication Des Antibiotique S | 9-fluoro-11beta,21-dihydroxy-16alpha,17-(2-propenylidenedioxy)-pregna-1,4-diene-3,20-dione and derivatives thereof |
DE2047105C3 (en) | 1970-09-18 | 1979-02-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 17-chloro steroids and process for their preparation |
IT1057859B (en) | 1972-04-28 | 1982-03-30 | Sigma Tao Ind Farmaceutiche Sp | Triamcinolone derivs - as antiinflammatory agents |
SE378110B (en) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
SE378109B (en) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
US4076737A (en) | 1975-02-20 | 1978-02-28 | Ciba-Geigy Corporation | Aldehydes of the pregnane series and derivatives thereof |
IL73337A (en) | 1984-10-28 | 1988-09-30 | Yissum Res Dev Co | Antitumor steroid-platinum complexes and method for the preparation thereof |
ES8605537A1 (en) | 1985-07-03 | 1986-02-01 | Elmu Sa | Cyclic ketal(s) prodn. |
SE8604059D0 (en) | 1986-09-25 | 1986-09-25 | Astra Pharma Prod | A METHOD OF CONTROLLING THE EPIMERIC DISTRIBUTION IN THE PREPARATION OF 16,17-ACETALS OF PREGNANE DERIVATIVES |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5116829A (en) | 1990-04-23 | 1992-05-26 | Kao Corporation | Steroid compounds |
US5183815A (en) | 1991-01-22 | 1993-02-02 | Merck & Co., Inc. | Bone acting agents |
LU91067I2 (en) | 1991-06-14 | 2004-04-02 | Genentech Inc | Trastuzumab and its variants and immunochemical derivatives including immotoxins |
SK87295A3 (en) | 1993-01-08 | 1996-04-03 | Astra Ab | Novel colon or ileum-specific steroid derivatives |
DE4311987A1 (en) | 1993-04-07 | 1994-10-13 | Schering Ag | New glucocorticoids |
US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
US5837698A (en) | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
AU3703900A (en) | 1999-02-24 | 2000-09-14 | Nitromed, Inc. | Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20070258987A1 (en) | 2000-11-28 | 2007-11-08 | Seattle Genetics, Inc. | Recombinant Anti-Cd30 Antibodies and Uses Thereof |
SE0101220D0 (en) | 2001-04-04 | 2001-04-04 | Astrazeneca Ab | New use |
US6908934B2 (en) | 2001-06-11 | 2005-06-21 | Merck & Co., Inc. | Therapeutic compounds for treating dyslipidemic conditions |
ITMI20020148A1 (en) | 2002-01-29 | 2003-07-29 | Nicox Sa | NEW CORTICOSTEROIDS |
US20050009798A1 (en) | 2002-02-20 | 2005-01-13 | Sepracor Inc. | Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists |
US7190468B2 (en) | 2002-07-17 | 2007-03-13 | Hewlett-Packard Development Company, L.P. | Background document rendering system and method |
ES2369542T3 (en) | 2002-07-31 | 2011-12-01 | Seattle Genetics, Inc. | CONJUGATES OF AURISTATINE AND ITS USE TO TREAT CANCER, AN AUTOIMMUNE DISEASE OR AN INFECTIOUS DISEASE. |
US7985422B2 (en) | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
AU2003265576A1 (en) | 2002-08-23 | 2004-03-11 | The Mclean Hospital Corporation | Corticosteroid conjugates and uses thereof |
PT2277551E (en) | 2002-09-06 | 2013-08-22 | Cerulean Pharma Inc | Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto |
CN1414008A (en) | 2002-10-17 | 2003-04-30 | 南开大学 | Steroid compound containing nitrogen and its preparation method |
US7015349B2 (en) | 2003-03-26 | 2006-03-21 | The Gillette Company | Reduction of hair growth |
ES2697327T3 (en) | 2003-11-06 | 2019-01-23 | Seattle Genetics Inc | Intermediate compound for the preparation of conjugates comprising auristatin derivatives and a linker |
WO2005063777A1 (en) | 2003-12-23 | 2005-07-14 | Corus Pharma | Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation |
US20050192257A1 (en) | 2004-02-26 | 2005-09-01 | Peyman Gholam A. | Predictors for patients at risk for glaucoma from steroid therapy |
AR048098A1 (en) | 2004-03-15 | 2006-03-29 | Wyeth Corp | CALIQUEAMYCIN CONJUGATES |
MXPA06014065A (en) | 2004-06-01 | 2007-01-31 | Genentech Inc | Antibody drug conjugates and methods. |
EP1602931A1 (en) | 2004-06-03 | 2005-12-07 | Universiteit Leiden | SR-A antagonists |
US7541330B2 (en) | 2004-06-15 | 2009-06-02 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
ATE411053T1 (en) | 2004-08-09 | 2008-10-15 | Deutsches Krebsforsch | ALBUMINE CONJUGATES CONTAINING A GLUCURON LINK |
TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
EP1817341A2 (en) | 2004-11-29 | 2007-08-15 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
WO2006135371A1 (en) | 2005-06-09 | 2006-12-21 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
AU2006259604A1 (en) | 2005-06-14 | 2006-12-28 | Gilead Sciences, Inc. | Substituted phenylphosphates as mutual prodrugs of steroids and beta -agonists for the treatment of pulmonary inflammation and bronchoconstriction |
CA2622640A1 (en) | 2005-11-02 | 2007-05-18 | Sicor Inc. | Improved process for the preparation of ciclesonide |
DK1977252T3 (en) | 2005-12-22 | 2013-03-04 | Health Prot Agency | Improved monocyte activation test with better ability to detect pyrogenic non-endotoxin contaminants in medical products |
US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
CA2677442A1 (en) | 2007-02-05 | 2008-08-14 | Nicox S.A. | Nitric oxide releasing steroids |
WO2008122039A2 (en) | 2007-04-02 | 2008-10-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selenocysteine mediated hybrid antibody molecules |
AU2008262489B2 (en) | 2007-05-23 | 2013-11-28 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
EP3569251A1 (en) | 2007-06-25 | 2019-11-20 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
WO2009001364A2 (en) | 2007-06-28 | 2008-12-31 | Capsutech Ltd | Targeting conjugates comprising active agents encapsulated in cyclodextrin-containing polymers |
CN101397328A (en) | 2007-09-27 | 2009-04-01 | 天津药业研究院有限公司 | Nitric oxide-releasing glucocorticosteroid |
HUE055815T2 (en) | 2007-10-05 | 2021-12-28 | Univ Wayne State | Dendrimers for sustained release of compounds |
WO2009085880A2 (en) | 2007-12-21 | 2009-07-09 | Schering Corporation | C-21 thioethers as glucocorticoid receptor agonists |
CL2008003803A1 (en) | 2007-12-21 | 2010-02-19 | Schering Corp | Substituted c20-21 steroid derived compounds, glucocorticoid receptor agonists; pharmaceutical composition comprising said compound; and use to treat or prevent an immune, autoimmune, or inflammatory disease or condition, such as inflammatory colitis and rheumatoid arthritis. |
SG189817A1 (en) | 2008-04-30 | 2013-05-31 | Immunogen Inc | Potent conjugates and hydrophilic linkers |
WO2009152171A1 (en) | 2008-06-10 | 2009-12-17 | Gilead Sciences, Inc. | Corticosteroid linked beta-agonist compounds for use in therapy |
JP5622117B2 (en) | 2008-07-21 | 2014-11-12 | ポリテリクスリミテッド | Novel reagents and methods for conjugating biomolecules |
EP2313436B1 (en) | 2008-07-22 | 2014-11-26 | Ablynx N.V. | Amino acid sequences directed against multitarget scavenger receptors and polypeptides |
ES2471145T3 (en) | 2009-03-09 | 2014-06-25 | Mikasa Seiyaku Co,. Ltd. | Steroid compound |
WO2010126953A1 (en) | 2009-04-29 | 2010-11-04 | Gilead Sciences, Inc. | Corticosteroid linked beta-agonist compounds for use in therapy |
WO2010132743A1 (en) | 2009-05-15 | 2010-11-18 | Gilead Sciences, Inc. | Corticosteroid beta-agonist compounds for use in therapy |
CA2770620A1 (en) | 2009-08-10 | 2011-02-17 | Mark Smith | Thiol protecting group |
WO2011020107A2 (en) | 2009-08-14 | 2011-02-17 | Georgetown University | Compositions and methods for detection and treatment of breast cancer |
GB0917044D0 (en) | 2009-09-29 | 2009-11-18 | Cytoguide As | Agents, uses and methods |
GB0917054D0 (en) * | 2009-09-29 | 2009-11-11 | Cytoguide As | Agents, uses and methods |
WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
US20110178287A1 (en) | 2010-01-19 | 2011-07-21 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
US9375473B2 (en) | 2010-02-19 | 2016-06-28 | Cornell Research Foundation, Inc. | Method to treat autoimmune demyelinating diseases and other autoimmune or inflammatory diseases |
US20130028917A1 (en) | 2010-04-15 | 2013-01-31 | Spirogen Developments Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
WO2012005982A2 (en) | 2010-07-06 | 2012-01-12 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Reporter for rna polymerase ii termination |
SG10201912639SA (en) | 2010-08-02 | 2020-02-27 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
CA2809487C (en) | 2010-09-01 | 2019-02-26 | Bayer Cropscience Ag | N-(tetrazol-5-yl)- and n-(triazol-5-yl)arylcarboxamides and use thereof as herbicides |
US9238690B2 (en) | 2010-10-29 | 2016-01-19 | Immunogen, Inc. | Non-antagonistic EGFR-binding molecules and immunoconjugates thereof |
US20120302505A1 (en) | 2011-04-21 | 2012-11-29 | Fetzer Oliver S | Cyclodextrin-based polymers for therapeutic delivery |
SG195183A1 (en) | 2011-05-27 | 2013-12-30 | Ambrx Inc | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
CA2850375C (en) | 2011-10-14 | 2019-07-02 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
ES2687246T3 (en) | 2011-10-14 | 2018-10-24 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and directed conjugates |
CA2850096C (en) | 2011-10-14 | 2018-07-03 | Spirogen Sarl | Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines |
CN103998450B (en) | 2011-10-14 | 2017-03-08 | 麦迪穆有限责任公司 | Pyrrolobenzodiazepines are tall and erect |
WO2013068874A1 (en) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Antibody-drug conjugates |
WO2013085925A1 (en) | 2011-12-05 | 2013-06-13 | Igenica, Inc. | Antibody-drug conjugates and related compounds, compositions, and methods |
GB201122325D0 (en) | 2011-12-23 | 2012-02-01 | Cytoguide As | Novel formulations |
JP2015521602A (en) | 2012-06-14 | 2015-07-30 | アンブルックス, インコーポレイテッドAmbrx, Inc. | Anti-PSMA antibodies conjugated to nuclear receptor ligand polypeptides |
CN104755104A (en) | 2012-10-11 | 2015-07-01 | 阿森迪斯药物股份有限公司 | Diagnosis, prevention and treatment of diseases of the joint |
EA201590622A1 (en) | 2012-10-16 | 2015-10-30 | Эндосайт, Инк. | CONJUGATES FOR DELIVERY OF MEDICINES CONTAINING NOT MEETING IN THE NATURE OF AMINO ACID AND METHODS OF APPLICATION |
LT3912642T (en) | 2012-10-23 | 2023-07-25 | Synaffix B.V. | Modified antibody, antibody-conjugate and process for the preparation thereof |
WO2014065575A1 (en) | 2012-10-25 | 2014-05-01 | 주식회사유한양행 | 4,5-dihydro-1h-pyrazole derivative or salts thereof, and pharmaceutical composition comprising same |
RU2018129572A (en) | 2012-12-24 | 2018-10-12 | Эббви Инк. | PROTEINS CONNECTING THE PROLACTIN RECEPTOR AND THEIR APPLICATION |
KR102401525B1 (en) | 2013-03-13 | 2022-05-24 | 씨젠 인크. | Cyclodextrin and antibody-drug conjugate formulations |
EP2988786A4 (en) | 2013-04-22 | 2016-12-21 | Avelas Biosciences Inc | Selective drug delivery compositions and methods of use |
WO2014197854A1 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Novel linkers for antibody-drug conjugates and related compounds, compositions, and methods of use |
AU2014283185B2 (en) | 2013-06-21 | 2019-05-02 | Innate Pharma | Enzymatic conjugation of polypeptides |
WO2015005459A1 (en) | 2013-07-10 | 2015-01-15 | 生化学工業株式会社 | Pharmaceutical composition for respiratory administration |
TWI641620B (en) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | Anti-prlr antibodies and uses thereof |
SG10201806917PA (en) | 2013-10-15 | 2018-09-27 | Seattle Genetics Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
GB201320091D0 (en) | 2013-11-14 | 2014-01-01 | Univ Manchester | Selective glucocorticoid receptor ligands |
CN103694375B (en) | 2013-12-13 | 2016-10-05 | 北京大学 | A kind of triterpene-cyclodextcovalent covalent compound and its production and use |
JP6527171B2 (en) | 2014-01-24 | 2019-06-05 | サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック | Orally ingestible compounds for the treatment of E. coli-induced inflammatory bowel disease such as Crohn's disease, processes for preparing them and their use as antiadhesive agents |
WO2015153401A1 (en) | 2014-04-04 | 2015-10-08 | Merck Sharp & Dohme Corp | Phosphate based linkers for intracellular delivery of drug conjugates |
IL311108A (en) | 2014-04-10 | 2024-04-01 | Daiichi Sankyo Co Ltd | Method for producing an anti-her3 antibody-drug conjugate |
EP3166638A1 (en) | 2014-06-13 | 2017-05-17 | Glykos Finland Oy | Payload-polymer-protein conjugates |
MX2017007055A (en) | 2014-12-03 | 2017-11-08 | Genentech Inc | Anti-staphylococcus aureus antibody rifamycin conjugates and uses thereof. |
CN107249642A (en) | 2014-12-03 | 2017-10-13 | 豪夫迈·罗氏有限公司 | Anti-Staphylococcus aureus antibody rifamycin conjugate and application thereof |
JP2018508463A (en) | 2014-12-09 | 2018-03-29 | アッヴィ・インコーポレイテッド | Bcl-xL inhibitory compound having low cell permeability and antibody drug conjugate comprising the same |
WO2016094517A1 (en) | 2014-12-09 | 2016-06-16 | Abbvie Inc. | Bcl-xl inhibitory compounds and antibody drug conjugates including the same |
WO2016120891A1 (en) | 2015-01-30 | 2016-08-04 | Coral Drugs Pvt. Ltd. | Novel process for preparation of glucocorticoid steroids |
CN107635405A (en) | 2015-02-06 | 2018-01-26 | 索伦托医疗有限公司 | Antibody drug conjugate |
WO2017006279A1 (en) | 2015-07-08 | 2017-01-12 | Aten Porus Lifesciences | Cyclodextrin-polymer complexes and compostions and methods of making and using the same |
EP3346997A4 (en) | 2015-09-10 | 2019-05-15 | Shasqi, Inc. | Bioorthogonal compositions |
US11510993B2 (en) | 2015-10-06 | 2022-11-29 | Merck Sharp & Dohme Llc | Antibody drug conjugate for anti-inflammatory applications |
US10869929B2 (en) | 2016-01-29 | 2020-12-22 | Merck Sharp & Dohme Corp. | Phosphonate linkers and their use to facilitate cellular retention of compounds |
EP3419670A2 (en) | 2016-02-26 | 2019-01-02 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
SG11201807827VA (en) | 2016-03-25 | 2018-10-30 | Seattle Genetics Inc | Process for the preparation of pegylated drug-linkers and intermediates thereof |
GB201608936D0 (en) | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
RU2745748C2 (en) | 2016-06-02 | 2021-03-31 | Эббви Инк. | Agonist of the glucocorticoid receptor and its immunoconjugates |
CN109562168A (en) | 2016-06-08 | 2019-04-02 | 艾伯维公司 | Anti-CD 98 antibody and antibody drug conjugates |
WO2018058001A1 (en) | 2016-09-23 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof |
JP7330101B2 (en) | 2016-11-08 | 2023-08-21 | レゲネロン ファーマシューティカルス,インコーポレーテッド | Steroids and their protein conjugates |
TWI781145B (en) | 2017-02-28 | 2022-10-21 | 美商伊繆諾金公司 | Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof |
JP2020520926A (en) | 2017-05-18 | 2020-07-16 | レゲネロン ファーマシューティカルス,インコーポレーテッド | Bis-octahydrophenanthrene carboxamide and protein conjugate thereof |
EP3624894A1 (en) | 2017-05-18 | 2020-03-25 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
WO2018218004A1 (en) | 2017-05-24 | 2018-11-29 | The Board Of Regents Of The University Of Texas System | Linkers for antibody drug conjugates |
WO2019034177A1 (en) | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | Antibody drug conjugate having two different drugs |
WO2019034176A1 (en) | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | Camptothecin-antibody conjugate |
KR20200085807A (en) | 2017-11-07 | 2020-07-15 | 리제너론 파마슈티칼스 인코포레이티드 | Hydrophilic linker for antibody drug conjugates |
JP7366028B2 (en) | 2018-01-08 | 2023-10-20 | レゲネロン ファーマシューティカルス,インコーポレーテッド | Steroids and their antibody conjugates |
JP7430643B2 (en) | 2018-04-06 | 2024-02-13 | シージェン インコーポレイテッド | Camptothecin peptide conjugate |
JP2021523147A (en) | 2018-05-09 | 2021-09-02 | レゲネロン ファーマシューティカルス,インコーポレーテッド | Anti-MSR1 antibody and how to use it |
SG11202106658XA (en) | 2018-12-21 | 2021-07-29 | Regeneron Pharma | Rifamycin analogs and antibody-drug conjugates thereof |
EP3908323A2 (en) | 2019-01-08 | 2021-11-17 | Regeneron Pharmaceuticals, Inc. | Traceless linkers and protein-conjugates thereof |
-
2017
- 2017-11-07 JP JP2019523684A patent/JP7330101B2/en active Active
- 2017-11-07 SG SG10202104259RA patent/SG10202104259RA/en unknown
- 2017-11-07 IL IL307357A patent/IL307357A/en unknown
- 2017-11-07 WO PCT/US2017/060434 patent/WO2018089373A2/en active Application Filing
- 2017-11-07 MX MX2019005330A patent/MX2019005330A/en unknown
- 2017-11-07 BR BR112019009019A patent/BR112019009019A2/en unknown
- 2017-11-07 KR KR1020247004647A patent/KR20240025695A/en active Application Filing
- 2017-11-07 KR KR1020197015823A patent/KR20190074310A/en not_active Application Discontinuation
- 2017-11-07 AU AU2017359043A patent/AU2017359043B2/en active Active
- 2017-11-07 CA CA3042428A patent/CA3042428A1/en active Pending
- 2017-11-07 IL IL266353A patent/IL266353B2/en unknown
- 2017-11-07 CN CN201780082517.1A patent/CN110291097A/en active Pending
- 2017-11-07 CN CN202211283749.2A patent/CN115651056A/en active Pending
- 2017-11-07 US US15/806,197 patent/US10711032B2/en active Active
- 2017-11-07 EP EP17801239.9A patent/EP3538539A2/en active Pending
-
2018
- 2018-11-06 US US16/761,493 patent/US20210332080A1/en active Pending
-
2019
- 2019-05-07 ZA ZA2019/02871A patent/ZA201902871B/en unknown
- 2019-05-07 MX MX2021012927A patent/MX2021012927A/en unknown
- 2019-05-07 CL CL2019001259A patent/CL2019001259A1/en unknown
- 2019-05-08 PH PH12019501021A patent/PH12019501021A1/en unknown
- 2019-06-07 CO CONC2019/0005966A patent/CO2019005966A2/en unknown
-
2020
- 2020-04-24 US US16/858,458 patent/US11760775B2/en active Active
-
2023
- 2023-07-28 US US18/361,275 patent/US20240101594A1/en active Pending
- 2023-08-08 JP JP2023129158A patent/JP2023153988A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
ZA201902871B (en) | 2023-12-20 |
AU2017359043B2 (en) | 2022-06-16 |
JP2023153988A (en) | 2023-10-18 |
JP2019536765A (en) | 2019-12-19 |
MX2019005330A (en) | 2019-09-11 |
KR20190074310A (en) | 2019-06-27 |
WO2018089373A9 (en) | 2018-07-12 |
US20180155389A1 (en) | 2018-06-07 |
US20240101594A1 (en) | 2024-03-28 |
JP7330101B2 (en) | 2023-08-21 |
US20210332080A1 (en) | 2021-10-28 |
EP3538539A2 (en) | 2019-09-18 |
BR112019009019A2 (en) | 2019-07-09 |
US10711032B2 (en) | 2020-07-14 |
CN115651056A (en) | 2023-01-31 |
IL266353B1 (en) | 2023-11-01 |
CO2019005966A2 (en) | 2019-07-10 |
CA3042428A1 (en) | 2018-05-17 |
CL2019001259A1 (en) | 2019-07-19 |
IL266353A (en) | 2019-06-30 |
US11760775B2 (en) | 2023-09-19 |
CN110291097A (en) | 2019-09-27 |
WO2018089373A3 (en) | 2018-06-21 |
US20210040144A1 (en) | 2021-02-11 |
AU2017359043A1 (en) | 2019-05-23 |
IL307357A (en) | 2023-11-01 |
PH12019501021A1 (en) | 2019-06-24 |
KR20240025695A (en) | 2024-02-27 |
WO2018089373A2 (en) | 2018-05-17 |
IL266353B2 (en) | 2024-03-01 |
MX2021012927A (en) | 2022-01-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL266353A (en) | Steroids and protein-conjugates thereof | |
HK1251426A1 (en) | Dispenser assembly and related methods | |
IL264813B (en) | 2-oxo-imidazopyridines and their use | |
IL261140A (en) | Anti-tnfalpha-antibodies and functional fragments thereof | |
IL249230A0 (en) | Combination comprising a glucocorticoid and edo-s101 | |
SG10201508941SA (en) | Intermodal devices and methods | |
IL261031A (en) | Anti-tnfalpha-antibodies and functional fragments thereof | |
GB201612858D0 (en) | New uses and methods | |
IL261261A (en) | Anti-tnfalpha-antibodies and functional fragments thereof | |
PL3565374T3 (en) | Region configuration methods and devices | |
IL261098A (en) | Anti-tnfalpha-antibodies and functional fragments thereof | |
GB2548839B (en) | New uses and methods | |
HK1247122A1 (en) | Combinations and uses thereof | |
GB201603311D0 (en) | New uses and methods | |
IL254241A0 (en) | Etv2 and uses thereof | |
GB2563869B (en) | Materials and methods | |
IL261793A (en) | Anti-tnfalpha-antibodies and functional fragments thereof | |
GB201517786D0 (en) | Methods and materials | |
GB2560211B (en) | Methods and devices | |
IL275211A (en) | Fast and partition-resilient blockchains | |
GB201513590D0 (en) | Devices and methods | |
GB201508028D0 (en) | Sandfalls and the like | |
GB201707279D0 (en) | Multiearphones and polyearphones | |
GB2545167B (en) | Cloches and use thereof | |
GB201513796D0 (en) | Materials and Devices |