MD921G2 - Arylpropionic derivatives, process for preparation and the pharmaceutical composition on base thereof - Google Patents

Arylpropionic derivatives, process for preparation and the pharmaceutical composition on base thereof

Info

Publication number
MD921G2
MD921G2 MD96-0285A MD960285A MD921G2 MD 921 G2 MD921 G2 MD 921G2 MD 960285 A MD960285 A MD 960285A MD 921 G2 MD921 G2 MD 921G2
Authority
MD
Moldova
Prior art keywords
preparation
base
pharmaceutical composition
arylpropionic
derivatives
Prior art date
Application number
MD96-0285A
Other languages
Romanian (ro)
Russian (ru)
Inventor
Germano Carganico
Casellas David Mauleon
Perez M. Luisa Garcia
Original Assignee
Laboratorios Menarini S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini S.A. filed Critical Laboratorios Menarini S.A.
Publication of MD921G2 publication Critical patent/MD921G2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to the propionic acid salts, namely the propionic acid trometaminic salt (+)-(S)-2-(3-benzoylphenyl) of formula (I):O H CH3O-H3N C(CH2OH)3
MD96-0285A 1992-11-10 1993-11-09 Arylpropionic derivatives, process for preparation and the pharmaceutical composition on base thereof MD921G2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES09202260A ES2058024B1 (en) 1992-11-10 1992-11-10 NEW ARILPROPIONIC DERIVATIVE, MANUFACTURING PROCEDURE OF THE SAME AND ITS USE AS AN ANALGESIC.
PCT/EP1993/003127 WO1994011332A1 (en) 1992-11-10 1993-11-09 A novel arylpropionic derivative, a process for the preparation and the use thereof as an analgesic agent

Publications (1)

Publication Number Publication Date
MD921G2 true MD921G2 (en) 1998-10-31

Family

ID=8278730

Family Applications (1)

Application Number Title Priority Date Filing Date
MD96-0285A MD921G2 (en) 1992-11-10 1993-11-09 Arylpropionic derivatives, process for preparation and the pharmaceutical composition on base thereof

Country Status (27)

Country Link
US (1) US5554789A (en)
EP (1) EP0668851B1 (en)
JP (1) JP3778516B2 (en)
KR (1) KR100284838B1 (en)
AT (1) ATE153649T1 (en)
AU (1) AU674040B2 (en)
BG (1) BG61723B1 (en)
BR (1) BR9307408A (en)
CA (1) CA2149013C (en)
CZ (1) CZ286621B6 (en)
DE (2) DE668851T1 (en)
DK (1) DK0668851T3 (en)
ES (2) ES2058024B1 (en)
FI (1) FI108637B (en)
GR (2) GR960300012T1 (en)
HK (1) HK1006306A1 (en)
HU (2) HU217973B (en)
MD (1) MD921G2 (en)
NO (2) NO304306B1 (en)
NZ (1) NZ257557A (en)
PL (1) PL175265B1 (en)
RO (1) RO118712B1 (en)
RU (1) RU2128160C1 (en)
SK (1) SK280550B6 (en)
UA (1) UA44233C2 (en)
UY (1) UY24179A1 (en)
WO (1) WO1994011332A1 (en)

Families Citing this family (32)

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ES2124196B1 (en) * 1997-06-04 1999-12-01 Menarini Lab PROCEDURE FOR THE MANUFACTURE OF A SEMI-SOLID PHARMACEUTICAL FORM CONTAINING DEXKETOPROPHEN TROMETAMOL AND ITS USE IN THE TOPICAL TREATMENT OF INFLAMMATION.
ATE445838T1 (en) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc COMPOSITIONS AND METHODS FOR MODULATING TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER
US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
WO2004054568A1 (en) * 2002-12-17 2004-07-01 Abbott Gmbh & Co. Kg Formulation comprising fenofibric acid, a physiologically acceptable salt or derivative thereof
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
EP1739072A1 (en) * 2005-06-15 2007-01-03 Laboratorios Menarini S.A. Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof
CA2663377A1 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
TWI364413B (en) * 2008-07-25 2012-05-21 Univ Nat Central Racemic ibuprofen amine salt and synthesis method thereof
JP5628816B2 (en) * 2008-10-31 2014-11-19 ツェー・アー・イー・エルバイオサイエンスシーズ、ゲーエムベーハー Choline and tromethamine salts of lycoferon
HUE059078T2 (en) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutathione-based drug delivery system
JP2012526144A (en) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド Transdermal delivery composition comprising active substance-calcium phosphate particle complex and method of use thereof
ES2350670B1 (en) * 2009-06-10 2011-12-07 Polichem, S.L. KETOPROPHENE VETERINARY COMPOSITION
CN101928214B (en) * 2009-06-19 2012-12-19 黄石世星药业有限责任公司 Method for synthesizing dexketoprofen trometamol
WO2011001213A1 (en) * 2009-06-30 2011-01-06 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi A process for preparing dexketoprofen trometamol form a and form b crystals
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102557976B (en) * 2010-12-15 2015-06-10 辽宁盛京制药有限公司 Bromfenac organic salt, and preparation method thereof, composition thereof and application thereof
TR201104864A2 (en) 2011-05-18 2012-12-21 Bi̇lgi̇ç Mahmut Water-soluble formulations containing dexketoprofen.
TR201205317A2 (en) 2011-05-18 2012-12-21 B�Lg�� Mahmut Effervescent formulations containing dexketoprofen.
CN102381986A (en) * 2011-07-25 2012-03-21 南京特丰药业股份有限公司 Preparation methods of S-(+)-ibuprofen tromethamine salt and oral solution thereof
WO2013022410A2 (en) * 2011-08-08 2013-02-14 Mahmut Bilgic Production method for effervescent formulations comprising dexketoprofen
WO2013095315A1 (en) 2011-12-19 2013-06-27 Mahmut Bilgic Formulations comprising dexketoprofen (particle size 300-2500 micrometer)
WO2013100877A1 (en) 2011-12-27 2013-07-04 Mahmut Bilgic Dexketoprofen formulations
EP2671569B1 (en) 2012-06-06 2015-09-16 Galenicum Health S.L. Stable pharmaceutical compositions with fast onset
EP2759293A1 (en) 2013-01-25 2014-07-30 Laboratorios Lesvi, S.L. Pharmaceutical compositions of (+)-(s)-2-(3-benzoylphenyl)propionic acid tromethamine salt
ES2512497T1 (en) 2013-02-06 2014-10-24 Galenicum Health S.L. Process for preparing a stable pharmaceutical composition comprising dexketoprofen trometamol
ITMI20130210A1 (en) 2013-02-14 2014-08-15 Menarini Lab PHARMACEUTICAL COMPOSITIONS CONTAINING DEXKETOPROPHENES AND TRAMADOL
TR201616365A1 (en) 2016-11-14 2018-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Oral pharmaceutical compositions of dexketoprofen and eletriptan
AU2017364349A1 (en) 2016-11-28 2019-07-11 Sarin PARAYIL Novel organic crystalline salt of haloacetic acid
TR201618765A2 (en) 2016-12-16 2018-07-23 Imuneks Farma Ilac Sanayi Ve Ticaret Anonim Sirketi Non-steroidal anti-inflammatory drugs and h2 receptor antagonist combinations for treatment of pain and inflammation
KR102462607B1 (en) * 2020-11-11 2022-11-03 대원제약주식회사 Pharmaceutical composition with improved stability comprising novel salt of pelubiprofen as an active ingredient
KR102552315B1 (en) * 2020-11-11 2023-07-06 대원제약주식회사 Pharmaceutical composition with reduced gastrointestinal disorder comprising novel salt of pelubiprofen as an active ingredient
KR20230140540A (en) * 2022-03-25 2023-10-06 일동제약(주) Novel salt of GLP-1 receptor agonist compound, preparation method thereof and pharmaceutical composition comprising thereof

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US427996A (en) * 1890-05-13 houg-hton
US3641127A (en) * 1967-01-27 1972-02-08 Rhone Poulenc Sa (3-benzoylphenyl) alkanoic acids
GB1291386A (en) * 1969-03-24 1972-10-04 Syntex Corp Improvements in or relating to 2-(6'-substituted-2'-naphthyl) propionic acid derivatives and salts thereof
US3821289A (en) * 1972-07-03 1974-06-28 Rorer Inc William H Tetrahydronaphthylalkanoic acids and their derivatives
DE2508895A1 (en) * 1974-03-07 1975-09-18 Prodotti Antibiotici Spa SALT OF PHENYLALCANCARBONIC ACIDS WITH BASIC AMINO ACIDS
GB1408853A (en) * 1972-03-17 1975-10-08 Upjohn Co Medical process and treatment
GB1488778A (en) * 1975-07-28 1977-10-12 Roussel Uclaf Salt of alpha-methyl-(5-benzoyl-2-thiophene)-acetic acid processes for preparing it and compositions containing it
US4097674A (en) * 1975-03-17 1978-06-27 Syntex Corporation 2-Naphthylacetic acid derivatives
EP0008226A2 (en) * 1978-08-08 1980-02-20 Fujisawa Pharmaceutical Co., Ltd. Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them
GB2059768A (en) * 1979-09-27 1981-04-29 Ilona Kahan Water-soluble derivatives of non-steroidal anti-inflammatory agnets and a process for the production thereof
EP0136470A2 (en) * 1983-08-05 1985-04-10 Merckle GmbH Injectable solution for the treatment of inflammations
FR2580641A1 (en) * 1985-04-19 1986-10-24 Seuref Ag ARYLALCANOIC DERIVATIVES OF IMIDAZOLIUM, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0227078A1 (en) * 1985-12-20 1987-07-01 Wisconsin Alumni Research Foundation Process for preparing (S)-alpha-methylarylacetic acids
US4748174A (en) * 1986-01-03 1988-05-31 Therapicon S.R.L. Water soluble salts of an NSAID with meglumine/glucamine
WO1989004658A1 (en) * 1987-11-17 1989-06-01 Abraham Sunshine Onset-hastened/enhanced analgesia using s(+) ketoprofen
EP0396839A2 (en) * 1989-05-12 1990-11-14 American Home Products Corporation Naphthalenepropionic acid salts

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1201726A (en) * 1959-06-20 1960-01-05 Process for obtaining flavonic derivatives from the leaves of certain plants
ES455698A1 (en) * 1977-02-07 1978-01-01 Invest Tecnica Aplicada Procedure for the preparation of a new butanolaminic derivative. (Machine-translation by Google Translate, not legally binding)
US4977181A (en) * 1987-12-18 1990-12-11 Ciba-Geigy Corporation Tromethamine salt of 1-methyl-beta-oxo-alpha-(phenylcarbamoyl)-2-pyrrolepropionitrile

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US427996A (en) * 1890-05-13 houg-hton
US3641127A (en) * 1967-01-27 1972-02-08 Rhone Poulenc Sa (3-benzoylphenyl) alkanoic acids
GB1291386A (en) * 1969-03-24 1972-10-04 Syntex Corp Improvements in or relating to 2-(6'-substituted-2'-naphthyl) propionic acid derivatives and salts thereof
GB1408853A (en) * 1972-03-17 1975-10-08 Upjohn Co Medical process and treatment
US3821289A (en) * 1972-07-03 1974-06-28 Rorer Inc William H Tetrahydronaphthylalkanoic acids and their derivatives
DE2508895A1 (en) * 1974-03-07 1975-09-18 Prodotti Antibiotici Spa SALT OF PHENYLALCANCARBONIC ACIDS WITH BASIC AMINO ACIDS
US4097674A (en) * 1975-03-17 1978-06-27 Syntex Corporation 2-Naphthylacetic acid derivatives
GB1488778A (en) * 1975-07-28 1977-10-12 Roussel Uclaf Salt of alpha-methyl-(5-benzoyl-2-thiophene)-acetic acid processes for preparing it and compositions containing it
EP0008226A2 (en) * 1978-08-08 1980-02-20 Fujisawa Pharmaceutical Co., Ltd. Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them
GB2059768A (en) * 1979-09-27 1981-04-29 Ilona Kahan Water-soluble derivatives of non-steroidal anti-inflammatory agnets and a process for the production thereof
EP0136470A2 (en) * 1983-08-05 1985-04-10 Merckle GmbH Injectable solution for the treatment of inflammations
FR2580641A1 (en) * 1985-04-19 1986-10-24 Seuref Ag ARYLALCANOIC DERIVATIVES OF IMIDAZOLIUM, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0227078A1 (en) * 1985-12-20 1987-07-01 Wisconsin Alumni Research Foundation Process for preparing (S)-alpha-methylarylacetic acids
US4748174A (en) * 1986-01-03 1988-05-31 Therapicon S.R.L. Water soluble salts of an NSAID with meglumine/glucamine
WO1989004658A1 (en) * 1987-11-17 1989-06-01 Abraham Sunshine Onset-hastened/enhanced analgesia using s(+) ketoprofen
EP0396839A2 (en) * 1989-05-12 1990-11-14 American Home Products Corporation Naphthalenepropionic acid salts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Yamagushi T. et al., Folia Pharmacol. Japon. 90, 2955, 1987. *

Also Published As

Publication number Publication date
PL175265B1 (en) 1998-12-31
HUT71903A (en) 1996-02-28
ES2058024A1 (en) 1994-10-16
NO304306B1 (en) 1998-11-30
KR100284838B1 (en) 2001-04-02
GR960300012T1 (en) 1996-03-31
US5554789A (en) 1996-09-10
GR3024344T3 (en) 1997-10-31
ES2081780T3 (en) 1997-07-01
HK1006306A1 (en) 1999-02-19
SK280550B6 (en) 2000-03-13
BG99609A (en) 1996-01-31
HU9802850D0 (en) 1999-02-01
EP0668851A1 (en) 1995-08-30
ATE153649T1 (en) 1997-06-15
JP3778516B2 (en) 2006-05-24
FI952230A0 (en) 1995-05-09
HU9501375D0 (en) 1995-06-28
DE69311130T2 (en) 1997-09-18
BR9307408A (en) 1999-08-24
FI952230A (en) 1995-05-09
PL308466A1 (en) 1995-07-24
CA2149013C (en) 2004-08-10
HU219975B (en) 2001-10-28
NO2006007I1 (en) 2006-08-14
ES2081780T1 (en) 1996-03-16
UY24179A1 (en) 1996-09-03
NZ257557A (en) 1996-01-26
JPH08503203A (en) 1996-04-09
EP0668851B1 (en) 1997-05-28
DE69311130D1 (en) 1997-07-03
SK60395A3 (en) 1995-09-13
CZ286621B6 (en) 2000-05-17
DE668851T1 (en) 1996-10-10
DK0668851T3 (en) 1997-12-22
CA2149013A1 (en) 1994-05-26
AU674040B2 (en) 1996-12-05
BG61723B1 (en) 1998-04-30
RO118712B1 (en) 2003-09-30
RU95112575A (en) 1997-06-20
FI108637B (en) 2002-02-28
RU2128160C1 (en) 1999-03-27
AU5421094A (en) 1994-06-08
HU217973B (en) 2000-05-28
ES2058024B1 (en) 1995-05-01
WO1994011332A1 (en) 1994-05-26
NO951790L (en) 1995-07-06
NO951790D0 (en) 1995-05-08
UA44233C2 (en) 2002-02-15
CZ114995A3 (en) 1995-10-18

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Legal Events

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MK4A Patent for invention expired