EA201491918A1 - Соединения - двойные агонисты gip-glp-1 и способы - Google Patents
Соединения - двойные агонисты gip-glp-1 и способыInfo
- Publication number
- EA201491918A1 EA201491918A1 EA201491918A EA201491918A EA201491918A1 EA 201491918 A1 EA201491918 A1 EA 201491918A1 EA 201491918 A EA201491918 A EA 201491918A EA 201491918 A EA201491918 A EA 201491918A EA 201491918 A1 EA201491918 A1 EA 201491918A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- gip
- glp
- methods
- connections
- double agonists
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Настоящее изобретение относится к укороченным аналогам GIP, которые содержат одну или более замен по сравнению с GIP дикого типа и которые могут иметь измененную, предпочтительно повышенную активность GLP-1, например, при исследовании в тесте на эффективность в условиях in vitro. Настоящее изобретение обеспечивает соединения, которые представляют собой двойные агонисты GIP-GLP-1, и связанные с ними способы.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261642439P | 2012-05-03 | 2012-05-03 | |
US201361765561P | 2013-02-15 | 2013-02-15 | |
PCT/EP2013/059319 WO2013164483A1 (en) | 2012-05-03 | 2013-05-03 | Gip-glp-1 dual agonist compounds and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201491918A1 true EA201491918A1 (ru) | 2015-07-30 |
EA028665B1 EA028665B1 (ru) | 2017-12-29 |
Family
ID=48325702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201491918A EA028665B1 (ru) | 2012-05-03 | 2013-05-03 | Соединения - двойные агонисты gip-glp-1 и способы |
Country Status (20)
Country | Link |
---|---|
US (2) | US10100097B2 (ru) |
EP (1) | EP2844669B1 (ru) |
JP (1) | JP6228187B2 (ru) |
KR (1) | KR102184241B1 (ru) |
CN (1) | CN104470948B (ru) |
AR (1) | AR090937A1 (ru) |
AU (1) | AU2013255751B2 (ru) |
BR (1) | BR112014027348B1 (ru) |
CA (1) | CA2872314C (ru) |
EA (1) | EA028665B1 (ru) |
HK (1) | HK1208232A1 (ru) |
IL (1) | IL235463A0 (ru) |
IN (1) | IN2014MN02304A (ru) |
MX (1) | MX356641B (ru) |
NZ (1) | NZ702333A (ru) |
PH (1) | PH12014502452A1 (ru) |
SG (1) | SG11201407137PA (ru) |
TR (1) | TR201815338T4 (ru) |
TW (1) | TWI689515B (ru) |
WO (1) | WO2013164483A1 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2652783C2 (ru) * | 2012-12-21 | 2018-05-03 | Санофи | Двойные агонисты glp1/gip или тройные агонисты glp1/gip/глюкагона |
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DK2454282T3 (en) | 2009-07-13 | 2015-05-04 | Zealand Pharma As | acetylated glucagonanaloger |
KR102184241B1 (ko) | 2012-05-03 | 2020-12-01 | 질랜드 파마 에이/에스 | Gip-glp-1 이원 작용제 화합물 및 방법 |
CN104662038B (zh) | 2012-07-23 | 2018-11-06 | 西兰制药公司 | 胰高血糖素类似物 |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
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RU2735762C2 (ru) | 2015-04-16 | 2020-11-06 | Зилэнд Фарма А/С | Ацилированный аналог глюкагона, его применение и способы получения |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2652783C2 (ru) * | 2012-12-21 | 2018-05-03 | Санофи | Двойные агонисты glp1/gip или тройные агонисты glp1/gip/глюкагона |
Also Published As
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TR201815338T4 (tr) | 2018-11-21 |
CN104470948B (zh) | 2018-06-15 |
CA2872314C (en) | 2021-08-31 |
KR20150003910A (ko) | 2015-01-09 |
JP2015517459A (ja) | 2015-06-22 |
MX2014013318A (es) | 2015-09-28 |
US20190135886A1 (en) | 2019-05-09 |
US10100097B2 (en) | 2018-10-16 |
AU2013255751A1 (en) | 2014-12-18 |
CA2872314A1 (en) | 2013-11-07 |
IN2014MN02304A (ru) | 2015-08-07 |
MX356641B (es) | 2018-06-07 |
NZ702333A (en) | 2017-06-30 |
US20150299281A1 (en) | 2015-10-22 |
BR112014027348B1 (pt) | 2022-12-20 |
KR102184241B1 (ko) | 2020-12-01 |
AR090937A1 (es) | 2014-12-17 |
SG11201407137PA (en) | 2014-11-27 |
EA028665B1 (ru) | 2017-12-29 |
HK1208232A1 (en) | 2016-02-26 |
JP6228187B2 (ja) | 2017-11-08 |
TW201348252A (zh) | 2013-12-01 |
CN104470948A (zh) | 2015-03-25 |
TWI689515B (zh) | 2020-04-01 |
BR112014027348A2 (pt) | 2017-06-27 |
EP2844669B1 (en) | 2018-08-01 |
IL235463A0 (en) | 2014-12-31 |
AU2013255751B2 (en) | 2017-10-05 |
PH12014502452A1 (en) | 2015-02-02 |
WO2013164483A1 (en) | 2013-11-07 |
EP2844669A1 (en) | 2015-03-11 |
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