MX2014013318A - Compuestos agonistas dobles de gip-glp-1 y procedimientos. - Google Patents

Compuestos agonistas dobles de gip-glp-1 y procedimientos.

Info

Publication number
MX2014013318A
MX2014013318A MX2014013318A MX2014013318A MX2014013318A MX 2014013318 A MX2014013318 A MX 2014013318A MX 2014013318 A MX2014013318 A MX 2014013318A MX 2014013318 A MX2014013318 A MX 2014013318A MX 2014013318 A MX2014013318 A MX 2014013318A
Authority
MX
Mexico
Prior art keywords
gip
glp
agonist compounds
methods
dual agonist
Prior art date
Application number
MX2014013318A
Other languages
English (en)
Other versions
MX356641B (es
Inventor
Ditte Riber
Torben Østerlund
Rasmus Just
Anne Pernille Tofteng Shelton
Kate Hansen
Lene Jessen
Original Assignee
Zealand Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharma As filed Critical Zealand Pharma As
Publication of MX2014013318A publication Critical patent/MX2014013318A/es
Publication of MX356641B publication Critical patent/MX356641B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invención se refiere a análogos truncados de GIP que comprenden una o más sustituciones en comparación con el GIP silvestre y que pueden tener la propiedad de una actividad de GLP-1 alterada, preferentemente incrementada, por ejemplo, como se evalúa en ensayos de eficacia in vitro. La invención proporciona compuestos agonistas dobles GIP-GLP-1 y métodos asociados.
MX2014013318A 2012-05-03 2013-05-03 Compuestos agonistas dobles de gip-glp-1 y procedimientos. MX356641B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261642439P 2012-05-03 2012-05-03
US201361765561P 2013-02-15 2013-02-15
PCT/EP2013/059319 WO2013164483A1 (en) 2012-05-03 2013-05-03 Gip-glp-1 dual agonist compounds and methods

Publications (2)

Publication Number Publication Date
MX2014013318A true MX2014013318A (es) 2015-09-28
MX356641B MX356641B (es) 2018-06-07

Family

ID=48325702

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013318A MX356641B (es) 2012-05-03 2013-05-03 Compuestos agonistas dobles de gip-glp-1 y procedimientos.

Country Status (20)

Country Link
US (2) US10100097B2 (es)
EP (1) EP2844669B1 (es)
JP (1) JP6228187B2 (es)
KR (1) KR102184241B1 (es)
CN (1) CN104470948B (es)
AR (1) AR090937A1 (es)
AU (1) AU2013255751B2 (es)
BR (1) BR112014027348B1 (es)
CA (1) CA2872314C (es)
EA (1) EA028665B1 (es)
HK (1) HK1208232A1 (es)
IL (1) IL235463A0 (es)
IN (1) IN2014MN02304A (es)
MX (1) MX356641B (es)
NZ (1) NZ702333A (es)
PH (1) PH12014502452A1 (es)
SG (1) SG11201407137PA (es)
TR (1) TR201815338T4 (es)
TW (1) TWI689515B (es)
WO (1) WO2013164483A1 (es)

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EP2844669A1 (en) 2015-03-11
TWI689515B (zh) 2020-04-01
IL235463A0 (en) 2014-12-31
AU2013255751A1 (en) 2014-12-18
NZ702333A (en) 2017-06-30
BR112014027348A2 (pt) 2017-06-27
BR112014027348B1 (pt) 2022-12-20
KR20150003910A (ko) 2015-01-09
HK1208232A1 (en) 2016-02-26
US10100097B2 (en) 2018-10-16
CA2872314C (en) 2021-08-31
KR102184241B1 (ko) 2020-12-01
EA028665B1 (ru) 2017-12-29
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CN104470948A (zh) 2015-03-25
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AU2013255751B2 (en) 2017-10-05
US20190135886A1 (en) 2019-05-09
JP2015517459A (ja) 2015-06-22
MX356641B (es) 2018-06-07
EA201491918A1 (ru) 2015-07-30
TW201348252A (zh) 2013-12-01
TR201815338T4 (tr) 2018-11-21
AR090937A1 (es) 2014-12-17
PH12014502452A1 (en) 2015-02-02
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CA2872314A1 (en) 2013-11-07
US20150299281A1 (en) 2015-10-22

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