MC1821A1 - Expression prononcee d'interleukin-2-humain dans des cellules de mammiferes - Google Patents

Expression prononcee d'interleukin-2-humain dans des cellules de mammiferes

Info

Publication number
MC1821A1
MC1821A1 MC871884A MC1884A MC1821A1 MC 1821 A1 MC1821 A1 MC 1821A1 MC 871884 A MC871884 A MC 871884A MC 1884 A MC1884 A MC 1884A MC 1821 A1 MC1821 A1 MC 1821A1
Authority
MC
Monaco
Prior art keywords
interleukin
human
mammalian cells
pronounced expression
pronounced
Prior art date
Application number
MC871884A
Other languages
English (en)
Inventor
Cullen Brian-Richard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1821A1 publication Critical patent/MC1821A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MC871884A 1986-05-12 1987-05-11 Expression prononcee d'interleukin-2-humain dans des cellules de mammiferes MC1821A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/862,082 US4992367A (en) 1986-05-12 1986-05-12 Enhanced expression of human interleukin-2 in mammalian cells

Publications (1)

Publication Number Publication Date
MC1821A1 true MC1821A1 (fr) 1988-03-18

Family

ID=25337602

Family Applications (1)

Application Number Title Priority Date Filing Date
MC871884A MC1821A1 (fr) 1986-05-12 1987-05-11 Expression prononcee d'interleukin-2-humain dans des cellules de mammiferes

Country Status (25)

Country Link
US (1) US4992367A (fr)
JP (1) JPS62278994A (fr)
AR (1) AR241794A1 (fr)
AT (1) AT389892B (fr)
AU (1) AU603576B2 (fr)
BE (1) BE1000717A5 (fr)
CH (1) CH675731A5 (fr)
DE (1) DE3715808A1 (fr)
DK (1) DK234087A (fr)
ES (2) ES2006476A6 (fr)
FI (1) FI872096A (fr)
FR (1) FR2598433B1 (fr)
GB (1) GB2190382B (fr)
GR (1) GR870727B (fr)
HU (1) HU205384B (fr)
IL (1) IL82475A0 (fr)
IT (1) IT1215478B (fr)
LU (1) LU86874A1 (fr)
MC (1) MC1821A1 (fr)
NL (1) NL8701132A (fr)
NO (1) NO871939L (fr)
NZ (1) NZ220246A (fr)
PT (1) PT84849B (fr)
SE (1) SE8701934L (fr)
ZA (1) ZA872768B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU633471B2 (en) * 1987-08-26 1993-02-04 Biogen Idec Ma Inc. Biological materials, processes for producing biological materials and for using such materials in therapy
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices
FR2636231A1 (fr) * 1988-09-09 1990-03-16 Sanofi Sa Cellules eucaryotes recombinees productrices d'interleukine-1 (beta) mature n-glycosylee, procede et vecteurs necessaires pour leur obtention et procede d'obtention d'interleukine-1 (beta) mature n-glycosylee
WO1990010069A1 (fr) * 1989-02-28 1990-09-07 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr ADN pAA 1213-23 ET pAC 262-33 DE PLASMIDE DE RECOMBINAISON CODANT POUR LA SYNTHESE D'INTERLEUKINE-2 HUMAINE, LEUR PROCEDE DE CONSTRUCTION ET SOUCHE DE BACTERIES ESCHERICHIA COLI RRI/pAC 262-33 EN TANT QUE PRODUCTEUR D'INTERLEUKINE-2 HUMAINE
IL95330A0 (en) * 1989-08-11 1991-06-30 Lilly Co Eli Expression of a functional insect specific toxin gene in mammalian cells
GB9106185D0 (en) * 1991-03-22 1991-05-08 Wellcome Found Biological control agents
US5856178A (en) * 1993-08-30 1999-01-05 Utah State University DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same
US5548075A (en) * 1993-08-30 1996-08-20 Utah State University DNA cassette and transgenic organisms carrying lytic peptide-encoding genes
US5641665A (en) * 1994-11-28 1997-06-24 Vical Incorporated Plasmids suitable for IL-2 expression
US5686246A (en) * 1995-08-03 1997-11-11 Kornman; Kenneth S. Detecting genetic predisposition to periodontal disease
EP0855918A4 (fr) 1995-10-17 2002-08-14 Univ Wayne State Interleukine-15 du poulet et ses utilisations
US6001613A (en) * 1996-05-24 1999-12-14 Board Of Regents Of University Of Nebraska Plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus, chimeric derivatives thereof, and method of producing an infectious bovine viral diarrhea virus using said plasmid
AUPP655698A0 (en) 1998-10-16 1998-11-05 Commonwealth Scientific And Industrial Research Organisation Delivery system for porcine somatotropin
US20070025958A1 (en) 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
KR20020043448A (ko) * 2000-12-04 2002-06-10 리송알렉스인근 인터루킨-2 재조합 단백질 및 그의 제조방법
US20040071671A1 (en) * 2001-02-20 2004-04-15 Leturcq Didier J. Cell therapy method for the treatment of tumors
ES2306771T3 (es) * 2001-02-20 2008-11-16 Ortho Mcneil Pharm Inc Un metodo de terapia celular para tratamiento de tumores.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2814039C3 (de) * 1978-03-31 1981-02-19 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von Hybrid-Bakterien
US4405712A (en) * 1981-07-01 1983-09-20 The United States Of America As Represented By The Department Of Health And Human Services LTR-Vectors
EP0091539B2 (fr) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gène codant pour interleukin-2 polypeptide, ADN recombinant portant ledit gène, lignées cellulaires possédant le recombinant ADN et procédé pour la préparation d'interleukin-2 utilisant lesdites cellules
AU556353B2 (en) * 1982-12-15 1986-10-30 Ajinomoto Co., Inc. Interleukin-2 polypeptide
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
EP0119621A1 (fr) * 1983-03-21 1984-09-26 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Interleukin-2
WO1985000817A1 (fr) * 1983-08-10 1985-02-28 Amgen Expression microbienne de l'interleukine ii
GB8327880D0 (en) * 1983-10-18 1983-11-16 Ajinomoto Kk Saccharomyces cerevisiae
WO1985002200A1 (fr) * 1983-11-14 1985-05-23 Chiron Corporation Production d'interleukine-2 en utilisant des genes clones pou r l'interleukine-2 et le facteur alpha de levure
FR2559782B1 (fr) * 1984-02-16 1986-07-18 Transgene Sa Vecteur d'expression dans les levures de l'interleukine-2, levures transformees et procede de preparation de l'interleukine-2
ATE48641T1 (de) * 1984-05-08 1989-12-15 Genetics Inst Ein menschlicher t-zellwachstumsfaktor.
DE3419995A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens
EP0172619A1 (fr) * 1984-06-20 1986-02-26 Takeda Chemical Industries, Ltd. Transformateur et son utilisation
CA1275954C (fr) * 1984-08-31 1990-11-06 Hing Cheug Wong Fragments augmentant l'expression en 3' et methode
FR2583770B1 (fr) * 1985-06-21 1988-08-19 Transgene Sa Expression de l'il-2 humaine dans les cellules de mammiferes par un poxvirus recombine
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices

Also Published As

Publication number Publication date
ZA872768B (en) 1988-04-27
JPS62278994A (ja) 1987-12-03
GB2190382B (en) 1990-08-15
GB8711072D0 (en) 1987-06-17
FI872096A (fi) 1987-11-13
AU603576B2 (en) 1990-11-22
NO871939L (no) 1987-11-13
ATA263787A (de) 1989-07-15
PT84849A (pt) 1987-06-01
DE3715808A1 (de) 1987-12-10
AU7270387A (en) 1987-11-19
IT8720479A0 (it) 1987-05-12
FR2598433B1 (fr) 1990-09-21
BE1000717A5 (fr) 1989-03-21
IT1215478B (it) 1990-02-14
NZ220246A (en) 1990-07-26
ES2012940A6 (es) 1990-04-16
HU205384B (en) 1992-04-28
DK234087D0 (da) 1987-05-08
AR241794A1 (es) 1992-12-30
CH675731A5 (fr) 1990-10-31
LU86874A1 (fr) 1988-06-13
PT84849B (pt) 1990-02-08
SE8701934D0 (sv) 1987-05-11
AT389892B (de) 1990-02-12
IL82475A0 (en) 1987-11-30
SE8701934L (sv) 1987-11-13
FR2598433A1 (fr) 1987-11-13
DK234087A (da) 1987-11-13
NO871939D0 (no) 1987-05-11
FI872096A0 (fi) 1987-05-12
ES2006476A6 (es) 1989-05-01
HUT45558A (en) 1988-07-28
US4992367A (en) 1991-02-12
NL8701132A (nl) 1987-12-01
GB2190382A (en) 1987-11-18
GR870727B (en) 1987-09-21

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