TNSN06188A1 - Derives de 3-cycloalkylaminopyrrolidine utiles comme modulateurs de recepteurs de chimiokines - Google Patents

Derives de 3-cycloalkylaminopyrrolidine utiles comme modulateurs de recepteurs de chimiokines

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Publication number
TNSN06188A1
TNSN06188A1 TNP2006000188A TNSN06188A TNSN06188A1 TN SN06188 A1 TNSN06188 A1 TN SN06188A1 TN P2006000188 A TNP2006000188 A TN P2006000188A TN SN06188 A TNSN06188 A TN SN06188A TN SN06188 A1 TNSN06188 A1 TN SN06188A1
Authority
TN
Tunisia
Prior art keywords
chimiokines
récepteurs
modulateurs
ccr2
ccr5
Prior art date
Application number
TNP2006000188A
Other languages
English (en)
Inventor
Brian Metclaf
Amy Qi Han
Darius J Robinson
Changsheng Zheng
Anlai Wang
Yingxin Zhang
Chu-Biao Xue
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of TNSN06188A1 publication Critical patent/TNSN06188A1/fr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

La présente invention concerne des dérivés 3-cycloalkylaminopyrrolidine de formule (I), (dans laquelle R1, R2, R3, R4, R5, R6, R7, X, Y et Z répondent aux définitions figurant dans le présent mémoire) qui sont utiles comme modulateurs de l'activité de récepteurs de chimiokines. En particulier, ces composés sont utiles comme modulateurs de récepteurs de chimiokines et, plus spécifiquement, comme modulateurs du récepteur CCR2 et/ou du récepteur CCR5. Les composés et compositions de la présente invention peuvent s'allier à de récepteurs de chimiokines, par exemple les récepteurs de chimiokines CCR2 et/ou CCR5, et sont utiles pour le traitement de maladies associées à une activité de chimiokine, par exemple de CCR2 et/ou de CCR5, telles que l'athérosclérose, une resténose, le lupus, le rejet d'un organe transplanté et la polyarthrite rhumatoïde.
TNP2006000188A 2003-12-18 2006-06-16 Derives de 3-cycloalkylaminopyrrolidine utiles comme modulateurs de recepteurs de chimiokines TNSN06188A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53127003P 2003-12-18 2003-12-18
PCT/US2004/042321 WO2005060665A2 (fr) 2003-12-18 2004-12-16 Derives 3-cycloalkylaminopyrrolidine utilises en tant que modulateurs des recepteurs de chimiokine

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TNSN06188A1 true TNSN06188A1 (fr) 2007-11-15

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TNP2006000188A TNSN06188A1 (fr) 2003-12-18 2006-06-16 Derives de 3-cycloalkylaminopyrrolidine utiles comme modulateurs de recepteurs de chimiokines

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US (5) US7576089B2 (fr)
EP (1) EP1696919B1 (fr)
JP (1) JP4740151B2 (fr)
KR (2) KR20080052683A (fr)
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AP (1) AP2439A (fr)
AU (1) AU2004305079B2 (fr)
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CA (1) CA2550596C (fr)
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EA (1) EA013631B1 (fr)
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HK (1) HK1166321A1 (fr)
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OA (1) OA13338A (fr)
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HK1166321A1 (en) 2012-10-26
NZ547316A (en) 2011-01-28
WO2005060665A2 (fr) 2005-07-07
KR20070008536A (ko) 2007-01-17
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MXPA06007000A (es) 2006-08-31
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UA82917C2 (en) 2008-05-26
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US20170050942A1 (en) 2017-02-23
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