ECSP15014138A - Etanercept correctamente plegado de alta pureza y excelente rendimiento - Google Patents
Etanercept correctamente plegado de alta pureza y excelente rendimientoInfo
- Publication number
- ECSP15014138A ECSP15014138A ECIEPI201514138A ECPI201514138A ECSP15014138A EC SP15014138 A ECSP15014138 A EC SP15014138A EC IEPI201514138 A ECIEPI201514138 A EC IEPI201514138A EC PI201514138 A ECPI201514138 A EC PI201514138A EC SP15014138 A ECSP15014138 A EC SP15014138A
- Authority
- EC
- Ecuador
- Prior art keywords
- high purity
- etanercept
- folded
- preparations
- folded etanercept
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Método de cromatografía de modo mixto para separar las conformaciones correctamente plegadas de las incorrectamente plegadas de una proteína dada. El método es muy eficaz en la separación de etanercept correctamente plegado del etanercept incorrectamente plegado y de agregados con rendimientos comercialmente atractivos que permiten obtener preparaciones de etanercept de una muy alta pureza en términos de etanercept correctamente plegado versus etanercept incorrectamente plegado. La invención está dirigida además a preparaciones de proteínas y formulaciones que comprenden proteínas correctamente plegadas obtenidas usando los métodos de la presente, y métodos de tratamiento que emplean las preparaciones de gran pureza obtenidas del método de modo mixto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261699552P | 2012-09-11 | 2012-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP15014138A true ECSP15014138A (es) | 2016-01-29 |
Family
ID=50233493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECIEPI201514138A ECSP15014138A (es) | 2012-09-11 | 2015-04-10 | Etanercept correctamente plegado de alta pureza y excelente rendimiento |
Country Status (32)
Country | Link |
---|---|
US (6) | US20140072560A1 (es) |
EP (1) | EP2895188B1 (es) |
JP (3) | JP2015533797A (es) |
KR (2) | KR102133699B1 (es) |
CN (2) | CN110051823A (es) |
AR (1) | AR092532A1 (es) |
AU (2) | AU2013315750B9 (es) |
BR (1) | BR112015005161A2 (es) |
CA (1) | CA2882551A1 (es) |
CL (1) | CL2015000572A1 (es) |
CO (1) | CO7400876A2 (es) |
CY (1) | CY1120062T1 (es) |
DK (1) | DK2895188T3 (es) |
DO (1) | DOP2015000055A (es) |
EA (1) | EA031324B1 (es) |
EC (1) | ECSP15014138A (es) |
ES (1) | ES2657377T3 (es) |
HR (1) | HRP20180182T1 (es) |
HU (1) | HUE036524T2 (es) |
IL (2) | IL237311B (es) |
IN (1) | IN2015KN00452A (es) |
LT (1) | LT2895188T (es) |
MX (2) | MX360044B (es) |
NO (1) | NO2972131T3 (es) |
PE (2) | PE20200607A1 (es) |
PL (1) | PL2895188T3 (es) |
PT (1) | PT2895188T (es) |
RS (1) | RS57013B1 (es) |
SG (1) | SG11201501460RA (es) |
SI (1) | SI2895188T1 (es) |
TW (2) | TWI716649B (es) |
WO (1) | WO2014043103A1 (es) |
Families Citing this family (17)
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EA012801B1 (ru) | 2005-06-14 | 2009-12-30 | Эмджен Инк. | Самобуферирующиеся композиции белков |
JP6113176B2 (ja) | 2011-10-18 | 2017-04-12 | コヒラス・バイオサイエンシズ・インコーポレイテッド | キシリトールによって安定化されたエタネルセプト製剤 |
US10493151B2 (en) | 2011-10-18 | 2019-12-03 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with sodium chloride |
IN2015KN00452A (es) * | 2012-09-11 | 2015-07-17 | Coherus Biosciences Inc | |
WO2015189832A1 (en) * | 2014-06-13 | 2015-12-17 | Lupin Limited | Process for the purification of tnfr:fc fusion protein |
ES2733298T3 (es) | 2014-07-18 | 2019-11-28 | Sandoz Ag | Cuantificación de TNFR2:Fc plegado erróneamente |
RU2670166C1 (ru) * | 2014-12-31 | 2018-10-18 | ЭлДжи КЕМ, ЛТД. | Способ получения слитого белка tnfr-fc с заданным содержанием примесей |
EP3268042A4 (en) | 2015-03-13 | 2018-08-01 | Samsung Bioepis Co., Ltd. | Anti-tnf-alpha polypeptide composition and use thereof |
AU2016355739A1 (en) * | 2015-11-18 | 2018-07-05 | Merck Patent Gmbh | Improved protein separation in ion exchange chromatography |
JP2018537458A (ja) * | 2015-11-18 | 2018-12-20 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 改善されたタンパク質分離のための逆pH塩勾配 |
EP3472177A2 (en) * | 2016-06-17 | 2019-04-24 | F. Hoffmann-La Roche AG | Purification of multispecific antibodies |
EP3528787A4 (en) | 2016-10-21 | 2020-05-06 | Amgen Inc. | PHARMACEUTICAL FORMULATIONS AND PROCESSES FOR THEIR PREPARATION |
CN110582510B (zh) * | 2017-03-24 | 2023-09-15 | 科学与工业研究委员会 | 用于纯化重组抗体片段的方法 |
US11253569B2 (en) | 2018-05-03 | 2022-02-22 | Seattle Children's Hospital | Methods of treating Kawasaki Disease |
CN112876567A (zh) * | 2019-11-29 | 2021-06-01 | 广东菲鹏制药股份有限公司 | Fc融合蛋白及其纯化方法 |
JP2024510480A (ja) * | 2021-03-16 | 2024-03-07 | カシーヴ バイオサイエンシズ,リミテッド・ライアビリティ・カンパニー | 融合タンパク質の新規製剤 |
WO2022234412A1 (en) * | 2021-05-03 | 2022-11-10 | Lupin Limited | A process for purification of fc-fusion proteins |
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2013
- 2013-09-10 IN IN452KON2015 patent/IN2015KN00452A/en unknown
- 2013-09-10 EP EP13838016.7A patent/EP2895188B1/en active Active
- 2013-09-10 EA EA201590542A patent/EA031324B1/ru unknown
- 2013-09-10 HU HUE13838016A patent/HUE036524T2/hu unknown
- 2013-09-10 RS RS20180095A patent/RS57013B1/sr unknown
- 2013-09-10 KR KR1020157009386A patent/KR102133699B1/ko active IP Right Grant
- 2013-09-10 PE PE2019002512A patent/PE20200607A1/es unknown
- 2013-09-10 CA CA2882551A patent/CA2882551A1/en active Pending
- 2013-09-10 CN CN201811633164.2A patent/CN110051823A/zh active Pending
- 2013-09-10 PT PT138380167T patent/PT2895188T/pt unknown
- 2013-09-10 JP JP2015531311A patent/JP2015533797A/ja active Pending
- 2013-09-10 AU AU2013315750A patent/AU2013315750B9/en not_active Ceased
- 2013-09-10 BR BR112015005161A patent/BR112015005161A2/pt not_active Application Discontinuation
- 2013-09-10 DK DK13838016.7T patent/DK2895188T3/en active
- 2013-09-10 PE PE2015000316A patent/PE20150996A1/es unknown
- 2013-09-10 SI SI201330936T patent/SI2895188T1/en unknown
- 2013-09-10 CN CN201380058650.5A patent/CN104902914B/zh active Active
- 2013-09-10 WO PCT/US2013/058994 patent/WO2014043103A1/en active Application Filing
- 2013-09-10 ES ES13838016.7T patent/ES2657377T3/es active Active
- 2013-09-10 LT LTEP13838016.7T patent/LT2895188T/lt unknown
- 2013-09-10 KR KR1020207019733A patent/KR102250937B1/ko active IP Right Grant
- 2013-09-10 MX MX2015003090A patent/MX360044B/es active IP Right Grant
- 2013-09-10 SG SG11201501460RA patent/SG11201501460RA/en unknown
- 2013-09-10 PL PL13838016T patent/PL2895188T3/pl unknown
- 2013-09-11 TW TW106136921A patent/TWI716649B/zh active
- 2013-09-11 TW TW102132831A patent/TWI609877B/zh active
- 2013-09-11 US US14/023,736 patent/US20140072560A1/en not_active Abandoned
- 2013-09-11 AR ARP130103250A patent/AR092532A1/es not_active Application Discontinuation
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2014
- 2014-03-13 NO NO14719160A patent/NO2972131T3/no unknown
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2015
- 2015-02-19 IL IL237311A patent/IL237311B/en active IP Right Grant
- 2015-03-06 CL CL2015000572A patent/CL2015000572A1/es unknown
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