MX2020004883A - Composiciones de exosomas modificados y metodos de cargar cargas de exosomas luminales. - Google Patents

Composiciones de exosomas modificados y metodos de cargar cargas de exosomas luminales.

Info

Publication number
MX2020004883A
MX2020004883A MX2020004883A MX2020004883A MX2020004883A MX 2020004883 A MX2020004883 A MX 2020004883A MX 2020004883 A MX2020004883 A MX 2020004883A MX 2020004883 A MX2020004883 A MX 2020004883A MX 2020004883 A MX2020004883 A MX 2020004883A
Authority
MX
Mexico
Prior art keywords
exosomes
methods
payloads
luminal
loading
Prior art date
Application number
MX2020004883A
Other languages
English (en)
Inventor
Kevin P Dooley
Russell E Mcconnell
Ke Xu
Sonya Haupt
John D Kulman
Douglas E Williams
Rane A Harrison
Damian J Houde
Madeleine Youniss
Original Assignee
Codiak Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codiak Biosciences Inc filed Critical Codiak Biosciences Inc
Publication of MX2020004883A publication Critical patent/MX2020004883A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5184—Virus capsids or envelopes enclosing drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Plant Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a métodos para preparar un exosoma terapéutico usando proteínas recientemente identificadas para ser enriquecidas en el lumen de exosomas. Específicamente, la presente invención proporciona métodos para localizar una proteína o péptido terapéutico en exosomas. Los métodos implican la generación de exosomas modificados en el lumen que incluyen una o más de las proteínas de exosoma a concentraciones mayores, una modificación o un fragmento de la proteína de exosoma, o una proteína de fusión de la proteína de exosoma y una proteína terapéutica o de carga.
MX2020004883A 2017-11-17 2018-11-16 Composiciones de exosomas modificados y metodos de cargar cargas de exosomas luminales. MX2020004883A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762587767P 2017-11-17 2017-11-17
US201862634750P 2018-02-23 2018-02-23
PCT/US2018/061679 WO2019099942A1 (en) 2017-11-17 2018-11-16 Compositions of engineered exosomes and methods of loading luminal exosomes payloads

Publications (1)

Publication Number Publication Date
MX2020004883A true MX2020004883A (es) 2020-08-06

Family

ID=66534134

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004883A MX2020004883A (es) 2017-11-17 2018-11-16 Composiciones de exosomas modificados y metodos de cargar cargas de exosomas luminales.

Country Status (11)

Country Link
US (3) US20200347112A1 (es)
JP (2) JP2021503300A (es)
KR (1) KR20200091390A (es)
CN (1) CN111511384A (es)
AR (1) AR115159A1 (es)
AU (1) AU2018367670A1 (es)
CA (2) CA3234784A1 (es)
IL (1) IL274634A (es)
MX (1) MX2020004883A (es)
SG (1) SG11202003871SA (es)
WO (1) WO2019099942A1 (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019246591A1 (en) 2018-06-21 2019-12-26 Codiak Biosciences, Inc. Methods of measuring extracellular vesicles and nanoparticles in complex matrices by light scattering
PT3672614T (pt) * 2018-11-16 2022-02-11 Codiak Biosciences Inc Vesículas extracelulares modificadas e suas utilizações
CA3128386A1 (en) * 2019-02-04 2020-08-13 Codiak Biosciences, Inc. Membrane protein scaffolds for exosome engineering
KR20220009389A (ko) * 2019-04-17 2022-01-24 코디악 바이오사이언시즈, 인크. 엑소좀 및 aav 의 조성물
US20240024220A1 (en) * 2019-05-11 2024-01-25 Youngsuk Yi Neurotoxin compositions and methods
WO2021003445A1 (en) 2019-07-03 2021-01-07 Codiak Biosciences, Inc. Extracellular vesicles targeting t cells and uses thereof
JP2022544288A (ja) 2019-08-14 2022-10-17 コディアック バイオサイエンシーズ， インコーポレイテッド ＣＥＢＰ／βを標的とする細胞外小胞－ＡＳＯ構築物
WO2021030768A1 (en) 2019-08-14 2021-02-18 Codiak Biosciences, Inc. Extracellular vesicles with stat3-antisense oligonucleotides
CN114829586A (zh) 2019-08-14 2022-07-29 科迪亚克生物科学公司 细胞外囊泡-nlrp3拮抗剂
BR112022002691A2 (pt) 2019-08-14 2022-08-23 Codiak Biosciences Inc Construtos de vesícula-aso extracelular visando stat6
CA3147701A1 (en) 2019-08-14 2021-02-18 Codiak Biosciences, Inc. Extracellular vesicles with antisense oligonucleotides targeting kras
WO2021062060A1 (en) 2019-09-25 2021-04-01 Codiak Biosciences, Inc. Sting agonist comprising exosomes combined with il-12 displaying exosomes for treating a tumour
US20230103726A1 (en) 2019-09-25 2023-04-06 Codiak Biosciences, Inc. Methods of producing extracellular vesicles
WO2021062057A1 (en) 2019-09-25 2021-04-01 Codiak Biosciences, Inc. Exogenous loading of exosomes via lyophilization
EP4034247A1 (en) 2019-09-25 2022-08-03 Codiak BioSciences, Inc. Sting agonist comprising exosomes for treating neuroimmunological disorders
EP4034081A1 (en) 2019-09-25 2022-08-03 Codiak BioSciences, Inc. Extracellular vesicle compositions
WO2021092193A1 (en) 2019-11-05 2021-05-14 Codiak Biosciences, Inc. High-throughput chromatography screening for extracellular vesicles
WO2021146616A1 (en) 2020-01-17 2021-07-22 Codiak Biosciences, Inc. Cholesterol assays for quantifying extracellular vesicles
EP4097474A4 (en) * 2020-01-27 2024-03-27 Mantra Bio Inc NON-NATURALLY OCCURRING VESICLES COMPRISING A CHIMERIC VESICLE LOCALIZATION COMPONENT, METHODS OF PREPARATION AND USES THEREOF
EP4099984A4 (en) 2020-02-05 2024-05-01 Diadem Biotherapeutics Inc ARTIFICIAL SYNAPSES
WO2021184020A1 (en) 2020-03-13 2021-09-16 Codiak Biosciences, Inc. Methods of treating neuroinflammation
WO2021184021A1 (en) 2020-03-13 2021-09-16 Codiak Biosciences, Inc. Extracellular vesicle-aso constructs targeting pmp22
EP4117717A1 (en) 2020-03-13 2023-01-18 Codiak BioSciences, Inc. Extracellular vesicles for treating neurological disorders
WO2021189047A2 (en) 2020-03-20 2021-09-23 Codiak Biosciences, Inc. Extracellular vesicles for therapy
WO2021228832A1 (en) 2020-05-11 2021-11-18 Erytech Pharma Red cell extracellular vesicles (rcevs) containing cargoes and methods of use and production thereof
US20230220068A1 (en) 2020-06-05 2023-07-13 Codiak Biosciences, Inc. Anti-transferrin extracellular vesicles
AU2021320419A1 (en) * 2020-08-07 2023-03-09 Amicus Therapeutics, Inc. Vesicle targeting proteins and uses of same
JP2023538077A (ja) 2020-08-17 2023-09-06 コディアック バイオサイエンシーズ， インコーポレイテッド がんの治療方法
CA3193107A1 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
WO2022066883A1 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Extracellular vesicles comprising kras antigens and uses thereof
WO2022066928A2 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
US20240082389A1 (en) 2020-09-23 2024-03-14 Lonza Sales Ag Methods of producing extracellular vesicles
WO2022076596A1 (en) 2020-10-06 2022-04-14 Codiak Biosciences, Inc. Extracellular vesicle-aso constructs targeting stat6
CN112410304A (zh) * 2020-11-12 2021-02-26 天津大学 一种基因修饰的外泌体及其制备方法和应用
CN112903999A (zh) * 2021-01-20 2021-06-04 蚌埠医学院第一附属医院（蚌埠医学院附属肿瘤医院） 一种用于纳米流式细胞仪检测的外泌体的制备方法及应用
IL305171A (en) 2021-02-17 2023-10-01 Lonza Sales Ag EXTRACELLULAR VESILE-NLRP3 antagonist
KR20230157346A (ko) * 2021-02-17 2023-11-16 론자 세일즈 아게 세포외 소포체를 로딩하는 방법
CN117120041A (zh) 2021-04-01 2023-11-24 隆萨销售股份有限公司 胞外囊泡组合物
WO2023027082A1 (ja) * 2021-08-23 2023-03-02 積水化学工業株式会社 ペプチド結合ハイブリッドリポソームエクソソーム、ペプチド結合エクソソーム、これらを含む組成物及びその形成方法
WO2023064924A1 (en) 2021-10-14 2023-04-20 Codiak Biosciences, Inc. Modified producer cells for extracellular vesicle production
WO2023085821A1 (ko) * 2021-11-10 2023-05-19 주식회사 씨케이엑소젠 엑소좀 기반 항바이러스 백신 및 이의 제조방법
WO2023091905A1 (en) * 2021-11-19 2023-05-25 Elmaleh David R Targeted extracellular vesicles and methods of use thereof
WO2023183794A2 (en) * 2022-03-24 2023-09-28 Mercury Bio, Inc. Direct production of sirnas in saccharomyces boulardii and packaging in extracellular vesicles (evs) for targeted gene silencing
CN117126886A (zh) * 2022-05-20 2023-11-28 谛邈生物科技(北京)有限公司 一种实现工程化EVs功能蛋白模块化装载的核酸构建体及其应用
CN116656705A (zh) * 2023-04-18 2023-08-29 河南中医药大学第一附属医院 pHLIP-Lamp2b-1/2融合蛋白重组质粒及其构建、应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1412498A2 (en) * 2001-07-17 2004-04-28 Novartis AG Polynucleotides expressed in dendritic cells and polypeptides encoded thereby
EP3569254B1 (en) * 2009-04-17 2022-07-20 Oxford University Innovation Limited Composition for delivery of genetic material
CN103002879B (zh) * 2010-07-01 2016-04-20 阿昂梅迪克斯公司 来自细胞原生质体的微泡及其应用
GB201121069D0 (en) * 2011-12-07 2012-01-18 Isis Innovation Delivery system
WO2016172598A1 (en) * 2015-04-22 2016-10-27 The Broad Institute Inc. Exosomes and uses thereof
US10624849B2 (en) * 2015-09-28 2020-04-21 Northwestern University Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites
WO2017117585A1 (en) * 2015-12-30 2017-07-06 The Regents Of The University Of California Methods for enhanced production and isolation of cell-derived vesicles
WO2017147719A1 (en) * 2016-03-04 2017-09-08 Exerkine Corporation Method for treating neuropathy

Also Published As

Publication number Publication date
JP2021503300A (ja) 2021-02-12
JP2024015074A (ja) 2024-02-01
AU2018367670A1 (en) 2020-05-07
US20240000944A1 (en) 2024-01-04
KR20200091390A (ko) 2020-07-30
WO2019099942A1 (en) 2019-05-23
US20190151456A1 (en) 2019-05-23
CA3234784A1 (en) 2019-05-23
CN111511384A (zh) 2020-08-07
AR115159A1 (es) 2020-12-02
SG11202003871SA (en) 2020-05-28
IL274634A (en) 2020-06-30
US20200347112A1 (en) 2020-11-05
CA3082588A1 (en) 2019-05-23

Similar Documents

Publication Publication Date Title
MX2020004883A (es) Composiciones de exosomas modificados y metodos de cargar cargas de exosomas luminales.
CL2021001278A1 (es) Vesículas extracelulares modificadas y sus usos
CO2020001872A2 (es) Preparación de exosomas terapéuticos mediante el uso de proteínas de membrana
CL2018001512A1 (es) Anticuerpos anti-cd73 humanizados.
CL2018001152A1 (es) Composiciones y métodos para el tratamiento del cáncer
CO2017001023A2 (es) Composiciones de portador-anticuerpo y métodos para realizarlas y utilizarlas
CL2019002534A1 (es) Plataforma de identificación de peptidos inmunogénicos personalizados.
CL2020003071A1 (es) Proteínas de unión multiespecíficas y mejoras con estas
CL2017000311A1 (es) Anticuerpos anti-lag3 y fragmentos de unión a antígeno
ECSP17048849A (es) Terapias de combinación para el tratamiento de cánceres
ECSP18096095A (es) Anticuerpos a la alfa-sinucleína y usos de los mismos
BR112016027773A2 (pt) peptídeo célula-penetrante, polinucleotídeo, proteína recombinante célula penetrante de toxina botulínica, vetor de expressão recombinante, bactéria, composição farmacêutica, composição cosmética e método para produzir uma proteína recombinante célula-penetrante de toxina botulínica
CL2022003377A1 (es) Péptidos y combinaciones para uso en inmunoterapia contra el cáncer de páncreas y otros cánceres (solicitud divisional 201703235)
CY1123963T1 (el) Καινοτομα πολυμερικα προφαρμακα hgh
MX2018011491A (es) Disposiciones de secuencia y secuencias para presentacion de neoepitopos.
CL2017001883A1 (es) Compuestos antisenescentes y usos de los mismos
SV2018005714A (es) Composiciones y metodos para disminuir la expresion de tau
AR095334A1 (es) Composiciones nutricionales que contienen un componente peptídico con propiedades estimulantes de la adiponectina y método para promover un peso corporal saludable
CL2020003447A1 (es) Composiciones y métodos para el tratamiento de enfermedades o condiciones relacionadas con inflamasomas
UY36173A (es) Metodo de tratamiento de enfermedades relacionadas con el factor inducible por hipoxia
CL2015001446A1 (es) Procedimiento de preparación de albumina humana con nivel de oxigeno disuelto reducido.
CL2023000892A1 (es) Composiciones terapéuticas y métodos para el tratamiento de la hepatitis b (divisional).
CL2020001781A1 (es) Un péptido de nudo de cistina (ckp) de origen no natural que se une a la proteína relacionada con el receptor de lipoproteína de baja densidad 6 (lrp6) humana. (divisional solicitud 201800668)
PE20190966A1 (es) Factor viii direccionado a los globulos rojos y metodo para su uso
CO2021003136A2 (es) Terapias de combinación