MA26874A1 - Arylpyrazines substituées - Google Patents
Arylpyrazines substituéesInfo
- Publication number
- MA26874A1 MA26874A1 MA26774A MA26774A MA26874A1 MA 26874 A1 MA26874 A1 MA 26874A1 MA 26774 A MA26774 A MA 26774A MA 26774 A MA26774 A MA 26774A MA 26874 A1 MA26874 A1 MA 26874A1
- Authority
- MA
- Morocco
- Prior art keywords
- arylpyrazines
- conditions
- diseases
- crf1 receptors
- substituted
- Prior art date
Links
- 201000010099 disease Diseases 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 108091005471 CRHR1 Proteins 0.000 abstract 3
- 230000001154 acute effect Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
Abstract
DEPOSANT Société dite : NEUROGEN CORPORATION REVENDICATION DE PRIORITES US 16 Février 2000 60/182,934 US 22 Mai 2000 60/206,455 Voir en annexe le titre de l'invention et le texte de l'abrégé "Arylpyrazines substituées" Il est proposé des arylpyrazines, comprenant des arylpyrazines qui peuvent se lier avec une forte affinité et une grande sélectivité aux récepteurs CRF1, y compris aux récepteurs CRF1 humains. Ainsi, la présente invention comprend des méthodes pour le traitement d'affections et de maladies associées aux récepteurs CRF1, comprenant des affections et maladies en rapport avec le système nerveux central, en particulier des affections et maladies affectives, et des affections et maladies neurologiques aigues et chroniques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18293400P | 2000-02-16 | 2000-02-16 | |
US20645500P | 2000-05-22 | 2000-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA26874A1 true MA26874A1 (fr) | 2004-12-20 |
Family
ID=26878562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA26774A MA26874A1 (fr) | 2000-02-16 | 2002-08-13 | Arylpyrazines substituées |
Country Status (34)
Country | Link |
---|---|
US (3) | US6995161B2 (fr) |
EP (1) | EP1255740B1 (fr) |
JP (1) | JP2004500383A (fr) |
KR (2) | KR20030031886A (fr) |
CN (1) | CN1231473C (fr) |
AP (1) | AP2002002620A0 (fr) |
AT (1) | ATE307121T1 (fr) |
AU (1) | AU783915B2 (fr) |
BG (2) | BG106968A (fr) |
BR (1) | BR0108363A (fr) |
CA (2) | CA2398937A1 (fr) |
CR (1) | CR6735A (fr) |
CZ (1) | CZ20022739A3 (fr) |
DE (1) | DE60114153T2 (fr) |
DK (1) | DK1255740T3 (fr) |
DZ (1) | DZ3293A1 (fr) |
EA (1) | EA006938B1 (fr) |
EE (1) | EE200200453A (fr) |
ES (1) | ES2247070T3 (fr) |
HK (1) | HK1051191A1 (fr) |
HR (1) | HRP20020747A2 (fr) |
HU (1) | HUP0301573A3 (fr) |
IL (1) | IL151020A0 (fr) |
IS (1) | IS2192B (fr) |
MA (1) | MA26874A1 (fr) |
MX (1) | MXPA02007868A (fr) |
NO (1) | NO324473B1 (fr) |
NZ (1) | NZ520484A (fr) |
OA (1) | OA12178A (fr) |
PL (1) | PL365238A1 (fr) |
SK (1) | SK11542002A3 (fr) |
TW (1) | TWI232215B (fr) |
WO (1) | WO2001060806A2 (fr) |
YU (1) | YU61002A (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1330452T3 (da) | 2000-09-20 | 2009-03-16 | Ortho Mcneil Janssen Pharm | Pyrazinderivater som modulatorer af tyrosinkinaser |
MXPA03010692A (es) * | 2001-05-22 | 2004-07-01 | Neurogen Corp | 5-sustituidas-2-arilpiridina como moduladores del factor 1 de liberacion de corticotropina. |
EP1399428A1 (fr) * | 2001-06-12 | 2004-03-24 | Neurogen Corporation | 2,5-diarylpyrazines, 2,5-diarylpyridines et 2,5-diarylpyrimidines utilises comme modulateurs de recepteurs crf1 |
SE0102439D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
SE0102438D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
US6852737B2 (en) * | 2001-08-06 | 2005-02-08 | Recordati Ireland Limited | Crude and crystalline forms of lercanidipine hydrochloride |
US6992087B2 (en) | 2001-11-21 | 2006-01-31 | Pfizer Inc | Substituted aryl 1,4-pyrazine derivatives |
AU2002343557A1 (en) * | 2001-11-21 | 2003-06-10 | Pharmacia And Upjohn Company | Substituted aryl 1,4-pyrazine derivatives |
US6964965B2 (en) | 2002-04-26 | 2005-11-15 | Pharmacia & Upjohn | Substituted pyrazine derivatives |
US7015227B2 (en) | 2002-06-21 | 2006-03-21 | Cgi Pharmaceuticals, Inc. | Certain amino-substituted monocycles as kinase modulators |
CA2496197A1 (fr) * | 2002-08-20 | 2004-03-04 | Neurogen Corporation | 2-arylpyrazines substituees en 5 comme modulateurs sur les recepteurs crf |
EP1539736A1 (fr) * | 2002-09-12 | 2005-06-15 | Pharmacia & Upjohn Company LLC | Derives 1,4-pyrazine substitues |
CA2499133A1 (fr) * | 2002-11-21 | 2004-06-03 | Pharmacia & Upjohn Company Llc | Composes de pyrazine en tant que modulateurs de crf |
SE0203753D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
SE0203754D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
DK2476667T3 (da) | 2003-02-26 | 2014-09-15 | Sugen Inc | Aminoheteroaryl-forbindelser som proteinkinase-inhibitorer |
CA2524519A1 (fr) * | 2003-05-09 | 2004-11-18 | Pharmacia & Upjohn Company Llc | Composes utilises comme antagonistes du recepteur de type 1 de la corticoliberine (crf) |
MXPA05012081A (es) | 2003-05-09 | 2006-02-22 | Pharmacia & Upjohn Co Llc | Derivados de pirimidina sustituidos. |
CN1812981A (zh) * | 2003-06-27 | 2006-08-02 | 万有制药株式会社 | 杂芳氧基含氮饱和杂环衍生物 |
CA2543644A1 (fr) * | 2003-10-27 | 2005-05-06 | Astellas Pharma Inc. | Derives de pyrazine et utilisation pharmaceutique de ce derive |
US20060211710A1 (en) * | 2005-03-17 | 2006-09-21 | Pfizer Inc | Substituted aryl 1,4-pyrazine derivatives |
US20070078135A1 (en) * | 2005-04-18 | 2007-04-05 | Neurogen Corporation | Substituted heteroaryl CB1 antagonists |
SI1963302T1 (sl) * | 2005-12-05 | 2013-04-30 | Pfizer Products Inc. | Polimorfne oblike inhibitorja c-met/hgfr |
ATE488237T1 (de) * | 2005-12-05 | 2010-12-15 | Pfizer Prod Inc | Verfahren zur behandlung von abnormalem zellwachstum |
SG157264A1 (en) * | 2008-06-02 | 2009-12-29 | Inzign Pte Ltd | A golf tee and method of producing a golf tee |
US7932256B2 (en) * | 2008-07-31 | 2011-04-26 | Bristol-Myers Squibb Company | (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile: a pyrazinone modulator of corticotropin-releasing factor receptor activity |
ES2702205T3 (es) | 2014-02-14 | 2019-02-27 | Takeda Pharmaceuticals Co | Moduladores pirazínicos de GPR6 |
WO2016105118A2 (fr) | 2014-12-24 | 2016-06-30 | 주식회사 엘지생명과학 | Dérivé de biaryle utilisable en tant qu'agoniste du gpr120 |
EP4302834A2 (fr) | 2016-07-12 | 2024-01-10 | Revolution Medicines, Inc. | 3-méthylpyrazines 2,5-disubstituées et 3-méthyl pyrazines 2,5,6-trisubstitués en tant qu'inhibiteurs allostériques de shp2 |
BR112019014527A2 (pt) | 2017-01-23 | 2020-02-27 | Revolution Medicines, Inc. | Compostos de piridina como inibidores de shp2 alostéricos |
WO2018136265A1 (fr) | 2017-01-23 | 2018-07-26 | Revolution Medicines, Inc. | Composés bicycliques utilisés en tant qu'inhibiteurs allostériques de shp2 |
RU2672470C1 (ru) * | 2017-07-10 | 2018-11-15 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Способ получения 2,3,5,6-тетрафенил(бензил)пиразина |
KR20200070295A (ko) | 2017-10-12 | 2020-06-17 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 피리딘, 피라진 및 트리아진 화합물 |
EP3724189B1 (fr) | 2017-12-15 | 2023-10-04 | Revolution Medicines, Inc. | Composés polycycliques comme inhibiteurs allosteriques de la shp2 |
AU2019256719A1 (en) * | 2018-04-20 | 2020-11-05 | Virginia Tech Intellectual Properties, Inc. | Oxadiazolopyrazines and oxadiazolopyridines useful as mitochondrial uncouplers |
US20220340546A1 (en) * | 2019-06-14 | 2022-10-27 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 |
GB202006076D0 (en) * | 2020-04-24 | 2020-06-10 | Univ Greenwich | Interleukin inhibitors |
Family Cites Families (20)
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---|---|---|---|---|
DE2425355A1 (de) | 1974-05-25 | 1975-12-04 | Basf Ag | Verfahren zur herstellung von pyrazinen |
SE421695B (sv) * | 1975-04-21 | 1982-01-25 | Merck & Co Inc | Sett att framstella piperazinylpyraziner |
FR2398738A1 (fr) * | 1977-06-22 | 1979-02-23 | Lilly Co Eli | Preparation de benzoylurees |
US4293552A (en) * | 1978-02-27 | 1981-10-06 | Eli Lilly And Company | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas |
US4211870A (en) * | 1979-04-06 | 1980-07-08 | Eli Lilly And Company | Preparation of substituted 2-aminopyrazines |
JPS59144772A (ja) * | 1983-02-08 | 1984-08-18 | Ube Ind Ltd | 液晶性ピラジン誘導体およびその製法 |
JPS625970A (ja) * | 1985-03-15 | 1987-01-12 | Terumo Corp | ピラジン誘導体およびこれを含有する血小板凝集抑制剤 |
JPH0739398B2 (ja) * | 1986-10-04 | 1995-05-01 | 宇部興産株式会社 | 液晶性ピラジン誘導体 |
NZ227684A (en) * | 1988-01-30 | 1991-07-26 | Merck Sharp & Dohme | Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions |
JPH0348666A (ja) | 1989-07-17 | 1991-03-01 | Rasa Kogyo Kk | 芳香族ジアミン化合物の製造方法 |
DE3940477A1 (de) * | 1989-12-07 | 1991-06-13 | Bayer Ag | Hetaryl-substituierte pyridinylpyrimidin-derivate |
GB2272216A (en) * | 1992-11-04 | 1994-05-11 | Merck Patent Gmbh | Liquid crystalline di-, tri- and tetra-fluorinated phenylpyrazines |
JP3398152B2 (ja) * | 1993-10-12 | 2003-04-21 | ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー | 1n−アルキル−n−アリールピリミジンアミンおよびその誘導体 |
AU7095496A (en) * | 1995-09-26 | 1997-04-17 | Nippon Soda Co., Ltd. | Pyrazole compounds, process for preparing the same, and agrohorticultural bactericide |
US6159980A (en) * | 1996-09-16 | 2000-12-12 | Dupont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
MA26473A1 (fr) * | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
BE1011077A3 (fr) | 1997-03-28 | 1999-04-06 | Univ Catholique Louvain | Composition pharmaceutique, cosmetique et/ou alimentaire aux proprietes anti-oxydantes. |
TR200002225T2 (tr) | 1998-01-28 | 2000-12-21 | Shionogi & Co., Ltd | Yeni trisiklik bileşimler |
GB9818881D0 (en) * | 1998-08-28 | 1998-10-21 | Glaxo Group Ltd | Compounds |
WO2000045800A2 (fr) | 1999-02-02 | 2000-08-10 | K.U. Leuven Research & Development | Effets immunosuppresseurs des derives de pteridine |
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2001
- 2001-02-16 OA OA1200200251A patent/OA12178A/en unknown
- 2001-02-16 US US09/788,315 patent/US6995161B2/en not_active Expired - Lifetime
- 2001-02-16 HU HU0301573A patent/HUP0301573A3/hu unknown
- 2001-02-16 KR KR1020027010403A patent/KR20030031886A/ko not_active Application Discontinuation
- 2001-02-16 KR KR1020077027017A patent/KR20080021603A/ko not_active Application Discontinuation
- 2001-02-16 DZ DZ013293A patent/DZ3293A1/fr active
- 2001-02-16 AT AT01910939T patent/ATE307121T1/de not_active IP Right Cessation
- 2001-02-16 MX MXPA02007868A patent/MXPA02007868A/es active IP Right Grant
- 2001-02-16 DK DK01910939T patent/DK1255740T3/da active
- 2001-02-16 NZ NZ520484A patent/NZ520484A/en unknown
- 2001-02-16 EE EEP200200453A patent/EE200200453A/xx unknown
- 2001-02-16 PL PL01365238A patent/PL365238A1/xx not_active Application Discontinuation
- 2001-02-16 JP JP2001560191A patent/JP2004500383A/ja active Pending
- 2001-02-16 IL IL15102001A patent/IL151020A0/xx unknown
- 2001-02-16 EA EA200200766A patent/EA006938B1/ru unknown
- 2001-02-16 TW TW090103566A patent/TWI232215B/zh not_active IP Right Cessation
- 2001-02-16 SK SK1154-2002A patent/SK11542002A3/sk not_active Application Discontinuation
- 2001-02-16 WO PCT/US2001/005264 patent/WO2001060806A2/fr active IP Right Grant
- 2001-02-16 CA CA002398937A patent/CA2398937A1/fr not_active Abandoned
- 2001-02-16 AP APAP/P/2002/002620A patent/AP2002002620A0/en unknown
- 2001-02-16 EP EP01910939A patent/EP1255740B1/fr not_active Expired - Lifetime
- 2001-02-16 BR BR0108363-5A patent/BR0108363A/pt not_active IP Right Cessation
- 2001-02-16 DE DE60114153T patent/DE60114153T2/de not_active Expired - Lifetime
- 2001-02-16 CA CA002651825A patent/CA2651825A1/fr not_active Abandoned
- 2001-02-16 CZ CZ20022739A patent/CZ20022739A3/cs unknown
- 2001-02-16 ES ES01910939T patent/ES2247070T3/es not_active Expired - Lifetime
- 2001-02-16 YU YU61002A patent/YU61002A/sh unknown
- 2001-02-16 CN CNB018051316A patent/CN1231473C/zh not_active Expired - Fee Related
- 2001-02-16 AU AU38494/01A patent/AU783915B2/en not_active Ceased
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2002
- 2002-07-29 IS IS6488A patent/IS2192B/is unknown
- 2002-07-31 BG BG106968A patent/BG106968A/bg unknown
- 2002-07-31 BG BG110174A patent/BG110174A/en unknown
- 2002-08-13 MA MA26774A patent/MA26874A1/fr unknown
- 2002-08-15 NO NO20023869A patent/NO324473B1/no not_active IP Right Cessation
- 2002-08-23 CR CR6735A patent/CR6735A/es not_active Application Discontinuation
- 2002-09-11 HR HRP20020747 patent/HRP20020747A2/hr not_active Application Discontinuation
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2003
- 2003-05-13 HK HK03103353A patent/HK1051191A1/xx not_active IP Right Cessation
-
2005
- 2005-04-15 US US11/107,148 patent/US7202250B2/en not_active Expired - Fee Related
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2007
- 2007-02-16 US US11/675,648 patent/US20070225287A1/en not_active Abandoned
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