TNSN08196A1 - Derives de pyrazine - Google Patents

Derives de pyrazine

Info

Publication number
TNSN08196A1
TNSN08196A1 TNP2008000196A TNSN08196A TNSN08196A1 TN SN08196 A1 TNSN08196 A1 TN SN08196A1 TN P2008000196 A TNP2008000196 A TN P2008000196A TN SN08196 A TNSN08196 A TN SN08196A TN SN08196 A1 TNSN08196 A1 TN SN08196A1
Authority
TN
Tunisia
Prior art keywords
des
composés
préparer
pour les
les
Prior art date
Application number
TNP2008000196A
Other languages
English (en)
Inventor
Karl Richard Gibson
Cedric Poinsard
Melanie Susanne Glossop
Stephen Martin Denton
Mark Ian Kemp
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of TNSN08196A1 publication Critical patent/TNSN08196A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne des composés de formule (I), des sels et solvates de ceux-ci, acceptables d'un point de vue pharmaceutique, des procédés pour les préparer, des produits intermédiaires utilisés pour les préparer, des compositions contenant ces composés, ainsi que les utilisations de tels composés dans le traitement de la douleur.
TNP2008000196A 2005-11-04 2008-05-02 Derives de pyrazine TNSN08196A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73366205P 2005-11-04 2005-11-04
PCT/IB2006/003055 WO2007052123A2 (fr) 2005-11-04 2006-10-23 Derives de pyrazine

Publications (1)

Publication Number Publication Date
TNSN08196A1 true TNSN08196A1 (fr) 2009-10-30

Family

ID=37890558

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2008000196A TNSN08196A1 (fr) 2005-11-04 2008-05-02 Derives de pyrazine

Country Status (27)

Country Link
US (1) US7572797B2 (fr)
EP (1) EP1945630B1 (fr)
JP (1) JP2009514937A (fr)
KR (1) KR20080066073A (fr)
CN (1) CN101356169A (fr)
AP (1) AP2008004468A0 (fr)
AR (1) AR057855A1 (fr)
AT (1) ATE525372T1 (fr)
AU (1) AU2006310215A1 (fr)
BR (1) BRPI0618129A2 (fr)
CA (1) CA2624621C (fr)
CR (1) CR9954A (fr)
DO (1) DOP2006000243A (fr)
EA (1) EA200801011A1 (fr)
EC (1) ECSP088412A (fr)
ES (1) ES2371932T3 (fr)
GT (1) GT200600475A (fr)
IL (1) IL191059A0 (fr)
MA (1) MA29926B1 (fr)
NL (1) NL2000284C2 (fr)
NO (1) NO20082496L (fr)
PE (1) PE20070715A1 (fr)
TN (1) TNSN08196A1 (fr)
TW (1) TW200804353A (fr)
UY (1) UY29893A1 (fr)
WO (1) WO2007052123A2 (fr)
ZA (1) ZA200803671B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9710536A (pt) 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
EP1741708A1 (fr) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Amides heterocycliques substitués contenant un linker cyclique ou insaturé, et leur utilisation comme agent pharmaceutique
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
NZ581614A (en) 2007-05-03 2011-06-30 Pfizer Ltd 2-pyridine carboxamide derivatives as sodium channel modulators
EP2155727A1 (fr) * 2007-05-03 2010-02-24 Pfizer Limited Dérivés n-[6-amino-5-(phényl)pyrazin-2-yl]-isoxazole-4-carboxamide et composés similaires en tant que modulateurs du canal nav1.8 pour le traitement de la douleur
US8614255B2 (en) * 2007-08-21 2013-12-24 Civitas Therapeutics, Inc. Pulmonary pharmaceutical formulations
MY152955A (en) 2007-12-10 2014-12-15 Novartis Ag Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel
WO2009101917A1 (fr) 2008-02-13 2009-08-20 Eisai R & D Management Co., Ltd. Dérivé de bicycloamine
EP2285803A4 (fr) 2008-05-23 2011-10-05 Amira Pharmaceuticals Inc Inhibiteur de la protéine d activation de 5-lipoxygénase
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013059677A1 (fr) * 2011-10-19 2013-04-25 Calcimedica, Inc. Composés qui modulent le calcium intracellulaire
CN104520296B (zh) * 2012-04-25 2016-11-16 拉夸里亚创药株式会社 作为ttx-s阻断剂的吡咯并吡啶酮衍生物
TWI644899B (zh) * 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
ES2706399T3 (es) 2013-02-04 2019-03-28 Janssen Pharmaceutica Nv Moduladores de FLAP
AU2015315167A1 (en) * 2014-09-10 2017-03-16 Epizyme, Inc. Isoxazole carboxamide compounds
ES2959658T3 (es) 2015-02-27 2024-02-27 Calcimedica Inc Tratamiento de la pancreatitis
CA2995094A1 (fr) 2015-08-07 2017-02-16 Calcimedica, Inc. Utilisation d'inhibiteurs du canal crac pour le traitement d'un accident vasculaire cerebral et d'une lesion cerebrale traumatique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA26473A1 (fr) * 1997-03-01 2004-12-20 Glaxo Group Ltd Composes pharmacologiquement actifs.
ES2333586T3 (es) * 2001-11-21 2010-02-24 PHARMACIA & UPJOHN COMPANY LLC Derivados de aril 1,4-pirazina sustituidos.
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
CA2543644A1 (fr) * 2003-10-27 2005-05-06 Astellas Pharma Inc. Derives de pyrazine et utilisation pharmaceutique de ce derive
US7705042B2 (en) * 2004-10-22 2010-04-27 Janssen Pharmaceutica Nv Class of arylamide compounds useful as inhibitors of c-fms kinase

Also Published As

Publication number Publication date
PE20070715A1 (es) 2007-08-11
ES2371932T3 (es) 2012-01-11
UY29893A1 (es) 2007-06-29
EP1945630B1 (fr) 2011-09-21
CA2624621A1 (fr) 2007-05-10
EP1945630A2 (fr) 2008-07-23
US20070105872A1 (en) 2007-05-10
CR9954A (es) 2008-05-28
NL2000284C2 (nl) 2007-09-28
NL2000284A1 (nl) 2007-05-07
WO2007052123A2 (fr) 2007-05-10
ECSP088412A (es) 2008-05-30
ZA200803671B (en) 2009-03-25
EA200801011A1 (ru) 2009-02-27
AU2006310215A1 (en) 2007-05-10
DOP2006000243A (es) 2007-05-31
MA29926B1 (fr) 2008-11-03
TW200804353A (en) 2008-01-16
NO20082496L (no) 2008-07-24
ATE525372T1 (de) 2011-10-15
GT200600475A (es) 2007-07-06
KR20080066073A (ko) 2008-07-15
BRPI0618129A2 (pt) 2011-08-16
CA2624621C (fr) 2010-11-30
JP2009514937A (ja) 2009-04-09
AR057855A1 (es) 2007-12-19
AP2008004468A0 (en) 2008-06-30
US7572797B2 (en) 2009-08-11
IL191059A0 (en) 2008-12-29
WO2007052123A3 (fr) 2007-07-12
CN101356169A (zh) 2009-01-28

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