SG11202003871SA - Compositions of engineered exosomes and methods of loading luminal exosomes payloads - Google Patents
Compositions of engineered exosomes and methods of loading luminal exosomes payloadsInfo
- Publication number
- SG11202003871SA SG11202003871SA SG11202003871SA SG11202003871SA SG11202003871SA SG 11202003871S A SG11202003871S A SG 11202003871SA SG 11202003871S A SG11202003871S A SG 11202003871SA SG 11202003871S A SG11202003871S A SG 11202003871SA SG 11202003871S A SG11202003871S A SG 11202003871SA
- Authority
- SG
- Singapore
- Prior art keywords
- exosomes
- payloads
- luminal
- loading
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5184—Virus capsids or envelopes enclosing drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
- C12N2509/10—Mechanical dissociation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Plant Pathology (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762587767P | 2017-11-17 | 2017-11-17 | |
| US201862634750P | 2018-02-23 | 2018-02-23 | |
| PCT/US2018/061679 WO2019099942A1 (en) | 2017-11-17 | 2018-11-16 | Compositions of engineered exosomes and methods of loading luminal exosomes payloads |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202003871SA true SG11202003871SA (en) | 2020-05-28 |
Family
ID=66534134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202003871SA SG11202003871SA (en) | 2017-11-17 | 2018-11-16 | Compositions of engineered exosomes and methods of loading luminal exosomes payloads |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20200347112A1 (es) |
| JP (2) | JP2021503300A (es) |
| KR (1) | KR20200091390A (es) |
| CN (1) | CN111511384A (es) |
| AR (1) | AR115159A1 (es) |
| AU (1) | AU2018367670A1 (es) |
| CA (2) | CA3234784A1 (es) |
| IL (1) | IL274634A (es) |
| MX (1) | MX2020004883A (es) |
| SG (1) | SG11202003871SA (es) |
| WO (1) | WO2019099942A1 (es) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019246591A1 (en) | 2018-06-21 | 2019-12-26 | Codiak Biosciences, Inc. | Methods of measuring extracellular vesicles and nanoparticles in complex matrices by light scattering |
| JP2022513049A (ja) * | 2018-11-16 | 2022-02-07 | コディアック バイオサイエンシーズ， インコーポレイテッド | 操作された細胞外小胞及びその使用 |
| CA3128386A1 (en) * | 2019-02-04 | 2020-08-13 | Codiak Biosciences, Inc. | Membrane protein scaffolds for exosome engineering |
| MX2021012540A (es) * | 2019-04-17 | 2022-01-18 | Codiak Biosciences Inc | Composiciones de exosomas y virus adenoasociados (aav). |
| WO2020231700A1 (en) * | 2019-05-11 | 2020-11-19 | Youngsuk Yi | Neurotoxin compositions and methods |
| EP3994158A1 (en) | 2019-07-03 | 2022-05-11 | Codiak BioSciences, Inc. | Extracellular vesicles targeting t cells and uses thereof |
| AU2020330133A1 (en) | 2019-08-14 | 2022-03-17 | Lonza Sales Ag | Extracellular vesicle-ASO constructs targeting CEBP/beta |
| US20230132093A1 (en) | 2019-08-14 | 2023-04-27 | Codiak Biosciences, Inc. | Extracellular vesicle-nlrp3 antagonist |
| US20230193274A1 (en) | 2019-08-14 | 2023-06-22 | Codiak Biosciences, Inc. | Extracellular vesicles with stat3-antisense oligonucleotides |
| JP2022544290A (ja) | 2019-08-14 | 2022-10-17 | コディアック バイオサイエンシーズ， インコーポレイテッド | Ｋｒａｓを標的とするアンチセンスオリゴヌクレオチドを有する細胞外小胞 |
| WO2021030776A1 (en) | 2019-08-14 | 2021-02-18 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting stat6 |
| JP2022549328A (ja) | 2019-09-25 | 2022-11-24 | コディアック バイオサイエンシーズ， インコーポレイテッド | 細胞外小胞組成物 |
| WO2021062290A1 (en) | 2019-09-25 | 2021-04-01 | Codiak Biosciences, Inc. | Methods of producing extracellular vesicles |
| US20230241089A1 (en) | 2019-09-25 | 2023-08-03 | Codiak Biosciences, Inc. | Sting agonist comprising exosomes for treating neuroimmunological disorders |
| JP2022551420A (ja) | 2019-09-25 | 2022-12-09 | コディアック バイオサイエンシーズ， インコーポレイテッド | 腫瘍を治療するためのｉｌ－１２提示エクソソームとｓｔｉｎｇアゴニスト含有エクソソームとの併用 |
| WO2021062057A1 (en) | 2019-09-25 | 2021-04-01 | Codiak Biosciences, Inc. | Exogenous loading of exosomes via lyophilization |
| US20220390437A1 (en) | 2019-11-05 | 2022-12-08 | Codiak Biosciences, Inc. | High-throughput chromatography screening for extracellular vesicles |
| US20230184791A1 (en) | 2020-01-17 | 2023-06-15 | Codiak Biosciences, Inc. | Cholesterol assays for quantifying extracellular vesicles |
| JP2023514975A (ja) * | 2020-01-27 | 2023-04-12 | マントラ バイオ，インコーポレイテッド | キメラ小胞局在化部分を含む非天然発生の小胞、その産生方法、およびその使用 |
| KR20220139926A (ko) | 2020-02-05 | 2022-10-17 | 다이아뎀 바이오쎄라퓨틱스 인크 | 인공 시냅스 |
| WO2021184021A1 (en) | 2020-03-13 | 2021-09-16 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting pmp22 |
| WO2021184020A1 (en) | 2020-03-13 | 2021-09-16 | Codiak Biosciences, Inc. | Methods of treating neuroinflammation |
| US20230114434A1 (en) | 2020-03-13 | 2023-04-13 | Codiak Biosciences, Inc. | Extracellular vesicles for treating neurological disorders |
| JP2023518414A (ja) | 2020-03-20 | 2023-05-01 | コディアック バイオサイエンシーズ， インコーポレイテッド | 治療のための細胞外小胞 |
| EP4149440A1 (en) | 2020-05-11 | 2023-03-22 | Erytech Pharma | Red cell extracellular vesicles (rcevs) containing cargoes and methods of use and production thereof |
| WO2021248133A1 (en) | 2020-06-05 | 2021-12-09 | Codiak Biosciences, Inc. | Anti-transferrin extracellular vesicles |
| US20240043494A1 (en) * | 2020-08-07 | 2024-02-08 | Amicus Therapeutics, Inc. | Vesicle Targeting Proteins And Uses Of Same |
| WO2022040223A1 (en) | 2020-08-17 | 2022-02-24 | Codiak Biosciences, Inc. | Methods of treating cancer |
| WO2022066928A2 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
| WO2022066883A1 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Extracellular vesicles comprising kras antigens and uses thereof |
| WO2022066934A2 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
| CA3192470A1 (en) | 2020-09-23 | 2022-03-31 | Tim SOOS | Methods of producing extracellular vesicles |
| US20230364127A1 (en) | 2020-10-06 | 2023-11-16 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting stat6 |
| CN112410304A (zh) * | 2020-11-12 | 2021-02-26 | 天津大学 | 一种基因修饰的外泌体及其制备方法和应用 |
| CN112903999A (zh) * | 2021-01-20 | 2021-06-04 | 蚌埠医学院第一附属医院（蚌埠医学院附属肿瘤医院） | 一种用于纳米流式细胞仪检测的外泌体的制备方法及应用 |
| US20240167036A1 (en) | 2021-02-17 | 2024-05-23 | Lonza Sales Ag | Extracellular vesicle-nlrp3 antagonist |
| KR20230157346A (ko) | 2021-02-17 | 2023-11-16 | 론자 세일즈 아게 | 세포외 소포체를 로딩하는 방법 |
| CN117120041A (zh) | 2021-04-01 | 2023-11-24 | 隆萨销售股份有限公司 | 胞外囊泡组合物 |
| JPWO2023027082A1 (es) * | 2021-08-23 | 2023-03-02 | ||
| IL311962A (en) | 2021-10-14 | 2024-06-01 | Lonza Sales Ag | Producer cells are adapted to produce extracellular vesicles |
| WO2023085821A1 (ko) * | 2021-11-10 | 2023-05-19 | 주식회사 씨케이엑소젠 | 엑소좀 기반 항바이러스 백신 및 이의 제조방법 |
| WO2023091905A1 (en) * | 2021-11-19 | 2023-05-25 | Elmaleh David R | Targeted extracellular vesicles and methods of use thereof |
| WO2023183794A2 (en) * | 2022-03-24 | 2023-09-28 | Mercury Bio, Inc. | Direct production of sirnas in saccharomyces boulardii and packaging in extracellular vesicles (evs) for targeted gene silencing |
| CN117126886A (zh) * | 2022-05-20 | 2023-11-28 | 谛邈生物科技(北京)有限公司 | 一种实现工程化EVs功能蛋白模块化装载的核酸构建体及其应用 |
| CN116656705A (zh) * | 2023-04-18 | 2023-08-29 | 河南中医药大学第一附属医院 | pHLIP-Lamp2b-1/2融合蛋白重组质粒及其构建、应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002327879A1 (en) * | 2001-07-17 | 2003-03-03 | Novartis Pharma Gmbh | Polynucleotides expressed in dendritic cells and polypeptides encoded thereby |
| PT2419144T (pt) * | 2009-04-17 | 2019-09-16 | Univ Oxford Innovation Ltd | Composição para a administração de material genético |
| US9149542B2 (en) * | 2010-07-01 | 2015-10-06 | Aeon Medix Inc. | Microvesicles derived from cell protoplast and use thereof |
| GB201121069D0 (en) * | 2011-12-07 | 2012-01-18 | Isis Innovation | Delivery system |
| WO2016172598A1 (en) * | 2015-04-22 | 2016-10-27 | The Broad Institute Inc. | Exosomes and uses thereof |
| US10624849B2 (en) * | 2015-09-28 | 2020-04-21 | Northwestern University | Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites |
| JP2019501179A (ja) * | 2015-12-30 | 2019-01-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 細胞由来ベシクルの向上された生成および単離のための方法 |
| WO2017147719A1 (en) * | 2016-03-04 | 2017-09-08 | Exerkine Corporation | Method for treating neuropathy |
-
2018
- 2018-11-16 CA CA3234784A patent/CA3234784A1/en active Pending
- 2018-11-16 AU AU2018367670A patent/AU2018367670A1/en active Pending
- 2018-11-16 JP JP2020545049A patent/JP2021503300A/ja active Pending
- 2018-11-16 WO PCT/US2018/061679 patent/WO2019099942A1/en active Application Filing
- 2018-11-16 US US16/765,116 patent/US20200347112A1/en not_active Abandoned
- 2018-11-16 CA CA3082588A patent/CA3082588A1/en active Pending
- 2018-11-16 US US16/194,230 patent/US20190151456A1/en not_active Abandoned
- 2018-11-16 CN CN201880072250.2A patent/CN111511384A/zh active Pending
- 2018-11-16 MX MX2020004883A patent/MX2020004883A/es unknown
- 2018-11-16 KR KR1020207011470A patent/KR20200091390A/ko not_active Application Discontinuation
- 2018-11-16 SG SG11202003871SA patent/SG11202003871SA/en unknown
-
2019
- 2019-05-23 AR ARP190101375A patent/AR115159A1/es unknown
-
2020
- 2020-05-13 IL IL274634A patent/IL274634A/en unknown
-
2022
- 2022-11-21 US US18/057,709 patent/US20240000944A1/en active Pending
-
2023
- 2023-11-28 JP JP2023200466A patent/JP2024015074A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018367670A1 (en) | 2020-05-07 |
| US20190151456A1 (en) | 2019-05-23 |
| CA3234784A1 (en) | 2019-05-23 |
| CA3082588A1 (en) | 2019-05-23 |
| KR20200091390A (ko) | 2020-07-30 |
| WO2019099942A1 (en) | 2019-05-23 |
| AR115159A1 (es) | 2020-12-02 |
| IL274634A (en) | 2020-06-30 |
| CN111511384A (zh) | 2020-08-07 |
| JP2024015074A (ja) | 2024-02-01 |
| US20240000944A1 (en) | 2024-01-04 |
| US20200347112A1 (en) | 2020-11-05 |
| JP2021503300A (ja) | 2021-02-12 |
| MX2020004883A (es) | 2020-08-06 |
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