PE20150996A1 - Etanercept correctamente plegado de alta pureza y excelente rendimiento - Google Patents

Etanercept correctamente plegado de alta pureza y excelente rendimiento

Info

Publication number
PE20150996A1
PE20150996A1 PE2015000316A PE2015000316A PE20150996A1 PE 20150996 A1 PE20150996 A1 PE 20150996A1 PE 2015000316 A PE2015000316 A PE 2015000316A PE 2015000316 A PE2015000316 A PE 2015000316A PE 20150996 A1 PE20150996 A1 PE 20150996A1
Authority
PE
Peru
Prior art keywords
etanercept
high purity
folded
preparations
folded etanercept
Prior art date
Application number
PE2015000316A
Other languages
English (en)
Inventor
Tsutomu Arakawa
Douglas H Farrar
Original Assignee
Coherus Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50233493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20150996(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Coherus Biosciences Inc filed Critical Coherus Biosciences Inc
Publication of PE20150996A1 publication Critical patent/PE20150996A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Referida a un metodo de cromatografia de modo mixto para separar las conformaciones correctamente plegadas de las incorrectamente plegadas de una proteina dada. Dicho metodo es aplicable en la separacion de etanercept correctamente plegado del etanercept incorrectamente plegado y de agregados con rendimientos comercialmente atractivos que permiten obtener preparaciones de etanercept de una muy alta pureza en terminos de etarnercept correctamente plegado versus etanercept incorrectamente plegado. Tambien esta referida a preparaciones de proteina y formulaciones que comprenden proteinas correctamente plegadas obtenidas usando los metodos de la presente, y metodos de tratamiento que emplean las preparaciones de gran pureza obtenidas del metodos del modo mixto
PE2015000316A 2012-09-11 2013-09-10 Etanercept correctamente plegado de alta pureza y excelente rendimiento PE20150996A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261699552P 2012-09-11 2012-09-11

Publications (1)

Publication Number Publication Date
PE20150996A1 true PE20150996A1 (es) 2015-08-01

Family

ID=50233493

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2019002512A PE20200607A1 (es) 2012-09-11 2013-09-10 Etanercept correctamente plegado de alta pureza y excelente rendimiento
PE2015000316A PE20150996A1 (es) 2012-09-11 2013-09-10 Etanercept correctamente plegado de alta pureza y excelente rendimiento

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2019002512A PE20200607A1 (es) 2012-09-11 2013-09-10 Etanercept correctamente plegado de alta pureza y excelente rendimiento

Country Status (32)

Country Link
US (6) US20140072560A1 (es)
EP (1) EP2895188B1 (es)
JP (3) JP2015533797A (es)
KR (2) KR102250937B1 (es)
CN (2) CN104902914B (es)
AR (1) AR092532A1 (es)
AU (2) AU2013315750B9 (es)
BR (1) BR112015005161A2 (es)
CA (1) CA2882551A1 (es)
CL (1) CL2015000572A1 (es)
CO (1) CO7400876A2 (es)
CY (1) CY1120062T1 (es)
DK (1) DK2895188T3 (es)
DO (1) DOP2015000055A (es)
EA (1) EA031324B1 (es)
EC (1) ECSP15014138A (es)
ES (1) ES2657377T3 (es)
HR (1) HRP20180182T1 (es)
HU (1) HUE036524T2 (es)
IL (2) IL237311B (es)
IN (1) IN2015KN00452A (es)
LT (1) LT2895188T (es)
MX (2) MX360044B (es)
NO (1) NO2972131T3 (es)
PE (2) PE20200607A1 (es)
PL (1) PL2895188T3 (es)
PT (1) PT2895188T (es)
RS (1) RS57013B1 (es)
SG (1) SG11201501460RA (es)
SI (1) SI2895188T1 (es)
TW (2) TWI609877B (es)
WO (1) WO2014043103A1 (es)

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BR112015005161A2 (pt) 2017-07-04
ECSP15014138A (es) 2016-01-29
HUE036524T2 (hu) 2018-07-30
JP2021100929A (ja) 2021-07-08
AR092532A1 (es) 2015-04-22
US10954295B2 (en) 2021-03-23
CA2882551A1 (en) 2014-03-20
ES2657377T3 (es) 2018-03-05
TW201803593A (zh) 2018-02-01
US20190300600A1 (en) 2019-10-03
JP2015533797A (ja) 2015-11-26
EP2895188A1 (en) 2015-07-22
US11001627B2 (en) 2021-05-11
HRP20180182T1 (hr) 2018-04-20
CN104902914A (zh) 2015-09-09
IL237311A0 (en) 2015-04-30
TWI609877B (zh) 2018-01-01
MX2018012749A (es) 2020-11-12
EP2895188A4 (en) 2016-05-25
CY1120062T1 (el) 2018-12-12
LT2895188T (lt) 2018-04-10
PT2895188T (pt) 2018-02-08
CN110051823A (zh) 2019-07-26
US20140072560A1 (en) 2014-03-13
CN104902914B (zh) 2019-01-01
TWI716649B (zh) 2021-01-21
US20190300601A1 (en) 2019-10-03
AU2013315750B9 (en) 2018-11-15
KR20200085937A (ko) 2020-07-15
JP6913066B2 (ja) 2021-08-04
IL267452B (en) 2021-05-31
IL237311B (en) 2019-07-31
DOP2015000055A (es) 2015-04-30
CL2015000572A1 (es) 2016-02-05
EA031324B1 (ru) 2018-12-28
US10947306B2 (en) 2021-03-16
EA201590542A1 (ru) 2015-07-30
MX360044B (es) 2018-10-19
AU2013315750B2 (en) 2018-07-12
US10954293B2 (en) 2021-03-23
RS57013B1 (sr) 2018-05-31
PE20200607A1 (es) 2020-03-10
IL267452A (en) 2019-08-29
PL2895188T3 (pl) 2018-06-29
TW201425331A (zh) 2014-07-01
MX2015003090A (es) 2015-07-14
AU2018247244B2 (en) 2020-05-28
AU2013315750A1 (en) 2015-03-05
EP2895188B1 (en) 2017-11-15
US20180037642A1 (en) 2018-02-08
AU2018247244A1 (en) 2018-11-01
US20190330325A1 (en) 2019-10-31
SI2895188T1 (en) 2018-05-31
US20190300602A1 (en) 2019-10-03
WO2014043103A1 (en) 2014-03-20
KR102250937B1 (ko) 2021-05-12
NO2972131T3 (es) 2018-04-21
KR102133699B1 (ko) 2020-07-14
KR20150056601A (ko) 2015-05-26
US10954294B2 (en) 2021-03-23
IN2015KN00452A (es) 2015-07-17
JP2019038817A (ja) 2019-03-14
DK2895188T3 (en) 2018-02-26
SG11201501460RA (en) 2015-04-29
CO7400876A2 (es) 2015-09-30

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