MX173630B - Derivados de aminoacido, procedimiento para su preparacion y su preparacion y medicamento que los contiene - Google Patents
Derivados de aminoacido, procedimiento para su preparacion y su preparacion y medicamento que los contieneInfo
- Publication number
- MX173630B MX173630B MX023619A MX2361990A MX173630B MX 173630 B MX173630 B MX 173630B MX 023619 A MX023619 A MX 023619A MX 2361990 A MX2361990 A MX 2361990A MX 173630 B MX173630 B MX 173630B
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- amino acid
- acid derivatives
- procedure
- product containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Confectionery (AREA)
- Cleaning Or Clearing Of The Surface Of Open Water (AREA)
- Measurement Of Force In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898927913A GB8927913D0 (en) | 1989-12-11 | 1989-12-11 | Amino acid derivatives |
| SG120493A SG120493G (en) | 1989-12-11 | 1993-11-02 | N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX23619A MX23619A (es) | 1993-10-01 |
| MX173630B true MX173630B (es) | 1994-03-18 |
Family
ID=26296345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX023619A MX173630B (es) | 1989-12-11 | 1990-12-06 | Derivados de aminoacido, procedimiento para su preparacion y su preparacion y medicamento que los contiene |
Country Status (48)
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040122000A1 (en) * | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
| US6878728B1 (en) | 1999-06-11 | 2005-04-12 | Vertex Pharmaceutical Incorporated | Inhibitors of aspartyl protease |
| US5614533A (en) * | 1987-03-13 | 1997-03-25 | Bio-Mega/Boehringer Ingelheim Research, Inc. | Substituted pipecolinic acid derivatives as HIV protease inhibitors |
| USH1649H (en) | 1987-07-31 | 1997-05-06 | Barrish; Joel C. | HIV protease inhibitor combinations |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| GB8927915D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Novel alcohols |
| US5430041A (en) * | 1991-05-10 | 1995-07-04 | Hoffmann-La Roche Inc. | Amino acid derivatives having antiviral activity |
| US5508407A (en) * | 1991-07-10 | 1996-04-16 | Eli Lilly And Company | Retroviral protease inhibitors |
| CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
| WO1993008184A1 (en) * | 1991-10-23 | 1993-04-29 | Merck & Co., Inc. | Hiv protease inhibitors |
| US5413999A (en) * | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| IL103613A (en) * | 1991-11-08 | 1999-05-09 | Merck & Co Inc | Hiv protease inhibitors process and intermediats for their preparation and pharmaceutical compositions containing them |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| WO1993018006A1 (en) | 1992-03-11 | 1993-09-16 | Narhex Limited | Amine derivatives of oxo- and hydroxy-substitued hydrocarbons |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| DE69300043T2 (de) * | 1992-03-13 | 1995-05-24 | Bio Mega Boehringer Ingelheim | Substituierte Pipecoline-Säurederivate als HIV-Protease-Hemmer. |
| CA2136312A1 (en) * | 1992-05-21 | 1993-11-25 | Michael Clare | Retroviral protease inhibitors |
| US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| DE69321845T2 (de) | 1992-08-25 | 1999-04-29 | Monsanto Co | Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
| US5783701A (en) | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
| US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| TW372972B (en) * | 1992-10-23 | 1999-11-01 | Novartis Ag | Antiretroviral acyl compounds |
| US5380849A (en) * | 1992-11-09 | 1995-01-10 | Merck & Co., Inc. | Process for optically pure decahydroisoqiunolines |
| US5430150A (en) * | 1992-12-16 | 1995-07-04 | American Cyanamid Company | Retroviral protease inhibitors |
| MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
| US5733906A (en) * | 1993-10-12 | 1998-03-31 | Eli Lilly And Company | Inhibitors of HIV Protease useful for the treatment of Aids |
| MX9308025A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus dela inmunodeficiencia humana, procedimiento para supreparacion y formulacion farmaceutica que los contiene. |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5491166A (en) * | 1992-12-22 | 1996-02-13 | Eli Lilly And Company | Inhibitors of HIV protease useful for the treatment of AIDS |
| US5434265A (en) * | 1992-12-22 | 1995-07-18 | Eli Lilly And Company | Inhibitors of HIV protease |
| US5846993A (en) * | 1992-12-22 | 1998-12-08 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5693815A (en) * | 1993-01-17 | 1997-12-02 | Schering Corporation | Peptides |
| US5939430A (en) * | 1993-02-22 | 1999-08-17 | Merrell Pharmaceuticals Inc. | Combinations of retroviral inhibitors |
| US5455353A (en) * | 1993-03-24 | 1995-10-03 | Hoffmann-La Roche Inc. | 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides |
| ES2125077T3 (es) | 1993-07-15 | 1999-02-16 | Hoffmann La Roche | Procedimiento de obtencion de una n-tert-butilamida. |
| JPH09508416A (ja) * | 1994-02-02 | 1997-08-26 | イーライ・リリー・アンド・カンパニー | Hivプロテアーゼ阻害剤および中間体 |
| CA2183653A1 (en) * | 1994-03-07 | 1995-09-14 | Roger Dennis Tung | Sulphonamide derivatives as aspartyl protease inhibitors |
| US5527829A (en) * | 1994-05-23 | 1996-06-18 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5470979A (en) * | 1994-07-01 | 1995-11-28 | American Cyanamid Company | Asymmetric synthesis of bicyclic amino acid esters |
| US5591885A (en) | 1994-09-23 | 1997-01-07 | Hoffman-La Roche Inc. | Process for the preparation of halogenated α-aminoketone compounds |
| US5523463A (en) * | 1994-09-23 | 1996-06-04 | Hoffmann-La Roche Inc. | Method of producing halogenated and alpha-aminoalchohols |
| US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
| US6008228A (en) * | 1995-06-06 | 1999-12-28 | Hoffman-La Roche Inc. | Pharmaceutical compositions containing proteinase inhibitors |
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| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| ATE299707T1 (de) | 1995-11-13 | 2005-08-15 | Vitaleech Bioscience N V | Antivirale isolate von blutegeln |
| US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5883252A (en) * | 1996-01-26 | 1999-03-16 | Vertex Pharmaceuticals Incorporated | Aspartyl protease inhibitors |
| US5587481A (en) * | 1996-02-20 | 1996-12-24 | The Monsanto Company | Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide |
| EP0823424A1 (de) * | 1996-08-09 | 1998-02-11 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von Chinargin |
| US5914404A (en) * | 1996-08-09 | 1999-06-22 | Hoffmann-La Roche Inc. | Process for the preparation of quinargine |
| US5925759A (en) | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
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| EP0847994B1 (de) | 1996-12-11 | 2003-04-09 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung gemischter Anhydride |
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| IL142460A0 (en) * | 1998-10-21 | 2002-03-10 | Fujisawa Pharmaceutical Co | A vitreous form of 8-[3-[n-[(e)-3-(6-acetamidopyridin-3-yl) acryloyl-glycyl] -n-methylamino] -2,6-dichlorobenzyloxy]-2-methylquinoline |
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| TWI733652B (zh) | 2014-07-11 | 2021-07-21 | 美商基利科學股份有限公司 | 用於治療HIV之toll樣受體調節劑 |
| EP3212196A4 (en) | 2014-10-29 | 2018-07-11 | Wisconsin Alumni Research Foundation | Boronic acid inhibitors of hiv protease |
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| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
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| US4329473A (en) * | 1979-06-01 | 1982-05-11 | Almquist Ronald G | Oxoalkanoic acid derivatives as inhibitors of angiotensin converting enzyme |
| SE421551B (sv) * | 1980-03-26 | 1982-01-04 | Sandvik Ab | Borrverktyg for rotations- och/eller slagborrning |
| US4470973A (en) * | 1982-07-19 | 1984-09-11 | E. R. Squibb & Sons, Inc. | Substituted peptide compounds |
| US4812442A (en) * | 1984-05-29 | 1989-03-14 | Merck & Co., Inc. | Tripeptide renin inhibitors |
| FR2575753B1 (fr) * | 1985-01-07 | 1987-02-20 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AT383762B (de) * | 1985-12-23 | 1987-08-25 | Plansee Metallwerk | Verfahren zur herstellung mehrkomponentiger, kongruent erschmelzender lotmaterialien |
| CA1286989C (en) * | 1985-12-26 | 1991-07-30 | A. Arthur Gottlieb | Immunoamplifiers and related compositions |
| WO1988000939A1 (fr) * | 1986-07-25 | 1988-02-11 | Banyu Pharmaceutical Co., Ltd. | Derives d'amino-alcools optiquement actifs et procede pour leur preparation |
| EP0264106B1 (en) * | 1986-10-14 | 1994-03-16 | Banyu Pharmaceutical Co., Ltd. | 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use |
| US4863905A (en) * | 1987-02-04 | 1989-09-05 | Warner-Lambert Company | Renin inhibitors II |
| FR2610934B1 (fr) * | 1987-02-13 | 1989-05-05 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE3717631A1 (de) * | 1987-05-26 | 1988-12-15 | Merck Patent Gmbh | Aminosaeurederivate |
| DE3733296A1 (de) * | 1987-10-02 | 1989-04-20 | Merck Patent Gmbh | Aminosaeurederivate |
| IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| DE4033062A1 (de) * | 1990-10-18 | 1992-04-23 | Merck Patent Gmbh | Aminosaeurederivate |
| GB8927915D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Novel alcohols |
-
1989
- 1989-12-11 GB GB898927913A patent/GB8927913D0/en active Pending
-
1990
- 1990-11-12 IN IN905MA1990 patent/IN172553B/en unknown
- 1990-11-13 EG EG68190A patent/EG19722A/xx active
- 1990-11-14 ZW ZW174/90A patent/ZW17490A1/xx unknown
- 1990-11-15 MT MT1075A patent/MTP1075B/xx unknown
- 1990-11-19 MW MW88/90A patent/MW8890A1/xx unknown
- 1990-11-19 US US07/615,534 patent/US5196438A/en not_active Expired - Lifetime
- 1990-11-21 CZ CS905765A patent/CZ280558B6/cs not_active IP Right Cessation
- 1990-11-21 SK SK5765-90A patent/SK280249B6/sk unknown
- 1990-11-21 CA CA002030433A patent/CA2030433C/en not_active Expired - Lifetime
- 1990-12-04 MC MC902159A patent/MC2195A1/fr unknown
- 1990-12-04 FI FI973895A patent/FI973895L/fi unknown
- 1990-12-04 RO RO146474A patent/RO107942B1/ro unknown
- 1990-12-04 FI FI905983A patent/FI100883B/fi active IP Right Grant
- 1990-12-04 ZA ZA909743A patent/ZA909743B/xx unknown
- 1990-12-05 IL IL9655090A patent/IL96550A/en not_active IP Right Cessation
- 1990-12-05 HU HU908076A patent/HU207298B/hu unknown
- 1990-12-06 MX MX023619A patent/MX173630B/es unknown
- 1990-12-07 SI SI9012315A patent/SI9012315B/sl unknown
- 1990-12-07 KR KR90020078A patent/KR970005912B1/ko not_active Expired - Lifetime
- 1990-12-07 AU AU67876/90A patent/AU634319B2/en not_active Expired
- 1990-12-07 IS IS3651A patent/IS1803B/is unknown
- 1990-12-10 ES ES90123697T patent/ES2072959T3/es not_active Expired - Lifetime
- 1990-12-10 CU CU90197A patent/CU22305A3/es unknown
- 1990-12-10 LU LU90014C patent/LU90014I2/fr unknown
- 1990-12-10 IE IE445390A patent/IE67523B1/en not_active IP Right Cessation
- 1990-12-10 CN CN90109931A patent/CN1034805C/zh not_active Expired - Lifetime
- 1990-12-10 NO NO905322A patent/NO176566C/no not_active IP Right Cessation
- 1990-12-10 PT PT96145A patent/PT96145B/pt not_active IP Right Cessation
- 1990-12-10 DK DK90123697.6T patent/DK0432695T3/da active
- 1990-12-10 DZ DZ900221A patent/DZ1467A1/fr active
- 1990-12-10 DE DE69019481T patent/DE69019481T2/de not_active Expired - Lifetime
- 1990-12-10 AT AT90123697T patent/ATE122661T1/de active
- 1990-12-10 DE DE1996175051 patent/DE19675051I2/de active Active
- 1990-12-10 EP EP90123697A patent/EP0432695B1/en not_active Expired - Lifetime
- 1990-12-10 JP JP2409792A patent/JP2807093B2/ja not_active Expired - Lifetime
- 1990-12-10 CN CN96107466A patent/CN1066329C/zh not_active Expired - Lifetime
- 1990-12-10 BR BR909006264A patent/BR9006264A/pt not_active Application Discontinuation
- 1990-12-10 GB GB9026776A patent/GB2239016B/en not_active Expired - Lifetime
- 1990-12-10 BG BG093425A patent/BG51452A3/xx unknown
- 1990-12-10 MA MA22289A patent/MA22014A1/fr unknown
- 1990-12-11 PL PL90288201A patent/PL165225B1/pl unknown
- 1990-12-11 RU SU904831985A patent/RU2071470C1/ru active
- 1990-12-11 OA OA59914A patent/OA09334A/xx unknown
-
1991
- 1991-08-28 ID IDP14891A patent/ID1018B/id unknown
-
1993
- 1993-03-12 HR HRP-2315/90A patent/HRP930341B1/xx not_active IP Right Cessation
- 1993-08-16 LT LTIP862A patent/LT3682B/lt not_active IP Right Cessation
- 1993-11-02 SG SG120493A patent/SG120493G/en unknown
- 1993-11-25 HK HK1290/93A patent/HK129093A/xx not_active IP Right Cessation
-
1995
- 1995-06-16 HU HU95P/P00230P patent/HU211342A9/hu unknown
- 1995-08-11 GR GR950402228T patent/GR3017114T3/el unknown
-
1996
- 1996-05-24 LV LV960153A patent/LV5738B4/xx unknown
-
1997
- 1997-03-07 NL NL970013C patent/NL970013I2/nl unknown
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