SG11201407137PA - Gip-glp-1 dual agonist compounds and methods - Google Patents
Gip-glp-1 dual agonist compounds and methodsInfo
- Publication number
- SG11201407137PA SG11201407137PA SG11201407137PA SG11201407137PA SG11201407137PA SG 11201407137P A SG11201407137P A SG 11201407137PA SG 11201407137P A SG11201407137P A SG 11201407137PA SG 11201407137P A SG11201407137P A SG 11201407137PA SG 11201407137P A SG11201407137P A SG 11201407137PA
- Authority
- SG
- Singapore
- Prior art keywords
- gip
- glp
- methods
- agonist compounds
- dual agonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261642439P | 2012-05-03 | 2012-05-03 | |
| US201361765561P | 2013-02-15 | 2013-02-15 | |
| PCT/EP2013/059319 WO2013164483A1 (en) | 2012-05-03 | 2013-05-03 | Gip-glp-1 dual agonist compounds and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201407137PA true SG11201407137PA (en) | 2014-11-27 |
Family
ID=48325702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201407137PA SG11201407137PA (en) | 2012-05-03 | 2013-05-03 | Gip-glp-1 dual agonist compounds and methods |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10100097B2 (en) |
| EP (1) | EP2844669B1 (en) |
| JP (1) | JP6228187B2 (en) |
| KR (1) | KR102184241B1 (en) |
| CN (1) | CN104470948B (en) |
| AR (1) | AR090937A1 (en) |
| AU (1) | AU2013255751B2 (en) |
| BR (1) | BR112014027348B1 (en) |
| CA (1) | CA2872314C (en) |
| EA (1) | EA028665B1 (en) |
| HK (1) | HK1208232A1 (en) |
| IL (1) | IL235463A0 (en) |
| IN (1) | IN2014MN02304A (en) |
| MX (1) | MX356641B (en) |
| NZ (1) | NZ702333A (en) |
| PH (1) | PH12014502452A1 (en) |
| SG (1) | SG11201407137PA (en) |
| TR (1) | TR201815338T4 (en) |
| TW (1) | TWI689515B (en) |
| WO (1) | WO2013164483A1 (en) |
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| ME02220B (en) | 2009-07-13 | 2016-02-20 | Zealand Pharma As | Acylated glucagon analogues |
| US10100097B2 (en) | 2012-05-03 | 2018-10-16 | Zealand Pharma A/S | GIP-GLP-1 dual agonist compounds and methods |
| CN104662038B (en) | 2012-07-23 | 2018-11-06 | 西兰制药公司 | Glucagon analogue |
| TWI608013B (en) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | Glucagon analogues |
| UA116217C2 (en) | 2012-10-09 | 2018-02-26 | Санофі | Exendin-4 derivatives as dual glp1/glucagon agonists |
| JP2016503046A (en) * | 2012-12-19 | 2016-02-01 | ノヴォ ノルディスク アー／エス | Novel GLP-1 receptor agonist having cholesterol efflux activity |
| BR112015014510A2 (en) * | 2012-12-21 | 2017-11-21 | Sanofi Sa | dual glp1 / gip or trigonal glp1 / gip / glucagon agonists |
| ES2900744T3 (en) | 2013-05-28 | 2022-03-18 | Takeda Pharmaceuticals Co | peptide compound |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| CN105745222A (en) | 2013-10-17 | 2016-07-06 | 西兰制药公司 | Acylated glucagon analogues |
| TWI670281B (en) * | 2013-11-06 | 2019-09-01 | 西蘭製藥公司 | Gip-glp-1 dual agonist compounds and methods |
| CA2929107C (en) | 2013-11-06 | 2023-09-26 | Zealand Pharma A/S | Glucagon-glp-1-gip triple agonist compounds |
| EP3077008B1 (en) | 2013-12-06 | 2023-10-04 | Jie Han | Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs |
| ES2883345T3 (en) * | 2014-10-29 | 2021-12-07 | Zealand Pharma As | GIP agonist compounds and methods |
| JOP20200119A1 (en) * | 2015-01-09 | 2017-06-16 | Lilly Co Eli | Gip and glp-1 co-agonist compounds |
| JP6989385B2 (en) | 2015-04-16 | 2022-01-05 | ジーランド ファーマ アクティーゼルスカブ | Acylated glucagon analog |
| WO2017060500A1 (en) | 2015-10-07 | 2017-04-13 | Cyprumed Gmbh | Pharmaceutical formulations for the oral delivery of peptide drugs |
| TWI622596B (en) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | Glucagon receptor agonists |
| JP6995042B2 (en) * | 2016-05-24 | 2022-02-04 | 武田薬品工業株式会社 | Peptide compound |
| WO2018065634A1 (en) | 2016-10-07 | 2018-04-12 | Cyprumed Gmbh | Pharmaceutical compositions for the nasal delivery of peptide or protein drugs |
| GB201620611D0 (en) | 2016-12-05 | 2017-01-18 | Univ Of Lancaster | Treatment of neurological diseases |
| WO2018104263A1 (en) | 2016-12-06 | 2018-06-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of enhancing the potency of incretin-based drugs in subjects in need thereof |
| JOP20180028A1 (en) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | Peptide compound |
| WO2019140030A1 (en) | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
| US10577905B2 (en) | 2018-02-12 | 2020-03-03 | Eagle Technology, Llc | Hydrocarbon resource recovery system and RF antenna assembly with latching inner conductor and related methods |
| US20210087250A1 (en) | 2018-04-06 | 2021-03-25 | Cyprumed Gmbh | Pharmaceutical compositions for the transmucosal delivery of therapeutic peptides and proteins |
| RU2020136305A (en) * | 2018-05-04 | 2022-05-05 | Ново Нордиск А/С | GIP DERIVATIVES AND THEIR APPLICATIONS |
| TWI705820B (en) | 2018-06-22 | 2020-10-01 | 美商美國禮來大藥廠 | Gip/glp1 agonist compositions |
| CA3178366A1 (en) * | 2018-07-23 | 2020-01-30 | Eli Lilly And Company | Gip/glp1 co-agonist compounds |
| CN112469431A (en) | 2018-07-23 | 2021-03-09 | 伊莱利利公司 | Methods of using GIP/GLP1 co-agonists for diabetes |
| WO2020067557A2 (en) * | 2018-09-24 | 2020-04-02 | Takeda Pharmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
| WO2020143625A1 (en) * | 2019-01-07 | 2020-07-16 | 鸿绪生物医药科技（北京）有限公司 | Novel polypeptide and therapeutic uses thereof |
| WO2020207477A1 (en) * | 2019-04-11 | 2020-10-15 | 江苏豪森药业集团有限公司 | Glp-1 and gip receptor dual agonist compounds and use thereof |
| TWI764209B (en) | 2019-08-01 | 2022-05-11 | 美商美國禮來大藥廠 | Gipr-agonist compounds |
| PE20221049A1 (en) | 2019-08-19 | 2022-06-30 | Lilly Co Eli | METHODS FOR PREPARING INCRETIN ANALOGS |
| JP2022551282A (en) | 2019-10-04 | 2022-12-08 | ハンミ ファーマシューティカル カンパニー リミテッド | Compositions Comprising Glucagon and GLP-1 Receptor and GIP Receptor Dual Agonists and Therapeutic Uses Thereof |
| CN110684082B (en) | 2019-10-08 | 2021-12-10 | 江苏诺泰澳赛诺生物制药股份有限公司 | GIP and GLP-1 dual-agonist polypeptide compound, pharmaceutically acceptable salt and application |
| CN114641303A (en) | 2019-11-11 | 2022-06-17 | 勃林格殷格翰国际有限公司 | NPY2 receptor agonists |
| WO2021093883A1 (en) * | 2019-11-15 | 2021-05-20 | 江苏豪森药业集团有限公司 | Dual receptor-acting agonist compounds and pharmaceutical composition thereof |
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| TW202216746A (en) | 2020-06-22 | 2022-05-01 | 印度商太陽製藥工業有限公司 | Long acting glp-1/gip dual agonists |
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| CN114617956B (en) * | 2020-12-10 | 2023-10-03 | 江苏中新医药有限公司 | High-efficiency hypoglycemic protein medicine |
| KR20230126712A (en) * | 2020-12-23 | 2023-08-30 | 제지앙 도어 바이오로직스 코., 엘티디. | long-acting glucagon derivatives |
| BR112023022400A2 (en) | 2021-05-07 | 2024-01-16 | Lilly Co Eli | ERODIBLE TABLET, MANUFACTURING METHOD AND USES THEREOF |
| EP4345105A1 (en) | 2021-06-01 | 2024-04-03 | Nanjing Zhine Medicine Technology Co., Ltd. | Polypeptide derivative having effect of dual targeted activation of glp-1r and gipr, preparation method therefor, and use thereof |
| WO2023030444A1 (en) * | 2021-09-02 | 2023-03-09 | 广东东阳光药业有限公司 | Glp-1/gip dual-targeted polypeptide and fusion protein and applications thereof |
| CN118103391A (en) * | 2021-11-12 | 2024-05-28 | 福建盛迪医药有限公司 | Pharmaceutical composition of GLP-1 receptor and GIP receptor dual agonist and application thereof |
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2013
- 2013-05-03 US US14/398,260 patent/US10100097B2/en active Active
- 2013-05-03 AU AU2013255751A patent/AU2013255751B2/en active Active
- 2013-05-03 TW TW102115949A patent/TWI689515B/en active
- 2013-05-03 NZ NZ702333A patent/NZ702333A/en unknown
- 2013-05-03 SG SG11201407137PA patent/SG11201407137PA/en unknown
- 2013-05-03 CN CN201380032714.4A patent/CN104470948B/en active Active
- 2013-05-03 KR KR1020147033952A patent/KR102184241B1/en active IP Right Grant
- 2013-05-03 CA CA2872314A patent/CA2872314C/en active Active
- 2013-05-03 EA EA201491918A patent/EA028665B1/en not_active IP Right Cessation
- 2013-05-03 BR BR112014027348-0A patent/BR112014027348B1/en active IP Right Grant
- 2013-05-03 AR ARP130101524A patent/AR090937A1/en unknown
- 2013-05-03 JP JP2015509461A patent/JP6228187B2/en active Active
- 2013-05-03 WO PCT/EP2013/059319 patent/WO2013164483A1/en active Application Filing
- 2013-05-03 TR TR2018/15338T patent/TR201815338T4/en unknown
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- 2013-05-03 IN IN2304MUN2014 patent/IN2014MN02304A/en unknown
- 2013-05-03 EP EP13720931.8A patent/EP2844669B1/en active Active
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2014
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- 2014-11-03 PH PH12014502452A patent/PH12014502452A1/en unknown
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- 2015-09-09 HK HK15108788.2A patent/HK1208232A1/en unknown
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| CA2872314A1 (en) | 2013-11-07 |
| BR112014027348A2 (en) | 2017-06-27 |
| EA201491918A1 (en) | 2015-07-30 |
| US20150299281A1 (en) | 2015-10-22 |
| CN104470948A (en) | 2015-03-25 |
| CN104470948B (en) | 2018-06-15 |
| IL235463A0 (en) | 2014-12-31 |
| BR112014027348B1 (en) | 2022-12-20 |
| MX356641B (en) | 2018-06-07 |
| AR090937A1 (en) | 2014-12-17 |
| MX2014013318A (en) | 2015-09-28 |
| US20190135886A1 (en) | 2019-05-09 |
| JP2015517459A (en) | 2015-06-22 |
| CA2872314C (en) | 2021-08-31 |
| PH12014502452A1 (en) | 2015-02-02 |
| EP2844669B1 (en) | 2018-08-01 |
| WO2013164483A1 (en) | 2013-11-07 |
| AU2013255751A1 (en) | 2014-12-18 |
| EP2844669A1 (en) | 2015-03-11 |
| NZ702333A (en) | 2017-06-30 |
| EA028665B1 (en) | 2017-12-29 |
| KR102184241B1 (en) | 2020-12-01 |
| TWI689515B (en) | 2020-04-01 |
| AU2013255751B2 (en) | 2017-10-05 |
| TR201815338T4 (en) | 2018-11-21 |
| TW201348252A (en) | 2013-12-01 |
| US10100097B2 (en) | 2018-10-16 |
| JP6228187B2 (en) | 2017-11-08 |
| HK1208232A1 (en) | 2016-02-26 |
| KR20150003910A (en) | 2015-01-09 |
| IN2014MN02304A (en) | 2015-08-07 |
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