MA32615B1 - Inhibiteurs de cmet - Google Patents
Inhibiteurs de cmetInfo
- Publication number
- MA32615B1 MA32615B1 MA33676A MA33676A MA32615B1 MA 32615 B1 MA32615 B1 MA 32615B1 MA 33676 A MA33676 A MA 33676A MA 33676 A MA33676 A MA 33676A MA 32615 B1 MA32615 B1 MA 32615B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- cmet inhibitors
- cmet
- methods
- relates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
La présente invention concerne des composés de formule suivante destinés à être utilisés avec le cmet : les variables étant telles que définies ici. L'invention concerne également des compositions pharmaceutiques, des kits et des articles de fabrication comprenant de tels composés; des procédés et des intermédiaires utiles pour fabriquer les composés; et des procédés d'utilisation desdits composés.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8895908P | 2008-08-14 | 2008-08-14 | |
US11791008P | 2008-11-25 | 2008-11-25 | |
US16100709P | 2009-03-17 | 2009-03-17 | |
PCT/US2009/053913 WO2010019899A1 (fr) | 2008-08-14 | 2009-08-14 | Inhibiteurs de cmet |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32615B1 true MA32615B1 (fr) | 2011-09-01 |
Family
ID=41202532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33676A MA32615B1 (fr) | 2008-08-14 | 2011-03-07 | Inhibiteurs de cmet |
Country Status (26)
Country | Link |
---|---|
US (1) | US8178534B2 (fr) |
EP (1) | EP2313407B1 (fr) |
JP (1) | JP5469666B2 (fr) |
KR (1) | KR20110039383A (fr) |
CN (1) | CN102124005B (fr) |
AR (1) | AR072936A1 (fr) |
AU (1) | AU2009281822B2 (fr) |
BR (1) | BRPI0917808A2 (fr) |
CA (1) | CA2731108A1 (fr) |
CO (1) | CO6351724A2 (fr) |
CR (1) | CR20110135A (fr) |
DO (1) | DOP2011000050A (fr) |
EA (1) | EA019723B1 (fr) |
EC (1) | ECSP11010889A (fr) |
ES (1) | ES2608761T3 (fr) |
GE (1) | GEP20125652B (fr) |
IL (1) | IL210734A0 (fr) |
MA (1) | MA32615B1 (fr) |
MX (1) | MX2011001732A (fr) |
MY (1) | MY150542A (fr) |
NZ (1) | NZ590617A (fr) |
PE (1) | PE20110275A1 (fr) |
TW (1) | TWI455939B (fr) |
UY (1) | UY32049A (fr) |
WO (1) | WO2010019899A1 (fr) |
ZA (1) | ZA201100467B (fr) |
Families Citing this family (78)
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TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
US20090197880A1 (en) * | 2007-07-13 | 2009-08-06 | Genelabs Technologies, Inc. | Anti-viral compounds, compositions, and methods of use |
WO2009033702A1 (fr) | 2007-09-14 | 2009-03-19 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 4-(aryl-x-phényl)-1h-pyridine-2-ones 1,3-disubstituées |
PT2203439E (pt) | 2007-09-14 | 2011-02-11 | Ortho Mcneil Janssen Pharm | 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridinil-2'- onas 1',3'-dissubstituídas |
TW200927731A (en) | 2007-09-14 | 2009-07-01 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
EP2220083B1 (fr) | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Dérivés d'imidazo[1,2-a]pyridines et leur utilisation en tant que modulateurs allostériques positifs de récepteurs mglur2 |
WO2009128520A1 (fr) * | 2008-04-18 | 2009-10-22 | 塩野義製薬株式会社 | Composé hétérocyclique présentant une activité inhibitrice sur p13k |
EP2344470B1 (fr) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | Dérivés de 3-azabicyclo[3.1.0]hexyle comme modulateurs des récepteurs métabotropiques du glutamate |
AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
CA2760741C (fr) | 2009-05-12 | 2018-05-01 | Addex Pharma S.A. | Derives de 1,2,3-triazolo[4,3-a]pyridine et leur utilisation pour le traitement ou la prevention de troubles neurologiques et psychiatriques |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
ES2409006T3 (es) | 2009-05-12 | 2013-06-24 | Janssen Pharmaceuticals Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2 |
EP2343294A1 (fr) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines substituées |
DK3511330T3 (da) | 2009-12-31 | 2020-12-21 | Hutchison Medipharma Ltd | Syntetisk mellemprodukt, der er anvendeligt til fremstilling af triazolopyridin-c-met-inhibitorer |
EP2571878B1 (fr) * | 2010-05-17 | 2018-10-17 | Incozen Therapeutics Pvt. Ltd. | Nouveau composés de 3,5-disubstitués-3h-imidazo[4,5-b]pyridine et 3,5- disubstitués -3h-[1,2,3]triazolo[4,5-b]pyridine utilisés comme modulateurs des protéines kinases |
WO2012003338A1 (fr) * | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | Combinaison d'un inhibiteur de cmet et d'un anticorps dirigé contre hgf et/ou cmet |
CA2815002C (fr) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | Derives 1,2,4-triazolo[4,3-a]pyridine et leur utilisation en tant que modulateurs allosteriques positifs des recepteurs mglur2 |
JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
CN103298810B (zh) | 2010-11-08 | 2016-03-16 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
WO2012088266A2 (fr) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Imidazopyridazines et benzimidazoles substitués en tant qu'inhibiteurs de fgfr3 |
CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
BR112014006223A8 (pt) * | 2011-09-15 | 2018-01-09 | Novartis Ag | 3-(quinolin-6-iltio)-[1,2,4-triazol[4,3-a] piradinas 6-substituídas, seus usos, composições farmacêuticas, e combinação |
CN103030654A (zh) * | 2011-10-09 | 2013-04-10 | 济南赛文医药技术有限公司 | 一种小分子c-Met蛋白激酶抑制剂 |
WO2013135674A1 (fr) * | 2012-03-12 | 2013-09-19 | Syngenta Participations Ag | Composés de 2-aryl-acétamide insecticides |
ME02651B (fr) | 2012-06-13 | 2017-06-20 | Incyte Holdings Corp | Composés tricycliques substitués utilisés comme inhibiteurs de fgfr |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
CA2909207C (fr) | 2013-04-19 | 2021-11-02 | Incyte Corporation | Heterocycles bicycliques utilises en tant qu'inhibiteurs de fgfr |
EP2995618B1 (fr) * | 2013-05-10 | 2019-01-09 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Dérivé de la [1,2,4]-triazole-[4,3-a]-pyridine, procédé de préparation correspondant ou application médicale correspondante |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
EP2818471A1 (fr) * | 2013-06-27 | 2014-12-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Composés bicycliques d'azote en tant qu'inhibiteurs de Scyl1 et Grk5 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
KR20200036063A (ko) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
JP6629740B2 (ja) | 2014-01-21 | 2020-01-15 | ヤンセン ファーマシューティカ エヌ.ベー. | 代謝型グルタミン酸作動性受容体サブタイプ2の正のアロステリック調節因子またはオルトステリックアゴニストを含む組み合わせ、およびそれらの使用 |
JP6602778B2 (ja) | 2014-02-13 | 2019-11-06 | インサイト・コーポレイション | Lsd1阻害剤としてのシクロプロピルアミン類 |
US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
TWI664164B (zh) | 2014-02-13 | 2019-07-01 | 美商英塞特控股公司 | 作為lsd1抑制劑之環丙胺 |
WO2015123408A1 (fr) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines en tant qu'inhibiteurs de lsd1 |
TW201613925A (en) | 2014-07-10 | 2016-04-16 | Incyte Corp | Imidazopyrazines as LSD1 inhibitors |
WO2016007727A1 (fr) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1 |
US9695167B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors |
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MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
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WO2016134294A1 (fr) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
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RU2729630C2 (ru) | 2015-06-25 | 2020-08-11 | Тайхо Фармасьютикал Ко., Лтд. | Терапевтическое средство для фиброза |
EP3334709A1 (fr) | 2015-08-12 | 2018-06-20 | Incyte Corporation | Sels d'un inhibiteur de lsd1 |
CN106924260B (zh) * | 2015-12-31 | 2018-05-25 | 北京浦润奥生物科技有限责任公司 | 化合物在制备用于治疗脑胶质瘤的药物中的用途 |
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EP3544978B1 (fr) | 2016-11-23 | 2020-11-04 | Bayer CropScience Aktiengesellschaft | Dérivés de 2-[3-(alkylsulfonyl)-2h-indazol-2-yl]-3h-imidazo[4,5-b]pyridine et composés similaires en tant que pesticides |
HRP20220636T1 (hr) | 2016-12-09 | 2022-07-22 | Denali Therapeutics Inc. | Spojevi korisni kao inhibitori ripk1 |
CA3053739C (fr) | 2017-02-15 | 2023-02-14 | Taiho Pharmaceutical Co., Ltd. | Composition pharmaceutique |
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BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
WO2019213544A2 (fr) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Formes solides d'un inhibiteur de fgfr et leurs procédés de préparation |
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BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
WO2021146424A1 (fr) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
TW202313611A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為fgfr抑制劑之三環雜環 |
TW202334164A (zh) | 2022-01-12 | 2023-09-01 | 美商戴納立製藥公司 | (S)-5-苄基-N-(5-甲基-4-側氧基-2,3,4,5-四氫吡啶並[3,2-b][1,4]氧氮呯-3-基)-4H-1,2,4-三唑-3-甲醯胺的晶型 |
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US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
CA2630884A1 (fr) | 2005-11-30 | 2007-06-07 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de c-met et leurs utilisations |
RS55630B1 (sr) * | 2005-12-21 | 2017-06-30 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
CA2659971A1 (fr) | 2006-08-04 | 2008-02-07 | Takeda Pharmaceutical Company Limited | Derive heterocyclique fusionne et son procede d'utilisation |
US7683060B2 (en) * | 2006-08-07 | 2010-03-23 | Incyte Corporation | Triazolotriazines as kinase inhibitors |
EP1900739A1 (fr) | 2006-08-30 | 2008-03-19 | Cellzome Ag | Dérivés de diazolodiazine comme inhibiteurs de kinases |
CN101594909A (zh) | 2006-09-07 | 2009-12-02 | 比奥根艾迪克Ma公司 | 用于治疗炎性病症、细胞增殖性失调、免疫失调的irak调节剂 |
BRPI0717320A2 (pt) | 2006-10-23 | 2013-10-22 | Sgx Pharmaceuticals Inc | Triazóis bicíclicos como moduladores de proteína cinase |
LT3034075T (lt) * | 2006-11-22 | 2018-11-26 | Incyte Holdings Corporation | Imidazotriazinai ir imidazopirimidinai kaip kinazės inhibitoriai |
PA8792501A1 (es) | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
WO2009106577A1 (fr) * | 2008-02-28 | 2009-09-03 | Novartis Ag | Dérivés d’imidazo[1,2-b]pyridazine pour le traitement de maladies médiées par la tyrosine kinase c-met |
-
2009
- 2009-08-13 UY UY0001032049A patent/UY32049A/es not_active Application Discontinuation
- 2009-08-14 NZ NZ590617A patent/NZ590617A/en not_active IP Right Cessation
- 2009-08-14 ES ES09791542.5T patent/ES2608761T3/es active Active
- 2009-08-14 MX MX2011001732A patent/MX2011001732A/es active IP Right Grant
- 2009-08-14 US US12/541,724 patent/US8178534B2/en not_active Expired - Fee Related
- 2009-08-14 TW TW098127469A patent/TWI455939B/zh not_active IP Right Cessation
- 2009-08-14 KR KR1020117005243A patent/KR20110039383A/ko not_active Application Discontinuation
- 2009-08-14 JP JP2011523198A patent/JP5469666B2/ja not_active Expired - Fee Related
- 2009-08-14 CA CA2731108A patent/CA2731108A1/fr not_active Abandoned
- 2009-08-14 WO PCT/US2009/053913 patent/WO2010019899A1/fr active Application Filing
- 2009-08-14 GE GEAP200912126A patent/GEP20125652B/en unknown
- 2009-08-14 EA EA201170295A patent/EA019723B1/ru not_active IP Right Cessation
- 2009-08-14 PE PE2011000152A patent/PE20110275A1/es not_active Application Discontinuation
- 2009-08-14 AR ARP090103156A patent/AR072936A1/es unknown
- 2009-08-14 BR BRPI0917808A patent/BRPI0917808A2/pt not_active IP Right Cessation
- 2009-08-14 CN CN200980131456.9A patent/CN102124005B/zh not_active Expired - Fee Related
- 2009-08-14 MY MYPI20110564 patent/MY150542A/en unknown
- 2009-08-14 AU AU2009281822A patent/AU2009281822B2/en not_active Expired - Fee Related
- 2009-08-14 EP EP09791542.5A patent/EP2313407B1/fr active Active
-
2011
- 2011-01-18 IL IL210734A patent/IL210734A0/en unknown
- 2011-01-18 ZA ZA2011/00467A patent/ZA201100467B/en unknown
- 2011-02-11 DO DO2011000050A patent/DOP2011000050A/es unknown
- 2011-03-07 MA MA33676A patent/MA32615B1/fr unknown
- 2011-03-11 CO CO11030354A patent/CO6351724A2/es active IP Right Grant
- 2011-03-14 CR CR20110135A patent/CR20110135A/es unknown
- 2011-03-14 EC EC2011010889A patent/ECSP11010889A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2009281822B2 (en) | 2014-11-13 |
US20100063054A1 (en) | 2010-03-11 |
EP2313407B1 (fr) | 2016-10-05 |
AR072936A1 (es) | 2010-09-29 |
CN102124005A (zh) | 2011-07-13 |
ECSP11010889A (es) | 2011-04-29 |
PE20110275A1 (es) | 2011-05-08 |
GEP20125652B (en) | 2012-09-25 |
MY150542A (en) | 2014-01-30 |
AU2009281822A1 (en) | 2010-02-18 |
CA2731108A1 (fr) | 2010-02-18 |
EA201170295A1 (ru) | 2011-08-30 |
CR20110135A (es) | 2011-09-27 |
US8178534B2 (en) | 2012-05-15 |
EA019723B1 (ru) | 2014-05-30 |
WO2010019899A1 (fr) | 2010-02-18 |
IL210734A0 (en) | 2011-03-31 |
DOP2011000050A (es) | 2011-03-15 |
EP2313407A1 (fr) | 2011-04-27 |
UY32049A (es) | 2010-03-26 |
CN102124005B (zh) | 2014-06-04 |
CO6351724A2 (es) | 2011-12-20 |
JP5469666B2 (ja) | 2014-04-16 |
NZ590617A (en) | 2012-05-25 |
KR20110039383A (ko) | 2011-04-15 |
TW201014857A (en) | 2010-04-16 |
TWI455939B (zh) | 2014-10-11 |
ES2608761T3 (es) | 2017-04-12 |
BRPI0917808A2 (pt) | 2019-09-24 |
JP2012500215A (ja) | 2012-01-05 |
MX2011001732A (es) | 2011-03-25 |
ZA201100467B (en) | 2012-03-28 |
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