MA19909A1 - Procede de preparation de nouveaux derives dichlores de la serie 16a-methyl pregnane. - Google Patents

Procede de preparation de nouveaux derives dichlores de la serie 16a-methyl pregnane.

Info

Publication number
MA19909A1
MA19909A1 MA20132A MA20132A MA19909A1 MA 19909 A1 MA19909 A1 MA 19909A1 MA 20132 A MA20132 A MA 20132A MA 20132 A MA20132 A MA 20132A MA 19909 A1 MA19909 A1 MA 19909A1
Authority
MA
Morocco
Prior art keywords
preparation
new
pregnane series
methyl pregnane
dichlorinated
Prior art date
Application number
MA20132A
Other languages
English (en)
Inventor
Georges Teutsch Jean
Benzoni Josette
Deraedt Roger
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of MA19909A1 publication Critical patent/MA19909A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/13—Monohydroxylic alcohols containing saturated rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA20132A 1982-10-05 1983-09-28 Procede de preparation de nouveaux derives dichlores de la serie 16a-methyl pregnane. MA19909A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8216668A FR2533928A1 (fr) 1982-10-05 1982-10-05 Nouveaux derives dichlores de la serie du 16a-methyl pregnane, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
MA19909A1 true MA19909A1 (fr) 1984-04-01

Family

ID=9277977

Family Applications (1)

Application Number Title Priority Date Filing Date
MA20132A MA19909A1 (fr) 1982-10-05 1983-09-28 Procede de preparation de nouveaux derives dichlores de la serie 16a-methyl pregnane.

Country Status (22)

Country Link
US (1) US4515787A (fr)
JP (1) JPS59116300A (fr)
AT (1) AT385996B (fr)
AU (1) AU563739B2 (fr)
BE (1) BE897906A (fr)
CA (1) CA1203234A (fr)
CH (1) CH659251A5 (fr)
DE (1) DE3336292A1 (fr)
DK (1) DK164062C (fr)
ES (1) ES526212A0 (fr)
FI (1) FI77668C (fr)
FR (1) FR2533928A1 (fr)
GB (1) GB2127827B (fr)
HU (1) HU190506B (fr)
IE (1) IE56022B1 (fr)
IT (1) IT1197713B (fr)
MA (1) MA19909A1 (fr)
NL (1) NL8303409A (fr)
NO (1) NO157864C (fr)
OA (1) OA07558A (fr)
SE (1) SE447388B (fr)
ZA (1) ZA836538B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2561919B1 (fr) * 1984-04-03 1986-12-19 Roussel Uclaf Composition pharmaceutique constituee d'une part, a titre de principe actif, par la 9a,11b-dichloro 16a-methyl 21-oxycarbonyldicyclohexyl methyloxy pregna-1,4-diene 3,20-dione et d'autre part, par un excipient pharmaceutique inerte apte a permettre l'action du produit dans le rectum ou le colon
GB8512738D0 (en) * 1984-09-04 1985-06-26 Gen Electric Silylation method
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
US7247607B2 (en) * 2001-11-08 2007-07-24 Green & Clean, Inc. Active soluble cleaning composite of natural state using soybean fatty acids and the making method thereof
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2342738A1 (fr) * 1976-03-02 1977-09-30 Roussel Uclaf Nouveaux derives halogenes de la serie du 16a-methyl pregnane
FR2381065A2 (fr) * 1977-02-22 1978-09-15 Roussel Uclaf Nouveaux derives halogenes de la serie du 16 a-methyl pregnane
FR2462443A1 (fr) * 1979-07-26 1981-02-13 Roussel Uclaf Nouveau derive halogene de la serie du 16a-methyl pregnane, son procede de preparation et son application comme medicament

Also Published As

Publication number Publication date
ES8405812A1 (es) 1984-06-16
AU563739B2 (en) 1987-07-23
FR2533928A1 (fr) 1984-04-06
GB2127827B (en) 1986-01-29
IE832337L (en) 1984-04-05
AT385996B (de) 1988-06-10
HU190506B (en) 1986-09-29
IT1197713B (it) 1988-12-06
FI77668B (fi) 1988-12-30
ES526212A0 (es) 1984-06-16
ZA836538B (en) 1984-10-31
NO832738L (no) 1984-04-06
ATA352783A (de) 1987-11-15
US4515787A (en) 1985-05-07
SE447388B (sv) 1986-11-10
AU1982483A (en) 1984-04-12
BE897906A (fr) 1984-04-04
GB2127827A (en) 1984-04-18
SE8304062L (sv) 1984-04-06
FR2533928B1 (fr) 1985-05-03
FI77668C (fi) 1989-04-10
JPH0412279B2 (fr) 1992-03-04
NL8303409A (nl) 1984-05-01
DK164062B (da) 1992-05-04
DK456483D0 (da) 1983-10-04
JPS59116300A (ja) 1984-07-05
DE3336292A1 (de) 1984-04-05
OA07558A (fr) 1985-03-31
SE8304062D0 (sv) 1983-07-20
GB8326527D0 (en) 1983-11-02
NO157864C (no) 1988-06-01
DK164062C (da) 1992-09-28
DE3336292C2 (fr) 1992-09-10
NO157864B (no) 1988-02-22
FI833602A (fi) 1984-04-06
FI833602A0 (fi) 1983-10-04
CH659251A5 (fr) 1987-01-15
CA1203234A (fr) 1986-04-15
IE56022B1 (en) 1991-03-27
DK456483A (da) 1984-04-06

Similar Documents

Publication Publication Date Title
PT76307A (fr) Procede de preparation de nouveaux derives 3-ceto delta 4,9 19-nor steroides
RO89714A (fr) Procede de preparation des derives de 5-methylthiopyrimidine
MA20110A1 (fr) Procede de preparation de derives du cepheme.
FR2527615B1 (fr) Procede de preparation du 26,26,26,27,27,27-hexafluoro-1a,25-dihydroxycholesterol
MC1527A1 (fr) Procede pour la preparation de derives de 1-sulfo-2-oxoazetidine
MA19783A1 (fr) Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines.
MA21348A1 (fr) Procede pour la preparation de nouveaux derives aminoalcoxyphenyle.
FR2517308B1 (fr) Procede de preparation de derives de 3-alcoxymethylcephalosporines
MA19909A1 (fr) Procede de preparation de nouveaux derives dichlores de la serie 16a-methyl pregnane.
MA19925A1 (fr) Procede de preparation de 3-aryl-7chloro-3, 4-dihydroacridine-1, 9-(2H-10H)-dione-1-oxines et -1-hydrazones
MA21167A1 (fr) Procede de preparation de nouveaux derives oxy-5 du tetrahydrofurane.
RO85384A (fr) Procede de preparation des derives de la pyridine
MA21130A1 (fr) Procede de preparation de nouveaux aminopropionamides .
FR2511681B1 (fr) Procede pour la preparation de derives de 3-exo-methylenecephame
FR2505820B1 (fr) Procede de preparation de derives de (7e-9z)-alcadienols
FR2549039B1 (fr) Procede de preparation de 3,3,3-trifluoro-2-trifluoro-mehylpropene
PT74559A (fr) Procede de preparation de trifluoromethylphenyl-tetrahydropyri-dines substituees
FR2562896B1 (fr) Procede de preparation de derives de 3-exomethylenecephame
BE890748A (fr) Procede de preparation de derives de 11-dedecen-1-yle
FR2535314B1 (fr) Procede de preparation de derives de 2-cyclopentenone
MA20092A1 (fr) Procede de preparation de derives de pyrimidinetrione.
BE896599A (fr) Procede perfectionne de preparation de l-lysine.
PT75135B (fr) Procede de preparation de nouveaux derives de benzoyl-phenylpiperidines
MA21352A1 (fr) Procede de preparation de nouveaux derives de thieno-imidazole substitues.
PT81139A (fr) Procede de preparation de nouveaux derives de (alcoxy-2) phenylpiperaziniques