CO2020001872A2 - Preparación de exosomas terapéuticos mediante el uso de proteínas de membrana - Google Patents

Preparación de exosomas terapéuticos mediante el uso de proteínas de membrana

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Publication number
CO2020001872A2
CO2020001872A2 CONC2020/0001872A CO2020001872A CO2020001872A2 CO 2020001872 A2 CO2020001872 A2 CO 2020001872A2 CO 2020001872 A CO2020001872 A CO 2020001872A CO 2020001872 A2 CO2020001872 A2 CO 2020001872A2
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Colombia
Prior art keywords
exosomes
proteins
exosome
preparation
membrane proteins
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CONC2020/0001872A
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English (en)
Inventor
Kevin P Dooley
Rane A Harrison
Russell E Mcconnell
Ke Xu
Damian Houde
Nikki Ross
Sonya Haupt
John D Kulman
Douglas E Williams
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Codiak Biosciences Inc
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Application filed by Codiak Biosciences Inc filed Critical Codiak Biosciences Inc
Publication of CO2020001872A2 publication Critical patent/CO2020001872A2/es

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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

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Abstract

La presente invención se refiere a métodos para preparar un exosoma terapéutico usando una proteína recientemente identificada para ser enriquecida en la superficie de exosomas. Específicamente, la presente invención proporciona métodos para usar las proteínas para purificación de afinidad de exosomas. También proporciona métodos para ubicar un péptido terapéutico en los exosomas, y dirigir exosomas a un órgano, tejido o célula específico al usar las proteínas. Los métodos implican la generación de exosomas modificados genéticamente en la superficie que incluyen una o más de las proteínas de exosomas a densidad mayor, o una variante o un fragmento de la proteína de exosoma.
CONC2020/0001872A 2017-08-25 2020-02-20 Preparación de exosomas terapéuticos mediante el uso de proteínas de membrana CO2020001872A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762550543P 2017-08-25 2017-08-25
US201862656956P 2018-04-12 2018-04-12
PCT/US2018/048026 WO2019040920A1 (en) 2017-08-25 2018-08-24 PREPARATION OF THERAPEUTIC EXOSOMES USING MEMBRANE PROTEINS

Publications (1)

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CO2020001872A2 true CO2020001872A2 (es) 2020-06-19

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US (4) US10195290B1 (es)
EP (1) EP3672573A4 (es)
JP (2) JP2020531018A (es)
KR (2) KR20240033086A (es)
CN (1) CN111212632B (es)
AU (1) AU2018321927A1 (es)
BR (1) BR112020003354A2 (es)
CA (1) CA3072352A1 (es)
CL (1) CL2020000428A1 (es)
CO (1) CO2020001872A2 (es)
IL (1) IL272786A (es)
MX (1) MX2020001790A (es)
PH (1) PH12020500308A1 (es)
SG (1) SG11202001008RA (es)
WO (1) WO2019040920A1 (es)

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