MD921G2 - Derivaţi arilpropionici, procedeu de obţinere a lor şi compoziţie farmaceutică pe baza lor - Google Patents
Derivaţi arilpropionici, procedeu de obţinere a lor şi compoziţie farmaceutică pe baza lorInfo
- Publication number
- MD921G2 MD921G2 MD96-0285A MD960285A MD921G2 MD 921 G2 MD921 G2 MD 921G2 MD 960285 A MD960285 A MD 960285A MD 921 G2 MD921 G2 MD 921G2
- Authority
- MD
- Moldova
- Prior art keywords
- preparation
- base
- pharmaceutical composition
- arylpropionic
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Invenţia se referă la sărurile acidului arilpropionic, şi anume la sarea de trometamină a acidului (+)-(S)-2-(3-benzoilfenil) propionic cu formula (I):Invenţia se referă, de asemenea, la un procedeu de obţinere a lor şi la o compoziţie farmaceutică, care conţine o cantitate terapeutic eficientă a acestor compuşi şi un purtător netoxic farmaceutic acceptabil.Rezultatul tehnic constă în obţinerea compuşilor cu acţiune analgezică şi antiinflamatoare mai pronunţată.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09202260A ES2058024B1 (es) | 1992-11-10 | 1992-11-10 | Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. |
PCT/EP1993/003127 WO1994011332A1 (en) | 1992-11-10 | 1993-11-09 | A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent |
Publications (1)
Publication Number | Publication Date |
---|---|
MD921G2 true MD921G2 (ro) | 1998-10-31 |
Family
ID=8278730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD96-0285A MD921G2 (ro) | 1992-11-10 | 1993-11-09 | Derivaţi arilpropionici, procedeu de obţinere a lor şi compoziţie farmaceutică pe baza lor |
Country Status (27)
Country | Link |
---|---|
US (1) | US5554789A (ro) |
EP (1) | EP0668851B1 (ro) |
JP (1) | JP3778516B2 (ro) |
KR (1) | KR100284838B1 (ro) |
AT (1) | ATE153649T1 (ro) |
AU (1) | AU674040B2 (ro) |
BG (1) | BG61723B1 (ro) |
BR (1) | BR9307408A (ro) |
CA (1) | CA2149013C (ro) |
CZ (1) | CZ286621B6 (ro) |
DE (2) | DE69311130T2 (ro) |
DK (1) | DK0668851T3 (ro) |
ES (2) | ES2058024B1 (ro) |
FI (1) | FI108637B (ro) |
GR (2) | GR960300012T1 (ro) |
HK (1) | HK1006306A1 (ro) |
HU (2) | HU217973B (ro) |
MD (1) | MD921G2 (ro) |
NO (2) | NO304306B1 (ro) |
NZ (1) | NZ257557A (ro) |
PL (1) | PL175265B1 (ro) |
RO (1) | RO118712B1 (ro) |
RU (1) | RU2128160C1 (ro) |
SK (1) | SK280550B6 (ro) |
UA (1) | UA44233C2 (ro) |
UY (1) | UY24179A1 (ro) |
WO (1) | WO1994011332A1 (ro) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2124196B1 (es) * | 1997-06-04 | 1999-12-01 | Menarini Lab | Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion. |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
US20080051411A1 (en) * | 2002-12-17 | 2008-02-28 | Cink Russell D | Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof |
EP1572190B1 (en) * | 2002-12-17 | 2007-04-18 | Abbott GmbH & Co. KG | Formulation comprising fenofibric acid, a physiologically acceptable salt or derivative thereof |
CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
EP1739072A1 (en) * | 2005-06-15 | 2007-01-03 | Laboratorios Menarini S.A. | Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof |
KR20090071598A (ko) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | 수용체 결합 단백질(rap)-접합체 투여에 의한 간 질환의 치료 |
TWI364413B (en) * | 2008-07-25 | 2012-05-21 | Univ Nat Central | Racemic ibuprofen amine salt and synthesis method thereof |
JP5628816B2 (ja) * | 2008-10-31 | 2014-11-19 | ツェー・アー・イー・エルバイオサイエンスシーズ、ゲーエムベーハー | リコフェロンのコリンおよびトロメタミン塩 |
PT2398500T (pt) | 2009-02-20 | 2019-06-14 | 2 Bbb Medicines B V | Sistema de entrega de medicamentos à base de glutationas |
TWI556839B (zh) | 2009-05-06 | 2016-11-11 | 研究室護膚股份有限公司 | 包含活性劑-磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法 |
ES2350670B1 (es) * | 2009-06-10 | 2011-12-07 | Polichem, S.L. | Composicion veterinaria de ketoprofeno |
CN101928214B (zh) * | 2009-06-19 | 2012-12-19 | 黄石世星药业有限责任公司 | 右旋酮洛芬氨丁三醇的一种合成方法 |
WO2011001213A1 (en) * | 2009-06-30 | 2011-01-06 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | A process for preparing dexketoprofen trometamol form a and form b crystals |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
CN102557976B (zh) * | 2010-12-15 | 2015-06-10 | 辽宁盛京制药有限公司 | 溴芬酸有机盐及其制备方法、其组合物及用途 |
TR201205317A2 (tr) | 2011-05-18 | 2012-12-21 | B�Lg�� Mahmut | Deksketoprofen içeren efervesan formülasyonlar. |
TR201104864A2 (tr) | 2011-05-18 | 2012-12-21 | Bi̇lgi̇ç Mahmut | Deksketoprofen içeren suda çözünebilir formülasyonlar. |
CN102381986A (zh) * | 2011-07-25 | 2012-03-21 | 南京特丰药业股份有限公司 | 一种右旋布洛芬氨丁三醇盐及其口服溶液的制备方法 |
WO2013022410A2 (en) | 2011-08-08 | 2013-02-14 | Mahmut Bilgic | Production method for effervescent formulations comprising dexketoprofen |
WO2013095315A1 (en) | 2011-12-19 | 2013-06-27 | Mahmut Bilgic | Formulations comprising dexketoprofen (particle size 300-2500 micrometer) |
WO2013100877A1 (en) | 2011-12-27 | 2013-07-04 | Mahmut Bilgic | Dexketoprofen formulations |
ES2501415T3 (es) | 2012-06-06 | 2016-02-22 | Galenicum Health S.L. | Composiciones farmacéuticas estables de acción rápida |
EP2759293A1 (en) | 2013-01-25 | 2014-07-30 | Laboratorios Lesvi, S.L. | Pharmaceutical compositions of (+)-(s)-2-(3-benzoylphenyl)propionic acid tromethamine salt |
ES2512497T1 (es) | 2013-02-06 | 2014-10-24 | Galenicum Health S.L. | Proceso para preparar una composición farmacéutica estable que comprende dexketoprofeno trometamol |
ITMI20130210A1 (it) | 2013-02-14 | 2014-08-15 | Menarini Lab | Composizioni farmaceutiche contenenti dexketoprofene e tramadolo |
TR201616365A1 (tr) | 2016-11-14 | 2018-05-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Deksketoprofen ve eletri̇ptanin oral farmasöti̇k kompozi̇syonlari |
AU2017364349A1 (en) | 2016-11-28 | 2019-07-11 | Sarin PARAYIL | Novel organic crystalline salt of haloacetic acid |
TR201618765A2 (tr) | 2016-12-16 | 2018-07-23 | Imuneks Farma Ilac Sanayi Ve Ticaret Anonim Sirketi | Ağrı ve enflamasyonun tedavisi için steroid olmayan anti-enflamatuvar ilaçlar ve H2 reseptörü antagonisti kombinasyonları. |
KR102552315B1 (ko) * | 2020-11-11 | 2023-07-06 | 대원제약주식회사 | 펠루비프로펜 신규 염을 주성분으로 하며 위장장애 부작용이 저감된 약학적 조성물 |
KR102462607B1 (ko) * | 2020-11-11 | 2022-11-03 | 대원제약주식회사 | 펠루비프로펜 신규 염을 주성분으로 하는 안정성이 증가된 약학적 조성물 |
TW202345815A (zh) * | 2022-03-25 | 2023-12-01 | 南韓商日東製藥股份有限公司 | Glp-1受體激動劑化合物之新穎鹽類、其製備方法以及包含其之醫藥組合物 |
Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US427996A (en) * | 1890-05-13 | houg-hton | ||
US3641127A (en) * | 1967-01-27 | 1972-02-08 | Rhone Poulenc Sa | (3-benzoylphenyl) alkanoic acids |
GB1291386A (en) * | 1969-03-24 | 1972-10-04 | Syntex Corp | Improvements in or relating to 2-(6'-substituted-2'-naphthyl) propionic acid derivatives and salts thereof |
US3821289A (en) * | 1972-07-03 | 1974-06-28 | Rorer Inc William H | Tetrahydronaphthylalkanoic acids and their derivatives |
DE2508895A1 (de) * | 1974-03-07 | 1975-09-18 | Prodotti Antibiotici Spa | Salze von phenylalkancarbonsaeuren mit basischen aminosaeuren |
GB1408853A (en) * | 1972-03-17 | 1975-10-08 | Upjohn Co | Medical process and treatment |
GB1488778A (en) * | 1975-07-28 | 1977-10-12 | Roussel Uclaf | Salt of alpha-methyl-(5-benzoyl-2-thiophene)-acetic acid processes for preparing it and compositions containing it |
US4097674A (en) * | 1975-03-17 | 1978-06-27 | Syntex Corporation | 2-Naphthylacetic acid derivatives |
EP0008226A2 (en) * | 1978-08-08 | 1980-02-20 | Fujisawa Pharmaceutical Co., Ltd. | Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them |
GB2059768A (en) * | 1979-09-27 | 1981-04-29 | Ilona Kahan | Water-soluble derivatives of non-steroidal anti-inflammatory agnets and a process for the production thereof |
EP0136470A2 (de) * | 1983-08-05 | 1985-04-10 | Merckle GmbH | Injizierbare Lösung zur Behandlung von Entzündungen |
FR2580641A1 (fr) * | 1985-04-19 | 1986-10-24 | Seuref Ag | Derives arylalcanoiques d'imidazolium, procede pour les preparer et compositions pharmaceutiques en contenant |
EP0227078A1 (en) * | 1985-12-20 | 1987-07-01 | Wisconsin Alumni Research Foundation | Process for preparing (S)-alpha-methylarylacetic acids |
US4748174A (en) * | 1986-01-03 | 1988-05-31 | Therapicon S.R.L. | Water soluble salts of an NSAID with meglumine/glucamine |
WO1989004658A1 (en) * | 1987-11-17 | 1989-06-01 | Abraham Sunshine | Onset-hastened/enhanced analgesia using s(+) ketoprofen |
EP0396839A2 (en) * | 1989-05-12 | 1990-11-14 | American Home Products Corporation | Naphthalenepropionic acid salts |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1201726A (fr) * | 1959-06-20 | 1960-01-05 | Procédé d'obtention de dérivés flavoniques à partir des feuilles de certains végétaux | |
ES455698A1 (es) * | 1977-02-07 | 1978-01-01 | Invest Tecnica Aplicada | Procedimiento para la preparacion de un nuevo derivado buta-nolaminico. |
WO1989005798A1 (en) * | 1987-12-18 | 1989-06-29 | Ciba-Geigy Ag | TROMETHAMINE SALT OF 1-METHYL-beta-OXO-alpha-(PHENYLCARBAMOYL)-2-PYRROLEPROPIONITRILE |
-
1992
- 1992-11-10 ES ES09202260A patent/ES2058024B1/es not_active Expired - Lifetime
-
1993
- 1993-09-11 UA UA95058442A patent/UA44233C2/uk unknown
- 1993-11-09 DE DE69311130T patent/DE69311130T2/de not_active Expired - Lifetime
- 1993-11-09 KR KR1019950701827A patent/KR100284838B1/ko not_active IP Right Cessation
- 1993-11-09 PL PL93308466A patent/PL175265B1/pl unknown
- 1993-11-09 DK DK93924604.7T patent/DK0668851T3/da active
- 1993-11-09 EP EP93924604A patent/EP0668851B1/en not_active Expired - Lifetime
- 1993-11-09 BR BR9307408A patent/BR9307408A/pt not_active Application Discontinuation
- 1993-11-09 DE DE0668851T patent/DE668851T1/de active Pending
- 1993-11-09 WO PCT/EP1993/003127 patent/WO1994011332A1/en active IP Right Grant
- 1993-11-09 RO RO95-00865A patent/RO118712B1/ro unknown
- 1993-11-09 AU AU54210/94A patent/AU674040B2/en not_active Expired
- 1993-11-09 SK SK603-95A patent/SK280550B6/sk not_active IP Right Cessation
- 1993-11-09 CA CA002149013A patent/CA2149013C/en not_active Expired - Lifetime
- 1993-11-09 MD MD96-0285A patent/MD921G2/ro unknown
- 1993-11-09 JP JP51169794A patent/JP3778516B2/ja not_active Expired - Lifetime
- 1993-11-09 ES ES93924604T patent/ES2081780T3/es not_active Expired - Lifetime
- 1993-11-09 AT AT93924604T patent/ATE153649T1/de active
- 1993-11-09 NZ NZ257557A patent/NZ257557A/en not_active IP Right Cessation
- 1993-11-09 US US08/428,231 patent/US5554789A/en not_active Expired - Lifetime
- 1993-11-09 HU HU9501375A patent/HU217973B/hu unknown
- 1993-11-09 HU HU9802850A patent/HU219975B/hu unknown
- 1993-11-09 RU RU95112575A patent/RU2128160C1/ru active
- 1993-11-09 CZ CZ19951149A patent/CZ286621B6/cs not_active IP Right Cessation
-
1995
- 1995-05-02 BG BG99609A patent/BG61723B1/bg unknown
- 1995-05-08 NO NO951790A patent/NO304306B1/no not_active IP Right Cessation
- 1995-05-09 FI FI952230A patent/FI108637B/fi not_active IP Right Cessation
-
1996
- 1996-03-14 UY UY24179A patent/UY24179A1/es not_active IP Right Cessation
- 1996-03-31 GR GR960300012T patent/GR960300012T1/el unknown
-
1997
- 1997-07-31 GR GR970401991T patent/GR3024344T3/el unknown
-
1998
- 1998-06-16 HK HK98105382A patent/HK1006306A1/xx not_active IP Right Cessation
-
2006
- 2006-07-31 NO NO2006007C patent/NO2006007I1/no unknown
Patent Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US427996A (en) * | 1890-05-13 | houg-hton | ||
US3641127A (en) * | 1967-01-27 | 1972-02-08 | Rhone Poulenc Sa | (3-benzoylphenyl) alkanoic acids |
GB1291386A (en) * | 1969-03-24 | 1972-10-04 | Syntex Corp | Improvements in or relating to 2-(6'-substituted-2'-naphthyl) propionic acid derivatives and salts thereof |
GB1408853A (en) * | 1972-03-17 | 1975-10-08 | Upjohn Co | Medical process and treatment |
US3821289A (en) * | 1972-07-03 | 1974-06-28 | Rorer Inc William H | Tetrahydronaphthylalkanoic acids and their derivatives |
DE2508895A1 (de) * | 1974-03-07 | 1975-09-18 | Prodotti Antibiotici Spa | Salze von phenylalkancarbonsaeuren mit basischen aminosaeuren |
US4097674A (en) * | 1975-03-17 | 1978-06-27 | Syntex Corporation | 2-Naphthylacetic acid derivatives |
GB1488778A (en) * | 1975-07-28 | 1977-10-12 | Roussel Uclaf | Salt of alpha-methyl-(5-benzoyl-2-thiophene)-acetic acid processes for preparing it and compositions containing it |
EP0008226A2 (en) * | 1978-08-08 | 1980-02-20 | Fujisawa Pharmaceutical Co., Ltd. | Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them |
GB2059768A (en) * | 1979-09-27 | 1981-04-29 | Ilona Kahan | Water-soluble derivatives of non-steroidal anti-inflammatory agnets and a process for the production thereof |
EP0136470A2 (de) * | 1983-08-05 | 1985-04-10 | Merckle GmbH | Injizierbare Lösung zur Behandlung von Entzündungen |
FR2580641A1 (fr) * | 1985-04-19 | 1986-10-24 | Seuref Ag | Derives arylalcanoiques d'imidazolium, procede pour les preparer et compositions pharmaceutiques en contenant |
EP0227078A1 (en) * | 1985-12-20 | 1987-07-01 | Wisconsin Alumni Research Foundation | Process for preparing (S)-alpha-methylarylacetic acids |
US4748174A (en) * | 1986-01-03 | 1988-05-31 | Therapicon S.R.L. | Water soluble salts of an NSAID with meglumine/glucamine |
WO1989004658A1 (en) * | 1987-11-17 | 1989-06-01 | Abraham Sunshine | Onset-hastened/enhanced analgesia using s(+) ketoprofen |
EP0396839A2 (en) * | 1989-05-12 | 1990-11-14 | American Home Products Corporation | Naphthalenepropionic acid salts |
Non-Patent Citations (1)
Title |
---|
Yamagushi T. et al., Folia Pharmacol. Japon. 90, 2955, 1987. * |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK4A | Patent for invention expired |