MA28972B1 - Indazoles, benzothiazoles , benzoisothiazoles, benzisoxazoles, et leur preparation et leurs utilisations - Google Patents
Indazoles, benzothiazoles , benzoisothiazoles, benzisoxazoles, et leur preparation et leurs utilisationsInfo
- Publication number
- MA28972B1 MA28972B1 MA29406A MA29406A MA28972B1 MA 28972 B1 MA28972 B1 MA 28972B1 MA 29406 A MA29406 A MA 29406A MA 29406 A MA29406 A MA 29406A MA 28972 B1 MA28972 B1 MA 28972B1
- Authority
- MA
- Morocco
- Prior art keywords
- indazoles
- benzothiazoles
- preparation
- receptors
- nach
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
De manière générale, la présente invention a trait au domaine de ligands pour des récepteurs nicotiniques de l'acétylcholine (récepteurs nACh), à l'activation de récepteurs nACh, et au traitement de conditions pathologiques liées aux récepteurs nicotiniques de l'acétylcholine déficients ou défectueux, notamment du cerveau. L'invention a également trait à de nouveaux composés (par exemple, indazoles et benzothiazoles), qui agissent comme ligands pour le sous-type A7 de récepteurs nACh, à des procédés de préparation desdits composés, à des compositions contenant de tels composés, et à leurs procédés d'utilisation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55595104P | 2004-03-25 | 2004-03-25 | |
US61603304P | 2004-10-06 | 2004-10-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA28972B1 true MA28972B1 (fr) | 2007-11-01 |
Family
ID=34968660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA29406A MA28972B1 (fr) | 2004-03-25 | 2006-10-20 | Indazoles, benzothiazoles , benzoisothiazoles, benzisoxazoles, et leur preparation et leurs utilisations |
Country Status (18)
Country | Link |
---|---|
US (4) | US20050234095A1 (fr) |
EP (2) | EP1735306A2 (fr) |
JP (2) | JP4995075B2 (fr) |
KR (1) | KR101176670B1 (fr) |
CN (1) | CN103724343A (fr) |
AU (1) | AU2005227324A1 (fr) |
BR (1) | BRPI0508771A (fr) |
CA (1) | CA2560741C (fr) |
CR (2) | CR8711A (fr) |
EC (1) | ECSP066951A (fr) |
IL (2) | IL178188A (fr) |
MA (1) | MA28972B1 (fr) |
MX (1) | MXPA06010852A (fr) |
NO (1) | NO20064826L (fr) |
NZ (1) | NZ550534A (fr) |
RU (1) | RU2417225C2 (fr) |
SG (1) | SG165199A1 (fr) |
WO (1) | WO2005092890A2 (fr) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
SE0202598D0 (sv) * | 2002-09-02 | 2002-09-02 | Astrazeneca Ab | Alpha-7 Nicotinic receptor agonists and statins in combination |
ATE487716T1 (de) * | 2004-04-22 | 2010-11-15 | Memory Pharm Corp | Indole, 1h-indazole, 1,2-benzisoxazole, 1,2- benzoisothiazole, deren herstellung und verwendungen |
WO2006069097A2 (fr) * | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Ligands du recepteur alpha-7 nicotinique ainsi que preparation et utilisations de ceux-ci |
KR20080067339A (ko) * | 2005-11-09 | 2008-07-18 | 메모리 파마슈티칼스 코포레이션 | 1h-인다졸, 벤조티아졸, 1,2-벤조이속사졸,1,2-벤조이소티아졸, 및 크로몬 및 그들의 제조법 및 용도 |
CA2654098A1 (fr) | 2006-06-13 | 2007-12-21 | Merck Frosst Canada Ltd. | Derives de l'azacyclopentane utilises en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase |
CL2008000836A1 (es) | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
EP2164847B1 (fr) | 2007-07-03 | 2011-09-14 | Actelion Pharmaceuticals Ltd. | Composés 3-aza-bicyclo[3.3.0]octane |
WO2009016564A2 (fr) | 2007-07-27 | 2009-02-05 | Actelion Pharmaceuticals Ltd | Dérivés de 2-aza-bicyclo[3.3.0]octane |
JP5544296B2 (ja) * | 2007-11-16 | 2014-07-09 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 代謝障害のためのカルボキサミド、スルホンアミド、およびアミン化合物 |
AP2010005345A0 (en) * | 2008-02-29 | 2010-08-31 | Pfizer | Indazole derivatives. |
WO2009106980A2 (fr) * | 2008-02-29 | 2009-09-03 | Pfizer Inc. | Dérivés d'indazole |
KR101098335B1 (ko) * | 2008-07-18 | 2011-12-26 | 성균관대학교산학협력단 | 신코나 기재 이작용성 유기 촉매 및 이를 이용한 메소-고리산무수물의 비대칭 고리 열림 반응을 통한 키랄성헤미에스터의 제조방법 |
BRPI0920187A2 (pt) | 2008-10-13 | 2019-08-27 | Hoffmann La Roche | método sem diazônio para fabricar um indazol intermediário na síntese de amidas bicíclicas do ácido 5-(triflúor-metóxi)-1h-3-indazol-carboxílico |
CA3017886A1 (fr) | 2008-11-19 | 2010-05-27 | Envivo Pharmaceuticals, Inc. | Traitement de troubles cognitifs par la (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide et les sels de qualite pharmaceutique de celle-ci |
HUE028259T2 (en) | 2009-08-10 | 2016-12-28 | Samumed Llc | Inhibitors of Wnt signaling signal indazole and their therapeutic use |
TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α7活化劑之用途 |
US9095596B2 (en) | 2009-10-15 | 2015-08-04 | Southern Research Institute | Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such |
EP3305073B1 (fr) | 2009-12-21 | 2019-05-15 | Samumed, LLC | 1h-pyrazolo [3,4-b] pyridines et leurs utilisations thérapeutiques |
US20110172428A1 (en) | 2010-01-12 | 2011-07-14 | Shan-Ming Kuang | Methods for the preparation of indazole-3-carboxylic acid and n-(s)-1-azabicyclo[2.2.2]oct-3-yl-1h-indazole-3-carboxamide hydrochloride salt |
CN102958927A (zh) | 2010-05-12 | 2013-03-06 | Abbvie公司 | 激酶的吲唑抑制剂 |
WO2011146511A1 (fr) | 2010-05-17 | 2011-11-24 | Envivo Pharmaceuticals, Inc. | Forme cristalline de monohydrate d'hydrochlorure de (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide |
US8242276B2 (en) | 2010-06-30 | 2012-08-14 | Hoffmann-La Roche Inc. | Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt |
EP2598135A1 (fr) | 2010-07-26 | 2013-06-05 | Gerhard Koenig | Traitement de troubles cognitifs par certains agonistes du récepteur alpha-7 de l'acide nicotinique en combinaison à des inhibiteurs d'acétylcholinestérase |
KR101928505B1 (ko) * | 2011-01-28 | 2018-12-12 | 에스케이바이오팜 주식회사 | 피리돈 유도체 및 이를 포함하는 약학적 조성물 |
SG11201400666PA (en) | 2011-09-14 | 2014-09-26 | Samumed Llc | Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors |
US9668969B1 (en) | 2012-02-22 | 2017-06-06 | Arturo Solis Herrera | Methods of using QIAPINE |
PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
HUE046216T2 (hu) | 2012-05-04 | 2020-02-28 | Samumed Llc | 1H-pirazolo [3,4-b]piridin-származékok és terápiás alkalmazásuk |
AU2013259871A1 (en) | 2012-05-08 | 2014-11-20 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
JOP20130213B1 (ar) * | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | معارضات لمستقبلht3-5 |
KR102226489B1 (ko) | 2012-07-27 | 2021-03-11 | 사토 파머슈티컬 가부시키가이샤 | 디플루오로메틸렌 화합물 |
CN105120862A (zh) | 2013-01-08 | 2015-12-02 | 萨穆梅德有限公司 | Wnt信号途径的3-(苯并咪唑-2-基)-吲唑抑制剂及其治疗应用 |
CA2905242C (fr) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Composes indoliques activant l'ampk |
JP2016526538A (ja) | 2013-06-20 | 2016-09-05 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 殺ダニ剤及び殺虫剤としてのアリールスルフィド誘導体及びアリールスルホキシド誘導体 |
SG11201607816UA (en) | 2014-03-20 | 2016-10-28 | Samumed Llc | 5-substituted indazole-3-carboxamides and preparation and use thereof |
KR101731624B1 (ko) * | 2014-07-01 | 2017-05-04 | 광주과학기술원 | 세포 리프로그래밍 유도용 조성물 |
WO2016040188A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques |
WO2016040185A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine et ses utilisations thérapeutiques |
WO2016040184A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques |
WO2016040190A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques |
WO2016040182A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine et ses utilisations thérapeutiques |
WO2016040193A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques |
WO2016040181A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques |
WO2016040180A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques |
US9783527B2 (en) * | 2014-09-16 | 2017-10-10 | Abbvie Inc. | Indazole ureas and method of use |
US10329306B2 (en) | 2014-09-29 | 2019-06-25 | Takeda Pharmaceutical Company Limited | Crystalline form of 1-(1-methyl-1H-pyrazol-4-yl)-N-((IR,5S,7S)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1H-indole-3-carboxamide |
CA2971413A1 (fr) | 2014-12-16 | 2016-06-23 | Axovant Sciences Gmbh | Composes amide de quinuclidine a substituants geminal, en tant qu'agonistes des recepteurs nicotiniques de l'acetylcholine ?7 |
MA41179A (fr) | 2014-12-19 | 2017-10-24 | Cancer Research Tech Ltd | Composés inhibiteurs de parg |
CN104628648A (zh) * | 2015-01-22 | 2015-05-20 | 湖南华腾制药有限公司 | 一种吲唑衍生物的制备方法 |
MX2017016231A (es) | 2015-06-10 | 2018-11-29 | Axovant Sciences Gmbh | Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina. |
US10519169B2 (en) | 2015-08-03 | 2019-12-31 | Samumed, Llc | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
WO2017024015A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines et leurs utilisations thérapeutiques |
US10188634B2 (en) | 2015-08-03 | 2019-01-29 | Samumed, Llc | 3-(3H-imidazo[4,5-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
US10226453B2 (en) | 2015-08-03 | 2019-03-12 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
WO2017023989A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines et leurs utilisations thérapeutiques |
WO2017024021A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles et leurs utilisations thérapeutiques |
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2005
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- 2005-03-25 EP EP05745169A patent/EP1735306A2/fr not_active Withdrawn
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- 2005-03-25 US US11/089,533 patent/US20050234095A1/en not_active Abandoned
- 2005-03-25 EP EP10013706A patent/EP2336128A1/fr not_active Withdrawn
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- 2005-03-25 CN CN201310692588.7A patent/CN103724343A/zh active Pending
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- 2005-03-25 MX MXPA06010852A patent/MXPA06010852A/es active IP Right Grant
- 2005-03-25 WO PCT/US2005/010120 patent/WO2005092890A2/fr active Application Filing
- 2005-03-25 SG SG200902028-0A patent/SG165199A1/en unknown
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- 2006-10-20 MA MA29406A patent/MA28972B1/fr unknown
- 2006-10-24 EC EC2006006951A patent/ECSP066951A/es unknown
- 2006-10-24 NO NO20064826A patent/NO20064826L/no not_active Application Discontinuation
- 2006-10-25 CR CR8711A patent/CR8711A/es unknown
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IL178188A (en) | 2012-10-31 |
KR20070015406A (ko) | 2007-02-02 |
WO2005092890A2 (fr) | 2005-10-06 |
IL178188A0 (en) | 2006-12-31 |
US8486937B2 (en) | 2013-07-16 |
US8691841B2 (en) | 2014-04-08 |
US20110319407A1 (en) | 2011-12-29 |
IL218692A0 (en) | 2012-05-31 |
US20050234095A1 (en) | 2005-10-20 |
JP2007530590A (ja) | 2007-11-01 |
KR101176670B1 (ko) | 2012-08-23 |
JP4995075B2 (ja) | 2012-08-08 |
RU2006137472A (ru) | 2008-04-27 |
EP2336128A1 (fr) | 2011-06-22 |
US20100105677A1 (en) | 2010-04-29 |
EP1735306A2 (fr) | 2006-12-27 |
ECSP066951A (es) | 2006-12-20 |
SG165199A1 (en) | 2010-10-28 |
CR20120010A (es) | 2012-02-13 |
CR8711A (es) | 2007-08-28 |
CA2560741A1 (fr) | 2005-10-06 |
CN103724343A (zh) | 2014-04-16 |
US8263619B2 (en) | 2012-09-11 |
MXPA06010852A (es) | 2007-01-16 |
BRPI0508771A (pt) | 2007-08-14 |
NZ550534A (en) | 2009-07-31 |
JP2011252002A (ja) | 2011-12-15 |
RU2417225C2 (ru) | 2011-04-27 |
WO2005092890A3 (fr) | 2006-02-02 |
AU2005227324A1 (en) | 2005-10-06 |
CA2560741C (fr) | 2013-08-06 |
US20130217683A1 (en) | 2013-08-22 |
NO20064826L (no) | 2006-12-20 |
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