ES2525837T3 - Antagonistas de ccr2 de ciclohexilamino-4-piperidinil-acetamida sustituida en posición 4 - Google Patents

Antagonistas de ccr2 de ciclohexilamino-4-piperidinil-acetamida sustituida en posición 4 Download PDF

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ES2525837T3
ES2525837T3 ES11794348.0T ES11794348T ES2525837T3 ES 2525837 T3 ES2525837 T3 ES 2525837T3 ES 11794348 T ES11794348 T ES 11794348T ES 2525837 T3 ES2525837 T3 ES 2525837T3
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alkyl
dihydrobenzofuran
ocf3
formula
cyclohexylamino
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James C. Lanter
Thomas P. Markotan
Nalin Subasinghe
Zhihua Sui
Xuqing Zhang
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P11/06—Antiasthmatics
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
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  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

Compuesto de Fórmula (I)**Fórmula** en la que: R1 es**Fórmula** 2,3-dihidroindol-3-ilo, indol-3-ilo, piridilo, pirimidilo, piridazilo, imidazolilo, oxazolilo, isoxazolilo, tiazolilo o pirrolilo; en la que dicho piridilo, pirimidilo, piridazilo, imidazolilo, oxazolilo, isoxazolilo, tiazolilo o pirrolilo está opcionalmente sustituido con OCH3, CH3, OCF3, CF3, OCF3, -CN o C(O)CH3; R2 es H, Cl, CH3, Oalquilo C(1-4) o F; R3 es H, F, Cl, CO2alquilo C(1-4), alquilo C(1-4), Oalquilo C(1-4), Salquilo C(1-4), OCF3, OCH2CF3, -CN, CO2H, C(O)alquilo C(1-4), C(O)NH2, C(O)NHalquilo C(1-4), C(O)N(alquilo C(1-4))2 o CF3; R4 es H, CH3, Oalquilo C(1-4) o F; o R4 puede tomarse junto con R3 y su fenilo fijado para formar un anillo bicíclico seleccionado del grupo que consiste en 2,3-dihidro-1H-inden-5-ilo, 2,3-dihidrobenzofuran-5-ilo, 2,2- difluorobenzo[d][1,3]dioxol-5-ilo, 2,2-dimetil-benzo[d][1,3]dioxol-5-ilo, 2,2-difluoro-2,3-dihidrobenzofuran-5-ilo, 2,2- dimetil-2,3-dihidrobenzofuran-5-ilo, croman-6-ilo y 2,3-dihidrobenzo[b][1,4]dioxin-6-ilo; X es H, OH, NH2 o F; Y es OH, NH2, OC(O)alquilo C(1-4), NHC(O)alquilo C(1-4), Oalquilo C(1-4), NHalquilo C(1-4), N(alquilo C(1-4))2 o NHOH; Z es NH o -HC>=CH-; y tautómeros, y sales farmacéuticamente aceptables de la misma.
ES11794348.0T 2010-12-01 2011-11-30 Antagonistas de ccr2 de ciclohexilamino-4-piperidinil-acetamida sustituida en posición 4 Active ES2525837T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41847910P 2010-12-01 2010-12-01
US418479P 2010-12-01
PCT/US2011/062593 WO2012075115A1 (en) 2010-12-01 2011-11-30 4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of ccr2

Publications (1)

Publication Number Publication Date
ES2525837T3 true ES2525837T3 (es) 2014-12-30

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ES11794348.0T Active ES2525837T3 (es) 2010-12-01 2011-11-30 Antagonistas de ccr2 de ciclohexilamino-4-piperidinil-acetamida sustituida en posición 4

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US (1) US8921559B2 (es)
EP (1) EP2646429B1 (es)
JP (1) JP5868418B2 (es)
KR (1) KR20130121891A (es)
CN (1) CN103228644B (es)
AU (1) AU2011336700B2 (es)
CA (1) CA2819508A1 (es)
ES (1) ES2525837T3 (es)
MX (1) MX345146B (es)
WO (1) WO2012075115A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2764840T3 (es) 2015-01-28 2020-06-04 Univ Bordeaux Uso de plerixafor para tratar y/o prevenir exacerbaciones agudas de la enfermedad pulmonar obstructiva crónica
CN111377849A (zh) * 2018-12-28 2020-07-07 中国人民解放军军事科学院军事医学研究院 化合物、其可药用盐及其医药用途

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EP2646429B1 (en) 2014-10-15
JP2013544841A (ja) 2013-12-19
CA2819508A1 (en) 2012-06-07
WO2012075115A1 (en) 2012-06-07
CN103228644A (zh) 2013-07-31
CN103228644B (zh) 2016-06-01
MX2013006256A (es) 2013-07-02
AU2011336700A1 (en) 2013-06-06
KR20130121891A (ko) 2013-11-06
JP5868418B2 (ja) 2016-02-24
US20120142733A1 (en) 2012-06-07
US8921559B2 (en) 2014-12-30
EP2646429A1 (en) 2013-10-09
MX345146B (es) 2017-01-17
AU2011336700B2 (en) 2016-12-22

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