MX2018012749A - Etanercept plegado correctamente con alta pureza y un rendimiento excelente. - Google Patents

Etanercept plegado correctamente con alta pureza y un rendimiento excelente.

Info

Publication number
MX2018012749A
MX2018012749A MX2018012749A MX2018012749A MX2018012749A MX 2018012749 A MX2018012749 A MX 2018012749A MX 2018012749 A MX2018012749 A MX 2018012749A MX 2018012749 A MX2018012749 A MX 2018012749A MX 2018012749 A MX2018012749 A MX 2018012749A
Authority
MX
Mexico
Prior art keywords
etanercept
correctly folded
high purity
folded etanercept
folded
Prior art date
Application number
MX2018012749A
Other languages
English (en)
Inventor
Tsutomu Arakawa
Douglas Farrar
Original Assignee
Coherus Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50233493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2018012749(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Coherus Biosciences Inc filed Critical Coherus Biosciences Inc
Publication of MX2018012749A publication Critical patent/MX2018012749A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se proporciona un método cromatográfico de modo mixto para separar correctamente de conformaciones correctamente plegadas de las incorrectamente plegadas de una determinada proteína; el método es altamente efectivo para separar etanercept correctamente plegado de etanercept incorrectamente plegado y agregados con rendimientos comercialmente atractivos capaces de producir preparaciones etanercept con muy alta pureza en términos de etanercept correctamente plegado contra etanercept incorrectamente plegado; la invención además se refiere a preparaciones de proteínas y formulaciones que comprende las proteínas correctamente plegadas obtenidas mediante los métodos actuales y los métodos de tratamiento con las preparaciones de alta pureza obtenidas por el método de modo mixto.
MX2018012749A 2012-09-11 2015-03-10 Etanercept plegado correctamente con alta pureza y un rendimiento excelente. MX2018012749A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261699552P 2012-09-11 2012-09-11

Publications (1)

Publication Number Publication Date
MX2018012749A true MX2018012749A (es) 2020-11-12

Family

ID=50233493

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015003090A MX360044B (es) 2012-09-11 2013-09-10 Etanercept plegado correctamente con alta pureza y un rendimiento excelente.
MX2018012749A MX2018012749A (es) 2012-09-11 2015-03-10 Etanercept plegado correctamente con alta pureza y un rendimiento excelente.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015003090A MX360044B (es) 2012-09-11 2013-09-10 Etanercept plegado correctamente con alta pureza y un rendimiento excelente.

Country Status (32)

Country Link
US (6) US20140072560A1 (es)
EP (1) EP2895188B1 (es)
JP (3) JP2015533797A (es)
KR (2) KR102250937B1 (es)
CN (2) CN104902914B (es)
AR (1) AR092532A1 (es)
AU (2) AU2013315750B9 (es)
BR (1) BR112015005161A2 (es)
CA (1) CA2882551A1 (es)
CL (1) CL2015000572A1 (es)
CO (1) CO7400876A2 (es)
CY (1) CY1120062T1 (es)
DK (1) DK2895188T3 (es)
DO (1) DOP2015000055A (es)
EA (1) EA031324B1 (es)
EC (1) ECSP15014138A (es)
ES (1) ES2657377T3 (es)
HR (1) HRP20180182T1 (es)
HU (1) HUE036524T2 (es)
IL (2) IL237311B (es)
IN (1) IN2015KN00452A (es)
LT (1) LT2895188T (es)
MX (2) MX360044B (es)
NO (1) NO2972131T3 (es)
PE (2) PE20200607A1 (es)
PL (1) PL2895188T3 (es)
PT (1) PT2895188T (es)
RS (1) RS57013B1 (es)
SG (1) SG11201501460RA (es)
SI (1) SI2895188T1 (es)
TW (2) TWI609877B (es)
WO (1) WO2014043103A1 (es)

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Also Published As

Publication number Publication date
BR112015005161A2 (pt) 2017-07-04
ECSP15014138A (es) 2016-01-29
HUE036524T2 (hu) 2018-07-30
JP2021100929A (ja) 2021-07-08
AR092532A1 (es) 2015-04-22
US10954295B2 (en) 2021-03-23
CA2882551A1 (en) 2014-03-20
ES2657377T3 (es) 2018-03-05
TW201803593A (zh) 2018-02-01
US20190300600A1 (en) 2019-10-03
JP2015533797A (ja) 2015-11-26
EP2895188A1 (en) 2015-07-22
US11001627B2 (en) 2021-05-11
HRP20180182T1 (hr) 2018-04-20
CN104902914A (zh) 2015-09-09
IL237311A0 (en) 2015-04-30
TWI609877B (zh) 2018-01-01
EP2895188A4 (en) 2016-05-25
CY1120062T1 (el) 2018-12-12
LT2895188T (lt) 2018-04-10
PT2895188T (pt) 2018-02-08
CN110051823A (zh) 2019-07-26
PE20150996A1 (es) 2015-08-01
US20140072560A1 (en) 2014-03-13
CN104902914B (zh) 2019-01-01
TWI716649B (zh) 2021-01-21
US20190300601A1 (en) 2019-10-03
AU2013315750B9 (en) 2018-11-15
KR20200085937A (ko) 2020-07-15
JP6913066B2 (ja) 2021-08-04
IL267452B (en) 2021-05-31
IL237311B (en) 2019-07-31
DOP2015000055A (es) 2015-04-30
CL2015000572A1 (es) 2016-02-05
EA031324B1 (ru) 2018-12-28
US10947306B2 (en) 2021-03-16
EA201590542A1 (ru) 2015-07-30
MX360044B (es) 2018-10-19
AU2013315750B2 (en) 2018-07-12
US10954293B2 (en) 2021-03-23
RS57013B1 (sr) 2018-05-31
PE20200607A1 (es) 2020-03-10
IL267452A (en) 2019-08-29
PL2895188T3 (pl) 2018-06-29
TW201425331A (zh) 2014-07-01
MX2015003090A (es) 2015-07-14
AU2018247244B2 (en) 2020-05-28
AU2013315750A1 (en) 2015-03-05
EP2895188B1 (en) 2017-11-15
US20180037642A1 (en) 2018-02-08
AU2018247244A1 (en) 2018-11-01
US20190330325A1 (en) 2019-10-31
SI2895188T1 (en) 2018-05-31
US20190300602A1 (en) 2019-10-03
WO2014043103A1 (en) 2014-03-20
KR102250937B1 (ko) 2021-05-12
NO2972131T3 (es) 2018-04-21
KR102133699B1 (ko) 2020-07-14
KR20150056601A (ko) 2015-05-26
US10954294B2 (en) 2021-03-23
IN2015KN00452A (es) 2015-07-17
JP2019038817A (ja) 2019-03-14
DK2895188T3 (en) 2018-02-26
SG11201501460RA (en) 2015-04-29
CO7400876A2 (es) 2015-09-30

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