DK1255740T3 - Substituerede arylpyraziner - Google Patents
Substituerede arylpyrazinerInfo
- Publication number
- DK1255740T3 DK1255740T3 DK01910939T DK01910939T DK1255740T3 DK 1255740 T3 DK1255740 T3 DK 1255740T3 DK 01910939 T DK01910939 T DK 01910939T DK 01910939 T DK01910939 T DK 01910939T DK 1255740 T3 DK1255740 T3 DK 1255740T3
- Authority
- DK
- Denmark
- Prior art keywords
- arylpyrazines
- substituted
- substituted arylpyrazines
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Photoreceptors In Electrophotography (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18293400P | 2000-02-16 | 2000-02-16 | |
US20645500P | 2000-05-22 | 2000-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1255740T3 true DK1255740T3 (da) | 2006-02-06 |
Family
ID=26878562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01910939T DK1255740T3 (da) | 2000-02-16 | 2001-02-16 | Substituerede arylpyraziner |
Country Status (34)
Country | Link |
---|---|
US (3) | US6995161B2 (da) |
EP (1) | EP1255740B1 (da) |
JP (1) | JP2004500383A (da) |
KR (2) | KR20030031886A (da) |
CN (1) | CN1231473C (da) |
AP (1) | AP2002002620A0 (da) |
AT (1) | ATE307121T1 (da) |
AU (1) | AU783915B2 (da) |
BG (2) | BG106968A (da) |
BR (1) | BR0108363A (da) |
CA (2) | CA2398937A1 (da) |
CR (1) | CR6735A (da) |
CZ (1) | CZ20022739A3 (da) |
DE (1) | DE60114153T2 (da) |
DK (1) | DK1255740T3 (da) |
DZ (1) | DZ3293A1 (da) |
EA (1) | EA006938B1 (da) |
EE (1) | EE200200453A (da) |
ES (1) | ES2247070T3 (da) |
HK (1) | HK1051191A1 (da) |
HR (1) | HRP20020747A2 (da) |
HU (1) | HUP0301573A3 (da) |
IL (1) | IL151020A0 (da) |
IS (1) | IS2192B (da) |
MA (1) | MA26874A1 (da) |
MX (1) | MXPA02007868A (da) |
NO (1) | NO324473B1 (da) |
NZ (1) | NZ520484A (da) |
OA (1) | OA12178A (da) |
PL (1) | PL365238A1 (da) |
SK (1) | SK11542002A3 (da) |
TW (1) | TWI232215B (da) |
WO (1) | WO2001060806A2 (da) |
YU (1) | YU61002A (da) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6710048B2 (en) | 2000-09-20 | 2004-03-23 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazine derivatives as modulators of tyrosine kinases |
KR20040015716A (ko) * | 2001-05-22 | 2004-02-19 | 뉴로젠 코포레이션 | Crf1 조절자로서의 5-치환된-2-아릴피리딘 |
HUP0400179A3 (en) * | 2001-06-12 | 2004-10-28 | Neurogen Corp Branford | 2,5-diarylpyrazines, 2,5-diarylpyridines and 2,5-diarylpyrimidines, their use and pharmaceutical compositions containing them |
SE0102438D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
SE0102439D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
US6852737B2 (en) * | 2001-08-06 | 2005-02-08 | Recordati Ireland Limited | Crude and crystalline forms of lercanidipine hydrochloride |
US6992087B2 (en) | 2001-11-21 | 2006-01-31 | Pfizer Inc | Substituted aryl 1,4-pyrazine derivatives |
DK1446387T3 (da) * | 2001-11-21 | 2009-12-21 | Pharmacia & Upjohn Co Llc | Substituerede aryl, 1,4-pyrazinderivater |
JP2005533014A (ja) * | 2002-04-26 | 2005-11-04 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 置換ピラジン誘導体 |
AU2003249369A1 (en) | 2002-06-21 | 2004-01-06 | Cellular Genomics, Inc. | Certain amino-substituted monocycles as kinase modulators |
EP1554258A1 (en) | 2002-08-20 | 2005-07-20 | Neurogen Corporation | 5-substituted-2-arylpyrazines as modulators of crf receptors |
AU2003269949A1 (en) * | 2002-09-12 | 2004-04-30 | Pharmacia & Upjohn Company Llc | Substituted 1,4-pyrazine derivatives |
BR0315845A (pt) * | 2002-11-21 | 2005-09-27 | Pharmacia & Upjohn Co Llc | Compostos de pirazina como moduladores de crf |
SE0203754D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
SE0203753D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
NZ541861A (en) | 2003-02-26 | 2009-05-31 | Sugen Inc | Aminoheteroaryl compounds as protein kinase inhibitors |
CA2524352A1 (en) | 2003-05-09 | 2004-11-18 | Pharmacia & Upjohn Company Llc | Substituted pyrimidine derivatives |
WO2004099201A1 (en) | 2003-05-09 | 2004-11-18 | Pharmacia & Upjohn Company Llc | Compounds as crf1 receptor antagonists |
AU2004257025B9 (en) * | 2003-06-27 | 2010-05-27 | Msd K.K. | Heteroaryloxy nitrogenous saturated heterocyclic derivative |
WO2005040151A1 (en) * | 2003-10-27 | 2005-05-06 | Astellas Pharma Inc. | Pyrazine derivatives and pharmaceutical use thereof |
US20060211710A1 (en) * | 2005-03-17 | 2006-09-21 | Pfizer Inc | Substituted aryl 1,4-pyrazine derivatives |
JP2008536950A (ja) * | 2005-04-18 | 2008-09-11 | ニューロジェン・コーポレーション | 置換ヘテロアリールのcb1拮抗薬 |
NZ568654A (en) * | 2005-12-05 | 2012-02-24 | Pfizer Prod Inc | Method of treating abnormal cell growth |
PT1963302E (pt) * | 2005-12-05 | 2013-04-09 | Pfizer Prod Inc | Polimorfos de um inibidor de c-met/hgfr |
SG157264A1 (en) * | 2008-06-02 | 2009-12-29 | Inzign Pte Ltd | A golf tee and method of producing a golf tee |
US7932256B2 (en) * | 2008-07-31 | 2011-04-26 | Bristol-Myers Squibb Company | (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile: a pyrazinone modulator of corticotropin-releasing factor receptor activity |
WO2015123533A1 (en) | 2014-02-14 | 2015-08-20 | Takeda Pharmaceutical Company Limited | Pyrazines modulators of gpr6 |
KR101829290B1 (ko) * | 2014-12-24 | 2018-02-19 | 주식회사 엘지화학 | Gpr120 효능제로서의 바이아릴 유도체 |
IL311645A (en) | 2016-07-12 | 2024-05-01 | Revolution Medicines Inc | 2,5-dimethomers of 3-methylpyrazines and 2,5,6-dimethomers of 3-methylpyrazines as allosteric SHP2 inhibitors |
CA3051054A1 (en) | 2017-01-23 | 2018-07-26 | Revolution Medicines, Inc. | Pyridine compounds as allosteric shp2 inhibitors |
MX2019008695A (es) | 2017-01-23 | 2019-09-11 | Revolution Medicines Inc | Compuestos biciclicos como inhibidores alostericos de shp2. |
RU2672470C1 (ru) * | 2017-07-10 | 2018-11-15 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Способ получения 2,3,5,6-тетрафенил(бензил)пиразина |
JP2020536881A (ja) | 2017-10-12 | 2020-12-17 | レヴォリューション・メディスンズ,インコーポレイテッド | アロステリックshp2阻害剤としてのピリジン、ピラジンおよびトリアジン化合物 |
CN111433205B (zh) | 2017-12-15 | 2024-01-19 | 锐新医药公司 | 作为变构shp2抑制剂的多环化合物 |
US20210253594A1 (en) * | 2018-04-20 | 2021-08-19 | Virginia Tech Intellectual Properties, Inc. | Oxadiazolopyrazines and oxadiazolopyridines useful as mitochondrial uncouplers |
EP3982949A4 (en) * | 2019-06-14 | 2023-10-11 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS |
GB202006076D0 (en) * | 2020-04-24 | 2020-06-10 | Univ Greenwich | Interleukin inhibitors |
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DE2425355A1 (de) | 1974-05-25 | 1975-12-04 | Basf Ag | Verfahren zur herstellung von pyrazinen |
EG12387A (en) * | 1975-04-21 | 1978-12-31 | Merck & Co Inc | Process for preparing of piperazinyl pyrazines |
FR2398738A1 (fr) * | 1977-06-22 | 1979-02-23 | Lilly Co Eli | Preparation de benzoylurees |
US4293552A (en) | 1978-02-27 | 1981-10-06 | Eli Lilly And Company | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas |
US4211870A (en) * | 1979-04-06 | 1980-07-08 | Eli Lilly And Company | Preparation of substituted 2-aminopyrazines |
JPS59144772A (ja) * | 1983-02-08 | 1984-08-18 | Ube Ind Ltd | 液晶性ピラジン誘導体およびその製法 |
JPS625970A (ja) | 1985-03-15 | 1987-01-12 | Terumo Corp | ピラジン誘導体およびこれを含有する血小板凝集抑制剤 |
JPH0739398B2 (ja) * | 1986-10-04 | 1995-05-01 | 宇部興産株式会社 | 液晶性ピラジン誘導体 |
NZ227684A (en) * | 1988-01-30 | 1991-07-26 | Merck Sharp & Dohme | Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions |
JPH0348666A (ja) | 1989-07-17 | 1991-03-01 | Rasa Kogyo Kk | 芳香族ジアミン化合物の製造方法 |
DE3940477A1 (de) * | 1989-12-07 | 1991-06-13 | Bayer Ag | Hetaryl-substituierte pyridinylpyrimidin-derivate |
GB2272216A (en) * | 1992-11-04 | 1994-05-11 | Merck Patent Gmbh | Liquid crystalline di-, tri- and tetra-fluorinated phenylpyrazines |
CN1142817A (zh) * | 1993-10-12 | 1997-02-12 | 杜邦麦克制药有限公司 | 1n-烷基-n-芳基嘧啶胺及其衍生物 |
AU7095496A (en) * | 1995-09-26 | 1997-04-17 | Nippon Soda Co., Ltd. | Pyrazole compounds, process for preparing the same, and agrohorticultural bactericide |
AU4270297A (en) | 1996-09-16 | 1998-04-02 | Du Pont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
MA26473A1 (fr) * | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
BE1011077A3 (fr) | 1997-03-28 | 1999-04-06 | Univ Catholique Louvain | Composition pharmaceutique, cosmetique et/ou alimentaire aux proprietes anti-oxydantes. |
KR100404358B1 (ko) | 1998-01-28 | 2003-11-03 | 시오노기세이야쿠가부시키가이샤 | 신규 삼환식 화합물 |
GB9818881D0 (en) * | 1998-08-28 | 1998-10-21 | Glaxo Group Ltd | Compounds |
AU780284B2 (en) | 1999-02-02 | 2005-03-10 | 4-Aza Bioscience Nv | Immunosurpressive effects of pteridine derivatives |
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2001
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- 2001-02-16 BR BR0108363-5A patent/BR0108363A/pt not_active IP Right Cessation
- 2001-02-16 AT AT01910939T patent/ATE307121T1/de not_active IP Right Cessation
- 2001-02-16 EE EEP200200453A patent/EE200200453A/xx unknown
- 2001-02-16 JP JP2001560191A patent/JP2004500383A/ja active Pending
- 2001-02-16 KR KR1020027010403A patent/KR20030031886A/ko not_active Application Discontinuation
- 2001-02-16 CA CA002398937A patent/CA2398937A1/en not_active Abandoned
- 2001-02-16 MX MXPA02007868A patent/MXPA02007868A/es active IP Right Grant
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- 2001-02-16 SK SK1154-2002A patent/SK11542002A3/sk not_active Application Discontinuation
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- 2001-02-16 CA CA002651825A patent/CA2651825A1/en not_active Abandoned
- 2001-02-16 CN CNB018051316A patent/CN1231473C/zh not_active Expired - Fee Related
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- 2001-02-16 US US09/788,315 patent/US6995161B2/en not_active Expired - Lifetime
- 2001-02-16 EP EP01910939A patent/EP1255740B1/en not_active Expired - Lifetime
- 2001-02-16 CZ CZ20022739A patent/CZ20022739A3/cs unknown
- 2001-02-16 ES ES01910939T patent/ES2247070T3/es not_active Expired - Lifetime
- 2001-02-16 KR KR1020077027017A patent/KR20080021603A/ko not_active Application Discontinuation
- 2001-02-16 DZ DZ013293A patent/DZ3293A1/fr active
- 2001-02-16 DE DE60114153T patent/DE60114153T2/de not_active Expired - Lifetime
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2002
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- 2002-07-31 BG BG110174A patent/BG110174A/en unknown
- 2002-08-13 MA MA26774A patent/MA26874A1/fr unknown
- 2002-08-15 NO NO20023869A patent/NO324473B1/no not_active IP Right Cessation
- 2002-08-23 CR CR6735A patent/CR6735A/es not_active Application Discontinuation
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