LU90008B1 - Acide(-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)-phenoxy)butyrique a titre d'inhibiteur de l'adhésion cellulaire - Google Patents

Acide(-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)-phenoxy)butyrique a titre d'inhibiteur de l'adhésion cellulaire Download PDF

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Publication number
LU90008B1
LU90008B1 LU90008A LU90008A LU90008B1 LU 90008 B1 LU90008 B1 LU 90008B1 LU 90008 A LU90008 A LU 90008A LU 90008 A LU90008 A LU 90008A LU 90008 B1 LU90008 B1 LU 90008B1
Authority
LU
Luxembourg
Prior art keywords
piperazin
phenoxy
pyridyl
methyl
butyric acid
Prior art date
Application number
LU90008A
Other languages
English (en)
French (fr)
Inventor
Stuart Dennett Mills
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/457,538 external-priority patent/US5652242A/en
Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of LU90008B1 publication Critical patent/LU90008B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
LU90008A 1995-06-01 1997-01-22 Acide(-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)-phenoxy)butyrique a titre d'inhibiteur de l'adhésion cellulaire LU90008B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/457,538 US5652242A (en) 1993-03-29 1995-06-01 Heterocyclic derivatives
GBGB9518188.9A GB9518188D0 (en) 1995-09-07 1995-09-07 Optically active derivative
PCT/GB1996/001260 WO1996038416A1 (en) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor

Publications (1)

Publication Number Publication Date
LU90008B1 true LU90008B1 (fr) 1997-04-16

Family

ID=26307696

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90008A LU90008B1 (fr) 1995-06-01 1997-01-22 Acide(-)-(3R)-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)-phenoxy)butyrique a titre d'inhibiteur de l'adhésion cellulaire

Country Status (31)

Country Link
EP (1) EP0796247A1 (xx)
JP (1) JP2885941B2 (xx)
KR (1) KR100245957B1 (xx)
AT (1) AT406675B (xx)
AU (1) AU710105B2 (xx)
BE (1) BE1009520A5 (xx)
BR (1) BR9606409A (xx)
CA (1) CA2194397A1 (xx)
CH (1) CH691808A5 (xx)
CZ (1) CZ26997A3 (xx)
DE (1) DE19680509T1 (xx)
DK (1) DK10697A (xx)
ES (1) ES2137886B1 (xx)
FI (1) FI970393A (xx)
GB (1) GB2304340B (xx)
GR (1) GR1002702B (xx)
HU (1) HUP9700274A3 (xx)
IE (1) IE960405A1 (xx)
IL (1) IL118477A0 (xx)
IT (1) IT1290839B1 (xx)
LU (1) LU90008B1 (xx)
MC (1) MC2418A1 (xx)
MX (1) MX9700379A (xx)
NL (1) NL1003243C2 (xx)
NO (1) NO307460B1 (xx)
NZ (1) NZ308597A (xx)
PL (1) PL318440A1 (xx)
SE (1) SE510812C2 (xx)
SK (1) SK13097A3 (xx)
TR (1) TR199700020T1 (xx)
WO (1) WO1996038416A1 (xx)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
GB9406144D0 (en) * 1993-03-29 1994-05-18 Zeneca Ltd Heterocyclic compounds
DK0691959T3 (da) * 1993-03-29 1999-04-26 Zeneca Ltd Heterocykliske derivater som blodpladeaggregations-inhibitorer

Also Published As

Publication number Publication date
TR199700020T1 (tr) 1997-04-22
AU710105B2 (en) 1999-09-16
ES2137886B1 (es) 2000-08-16
NL1003243C2 (nl) 1996-12-04
FI970393A0 (fi) 1997-01-30
ES2137886A1 (es) 1999-12-16
NZ308597A (en) 1998-11-25
HU9700274D0 (en) 1997-04-28
BE1009520A5 (fr) 1997-04-01
CH691808A5 (de) 2001-10-31
MX9700379A (es) 1997-04-30
AT406675B (de) 2000-07-25
EP0796247A1 (en) 1997-09-24
SE9700203L (sv) 1997-01-24
ATA900596A (de) 1999-12-15
KR100245957B1 (ko) 2000-04-01
NO970437D0 (no) 1997-01-31
HUP9700274A3 (en) 2000-02-28
IT1290839B1 (it) 1998-12-14
GB2304340B (en) 1998-07-29
CZ26997A3 (en) 1997-08-13
GB9627127D0 (en) 1997-02-19
BR9606409A (pt) 1997-09-30
SK13097A3 (en) 1997-08-06
AU5827296A (en) 1996-12-18
NO970437L (no) 1997-02-20
HUP9700274A2 (hu) 1999-06-28
IE960405A1 (en) 1996-12-11
IL118477A0 (en) 1996-09-12
JP2885941B2 (ja) 1999-04-26
ITMI961113A1 (it) 1997-12-01
JPH09512836A (ja) 1997-12-22
PL318440A1 (en) 1997-06-09
GB2304340A (en) 1997-03-19
MC2418A1 (fr) 1997-05-23
GR1002702B (el) 1997-05-22
DK10697A (da) 1997-04-01
DE19680509T1 (de) 1997-12-04
SE9700203D0 (sv) 1997-01-24
CA2194397A1 (en) 1996-12-05
NO307460B1 (no) 2000-04-10
WO1996038416A1 (en) 1996-12-05
SE510812C2 (sv) 1999-06-28
FI970393A (fi) 1997-01-30
ITMI961113A0 (it) 1996-05-31
KR970704689A (ko) 1997-09-06

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