MX158754A - Procedimiento para la preparacion de compuestos derivados y sus esteroisomeros,del acido 16-fenoxi-y 16 fenoxi;-substituido-prostatrienoico - Google Patents

Procedimiento para la preparacion de compuestos derivados y sus esteroisomeros,del acido 16-fenoxi-y 16 fenoxi;-substituido-prostatrienoico

Info

Publication number
MX158754A
MX158754A MX203853A MX20385384A MX158754A MX 158754 A MX158754 A MX 158754A MX 203853 A MX203853 A MX 203853A MX 20385384 A MX20385384 A MX 20385384A MX 158754 A MX158754 A MX 158754A
Authority
MX
Mexico
Prior art keywords
fenoxi
prostatrienoic
steroisomers
substituted
procedure
Prior art date
Application number
MX203853A
Other languages
English (en)
Spanish (es)
Inventor
Gary Francis Cooper
Douglas Leslie Wrem
Albert Van Reynolds
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of MX158754A publication Critical patent/MX158754A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MX203853A 1983-12-22 1984-12-20 Procedimiento para la preparacion de compuestos derivados y sus esteroisomeros,del acido 16-fenoxi-y 16 fenoxi;-substituido-prostatrienoico MX158754A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/564,386 US4600785A (en) 1983-12-22 1983-12-22 Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives

Publications (1)

Publication Number Publication Date
MX158754A true MX158754A (es) 1989-03-10

Family

ID=24254259

Family Applications (2)

Application Number Title Priority Date Filing Date
MX203853A MX158754A (es) 1983-12-22 1984-12-20 Procedimiento para la preparacion de compuestos derivados y sus esteroisomeros,del acido 16-fenoxi-y 16 fenoxi;-substituido-prostatrienoico
MX1259988A MX12599A (es) 1983-12-22 1988-08-09 Procedimiento para la preparacion de (4,5,6r,8r) metil -9- oxo-11 alfa, 15 alfa-dihidroxi-16-fenoxi-17,18,19,20- tetranorprosta-4,5,13 (e)-trienoato, cristalino

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX1259988A MX12599A (es) 1983-12-22 1988-08-09 Procedimiento para la preparacion de (4,5,6r,8r) metil -9- oxo-11 alfa, 15 alfa-dihidroxi-16-fenoxi-17,18,19,20- tetranorprosta-4,5,13 (e)-trienoato, cristalino

Country Status (28)

Country Link
US (1) US4600785A (de)
EP (1) EP0146935B1 (de)
JP (3) JPH0635431B2 (de)
KR (1) KR900000684B1 (de)
CN (1) CN85101840A (de)
AR (1) AR241015A1 (de)
AT (1) ATE50986T1 (de)
AU (1) AU585844B2 (de)
CA (4) CA1267892A (de)
CS (5) CS600884A2 (de)
DD (2) DD249700A5 (de)
DE (1) DE3481610D1 (de)
DK (1) DK617084A (de)
ES (4) ES8604389A1 (de)
FI (1) FI845069L (de)
GR (1) GR82514B (de)
HU (2) HU197302B (de)
IL (1) IL73881A (de)
IN (1) IN160437B (de)
MX (2) MX158754A (de)
NO (1) NO845148L (de)
NZ (1) NZ210667A (de)
PH (2) PH22893A (de)
PL (2) PL154330B1 (de)
PT (1) PT79720A (de)
RO (2) RO91666B (de)
SU (3) SU1473709A3 (de)
ZA (1) ZA849967B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929740A (en) * 1984-10-09 1990-05-29 Syntex (U.S.A.) Inc. Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
CA1246560A (en) * 1984-10-09 1988-12-13 Gary F. Cooper Intermediates for making 16-phenoxy and 16- substituted phenoxy-prostatrienoic acid derivatives
US4778904A (en) * 1985-09-13 1988-10-18 Syntex (U.S.A.) Inc. Intermediates for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4755531A (en) * 1986-08-11 1988-07-05 Syntex (U.S.A.) Inc. Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents
US4689419A (en) * 1986-11-14 1987-08-25 G. D. Searle & Co. Novel intermediate compounds in a process for producing 16-phenoxy- and 16-substituted phenoxy-9-keto-prostatrienoic acid derivatives
US5248788A (en) * 1988-12-13 1993-09-28 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US4916238A (en) * 1988-12-13 1990-04-10 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US5571936A (en) * 1994-09-30 1996-11-05 Korea Institute Of Science And Technology Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304907A (en) * 1972-05-10 1981-12-08 The Upjohn Company Bicyclo lactone intermediates for prostaglandin analogs
JPS5434724B2 (de) * 1974-09-19 1979-10-29
GB1590022A (en) * 1976-08-23 1981-05-28 Ono Pharmaceutical Co Prostaglandin analogues
US4178457A (en) * 1978-07-10 1979-12-11 Syntex (U.S.A.) Inc. (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof
DE3030477C2 (de) * 1980-08-12 1986-10-16 Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe Iridoid-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung
US4389414A (en) * 1981-05-11 1983-06-21 Syntex (U.S.A.) Inc. Prostaglandin compositions
EP0100052A1 (de) * 1982-07-19 1984-02-08 Syntex (U.S.A.) Inc. Zusammensetzungen des PGE-Typs eingekapselt durch säureisolierte Gelatine
HU196174B (en) * 1984-07-31 1988-10-28 Syntex Inc Process for preparing new prostaglandin derivatives and pharmaceutical compositions containing such active substance
US4618696A (en) * 1984-07-31 1986-10-21 Syntex (U.S.A.) Inc. 9-oxo-15α-hydroxy-16-phenoxy and 16-substituted phenoxy 17,18,19,20-tetranorprosta-4,5,13,(E)-trienoates
CA1246560A (en) * 1984-10-09 1988-12-13 Gary F. Cooper Intermediates for making 16-phenoxy and 16- substituted phenoxy-prostatrienoic acid derivatives

Also Published As

Publication number Publication date
SU1342411A3 (ru) 1987-09-30
JPH0772170B2 (ja) 1995-08-02
AU585844B2 (en) 1989-06-29
KR850004589A (ko) 1985-07-25
IN160437B (de) 1987-07-11
CS257796B2 (en) 1988-06-15
ES8607229A1 (es) 1986-06-01
PL255723A1 (en) 1986-07-29
CS257784B2 (en) 1988-06-15
PH23728A (en) 1989-11-03
MX12599A (es) 1993-05-01
ES8609234A1 (es) 1986-08-01
DE3481610D1 (de) 1990-04-19
RO91666A (ro) 1987-07-30
CA1283408C (en) 1991-04-23
PL154330B1 (en) 1991-08-30
ES538899A0 (es) 1986-02-01
CS600784A2 (en) 1987-09-17
JPH0539262A (ja) 1993-02-19
ES548460A0 (es) 1986-06-01
SU1473709A3 (ru) 1989-04-15
RO91666B (ro) 1987-07-31
EP0146935B1 (de) 1990-03-14
SU1356959A3 (ru) 1987-11-30
EP0146935A3 (en) 1987-05-06
CA1267892A (en) 1990-04-17
JPH0635431B2 (ja) 1994-05-11
ES548459A0 (es) 1986-08-01
JPH0539263A (ja) 1993-02-19
ZA849967B (en) 1986-08-27
ATE50986T1 (de) 1990-03-15
CA1276931C (en) 1990-11-27
RO94561A7 (ro) 1988-06-30
PT79720A (en) 1985-01-01
FI845069A0 (fi) 1984-12-20
IL73881A0 (en) 1985-03-31
KR900000684B1 (ko) 1990-02-03
AR241015A1 (es) 1991-04-30
HU197302B (en) 1989-03-28
HU196732B (en) 1989-01-30
NO845148L (no) 1985-06-24
PL251088A1 (en) 1985-12-17
CS1013284A2 (en) 1987-09-17
US4600785A (en) 1986-07-15
IL73881A (en) 1990-01-18
AR241015A2 (es) 1991-04-30
ES8604389A1 (es) 1986-02-01
CS600884A2 (en) 1987-09-17
DK617084A (da) 1985-06-23
JPH0717597B2 (ja) 1995-03-01
PH22893A (en) 1989-01-19
CA1283409C (en) 1991-04-23
ES8607228A1 (es) 1986-06-01
JPS60169459A (ja) 1985-09-02
AU3712084A (en) 1985-07-04
DD249700A5 (de) 1987-09-16
HUT36090A (en) 1985-08-28
CN85101840A (zh) 1987-01-17
GR82514B (en) 1985-04-11
EP0146935A2 (de) 1985-07-03
DK617084D0 (da) 1984-12-20
FI845069L (fi) 1985-06-23
DD241254A5 (de) 1986-12-03
CS257797B2 (en) 1988-06-15
NZ210667A (en) 1988-08-30
ES548453A0 (es) 1986-06-01

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