CL2015000572A1 - Etanercept correctamente plegado de alta pureza y excelente rendimiento. - Google Patents
Etanercept correctamente plegado de alta pureza y excelente rendimiento.Info
- Publication number
- CL2015000572A1 CL2015000572A1 CL2015000572A CL2015000572A CL2015000572A1 CL 2015000572 A1 CL2015000572 A1 CL 2015000572A1 CL 2015000572 A CL2015000572 A CL 2015000572A CL 2015000572 A CL2015000572 A CL 2015000572A CL 2015000572 A1 CL2015000572 A1 CL 2015000572A1
- Authority
- CL
- Chile
- Prior art keywords
- etanercept
- high purity
- correctly folded
- preparations
- folded
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
METODO DE CROMATOGRAFIA DE MODO MIXTO PARA SEPARAR LAS CONFORMACIONES CORRECTAMENTE PLEGADAS DE LAS INCORRCTAMENTE PLEGADAS DE UNA PROTEINA DADA. EL METODO ES MUY EFICAZ EN LA SEPARACIÓN DE ETANERCEPT CORRECTAMENTE PLEGADO DEL ETANERCEPT INCORRECTAMENTE PLEGADO Y DE AGREGADOS CON RENDIMIENTOS COMERCIALMENTE ATRACTIVOS QUE PERMITEN OBTENER PREPARACIONES DE ETANERCEPT DE UNA MUY ALTA PUREZA EN TÉNRMINOS DE ETANERCEPT CORRECTAMENTE PLEGADO VERSUS ETANERCEPT INCORRECTARNENTE PLEGADO. LA INVENCIÓN ESTÁ DIRIGIDA ADEMÁS A PREPARACIONES DE PROTEINAS Y FORMULACIONES QUE COMPRENDEN PROTEINAS CORRECTAMENTE PLEGADAS OBTENIDAS USANDO LOS MÉTODOS DE LA PR ESENTE, Y MÉTODOS DE TRATAMIENTO QUE EMPLEAN LAS PREPARACIONES DE GRAN PUREZA OBTENIDAS DEL METODO DE MODO MIXTO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261699552P | 2012-09-11 | 2012-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015000572A1 true CL2015000572A1 (es) | 2016-02-05 |
Family
ID=50233493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015000572A CL2015000572A1 (es) | 2012-09-11 | 2015-03-06 | Etanercept correctamente plegado de alta pureza y excelente rendimiento. |
Country Status (32)
Country | Link |
---|---|
US (6) | US20140072560A1 (es) |
EP (1) | EP2895188B1 (es) |
JP (3) | JP2015533797A (es) |
KR (2) | KR102133699B1 (es) |
CN (2) | CN110051823A (es) |
AR (1) | AR092532A1 (es) |
AU (2) | AU2013315750B9 (es) |
BR (1) | BR112015005161A2 (es) |
CA (1) | CA2882551A1 (es) |
CL (1) | CL2015000572A1 (es) |
CO (1) | CO7400876A2 (es) |
CY (1) | CY1120062T1 (es) |
DK (1) | DK2895188T3 (es) |
DO (1) | DOP2015000055A (es) |
EA (1) | EA031324B1 (es) |
EC (1) | ECSP15014138A (es) |
ES (1) | ES2657377T3 (es) |
HR (1) | HRP20180182T1 (es) |
HU (1) | HUE036524T2 (es) |
IL (2) | IL237311B (es) |
IN (1) | IN2015KN00452A (es) |
LT (1) | LT2895188T (es) |
MX (2) | MX360044B (es) |
NO (1) | NO2972131T3 (es) |
PE (2) | PE20200607A1 (es) |
PL (1) | PL2895188T3 (es) |
PT (1) | PT2895188T (es) |
RS (1) | RS57013B1 (es) |
SG (1) | SG11201501460RA (es) |
SI (1) | SI2895188T1 (es) |
TW (2) | TWI609877B (es) |
WO (1) | WO2014043103A1 (es) |
Families Citing this family (17)
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EP1909831A4 (en) | 2005-06-14 | 2013-02-20 | Amgen Inc | PREPARATIONS OF SPONTANEOUS TAMPING PROTEINS |
US10493151B2 (en) | 2011-10-18 | 2019-12-03 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with sodium chloride |
WO2013059406A1 (en) | 2011-10-18 | 2013-04-25 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with metal ions |
BR112015005161A2 (pt) * | 2012-09-11 | 2017-07-04 | Coherus Biosciences Inc | etanercepte corretamente dobrado em alta pureza e excelente rendimento |
EP3155009A1 (en) * | 2014-06-13 | 2017-04-19 | Lupin Limited | Process for the purification of tnfr:fc fusion protein |
EP2975050B1 (en) * | 2014-07-18 | 2019-05-29 | Sandoz Ag | Quantification of misfolded TNFR2:Fc |
KR102018608B1 (ko) * | 2014-12-31 | 2019-09-06 | 주식회사 엘지화학 | 목적하는 함량으로 불순물을 포함하는 TNFR-Fc 융합 단백질의 제조방법 |
EP3268042A4 (en) | 2015-03-13 | 2018-08-01 | Samsung Bioepis Co., Ltd. | Anti-tnf-alpha polypeptide composition and use thereof |
JP2018538268A (ja) * | 2015-11-18 | 2018-12-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | イオン交換クロマトグラフィーにおける改善されたタンパク質分離 |
CA3005484A1 (en) * | 2015-11-18 | 2017-05-26 | Merck Patent Gmbh | Opposite ph-salt gradients for improved protein separations |
AR108800A1 (es) * | 2016-06-17 | 2018-09-26 | Genentech Inc | Purificación de anticuerpos multiespecíficos |
BR112019007858A2 (pt) | 2016-10-21 | 2019-07-02 | Amgen Inc | formulações farmacêuticas e métodos para produzir as mesmas |
JP2020511516A (ja) * | 2017-03-24 | 2020-04-16 | カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチCouncil Of Scientific & Industrial Research | 組換え抗体断片の精製方法 |
US11253569B2 (en) | 2018-05-03 | 2022-02-22 | Seattle Children's Hospital | Methods of treating Kawasaki Disease |
CN112876567A (zh) * | 2019-11-29 | 2021-06-01 | 广东菲鹏制药股份有限公司 | Fc融合蛋白及其纯化方法 |
AU2022236913A1 (en) * | 2021-03-16 | 2023-10-26 | Kashiv Biosciences, Llc | Novel formulation of fusion protein |
WO2022234412A1 (en) * | 2021-05-03 | 2022-11-10 | Lupin Limited | A process for purification of fc-fusion proteins |
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BR112015005161A2 (pt) * | 2012-09-11 | 2017-07-04 | Coherus Biosciences Inc | etanercepte corretamente dobrado em alta pureza e excelente rendimento |
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2013
- 2013-09-10 BR BR112015005161A patent/BR112015005161A2/pt not_active Application Discontinuation
- 2013-09-10 CN CN201811633164.2A patent/CN110051823A/zh active Pending
- 2013-09-10 PE PE2019002512A patent/PE20200607A1/es unknown
- 2013-09-10 PT PT138380167T patent/PT2895188T/pt unknown
- 2013-09-10 AU AU2013315750A patent/AU2013315750B9/en not_active Ceased
- 2013-09-10 LT LTEP13838016.7T patent/LT2895188T/lt unknown
- 2013-09-10 DK DK13838016.7T patent/DK2895188T3/en active
- 2013-09-10 IN IN452KON2015 patent/IN2015KN00452A/en unknown
- 2013-09-10 MX MX2015003090A patent/MX360044B/es active IP Right Grant
- 2013-09-10 ES ES13838016.7T patent/ES2657377T3/es active Active
- 2013-09-10 PL PL13838016T patent/PL2895188T3/pl unknown
- 2013-09-10 SG SG11201501460RA patent/SG11201501460RA/en unknown
- 2013-09-10 EP EP13838016.7A patent/EP2895188B1/en active Active
- 2013-09-10 CA CA2882551A patent/CA2882551A1/en active Pending
- 2013-09-10 CN CN201380058650.5A patent/CN104902914B/zh active Active
- 2013-09-10 RS RS20180095A patent/RS57013B1/sr unknown
- 2013-09-10 PE PE2015000316A patent/PE20150996A1/es unknown
- 2013-09-10 WO PCT/US2013/058994 patent/WO2014043103A1/en active Application Filing
- 2013-09-10 JP JP2015531311A patent/JP2015533797A/ja active Pending
- 2013-09-10 KR KR1020157009386A patent/KR102133699B1/ko active IP Right Grant
- 2013-09-10 SI SI201330936T patent/SI2895188T1/en unknown
- 2013-09-10 EA EA201590542A patent/EA031324B1/ru unknown
- 2013-09-10 HU HUE13838016A patent/HUE036524T2/hu unknown
- 2013-09-10 KR KR1020207019733A patent/KR102250937B1/ko active IP Right Grant
- 2013-09-11 TW TW102132831A patent/TWI609877B/zh active
- 2013-09-11 US US14/023,736 patent/US20140072560A1/en not_active Abandoned
- 2013-09-11 TW TW106136921A patent/TWI716649B/zh active
- 2013-09-11 AR ARP130103250A patent/AR092532A1/es not_active Application Discontinuation
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2014
- 2014-03-13 NO NO14719160A patent/NO2972131T3/no unknown
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2015
- 2015-02-19 IL IL237311A patent/IL237311B/en active IP Right Grant
- 2015-03-06 CL CL2015000572A patent/CL2015000572A1/es unknown
- 2015-03-10 DO DO2015000055A patent/DOP2015000055A/es unknown
- 2015-03-10 MX MX2018012749A patent/MX2018012749A/es unknown
- 2015-04-07 CO CO15076746A patent/CO7400876A2/es unknown
- 2015-04-10 EC ECIEPI201514138A patent/ECSP15014138A/es unknown
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2017
- 2017-09-29 US US15/720,291 patent/US11001627B2/en active Active
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2018
- 2018-01-31 HR HRP20180182TT patent/HRP20180182T1/hr unknown
- 2018-02-13 CY CY20181100172T patent/CY1120062T1/el unknown
- 2018-10-10 AU AU2018247244A patent/AU2018247244B2/en not_active Ceased
- 2018-10-11 JP JP2018192476A patent/JP6913066B2/ja active Active
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2019
- 2019-06-17 US US16/443,594 patent/US10954294B2/en active Active
- 2019-06-17 US US16/443,514 patent/US10954293B2/en active Active
- 2019-06-17 US US16/443,688 patent/US10947306B2/en active Active
- 2019-06-17 US US16/443,721 patent/US10954295B2/en active Active
- 2019-06-18 IL IL267452A patent/IL267452B/en active IP Right Grant
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2021
- 2021-02-22 JP JP2021025939A patent/JP2021100929A/ja active Pending
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