CL2020000428A1 - Preparación de exosomas terapéuticos mediante el uso de proteínas de membrana. - Google Patents

Preparación de exosomas terapéuticos mediante el uso de proteínas de membrana.

Info

Publication number
CL2020000428A1
CL2020000428A1 CL2020000428A CL2020000428A CL2020000428A1 CL 2020000428 A1 CL2020000428 A1 CL 2020000428A1 CL 2020000428 A CL2020000428 A CL 2020000428A CL 2020000428 A CL2020000428 A CL 2020000428A CL 2020000428 A1 CL2020000428 A1 CL 2020000428A1
Authority
CL
Chile
Prior art keywords
exosomes
proteins
exosome
preparation
membrane proteins
Prior art date
Application number
CL2020000428A
Other languages
English (en)
Inventor
Kevin P Dooley
Rane A Harrison
Russell E Mcconnell
Ke Xu
Damian Houde
Nikki Ross
Sonya Haupt
John D Kulman
Douglas E Williams
Original Assignee
Codiak Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codiak Biosciences Inc filed Critical Codiak Biosciences Inc
Publication of CL2020000428A1 publication Critical patent/CL2020000428A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6917—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a lipoprotein vesicle, e.g. HDL or LDL proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a métodos para preparar un exosoma terapéutico usando una proteína recientemente identificada para ser enriquecida en la superficie de exosomas. Específicamente, la presente invención proporciona métodos para usar las proteínas para purificación de afinidad de exosomas. También proporciona métodos para ubicar un péptido terapéutico en los exosomas, y dirigir exosomas a un órgano, tejido o célula específico al usar las proteínas. Los métodos implican la generación de exosomas modificados genéticamente en la superficie que incluyen una o más de las proteínas de exosomas a densidad mayor, o una variante o un fragmento de la proteína de exosoma.
CL2020000428A 2017-08-25 2020-02-20 Preparación de exosomas terapéuticos mediante el uso de proteínas de membrana. CL2020000428A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762550543P 2017-08-25 2017-08-25
US201862656956P 2018-04-12 2018-04-12

Publications (1)

Publication Number Publication Date
CL2020000428A1 true CL2020000428A1 (es) 2020-11-27

Family

ID=65200359

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020000428A CL2020000428A1 (es) 2017-08-25 2020-02-20 Preparación de exosomas terapéuticos mediante el uso de proteínas de membrana.

Country Status (15)

Country Link
US (4) US10195290B1 (es)
EP (1) EP3672573A4 (es)
JP (2) JP2020531018A (es)
KR (2) KR20200071065A (es)
CN (1) CN111212632B (es)
AU (1) AU2018321927A1 (es)
BR (1) BR112020003354A2 (es)
CA (1) CA3072352A1 (es)
CL (1) CL2020000428A1 (es)
CO (1) CO2020001872A2 (es)
IL (1) IL272786A (es)
MX (1) MX2020001790A (es)
PH (1) PH12020500308A1 (es)
SG (1) SG11202001008RA (es)
WO (1) WO2019040920A1 (es)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111212632B (zh) 2017-08-25 2024-04-16 隆萨销售股份公司 使用膜蛋白制备治疗性外来体
MX2020006672A (es) * 2017-12-28 2020-08-31 Codiak Biosciences Inc Exosomas para inmunooncologia y terapia antiinflamatoria.
CN111918967A (zh) 2018-02-12 2020-11-10 科迪亚克生物科学公司 用于巨噬细胞极化的方法和组合物
AU2019237508A1 (en) 2018-03-23 2020-10-01 Lonza Sales Ag Extracellular vesicles comprising STING-agonist
US20210262931A1 (en) * 2018-06-21 2021-08-26 Codiak Biosciences, Inc. Methods of measuring extracellular vesicles and nanoparticles in complex matrices by light scattering
EP3841112A1 (en) 2018-08-24 2021-06-30 Codiak BioSciences, Inc. Extracellular vesicles targeting dendritic cells and uses thereof
US20200102563A1 (en) * 2018-10-02 2020-04-02 Exosome Therapeutics, Inc. Exosome loaded therapeutics for treating sickle cell disease
AU2019378591A1 (en) 2018-11-16 2021-06-17 Lonza Sales Ag Engineered extracellular vesicles and uses thereof
MX2021009337A (es) * 2019-02-04 2021-10-13 Codiak Biosciences Inc Cadenas principales de proteínas de la membrana para la modificación genética de exosomas.
EP3920958A1 (en) 2019-02-04 2021-12-15 Codiak BioSciences, Inc. Treatment of cancer metastasis by targeting exosome proteins
US20220195531A1 (en) * 2019-03-21 2022-06-23 Applied Stemcell, Inc. Exosomes containing rna with specific mutation
EP3941607A1 (en) 2019-03-21 2022-01-26 Codiak BioSciences, Inc. Process for preparing extracellular vesicles
US20220168415A1 (en) 2019-03-21 2022-06-02 Codiak Biosciences, Inc. Extracellular vesicles for vaccine delivery
CN113747925A (zh) 2019-03-21 2021-12-03 科迪亚克生物科学公司 胞外囊泡缀合物及其用途
US20220218811A1 (en) * 2019-04-17 2022-07-14 Codiak Biosciences, Inc. Methods of treating tuberculosis
KR20220009389A (ko) 2019-04-17 2022-01-24 코디악 바이오사이언시즈, 인크. 엑소좀 및 aav 의 조성물
US20220236155A1 (en) * 2019-05-21 2022-07-28 H.U. Group Research Institute G.K. Method for washing extracellular vesicle
WO2021003425A1 (en) 2019-07-03 2021-01-07 Codiak Biosciences, Inc. Methods of inducing hematopoiesis
WO2021003445A1 (en) 2019-07-03 2021-01-07 Codiak Biosciences, Inc. Extracellular vesicles targeting t cells and uses thereof
JP2022543851A (ja) * 2019-08-06 2022-10-14 オハイオ・ステイト・イノベーション・ファウンデーション 治療用細胞外小胞
JP2022544289A (ja) 2019-08-14 2022-10-17 コディアック バイオサイエンシーズ， インコーポレイテッド Ｓｔａｔ６を標的とする細胞外小胞－ａｓｏ構築物
MX2022001769A (es) 2019-08-14 2022-06-09 Codiak Biosciences Inc Construcciones de vesícula extracelular-oligonucleótido antisentido (aso) que se dirigen a la proteína beta de unión al potenciador ccaat (cebp)/beta.
WO2021030768A1 (en) 2019-08-14 2021-02-18 Codiak Biosciences, Inc. Extracellular vesicles with stat3-antisense oligonucleotides
CN114641570A (zh) 2019-08-14 2022-06-17 科迪亚克生物科学公司 具有靶向kras的反义寡核苷酸的细胞外囊泡
EP4013876A1 (en) 2019-08-14 2022-06-22 Codiak BioSciences, Inc. Extracellular vesicle-nlrp3 antagonist
KR20220078565A (ko) 2019-08-14 2022-06-10 코디악 바이오사이언시즈, 인크. 분자에 연결된 세포외 소포 및 이의 용도
WO2021041473A1 (en) * 2019-08-27 2021-03-04 The Trustees Of Columbia University In The City Of New York Engineered exosomes for targeted delivery
US20230241089A1 (en) 2019-09-25 2023-08-03 Codiak Biosciences, Inc. Sting agonist comprising exosomes for treating neuroimmunological disorders
EP4034276A1 (en) 2019-09-25 2022-08-03 Codiak BioSciences, Inc. Methods of producing extracellular vesicles
KR20220094221A (ko) 2019-09-25 2022-07-05 코디악 바이오사이언시즈, 인크. 종양의 치료를 위한 il-12 디스플레잉 엑소좀과 조합된 sting 효능제 포함 엑소좀
EP4034081A1 (en) * 2019-09-25 2022-08-03 Codiak BioSciences, Inc. Extracellular vesicle compositions
WO2021062057A1 (en) 2019-09-25 2021-04-01 Codiak Biosciences, Inc. Exogenous loading of exosomes via lyophilization
JP7402491B2 (ja) * 2019-10-24 2023-12-21 国立大学法人広島大学 エクソソームの単離方法、エクソソームの単離キット、およびエクソソームの除去方法
WO2021092193A1 (en) 2019-11-05 2021-05-14 Codiak Biosciences, Inc. High-throughput chromatography screening for extracellular vesicles
JP7357599B2 (ja) * 2019-12-30 2023-10-06 財團法人工業技術研究院 細胞外小胞分離法、コロイド粒子とその調製方法
WO2021146616A1 (en) 2020-01-17 2021-07-22 Codiak Biosciences, Inc. Cholesterol assays for quantifying extracellular vesicles
WO2021154888A1 (en) * 2020-01-27 2021-08-05 Mantra Bio. Inc. Non-naturally occurring vesicles comprising a chimeric vesicle localization moiety, methods of making and uses thereof
CA3169228A1 (en) 2020-02-05 2021-08-12 Diadem Biotherapeutics Inc. Artificial synapses
WO2021184021A1 (en) 2020-03-13 2021-09-16 Codiak Biosciences, Inc. Extracellular vesicle-aso constructs targeting pmp22
WO2021184020A1 (en) 2020-03-13 2021-09-16 Codiak Biosciences, Inc. Methods of treating neuroinflammation
JP2023517241A (ja) * 2020-03-13 2023-04-24 コディアック バイオサイエンシーズ， インコーポレイテッド 細胞外ベシクルの標的送達
EP4117717A1 (en) 2020-03-13 2023-01-18 Codiak BioSciences, Inc. Extracellular vesicles for treating neurological disorders
CA3171623A1 (en) 2020-03-20 2021-09-23 Codiak Biosciences, Inc. Extracellular vesicles for therapy
WO2021195154A1 (en) * 2020-03-23 2021-09-30 Avem Holdings, Llc Isolation and purification of exosomes for regenerative medicine
WO2021237100A1 (en) 2020-05-21 2021-11-25 Codiak Biosciences, Inc. Methods of targeting extracellular vesicles to lung
US20230220068A1 (en) 2020-06-05 2023-07-13 Codiak Biosciences, Inc. Anti-transferrin extracellular vesicles
WO2022040223A1 (en) 2020-08-17 2022-02-24 Codiak Biosciences, Inc. Methods of treating cancer
US20240082389A1 (en) 2020-09-23 2024-03-14 Lonza Sales Ag Methods of producing extracellular vesicles
US20230366794A1 (en) 2020-09-23 2023-11-16 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
WO2022066928A2 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
WO2022066883A1 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Extracellular vesicles comprising kras antigens and uses thereof
WO2022076596A1 (en) 2020-10-06 2022-04-14 Codiak Biosciences, Inc. Extracellular vesicle-aso constructs targeting stat6
CN113252616B (zh) * 2021-01-29 2022-05-03 厦门大学 一种外泌体的糖基化研究方法
CN117157093A (zh) 2021-02-17 2023-12-01 隆萨销售股份有限公司 细胞外囊泡-nlrp3拮抗剂
IL305176A (en) 2021-02-17 2023-10-01 Lonza Sales Ag An extracellular vesicle is linked to a biologically active molecule via an optimal linker and an anchored moiety
IL305172A (en) 2021-02-17 2023-10-01 Lonza Sales Ag Methods for loading extracellular vesicles
CA3213989A1 (en) 2021-04-01 2022-10-06 Conlin O'NEIL Extracellular vesicle compositions
KR20230172538A (ko) * 2021-04-14 2023-12-22 안자리움 바이오사이언시스 아게 Fc-유래된 폴리펩티드
AU2022315530A1 (en) 2021-07-20 2024-01-18 Ags Therapeutics Sas Extracellular vesicles from microalgae, their preparation, and uses
WO2023027082A1 (ja) * 2021-08-23 2023-03-02 積水化学工業株式会社 ペプチド結合ハイブリッドリポソームエクソソーム、ペプチド結合エクソソーム、これらを含む組成物及びその形成方法
WO2023056468A1 (en) 2021-09-30 2023-04-06 Codiak Biosciences, Inc. Extracellular vesicle comprising cholesterol tagged sting-agonist
CN118119702A (zh) 2021-10-14 2024-05-31 隆萨销售股份有限公司 用于细胞外囊泡产生的经修饰的生产者细胞
CN113832003A (zh) * 2021-10-20 2021-12-24 上海芙普瑞生物科技有限公司 一种便于提取制备脂肪干细胞外泌体的设备及提取工艺
WO2023091497A1 (en) * 2021-11-16 2023-05-25 Mayo Foundation For Medical Education And Research Compositions and methods for tendon repair
WO2023127645A1 (ja) * 2021-12-28 2023-07-06 積水化学工業株式会社 エクソソーム、それを形成するための方法、及びそれを含有する組成物
CN114112867A (zh) * 2022-01-26 2022-03-01 天九再生医学(天津)科技有限公司 外泌体纯度分析方法
WO2023144127A1 (en) 2022-01-31 2023-08-03 Ags Therapeutics Sas Extracellular vesicles from microalgae, their biodistribution upon administration, and uses
US20230381226A1 (en) * 2022-05-24 2023-11-30 Shiftbio Inc. Surface-engineered extracellular vesicles and therapeutic uses thereof
WO2023232976A1 (en) 2022-06-03 2023-12-07 Ags Therapeutics Sas Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses
CN117802045A (zh) * 2022-09-30 2024-04-02 北京恩康医药有限公司 一种工程化细胞外囊泡的构建及其应用
CN118201601A (zh) * 2022-09-30 2024-06-14 谛邈生物科技（新加坡）有限公司 一种向adam10基因敲除的hek293细胞外泌体中装载二聚体cd24的方法
WO2024088808A1 (en) 2022-10-24 2024-05-02 Ags Therapeutics Sas Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof
WO2024112359A1 (en) * 2022-11-21 2024-05-30 The Johns Hopkins University Genetic enhancement of exosome production

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747660A (en) 1995-11-06 1998-05-05 The University Of Colorado Nucleic acid encoding prostaglandin F2α receptor regulatory protein
JP2003535832A (ja) * 2000-06-09 2003-12-02 ブリカス，テニ ポリヌクレオチドおよび薬物の標的化リポソームへのカプセル化
US20040049010A1 (en) 2001-10-26 2004-03-11 Warren Bridget A Transmembrane proteins
US7803906B2 (en) * 2002-03-22 2010-09-28 Gene Signal International Sa Composition comprising an angiogenesis related protein
JP5129149B2 (ja) 2005-10-31 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を処置および診断するための組成物および方法
US9085778B2 (en) 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
AU2011316477A1 (en) 2010-10-11 2013-05-02 Medsaic Pty Ltd Assay for disease detection
US9777042B2 (en) * 2011-12-15 2017-10-03 Morehouse School Of Medicine Method of purifying HIV/SIV Nef from exosomal fusion proteins
US20150301058A1 (en) * 2012-11-26 2015-10-22 Caris Science, Inc. Biomarker compositions and methods
CN105658796B (zh) * 2012-12-12 2021-10-26 布罗德研究所有限公司 用于序列操纵的crispr-cas组分系统、方法以及组合物
WO2014138793A1 (en) 2013-03-13 2014-09-18 The University Of Queensland A method of isolating cells for therapy and prophylaxis
KR20150043937A (ko) 2013-10-15 2015-04-23 삼성전자주식회사 개체의 간암 진단용 조성물, 개체의 간암 진단하는 방법 및 개체의 간암 진단에 필요한 정보를 얻는 방법
CA2964114A1 (en) 2014-10-09 2016-04-14 Anthrogenesis Corporation Placenta-derived adherent cell exosomes and uses thereof
WO2016077639A2 (en) * 2014-11-12 2016-05-19 VL27, Inc. Nanovesicular therapies
WO2017075708A1 (en) * 2015-11-05 2017-05-11 Exerkine Corporation Exosomes useful to treat cystic fibrosis
CN108883138A (zh) 2015-12-30 2018-11-23 加利福利亚大学董事会 增强细胞衍生的囊泡的生产和分离的方法
RU2018136151A (ru) 2016-03-15 2020-04-15 Кодиак Байосайнсиз, Инк. Терапевтические мембранные везикулы
WO2018226758A2 (en) 2017-06-05 2018-12-13 The Regents Of The University Of California Methods for enhanced production and isolation of cell-derived vesicles and treatment of inflammation and neurological damage
CN111212632B (zh) 2017-08-25 2024-04-16 隆萨销售股份公司 使用膜蛋白制备治疗性外来体

Also Published As

Publication number Publication date
WO2019040920A1 (en) 2019-02-28
US20190117792A1 (en) 2019-04-25
PH12020500308A1 (en) 2021-02-08
MX2020001790A (es) 2020-07-22
CA3072352A1 (en) 2019-02-28
US20200222556A1 (en) 2020-07-16
US10561740B2 (en) 2020-02-18
EP3672573A4 (en) 2021-05-26
SG11202001008RA (en) 2020-03-30
KR20240033086A (ko) 2024-03-12
KR20200071065A (ko) 2020-06-18
JP2020531018A (ja) 2020-11-05
CN111212632A (zh) 2020-05-29
AU2018321927A1 (en) 2020-02-27
JP2023160981A (ja) 2023-11-02
CO2020001872A2 (es) 2020-06-19
BR112020003354A2 (pt) 2020-08-18
WO2019040920A8 (en) 2019-04-04
EP3672573A1 (en) 2020-07-01
US11679164B2 (en) 2023-06-20
CN111212632B (zh) 2024-04-16
US20190060483A1 (en) 2019-02-28
IL272786A (en) 2020-04-30
US10195290B1 (en) 2019-02-05
US20240009322A1 (en) 2024-01-11

Similar Documents

Publication Publication Date Title
CO2020001872A2 (es) Preparación de exosomas terapéuticos mediante el uso de proteínas de membrana
CL2021001278A1 (es) Vesículas extracelulares modificadas y sus usos
MX2020004883A (es) Composiciones de exosomas modificados y metodos de cargar cargas de exosomas luminales.
PE20190563A1 (es) Genes de mini-distrofina optimizados y casetes de expresion y su uso
CY1121632T1 (el) Η rv2386c πρωτεϊνη φυματιωσης, συνθεσεις και χρησεις αυτης
ECSP17059343A (es) ARNi VARIANTE
CO2018007203A2 (es) Focalización de péptidos para dirigir virus adenoasociados (aavs)
GT201400166A (es) Miméticos de apelina sintéticos para el tratamiento de insuficiencia cardiaca
CO2017012893A2 (es) Composiciones farmacéuticas que comprenden péptidos neo-antígenos o una sal de los mismos y métodos para preparar las mismas
CO2020015153A2 (es) Compuestos inhibidores de rip1 y métodos para preparar y usar los mismos
ECSP11011367A (es) Composición farmacéutica
AR101953A1 (es) Proteínas de fusión, bacterias recombinantes y métodos de uso de las bacterias recombinantes
DOP2015000055A (es) Etanercept correctamente plegado de alta pureza y excelente rendimiento
CO6400198A2 (es) Composiciones y metodos novedosos
AR083561A1 (es) Preparacion de una construccion antigenica
CO6341637A2 (es) \\\\\\\"composiciones y metodos novedosos\\\\\\\"
EA201170493A1 (ru) Микроорганизмы и вакцины, зависимые от репликации неприродных аминокислот
ES2722773T3 (es) Polipéptidos de fHbp meningocócicos modificados
CY1122615T1 (el) Θεραπεια με βλαστοκυτταρα σε παθολογιες τουενδομητριου
PE20191407A1 (es) Uso de gaboxadol en el tratamiento de tinnitus
CO2017012675A2 (es) Péptidos lipidados resistentes a proteasas
AR113134A1 (es) Arni variante
AR100134A1 (es) Métodos y composiciones de administración tópica para el cuidado de la piel
CL2018000668A1 (es) Plataforma de andamio con nudo de tierra.
AR115883A1 (es) Composición farmacéutica para el tratamiento de la adicción a sustancias psicoactivas y/o para la prevención de las recaídas a dicha adicción