MD921G2 - Derivaţi arilpropionici, procedeu de obţinere a lor şi compoziţie farmaceutică pe baza lor - Google Patents

Derivaţi arilpropionici, procedeu de obţinere a lor şi compoziţie farmaceutică pe baza lor

Info

Publication number
MD921G2
MD921G2 MD96-0285A MD960285A MD921G2 MD 921 G2 MD921 G2 MD 921G2 MD 960285 A MD960285 A MD 960285A MD 921 G2 MD921 G2 MD 921G2
Authority
MD
Moldova
Prior art keywords
preparation
base
pharmaceutical composition
arylpropionic
derivatives
Prior art date
Application number
MD96-0285A
Other languages
English (en)
Russian (ru)
Inventor
Germano Carganico
Casellas David Mauleon
Perez M. Luisa Garcia
Original Assignee
Laboratorios Menarini S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini S.A. filed Critical Laboratorios Menarini S.A.
Publication of MD921G2 publication Critical patent/MD921G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Invenţia se referă la sărurile acidului arilpropionic, şi anume la sarea de trometamină a acidului (+)-(S)-2-(3-benzoilfenil) propionic cu formula (I):Invenţia se referă, de asemenea, la un procedeu de obţinere a lor şi la o compoziţie farmaceutică, care conţine o cantitate terapeutic eficientă a acestor compuşi şi un purtător netoxic farmaceutic acceptabil.Rezultatul tehnic constă în obţinerea compuşilor cu acţiune analgezică şi antiinflamatoare mai pronunţată.
MD96-0285A 1992-11-10 1993-11-09 Derivaţi arilpropionici, procedeu de obţinere a lor şi compoziţie farmaceutică pe baza lor MD921G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES09202260A ES2058024B1 (es) 1992-11-10 1992-11-10 Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.
PCT/EP1993/003127 WO1994011332A1 (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent

Publications (1)

Publication Number Publication Date
MD921G2 true MD921G2 (ro) 1998-10-31

Family

ID=8278730

Family Applications (1)

Application Number Title Priority Date Filing Date
MD96-0285A MD921G2 (ro) 1992-11-10 1993-11-09 Derivaţi arilpropionici, procedeu de obţinere a lor şi compoziţie farmaceutică pe baza lor

Country Status (27)

Country Link
US (1) US5554789A (ro)
EP (1) EP0668851B1 (ro)
JP (1) JP3778516B2 (ro)
KR (1) KR100284838B1 (ro)
AT (1) ATE153649T1 (ro)
AU (1) AU674040B2 (ro)
BG (1) BG61723B1 (ro)
BR (1) BR9307408A (ro)
CA (1) CA2149013C (ro)
CZ (1) CZ286621B6 (ro)
DE (2) DE668851T1 (ro)
DK (1) DK0668851T3 (ro)
ES (2) ES2058024B1 (ro)
FI (1) FI108637B (ro)
GR (2) GR960300012T1 (ro)
HK (1) HK1006306A1 (ro)
HU (2) HU219975B (ro)
MD (1) MD921G2 (ro)
NO (2) NO304306B1 (ro)
NZ (1) NZ257557A (ro)
PL (1) PL175265B1 (ro)
RO (1) RO118712B1 (ro)
RU (1) RU2128160C1 (ro)
SK (1) SK280550B6 (ro)
UA (1) UA44233C2 (ro)
UY (1) UY24179A1 (ro)
WO (1) WO1994011332A1 (ro)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2124196B1 (es) * 1997-06-04 1999-12-01 Menarini Lab Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion.
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
CN101480384A (zh) * 2002-12-17 2009-07-15 阿伯特有限及两合公司 包含非诺贝酸、其生理可接受的盐或衍生物的制剂
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
EP1739072A1 (en) * 2005-06-15 2007-01-03 Laboratorios Menarini S.A. Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
TWI364413B (en) * 2008-07-25 2012-05-21 Univ Nat Central Racemic ibuprofen amine salt and synthesis method thereof
WO2010049525A1 (en) * 2008-10-31 2010-05-06 C-A-I-R Biosciences Gmbh Choline and tromethamine salt of licofelone
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
ES2350670B1 (es) * 2009-06-10 2011-12-07 Polichem, S.L. Composicion veterinaria de ketoprofeno
CN101928214B (zh) * 2009-06-19 2012-12-19 黄石世星药业有限责任公司 右旋酮洛芬氨丁三醇的一种合成方法
EP2475636A1 (en) * 2009-06-30 2012-07-18 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi A process for preparing dexketoprofen trometamol form a and form b crystals
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102557976B (zh) * 2010-12-15 2015-06-10 辽宁盛京制药有限公司 溴芬酸有机盐及其制备方法、其组合物及用途
TR201205317A2 (tr) 2011-05-18 2012-12-21 B�Lg�� Mahmut Deksketoprofen içeren efervesan formülasyonlar.
TR201104864A2 (tr) 2011-05-18 2012-12-21 Bi̇lgi̇ç Mahmut Deksketoprofen içeren suda çözünebilir formülasyonlar.
CN102381986A (zh) * 2011-07-25 2012-03-21 南京特丰药业股份有限公司 一种右旋布洛芬氨丁三醇盐及其口服溶液的制备方法
WO2013022410A2 (en) 2011-08-08 2013-02-14 Mahmut Bilgic Production method for effervescent formulations comprising dexketoprofen
WO2013095315A1 (en) 2011-12-19 2013-06-27 Mahmut Bilgic Formulations comprising dexketoprofen (particle size 300-2500 micrometer)
WO2013100877A1 (en) 2011-12-27 2013-07-04 Mahmut Bilgic Dexketoprofen formulations
ES2501415T3 (es) 2012-06-06 2016-02-22 Galenicum Health S.L. Composiciones farmacéuticas estables de acción rápida
EP2759293A1 (en) 2013-01-25 2014-07-30 Laboratorios Lesvi, S.L. Pharmaceutical compositions of (+)-(s)-2-(3-benzoylphenyl)propionic acid tromethamine salt
EP2764875A1 (en) 2013-02-06 2014-08-13 Galenicum Health S.L. Process for preparing a stable pharmaceutical composition comprising dexketoprofen trometamol
ITMI20130210A1 (it) 2013-02-14 2014-08-15 Menarini Lab Composizioni farmaceutiche contenenti dexketoprofene e tramadolo
TR201616365A1 (tr) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari
WO2018096517A1 (en) * 2016-11-28 2018-05-31 Parayil Sarin Novel organic crystalline salt of haloacetic acid
TR201618765A2 (tr) 2016-12-16 2018-07-23 Imuneks Farma Ilac Sanayi Ve Ticaret Anonim Sirketi Ağrı ve enflamasyonun tedavisi için steroid olmayan anti-enflamatuvar ilaçlar ve H2 reseptörü antagonisti kombinasyonları.
KR102552315B1 (ko) * 2020-11-11 2023-07-06 대원제약주식회사 펠루비프로펜 신규 염을 주성분으로 하며 위장장애 부작용이 저감된 약학적 조성물
KR102462607B1 (ko) * 2020-11-11 2022-11-03 대원제약주식회사 펠루비프로펜 신규 염을 주성분으로 하는 안정성이 증가된 약학적 조성물
WO2023182869A1 (en) * 2022-03-25 2023-09-28 Ildong Pharmaceutical Co., Ltd. Novel salt of glp-1 receptor agonist compound, preparation method thereof and pharmaceutical composition comprising thereof

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US427996A (en) * 1890-05-13 houg-hton
US3641127A (en) * 1967-01-27 1972-02-08 Rhone Poulenc Sa (3-benzoylphenyl) alkanoic acids
GB1291386A (en) * 1969-03-24 1972-10-04 Syntex Corp Improvements in or relating to 2-(6'-substituted-2'-naphthyl) propionic acid derivatives and salts thereof
US3821289A (en) * 1972-07-03 1974-06-28 Rorer Inc William H Tetrahydronaphthylalkanoic acids and their derivatives
DE2508895A1 (de) * 1974-03-07 1975-09-18 Prodotti Antibiotici Spa Salze von phenylalkancarbonsaeuren mit basischen aminosaeuren
GB1408853A (en) * 1972-03-17 1975-10-08 Upjohn Co Medical process and treatment
GB1488778A (en) * 1975-07-28 1977-10-12 Roussel Uclaf Salt of alpha-methyl-(5-benzoyl-2-thiophene)-acetic acid processes for preparing it and compositions containing it
US4097674A (en) * 1975-03-17 1978-06-27 Syntex Corporation 2-Naphthylacetic acid derivatives
EP0008226A2 (en) * 1978-08-08 1980-02-20 Fujisawa Pharmaceutical Co., Ltd. Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them
GB2059768A (en) * 1979-09-27 1981-04-29 Ilona Kahan Water-soluble derivatives of non-steroidal anti-inflammatory agnets and a process for the production thereof
EP0136470A2 (de) * 1983-08-05 1985-04-10 Merckle GmbH Injizierbare Lösung zur Behandlung von Entzündungen
FR2580641A1 (fr) * 1985-04-19 1986-10-24 Seuref Ag Derives arylalcanoiques d'imidazolium, procede pour les preparer et compositions pharmaceutiques en contenant
EP0227078A1 (en) * 1985-12-20 1987-07-01 Wisconsin Alumni Research Foundation Process for preparing (S)-alpha-methylarylacetic acids
US4748174A (en) * 1986-01-03 1988-05-31 Therapicon S.R.L. Water soluble salts of an NSAID with meglumine/glucamine
WO1989004658A1 (en) * 1987-11-17 1989-06-01 Abraham Sunshine Onset-hastened/enhanced analgesia using s(+) ketoprofen
EP0396839A2 (en) * 1989-05-12 1990-11-14 American Home Products Corporation Naphthalenepropionic acid salts

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FR1201726A (fr) * 1959-06-20 1960-01-05 Procédé d'obtention de dérivés flavoniques à partir des feuilles de certains végétaux
ES455698A1 (es) * 1977-02-07 1978-01-01 Invest Tecnica Aplicada Procedimiento para la preparacion de un nuevo derivado buta-nolaminico.
JPH02502534A (ja) * 1987-12-18 1990-08-16 チバ‐ガイギー　アクチェンゲゼルシャフト １‐メチル‐β‐オキソ‐α‐（フェニルカルバモイル）‐２‐ピロールプロピオニトリルのトロメタミン塩

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US427996A (en) * 1890-05-13 houg-hton
US3641127A (en) * 1967-01-27 1972-02-08 Rhone Poulenc Sa (3-benzoylphenyl) alkanoic acids
GB1291386A (en) * 1969-03-24 1972-10-04 Syntex Corp Improvements in or relating to 2-(6'-substituted-2'-naphthyl) propionic acid derivatives and salts thereof
GB1408853A (en) * 1972-03-17 1975-10-08 Upjohn Co Medical process and treatment
US3821289A (en) * 1972-07-03 1974-06-28 Rorer Inc William H Tetrahydronaphthylalkanoic acids and their derivatives
DE2508895A1 (de) * 1974-03-07 1975-09-18 Prodotti Antibiotici Spa Salze von phenylalkancarbonsaeuren mit basischen aminosaeuren
US4097674A (en) * 1975-03-17 1978-06-27 Syntex Corporation 2-Naphthylacetic acid derivatives
GB1488778A (en) * 1975-07-28 1977-10-12 Roussel Uclaf Salt of alpha-methyl-(5-benzoyl-2-thiophene)-acetic acid processes for preparing it and compositions containing it
EP0008226A2 (en) * 1978-08-08 1980-02-20 Fujisawa Pharmaceutical Co., Ltd. Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them
GB2059768A (en) * 1979-09-27 1981-04-29 Ilona Kahan Water-soluble derivatives of non-steroidal anti-inflammatory agnets and a process for the production thereof
EP0136470A2 (de) * 1983-08-05 1985-04-10 Merckle GmbH Injizierbare Lösung zur Behandlung von Entzündungen
FR2580641A1 (fr) * 1985-04-19 1986-10-24 Seuref Ag Derives arylalcanoiques d'imidazolium, procede pour les preparer et compositions pharmaceutiques en contenant
EP0227078A1 (en) * 1985-12-20 1987-07-01 Wisconsin Alumni Research Foundation Process for preparing (S)-alpha-methylarylacetic acids
US4748174A (en) * 1986-01-03 1988-05-31 Therapicon S.R.L. Water soluble salts of an NSAID with meglumine/glucamine
WO1989004658A1 (en) * 1987-11-17 1989-06-01 Abraham Sunshine Onset-hastened/enhanced analgesia using s(+) ketoprofen
EP0396839A2 (en) * 1989-05-12 1990-11-14 American Home Products Corporation Naphthalenepropionic acid salts

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Title
Yamagushi T. et al., Folia Pharmacol. Japon. 90, 2955, 1987. *

Also Published As

Publication number Publication date
HK1006306A1 (en) 1999-02-19
FI952230A0 (fi) 1995-05-09
BR9307408A (pt) 1999-08-24
ES2058024A1 (es) 1994-10-16
ES2081780T3 (es) 1997-07-01
NO951790D0 (no) 1995-05-08
HU219975B (hu) 2001-10-28
ES2081780T1 (es) 1996-03-16
BG99609A (bg) 1996-01-31
EP0668851B1 (en) 1997-05-28
JPH08503203A (ja) 1996-04-09
US5554789A (en) 1996-09-10
WO1994011332A1 (en) 1994-05-26
RO118712B1 (ro) 2003-09-30
AU5421094A (en) 1994-06-08
UA44233C2 (uk) 2002-02-15
PL308466A1 (en) 1995-07-24
NZ257557A (en) 1996-01-26
GR3024344T3 (en) 1997-10-31
CZ286621B6 (cs) 2000-05-17
NO304306B1 (no) 1998-11-30
AU674040B2 (en) 1996-12-05
HU217973B (hu) 2000-05-28
ATE153649T1 (de) 1997-06-15
PL175265B1 (pl) 1998-12-31
NO2006007I1 (no) 2006-08-14
FI108637B (fi) 2002-02-28
RU95112575A (ru) 1997-06-20
DE69311130D1 (de) 1997-07-03
CA2149013A1 (en) 1994-05-26
DE668851T1 (de) 1996-10-10
FI952230A (fi) 1995-05-09
HU9501375D0 (en) 1995-06-28
SK280550B6 (sk) 2000-03-13
JP3778516B2 (ja) 2006-05-24
KR100284838B1 (ko) 2001-04-02
GR960300012T1 (en) 1996-03-31
UY24179A1 (es) 1996-09-03
NO951790L (no) 1995-07-06
EP0668851A1 (en) 1995-08-30
ES2058024B1 (es) 1995-05-01
DK0668851T3 (da) 1997-12-22
DE69311130T2 (de) 1997-09-18
BG61723B1 (bg) 1998-04-30
CZ114995A3 (en) 1995-10-18
SK60395A3 (en) 1995-09-13
HUT71903A (en) 1996-02-28
CA2149013C (en) 2004-08-10
RU2128160C1 (ru) 1999-03-27
HU9802850D0 (en) 1999-02-01

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