ME01858B - Jedinjenje triazolopiridina i njegovo dejstvo kao inhibitora prolil hidroksilaze i induktora proizvodnje eritropoetina - Google Patents
Jedinjenje triazolopiridina i njegovo dejstvo kao inhibitora prolil hidroksilaze i induktora proizvodnje eritropoetinaInfo
- Publication number
- ME01858B ME01858B MEP-2014-82A MEP8214A ME01858B ME 01858 B ME01858 B ME 01858B ME P8214 A MEP8214 A ME P8214A ME 01858 B ME01858 B ME 01858B
- Authority
- ME
- Montenegro
- Prior art keywords
- eritropoetin
- manufacturer
- action
- prolyl hydroxylase
- hydroxylase inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009169565 | 2009-07-17 | ||
| US27312709P | 2009-07-30 | 2009-07-30 | |
| EP10799914.6A EP2455381B9 (en) | 2009-07-17 | 2010-07-16 | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
| PCT/JP2010/062037 WO2011007856A1 (ja) | 2009-07-17 | 2010-07-16 | トリアゾロピリジン化合物、ならびにそのプロリル水酸化酵素阻害剤およびエリスロポエチン産生誘導剤としての作用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01858B true ME01858B (me) | 2014-12-20 |
Family
ID=43449466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2014-82A ME01858B (me) | 2009-07-17 | 2010-07-16 | Jedinjenje triazolopiridina i njegovo dejstvo kao inhibitora prolil hidroksilaze i induktora proizvodnje eritropoetina |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US8283465B2 (https=) |
| EP (3) | EP3594213A1 (https=) |
| JP (9) | JP5021797B2 (https=) |
| KR (5) | KR101850661B1 (https=) |
| CN (1) | CN102471337B (https=) |
| AR (1) | AR077417A1 (https=) |
| AU (1) | AU2010271732B2 (https=) |
| BR (1) | BR112012001157A2 (https=) |
| CA (1) | CA2768505C (https=) |
| CO (1) | CO6430426A2 (https=) |
| DK (1) | DK2455381T5 (https=) |
| ES (1) | ES2477968T3 (https=) |
| HR (1) | HRP20140705T1 (https=) |
| IL (1) | IL217541A (https=) |
| ME (1) | ME01858B (https=) |
| MX (1) | MX2012000766A (https=) |
| MY (1) | MY160814A (https=) |
| NZ (1) | NZ598242A (https=) |
| PE (1) | PE20120629A1 (https=) |
| PL (1) | PL2455381T3 (https=) |
| PT (1) | PT2455381E (https=) |
| RS (1) | RS53499B1 (https=) |
| RU (1) | RU2538963C2 (https=) |
| SG (1) | SG178049A1 (https=) |
| SI (1) | SI2455381T1 (https=) |
| SM (1) | SMT201500122B (https=) |
| TW (1) | TWI485150B (https=) |
| WO (1) | WO2011007856A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3594213A1 (en) * | 2009-07-17 | 2020-01-15 | Japan Tobacco Inc. | Triazolopyridine compounds and action thereof as prolyl hydroxylase inhibitors and erythropoietin production inducers |
| JP2011168582A (ja) * | 2010-01-21 | 2011-09-01 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤 |
| WO2012065297A1 (en) * | 2010-11-16 | 2012-05-24 | Impact Therapeutics, Inc. | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF |
| CN104936591B (zh) | 2012-11-26 | 2018-05-29 | 国立大学法人东北大学 | 促红细胞生成素表达增强剂 |
| JO3781B1 (ar) | 2012-12-24 | 2021-01-31 | Cadila Healthcare Ltd | مشتقات الكينولون |
| JP2016521747A (ja) | 2013-06-13 | 2016-07-25 | アケビア セラピューティクス インコーポレイテッドＡｋｅｂｉａ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 貧血治療のための組成物及び方法 |
| RU2534804C1 (ru) * | 2013-08-05 | 2014-12-10 | Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") | ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ |
| SG11201602572YA (en) * | 2013-10-03 | 2016-04-28 | Kura Oncology Inc | Inhibitors of erk and methods of use |
| WO2016034108A1 (zh) | 2014-09-02 | 2016-03-10 | 广东东阳光药业有限公司 | 喹啉酮类化合物及其应用 |
| JP2018039733A (ja) * | 2014-12-22 | 2018-03-15 | 株式会社富士薬品 | 新規複素環誘導体 |
| GB201504565D0 (en) * | 2015-03-18 | 2015-05-06 | Takeda Pharmaceutical | Novel compounds |
| CN106146395B (zh) * | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
| EP4667059A3 (en) | 2015-05-28 | 2026-04-08 | Japan Tobacco Inc. | Method for treating or preventing diabetic nephropathy |
| KR102523786B1 (ko) * | 2016-11-25 | 2023-04-20 | 니뽄 다바코 산교 가부시키가이샤 | 트리아졸로피리딘 화합물의 제조 방법 |
| CA3062972C (en) * | 2017-05-09 | 2021-09-14 | Kind Pharmaceutical | Indolizine derivatives and their application in medicine |
| KR20200064101A (ko) * | 2017-10-04 | 2020-06-05 | 니뽄 다바코 산교 가부시키가이샤 | 질소 함유 헤테로아릴 화합물 및 그의 의약 용도 |
| CN107739378A (zh) * | 2017-11-14 | 2018-02-27 | 杭州安道药业有限公司 | 吲哚嗪衍生物及其在医药上的应用 |
| CA3106385A1 (en) | 2018-09-13 | 2020-03-19 | Kissei Pharmaceutical Co., Ltd. | Imidazopyridinone compound |
| CN110105355B (zh) * | 2019-05-24 | 2021-09-21 | 烟台大学 | 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法 |
| KR20220152276A (ko) * | 2020-03-11 | 2022-11-15 | 깃세이 야쿠힌 고교 가부시키가이샤 | 이미다조피리디논 화합물 또는 그 염의 결정 |
| JP7504822B2 (ja) * | 2020-03-12 | 2024-06-24 | キッセイ薬品工業株式会社 | イミダゾピリジノン化合物を含む医薬組成物 |
| WO2021216530A1 (en) | 2020-04-20 | 2021-10-28 | Akebia Therapeutics, Inc. | Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer |
| WO2022150623A1 (en) | 2021-01-08 | 2022-07-14 | Akebia Therapeutics, Inc. | Compounds and composition for the treatment of anemia |
| CN113387948B (zh) * | 2021-02-06 | 2022-06-10 | 成都诺和晟泰生物科技有限公司 | 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途 |
| EP4308120A4 (en) | 2021-03-19 | 2024-11-27 | Zydus Lifesciences Limited | TREATMENT OF SICKLE CELL ANEMIA |
| EP4347022A1 (en) | 2021-05-27 | 2024-04-10 | Keryx Biopharmaceuticals, Inc. | Pediatric formulations of ferric citrate |
| CN113582843A (zh) * | 2021-09-09 | 2021-11-02 | 无锡捷化医药科技有限公司 | 一种5-氯-2-氟-3-羟基苯甲酸乙酯的制备方法 |
| CN116496269B (zh) * | 2021-12-02 | 2025-02-28 | 苏中药业集团股份有限公司 | 一种脯氨酰羟化酶抑制剂及其用途 |
| CN114031619A (zh) * | 2021-12-17 | 2022-02-11 | 山东汇海医药化工有限公司 | 一种图卡替尼中间体的制备方法 |
| CN117327066A (zh) * | 2022-06-30 | 2024-01-02 | 上海济煜医药科技有限公司 | 一种新多晶型、其制备方法及其用于制备药物的用途 |
| JP2025529533A (ja) * | 2022-09-19 | 2025-09-04 | 蘇中薬業集団股▲ふん▼有限公司 | プロリルヒドロキシラーゼ阻害剤およびその用途 |
| TWI905781B (zh) * | 2023-06-02 | 2025-11-21 | 大陸商蘇中藥業集團股份有限公司 | 脯胺醯羥化酶抑制劑及其用途 |
| TW202506675A (zh) * | 2023-08-08 | 2025-02-16 | 美商富曼西公司 | 用於防治和對抗無脊椎有害生物的連接的雙環化合物 |
| WO2025087207A1 (zh) | 2023-10-24 | 2025-05-01 | 杭州安道药业有限公司 | 含有缺氧诱导因子-脯酰胺羟基化酶抑制剂的长效口服药物及其应用 |
| TW202529740A (zh) * | 2023-12-19 | 2025-08-01 | 美商阿克比治療有限公司 | Ｐｈｄ抑制劑化合物、組成物及使用方法 |
| WO2025167738A1 (zh) * | 2024-02-05 | 2025-08-14 | 深圳信立泰药业股份有限公司 | 化合物在制备治疗非髓系恶性肿瘤患者的贫血药物中的应用 |
| CN119700755B (zh) * | 2024-02-05 | 2026-01-30 | 深圳信立泰药业股份有限公司 | 化合物在制备预防和/或治疗高原病的药物中的应用 |
| CN119039291A (zh) * | 2024-09-09 | 2024-11-29 | 南京药坦生物科技有限公司 | 一种恩那度司他中间体及其制备方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19746287A1 (de) | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6355653B1 (en) * | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
| US6514989B1 (en) * | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
| MXPA04003277A (es) * | 2001-10-08 | 2004-07-23 | Hoffmann La Roche | Amida del acido 8-amino-?1,2,4?triazolo?1,5-a?piridina-6-carboxilico. |
| US7544699B2 (en) | 2003-08-08 | 2009-06-09 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| AU2005268893B2 (en) * | 2004-08-05 | 2011-10-13 | F. Hoffmann-La Roche Ag | Indole, indazole or indoline derivatives |
| FR2889383A1 (fr) * | 2005-08-01 | 2007-02-02 | France Telecom | Procede et dispositif de detection pour systeme mimo, systeme mimo, programme et support d'information |
| AR059733A1 (es) * | 2006-03-07 | 2008-04-23 | Smithkline Beecham Corp | Compuesto derivado de glicina n- sustituida con heteroaromaticos bicicicos, composicion farmaceutica que lo comprende, uso para preparar un medicamento para tratar la anemia y proceso para su preparacion |
| US20090176825A1 (en) | 2006-05-16 | 2009-07-09 | Fitch Duke M | Prolyl hydroxylase inhibitors |
| JO2934B1 (en) | 2006-06-23 | 2015-09-15 | سميث كلاين بيتشام كوربوريشن | Prolyl hydroxylase inhibitors |
| PL3357911T3 (pl) * | 2006-06-26 | 2022-09-05 | Akebia Therapeutics Inc. | Inhibitory prolilohydroksylazy i sposoby ich użycia |
| AU2007272009A1 (en) | 2006-07-12 | 2008-01-17 | Syngenta Limited | Triazolopyridine derivatives as herbicides |
| TW200845991A (en) | 2007-01-12 | 2008-12-01 | Smithkline Beecham Corp | N-substituted glycine derivatives: hydroxylase inhibitors |
| US8048894B2 (en) | 2007-04-18 | 2011-11-01 | Amgen Inc. | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
| EP2155746A2 (en) | 2007-05-04 | 2010-02-24 | Amgen, Inc | Diazaquinolones that inhibit prolyl hydroxylase activity |
| JP5408434B2 (ja) | 2007-07-03 | 2014-02-05 | アステラス製薬株式会社 | アミド化合物 |
| EA201000915A1 (ru) * | 2007-11-30 | 2011-02-28 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Ингибиторы пролилгидроксилазы |
| JP2011505367A (ja) * | 2007-11-30 | 2011-02-24 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | プロリルヒドロキシラーゼ阻害剤 |
| US8324241B2 (en) * | 2008-04-11 | 2012-12-04 | Bristol-Myers Squibb Company | Triazolo compounds useful as DGAT1 inhibitors |
| US20110039895A1 (en) * | 2008-04-30 | 2011-02-17 | Glaxo Smith Kline LLC., a corporation | Prolyl hydroxylase inhibitors |
| WO2009146358A1 (en) | 2008-05-29 | 2009-12-03 | Sirtris Pharmaceuticals, Inc. | Imidazopyridine and related analogs as sirtuin modulators |
| HRP20160488T1 (hr) | 2008-12-19 | 2016-06-17 | Leo Pharma A/S | Triazolopiridini kao inhibitori fosfodiesteraze za liječenje kožnih bolesti |
| EP3594213A1 (en) * | 2009-07-17 | 2020-01-15 | Japan Tobacco Inc. | Triazolopyridine compounds and action thereof as prolyl hydroxylase inhibitors and erythropoietin production inducers |
-
2010
- 2010-07-16 EP EP19188636.5A patent/EP3594213A1/en not_active Withdrawn
- 2010-07-16 BR BR112012001157A patent/BR112012001157A2/pt not_active Application Discontinuation
- 2010-07-16 EP EP10799914.6A patent/EP2455381B9/en active Active
- 2010-07-16 PT PT107999146T patent/PT2455381E/pt unknown
- 2010-07-16 KR KR1020177003353A patent/KR101850661B1/ko active Active
- 2010-07-16 TW TW099123410A patent/TWI485150B/zh active
- 2010-07-16 US US12/837,679 patent/US8283465B2/en active Active
- 2010-07-16 MX MX2012000766A patent/MX2012000766A/es active IP Right Grant
- 2010-07-16 ME MEP-2014-82A patent/ME01858B/me unknown
- 2010-07-16 RS RSP20140406 patent/RS53499B1/sr unknown
- 2010-07-16 HR HRP20140705AT patent/HRP20140705T1/hr unknown
- 2010-07-16 KR KR1020127004258A patent/KR101706803B1/ko active Active
- 2010-07-16 SI SI201030682T patent/SI2455381T1/sl unknown
- 2010-07-16 NZ NZ598242A patent/NZ598242A/xx unknown
- 2010-07-16 AR ARP100102614A patent/AR077417A1/es active IP Right Grant
- 2010-07-16 MY MYPI2012000223A patent/MY160814A/en unknown
- 2010-07-16 EP EP14160395.1A patent/EP2746282A1/en not_active Withdrawn
- 2010-07-16 RU RU2012105467/04A patent/RU2538963C2/ru active
- 2010-07-16 KR KR1020267000195A patent/KR20260012830A/ko active Pending
- 2010-07-16 DK DK10799914.6T patent/DK2455381T5/en active
- 2010-07-16 AU AU2010271732A patent/AU2010271732B2/en active Active
- 2010-07-16 WO PCT/JP2010/062037 patent/WO2011007856A1/ja not_active Ceased
- 2010-07-16 KR KR1020237040564A patent/KR20230165366A/ko not_active Ceased
- 2010-07-16 PL PL10799914T patent/PL2455381T3/pl unknown
- 2010-07-16 PE PE2012000056A patent/PE20120629A1/es active IP Right Grant
- 2010-07-16 ES ES10799914.6T patent/ES2477968T3/es active Active
- 2010-07-16 KR KR1020187010331A patent/KR20180042443A/ko not_active Ceased
- 2010-07-16 JP JP2010161144A patent/JP5021797B2/ja active Active
- 2010-07-16 SG SG2012003570A patent/SG178049A1/en unknown
- 2010-07-16 CN CN201080032238.2A patent/CN102471337B/zh active Active
- 2010-07-16 CA CA2768505A patent/CA2768505C/en active Active
-
2012
- 2012-01-15 IL IL217541A patent/IL217541A/en active IP Right Grant
- 2012-01-31 CO CO12014916A patent/CO6430426A2/es active IP Right Grant
- 2012-04-26 JP JP2012101381A patent/JP2012144571A/ja not_active Ceased
- 2012-09-06 US US13/605,329 patent/US20130096155A1/en not_active Abandoned
-
2014
- 2014-10-09 JP JP2014207896A patent/JP2015003933A/ja active Pending
-
2015
- 2015-05-22 SM SM201500122T patent/SMT201500122B/xx unknown
- 2015-06-25 US US14/749,966 patent/US20160145254A1/en not_active Abandoned
- 2015-12-08 JP JP2015239065A patent/JP2016040321A/ja active Pending
-
2017
- 2017-07-10 JP JP2017134270A patent/JP6434575B2/ja not_active Expired - Fee Related
-
2018
- 2018-11-08 JP JP2018210486A patent/JP2019019144A/ja active Pending
-
2020
- 2020-04-20 JP JP2020074508A patent/JP2020111612A/ja not_active Ceased
-
2022
- 2022-06-29 JP JP2022104161A patent/JP2022126843A/ja not_active Ceased
-
2024
- 2024-04-24 JP JP2024070200A patent/JP2024091878A/ja active Pending
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| ATE522533T1 (de) | Pyrazolopyrimidinonkinaseinhibitor | |
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| SI2496236T1 (sl) | Prolilhidroksilazni inhibitorji | |
| FI20085647A0 (fi) | Manipulaattori | |
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