LU86874A1 - Erhoehte expression von human-interleukin-2 in saeugerzellen - Google Patents

Erhoehte expression von human-interleukin-2 in saeugerzellen Download PDF

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Publication number
LU86874A1
LU86874A1 LU86874A LU86874A LU86874A1 LU 86874 A1 LU86874 A1 LU 86874A1 LU 86874 A LU86874 A LU 86874A LU 86874 A LU86874 A LU 86874A LU 86874 A1 LU86874 A1 LU 86874A1
Authority
LU
Luxembourg
Prior art keywords
gene
sequence
dna
hil
mammalian cell
Prior art date
Application number
LU86874A
Other languages
German (de)
English (en)
Inventor
Bryan Richard Cullen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of LU86874A1 publication Critical patent/LU86874A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
LU86874A 1986-05-12 1987-05-08 Erhoehte expression von human-interleukin-2 in saeugerzellen LU86874A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86208286 1986-05-12
US06/862,082 US4992367A (en) 1986-05-12 1986-05-12 Enhanced expression of human interleukin-2 in mammalian cells

Publications (1)

Publication Number Publication Date
LU86874A1 true LU86874A1 (fr) 1988-06-13

Family

ID=25337602

Family Applications (1)

Application Number Title Priority Date Filing Date
LU86874A LU86874A1 (fr) 1986-05-12 1987-05-08 Erhoehte expression von human-interleukin-2 in saeugerzellen

Country Status (25)

Country Link
US (1) US4992367A (fr)
JP (1) JPS62278994A (fr)
AR (1) AR241794A1 (fr)
AT (1) AT389892B (fr)
AU (1) AU603576B2 (fr)
BE (1) BE1000717A5 (fr)
CH (1) CH675731A5 (fr)
DE (1) DE3715808A1 (fr)
DK (1) DK234087A (fr)
ES (2) ES2006476A6 (fr)
FI (1) FI872096A (fr)
FR (1) FR2598433B1 (fr)
GB (1) GB2190382B (fr)
GR (1) GR870727B (fr)
HU (1) HU205384B (fr)
IL (1) IL82475A0 (fr)
IT (1) IT1215478B (fr)
LU (1) LU86874A1 (fr)
MC (1) MC1821A1 (fr)
NL (1) NL8701132A (fr)
NO (1) NO871939L (fr)
NZ (1) NZ220246A (fr)
PT (1) PT84849B (fr)
SE (1) SE8701934L (fr)
ZA (1) ZA872768B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8820676A (nl) * 1987-08-26 1989-07-03 Biogen Inc Biologische materialen, werkwijzen ter bereiding van biologische materialen en de toepassing van dergelijke materialen in therapie.
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices
FR2636231A1 (fr) * 1988-09-09 1990-03-16 Sanofi Sa Cellules eucaryotes recombinees productrices d'interleukine-1 (beta) mature n-glycosylee, procede et vecteurs necessaires pour leur obtention et procede d'obtention d'interleukine-1 (beta) mature n-glycosylee
WO1990010069A1 (fr) * 1989-02-28 1990-09-07 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr ADN pAA 1213-23 ET pAC 262-33 DE PLASMIDE DE RECOMBINAISON CODANT POUR LA SYNTHESE D'INTERLEUKINE-2 HUMAINE, LEUR PROCEDE DE CONSTRUCTION ET SOUCHE DE BACTERIES ESCHERICHIA COLI RRI/pAC 262-33 EN TANT QUE PRODUCTEUR D'INTERLEUKINE-2 HUMAINE
IL95330A0 (en) * 1989-08-11 1991-06-30 Lilly Co Eli Expression of a functional insect specific toxin gene in mammalian cells
GB9106185D0 (en) * 1991-03-22 1991-05-08 Wellcome Found Biological control agents
US5856178A (en) * 1993-08-30 1999-01-05 Utah State University DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same
US5548075A (en) * 1993-08-30 1996-08-20 Utah State University DNA cassette and transgenic organisms carrying lytic peptide-encoding genes
US5641665A (en) * 1994-11-28 1997-06-24 Vical Incorporated Plasmids suitable for IL-2 expression
US5686246A (en) * 1995-08-03 1997-11-11 Kornman; Kenneth S. Detecting genetic predisposition to periodontal disease
US6190901B1 (en) 1995-10-17 2001-02-20 Wayne State University Chicken interleukin-15 and uses thereof
US6001613A (en) * 1996-05-24 1999-12-14 Board Of Regents Of University Of Nebraska Plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus, chimeric derivatives thereof, and method of producing an infectious bovine viral diarrhea virus using said plasmid
AUPP655698A0 (en) * 1998-10-16 1998-11-05 Commonwealth Scientific And Industrial Research Organisation Delivery system for porcine somatotropin
US20070025958A1 (en) 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
KR20020043448A (ko) * 2000-12-04 2002-06-10 리송알렉스인근 인터루킨-2 재조합 단백질 및 그의 제조방법
ATE396691T1 (de) * 2001-02-20 2008-06-15 Ortho Mcneil Pharm Inc Zelltherapieverfahren für die behandlung von tumoren
US20040071671A1 (en) * 2001-02-20 2004-04-15 Leturcq Didier J. Cell therapy method for the treatment of tumors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2814039C3 (de) * 1978-03-31 1981-02-19 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von Hybrid-Bakterien
US4405712A (en) * 1981-07-01 1983-09-20 The United States Of America As Represented By The Department Of Health And Human Services LTR-Vectors
US4738927A (en) * 1982-03-31 1988-04-19 Ajinomoto Co. Inc. Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell
AU556353B2 (en) * 1982-12-15 1986-10-30 Ajinomoto Co., Inc. Interleukin-2 polypeptide
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
EP0119621A1 (fr) * 1983-03-21 1984-09-26 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Interleukin-2
WO1985000817A1 (fr) * 1983-08-10 1985-02-28 Amgen Expression microbienne de l'interleukine ii
GB8327880D0 (en) * 1983-10-18 1983-11-16 Ajinomoto Kk Saccharomyces cerevisiae
EP0162898A4 (fr) * 1983-11-14 1987-07-23 Chiron Corp Production d'interleukine-2 en utilisant des genes clones pou r l'interleukine-2 et le facteur alpha de levure.
FR2559782B1 (fr) * 1984-02-16 1986-07-18 Transgene Sa Vecteur d'expression dans les levures de l'interleukine-2, levures transformees et procede de preparation de l'interleukine-2
EP0163603B1 (fr) * 1984-05-08 1989-12-13 Genetics Institute, Inc. Facteur humain de croissance de cellule-T
DE3419995A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens
EP0172619A1 (fr) * 1984-06-20 1986-02-26 Takeda Chemical Industries, Ltd. Transformateur et son utilisation
CA1275954C (fr) * 1984-08-31 1990-11-06 Hing Cheug Wong Fragments augmentant l'expression en 3' et methode
FR2583770B1 (fr) * 1985-06-21 1988-08-19 Transgene Sa Expression de l'il-2 humaine dans les cellules de mammiferes par un poxvirus recombine
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices

Also Published As

Publication number Publication date
ZA872768B (en) 1988-04-27
IL82475A0 (en) 1987-11-30
FI872096A0 (fi) 1987-05-12
DE3715808A1 (de) 1987-12-10
ES2012940A6 (es) 1990-04-16
HUT45558A (en) 1988-07-28
PT84849A (pt) 1987-06-01
BE1000717A5 (fr) 1989-03-21
SE8701934L (sv) 1987-11-13
DK234087D0 (da) 1987-05-08
FI872096A (fi) 1987-11-13
AU603576B2 (en) 1990-11-22
AR241794A1 (es) 1992-12-30
FR2598433A1 (fr) 1987-11-13
MC1821A1 (fr) 1988-03-18
GB2190382B (en) 1990-08-15
NO871939D0 (no) 1987-05-11
CH675731A5 (fr) 1990-10-31
SE8701934D0 (sv) 1987-05-11
AU7270387A (en) 1987-11-19
NZ220246A (en) 1990-07-26
NO871939L (no) 1987-11-13
GR870727B (en) 1987-09-21
PT84849B (pt) 1990-02-08
FR2598433B1 (fr) 1990-09-21
DK234087A (da) 1987-11-13
IT8720479A0 (it) 1987-05-12
GB8711072D0 (en) 1987-06-17
NL8701132A (nl) 1987-12-01
HU205384B (en) 1992-04-28
ES2006476A6 (es) 1989-05-01
ATA263787A (de) 1989-07-15
GB2190382A (en) 1987-11-18
US4992367A (en) 1991-02-12
AT389892B (de) 1990-02-12
IT1215478B (it) 1990-02-14
JPS62278994A (ja) 1987-12-03

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