ES2057116T3 - Derivados de acido n-(5,6,7,8-tetrahidropirido-(2,3-d)pirimidin-6-ilalcanoil) glutamico. - Google Patents

Derivados de acido n-(5,6,7,8-tetrahidropirido-(2,3-d)pirimidin-6-ilalcanoil) glutamico.

Info

Publication number
ES2057116T3
ES2057116T3 ES89304499T ES89304499T ES2057116T3 ES 2057116 T3 ES2057116 T3 ES 2057116T3 ES 89304499 T ES89304499 T ES 89304499T ES 89304499 T ES89304499 T ES 89304499T ES 2057116 T3 ES2057116 T3 ES 2057116T3
Authority
ES
Spain
Prior art keywords
hydrogen
carbon
tetrahidropirido
ilalcanoil
glutamico
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89304499T
Other languages
English (en)
Inventor
Edward C Taylor
Chuan Shih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Princeton University
Original Assignee
Eli Lilly and Co
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/198,201 external-priority patent/US4882333A/en
Priority claimed from US07/198,207 external-priority patent/US4882334A/en
Application filed by Eli Lilly and Co, Princeton University filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2057116T3 publication Critical patent/ES2057116T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

UN COMPUESTO SE LECCIONADO DEL GRUPO CONSISTENTE EN UN DERIVADO DE ACIDO GLUTAMICO DE LA FORMULA(I) O (II), R1 ES - OH O - NH2; R2 ES H O UN GRUPO PROTECTOR CABOXI; R3 ES UN ENLACE C - C, ALQUILENO DE 1 A 4 C, CICLOHEXILENO O (III); R4 ES H O UN GRUPO PROTECTOR AMINO; Q ES - S - O - O -; R5 ES H, CL O FLUORO, Y LA CONFIGURACION ACERCA DEL C DESIGNADO ES S; Y LAS SALES DE ESTO FARMACEUTICAMENTE ACEPTABLES. TAMBIEN SE PRESENTA UN METODO PARA COMBATIR EL CRECIMIENTO NEOPLASICO EN UN MAMIFERO Y UNA COMPOSICION FARMACEUTICA PARA COMBATIR EL CRECIMIENTO NEOPLASICO EN UN MAMIFERO HACIENDO USO DEL COMPUESTO CITADO ARRIBA.
ES89304499T 1988-05-25 1989-05-04 Derivados de acido n-(5,6,7,8-tetrahidropirido-(2,3-d)pirimidin-6-ilalcanoil) glutamico. Expired - Lifetime ES2057116T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/198,201 US4882333A (en) 1988-05-25 1988-05-25 N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
US07/198,207 US4882334A (en) 1988-05-25 1988-05-25 N-(5,6,7,8-tetrahydropyrido]2,3-d]pyrimidin-6-ylethl-thineyl-and furylcarbonyl)-glutamic acid derivatives

Publications (1)

Publication Number Publication Date
ES2057116T3 true ES2057116T3 (es) 1994-10-16

Family

ID=26893557

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89304499T Expired - Lifetime ES2057116T3 (es) 1988-05-25 1989-05-04 Derivados de acido n-(5,6,7,8-tetrahidropirido-(2,3-d)pirimidin-6-ilalcanoil) glutamico.

Country Status (18)

Country Link
EP (1) EP0343801B1 (es)
JP (1) JP2818198B2 (es)
KR (1) KR0131589B1 (es)
CN (1) CN1025334C (es)
AT (1) ATE109480T1 (es)
AU (1) AU611027B2 (es)
CA (1) CA1340631C (es)
CY (1) CY2055B1 (es)
DE (1) DE68917211T2 (es)
DK (1) DK172753B1 (es)
ES (1) ES2057116T3 (es)
HK (1) HK1000284A1 (es)
HU (1) HU205356B (es)
IE (1) IE63620B1 (es)
IL (1) IL90179A (es)
NZ (1) NZ229242A (es)
PT (1) PT90635B (es)
RU (1) RU2002747C1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
CZ66893A3 (en) * 1992-04-23 1993-12-15 Lilly Co Eli Application of gar - transformylase inhibitor
US5608082A (en) * 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
CA2184783A1 (en) * 1995-09-08 1997-03-09 William J. Gill Nonclassical antifolates
AU7073296A (en) * 1996-05-01 1997-11-19 Eli Lilly And Company 5,6,7,8-tetrahydropyrido{2,3-d}pyrimidines
WO1999041230A1 (en) * 1998-02-11 1999-08-19 Eli Lilly And Company Processes and intermediates useful to make antifolates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
IE60038B1 (en) * 1986-06-30 1994-05-18 Univ Princeton 4(3H)-oxo-5, 6, 7, 8-tetrahydropyrido-[2, 3-d]pyrimidine derivatives

Also Published As

Publication number Publication date
IL90179A (en) 1994-02-27
AU611027B2 (en) 1991-05-30
NZ229242A (en) 1990-10-26
DE68917211T2 (de) 1994-11-24
DK215289A (da) 1989-11-26
DE68917211D1 (de) 1994-09-08
AU3510989A (en) 1989-11-30
CA1340631C (en) 1999-07-06
IE63620B1 (en) 1995-05-17
KR900018100A (ko) 1990-12-20
EP0343801A3 (en) 1991-05-02
HU205356B (en) 1992-04-28
IE891767L (en) 1989-11-25
DK172753B1 (da) 1999-06-28
DK215289D0 (da) 1989-05-02
JP2818198B2 (ja) 1998-10-30
IL90179A0 (en) 1989-12-15
CY2055B1 (en) 1998-06-12
PT90635B (pt) 1994-10-31
RU2002747C1 (ru) 1993-11-15
CN1038098A (zh) 1989-12-20
KR0131589B1 (ko) 1998-04-17
EP0343801B1 (en) 1994-08-03
HK1000284A1 (en) 1998-02-20
EP0343801A2 (en) 1989-11-29
CN1025334C (zh) 1994-07-06
ATE109480T1 (de) 1994-08-15
PT90635A (pt) 1989-11-30
HUT50342A (en) 1990-01-29
JPH0267281A (ja) 1990-03-07

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