MX2018011491A - Disposiciones de secuencia y secuencias para presentacion de neoepitopos. - Google Patents

Disposiciones de secuencia y secuencias para presentacion de neoepitopos.

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Publication number
MX2018011491A
MX2018011491A MX2018011491A MX2018011491A MX2018011491A MX 2018011491 A MX2018011491 A MX 2018011491A MX 2018011491 A MX2018011491 A MX 2018011491A MX 2018011491 A MX2018011491 A MX 2018011491A MX 2018011491 A MX2018011491 A MX 2018011491A
Authority
MX
Mexico
Prior art keywords
sequences
sequence arrangements
neoepitope presentation
polytope
neoepitope
Prior art date
Application number
MX2018011491A
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English (en)
Inventor
Soon-Shiong Patrick
Nguyen Andrew
Niazi Kayvan
Rabizadeh Shahrooz
Charles Benz Stephen
Original Assignee
Nantcell Inc
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Publication date
Application filed by Nantcell Inc filed Critical Nantcell Inc
Publication of MX2018011491A publication Critical patent/MX2018011491A/es

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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
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    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A—HUMAN NECESSITIES
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    • C12N2840/002—Vectors comprising a special translation-regulating system controllable or inducible
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

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Abstract

Se presentan sistemas y metodos que permiten la seleccion de neoepitopos tumorales que despues se usan para generar un politopo recombinante que se optimiza para el trafico y procesamiento adecuados. En los metodos preferidos, el politopo se codifica en un sistema de expresion viral que se usa como un agente terapeutico.
MX2018011491A 2016-03-24 2017-03-23 Disposiciones de secuencia y secuencias para presentacion de neoepitopos. MX2018011491A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662312974P 2016-03-24 2016-03-24
US201662313621P 2016-03-25 2016-03-25
US201662314366P 2016-03-28 2016-03-28
PCT/US2017/023894 WO2017222619A2 (en) 2016-03-24 2017-03-23 Sequence arrangements and sequences for neoepitope presentation

Publications (1)

Publication Number Publication Date
MX2018011491A true MX2018011491A (es) 2019-08-01

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MX2018011491A MX2018011491A (es) 2016-03-24 2017-03-23 Disposiciones de secuencia y secuencias para presentacion de neoepitopos.

Country Status (12)

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US (2) US11154597B2 (es)
EP (1) EP3475434A4 (es)
JP (1) JP2019513021A (es)
KR (1) KR20180117227A (es)
CN (1) CN109563521A (es)
AU (1) AU2017281126A1 (es)
CA (1) CA3018741A1 (es)
IL (1) IL261813A (es)
MX (1) MX2018011491A (es)
SG (1) SG11201807770RA (es)
TW (1) TW201742923A (es)
WO (1) WO2017222619A2 (es)

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US20170312351A1 (en) 2017-11-02
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